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Article: Male histone deacetylase 6 (HDAC6) knockout mice have enhanced ventilatory responses to hypoxic challenge.

Getsy, Paulina M / Coffee, Gregory A / Kelley, Thomas J / Lewis, Stephen J

2024 Volume 14, Page(s) 1332810

Abstract: Histone deacetylase 6 (HDAC6) is a class II histone deacetylase that is predominantly localized in the cytoplasm of cells. HDAC6 associates with microtubules and regulates acetylation of tubulin and other proteins. The possibility that HDAC6 participates ...

Abstract	Histone deacetylase 6 (HDAC6) is a class II histone deacetylase that is predominantly localized in the cytoplasm of cells. HDAC6 associates with microtubules and regulates acetylation of tubulin and other proteins. The possibility that HDAC6 participates in hypoxic signaling is supported by evidence that 1) hypoxic gas challenges cause microtubule depolymerization, 2) expression of hypoxia inducible factor alpha (HIF-1α) is regulated by microtubule alterations in response to hypoxia, and 3) inhibition of HDAC6 prevents HIF-1α expression and protects tissue from hypoxic/ischemic insults. The aim of this study was to address whether the absence of HDAC6 alters ventilatory responses during and/or after hypoxic gas challenge (10% O
Language	English
Publishing date	2024-02-06
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2564217-0
ISSN	1664-042X
ISSN	1664-042X
DOI	10.3389/fphys.2023.1332810
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Article: Loss of ganglioglomerular nerve input to the carotid body impacts the hypoxic ventilatory response in freely-moving rats.

Getsy, Paulina M / Coffee, Gregory A / Lewis, Stephen J

Frontiers in physiology

2023 Volume 14, Page(s) 1007043

Abstract: The carotid bodies are the primary sensors of blood pH, ... ...

Abstract	The carotid bodies are the primary sensors of blood pH, pO
Language	English
Publishing date	2023-03-16
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2564217-0
ISSN	1664-042X
ISSN	1664-042X
DOI	10.3389/fphys.2023.1007043
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Article ; Online: Recognition of posterior thoracolumbar instrumentations used in spinal deformity surgery and techniques for implant removal.

Kato, So / Lewis, Stephen J

Journal of clinical neuroscience : official journal of the Neurosurgical Society of Australasia

2021 Volume 86, Page(s) 217–222

Abstract: Spinal surgeries requiring implant removals/revisions are becoming more common, as a long time has passed since contemporary spinal instrumentation was developed and utilized. Recognizing implants and manufacturers preoperatively from radiographs and ... ...

Abstract	Spinal surgeries requiring implant removals/revisions are becoming more common, as a long time has passed since contemporary spinal instrumentation was developed and utilized. Recognizing implants and manufacturers preoperatively from radiographs and preparing appropriate instruments for removal are mandatory. The objective of the present paper was to review the various designs of contemporary posterior thoracolumbar spinal implants along with their radiographic features to facilitate the identification of previously used systems in removal or revision surgeries. We focused on contemporary spinal implants that have been commonly used in spinal deformity surgery since the development of screw-and-rod constructs up to 2005. The pertinent information was requested from three major manufacturers (DePuy Synthes, Medtronic and Stryker). Characteristics of each system are reviewed with radiographic features, and the instruments needed for revision are summarized. We propose a systematic identification diagram. Rod loading can be categorized as offset-loading, side-loading or top-loading. Screw design can be cylindrical, conical or dual-core threading. Each system has unique features that can facilitate identification. Identifying the materials and diameters of the rod is also imperative. When removal of an unidentified system is needed or removal of an identified system fails, the short rod has to remain loaded on the screw and the implant removed en bloc as an isolated piece. Understanding the radiographic features of spinal implants used in previous surgeries will help surgeons prepare for the increasing incidence of revision surgeries.
MeSH term(s)	Bone Screws ; Device Removal/methods ; Female ; Humans ; Internal Fixators ; Lumbar Vertebrae/diagnostic imaging ; Lumbar Vertebrae/surgery ; Male ; Neurosurgical Procedures/instrumentation ; Neurosurgical Procedures/methods ; Retrospective Studies ; Spinal Diseases/diagnostic imaging ; Spinal Diseases/surgery ; Spinal Fusion/instrumentation ; Spinal Fusion/methods ; Thoracic Vertebrae/diagnostic imaging ; Thoracic Vertebrae/surgery
Language	English
Publishing date	2021-02-10
Publishing country	Scotland
Document type	Journal Article ; Review
ZDB-ID	1193674-5
ISSN	1532-2653 ; 0967-5868
ISSN (online)	1532-2653
ISSN	0967-5868
DOI	10.1016/j.jocn.2021.01.045
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Article ; Online: Post-operative bracing following adult spine deformity surgery: Results from the AO Spine surveillance of post-operative management of patients with adult spine deformity.

Kato, So / Smith, Justin S / Driesman, Devin / Shaffrey, Christopher I / Lenke, Lawrence G / Lewis, Stephen J

PloS one

2024 Volume 19, Issue 4, Page(s) e0297541

Abstract: Study design: Cross-sectional international survey with a literature review.: Objectives: While some surgeons favor spine bracing after surgery for adult spine deformity (ASD) to help prevent mechanical failures, there is a lack of evidence. The ... ...

Abstract	Study design: Cross-sectional international survey with a literature review. Objectives: While some surgeons favor spine bracing after surgery for adult spine deformity (ASD) to help prevent mechanical failures, there is a lack of evidence. The objective of the present study was to better understand the current trend in the use of bracing following ASD surgery based on an international survey. Methods: An e-mail-based online survey was conducted among over 6000 international AO Spine members regarding the post-operative management of patients with ASD. The details of brace prescription, indications and influencing factors were solicited. Descriptive data were summarized based on different demographic groups and fusion levels for the responding surgeons who annually perform at least 10 long-segment fusions of >5 levels extending to the pelvis. Results: A total of 116 responses were received, including 71 surgeons (61%) who used post-operative bracing for >5 levels of long fusion. The most common reason for bracing was pain management (55%) and bone quality was the strongest influencing factor (69%). Asia-Pacific surgeons had the highest rate of bracing (88%), while North American surgeons had the lowest (45%). The most common type of brace used were TLSO for cases with an uppermost instrumented vertebra (UIV) in the low- or mid-thoracic spine and a cervical brace for UIV at T1-3. The majority (56%) used bracing for 6-12 weeks after surgery. Conclusions: The present survey demonstrated significant interest in bracing following ASD surgery, however, there is substantial variability in post-operative bracing practice. A formal study on the role of bracing in ASD surgery is needed.
MeSH term(s)	Adult ; Humans ; Cross-Sectional Studies ; Spine/surgery ; Braces ; Orthotic Devices ; Surveys and Questionnaires ; Spinal Fusion/methods ; Retrospective Studies
Language	English
Publishing date	2024-04-16
Publishing country	United States
Document type	Review ; Journal Article
ZDB-ID	2267670-3
ISSN	1932-6203 ; 1932-6203
ISSN (online)	1932-6203
ISSN	1932-6203
DOI	10.1371/journal.pone.0297541
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Article: Male histone deacetylase 6 (HDAC6) knockout mice have enhanced ventilatory responses to hypoxic challenge.

Getsy, Paulina M / Coffee, Gregory A / Kelley, Thomas J / Lewis, Stephen J

Research square

2023

Abstract: Histone deacetylase 6 (HDAC6) is a class II histone deacetylase that is predominantly localized in the cytoplasm of cells. HDAC6 associates with microtubules, regulating acetylation of tubulin and other proteins. The possibility that HDAC6 participates ... ...

Abstract	Histone deacetylase 6 (HDAC6) is a class II histone deacetylase that is predominantly localized in the cytoplasm of cells. HDAC6 associates with microtubules, regulating acetylation of tubulin and other proteins. The possibility that HDAC6 participates in hypoxic signaling is supported by evidence that (1) hypoxic gas challenges cause microtubule depolymerization, (2) expression of hypoxia inducible factor alpha (HIF)-1α is regulated by microtubule alterations in response to hypoxia, and (3) inhibition of HDAC6 prevents HIF-1α expression and protects tissue from hypoxic/ischemic insults. The aim of this study was to address whether the absence of HDAC6 alters ventilatory responses during and/or after hypoxic gas challenges (10% O
Language	English
Publishing date	2023-06-13
Publishing country	United States
Document type	Preprint
DOI	10.21203/rs.3.rs-3005686/v1
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Article ; Online: Advances in D-Amino Acids in Neurological Research.

Seckler, James M / Lewis, Stephen J

International journal of molecular sciences

2020 Volume 21, Issue 19

Abstract: D-amino acids have been known to exist in the human brain for nearly 40 years, and they continue to be a field of active study to today. This review article aims to give a concise overview of the recent advances in D-amino acid research as they relate to ...

Abstract	D-amino acids have been known to exist in the human brain for nearly 40 years, and they continue to be a field of active study to today. This review article aims to give a concise overview of the recent advances in D-amino acid research as they relate to the brain and neurological disorders. This work has largely been focused on modulation of the N-methyl-D-aspartate (NMDA) receptor and its relationship to Alzheimer's disease and Schizophrenia, but there has been a wealth of novel research which has elucidated a novel role for several D-amino acids in altering brain chemistry in a neuroprotective manner. D-amino acids which have no currently known activity in the brain but which have active derivatives will also be reviewed.
MeSH term(s)	Alzheimer Disease/metabolism ; Alzheimer Disease/pathology ; Amino Acids/metabolism ; Brain/metabolism ; Brain/pathology ; Brain Chemistry ; Humans ; N-Methylaspartate/genetics ; N-Methylaspartate/metabolism ; Receptors, N-Methyl-D-Aspartate/genetics ; Receptors, N-Methyl-D-Aspartate/metabolism ; Schizophrenia/metabolism ; Schizophrenia/pathology
Chemical Substances	Amino Acids ; Receptors, N-Methyl-D-Aspartate ; N-Methylaspartate (6384-92-5)
Language	English
Publishing date	2020-10-03
Publishing country	Switzerland
Document type	Journal Article ; Review
ZDB-ID	2019364-6
ISSN	1422-0067 ; 1422-0067 ; 1661-6596
ISSN (online)	1422-0067
ISSN	1422-0067 ; 1661-6596
DOI	10.3390/ijms21197325
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Article ; Online: The effect of post-discharge oral nutritional supplements on outcomes after gastrointestinal surgery: A systematic review and meta-analysis

Rowley, Annabel / Adiamah, Alfred / Kushairi, Anisa / Lewis, Stephen J. / Lobo, Dileep N.

Clinical Nutrition. 2023 May 05,

2023

Abstract: Malnutrition is a risk-factor for adverse postoperative outcomes. This systematic review and meta-analysis evaluated the impact of post-discharge oral nutritional supplements (ONS) on outcomes in patients undergoing gastrointestinal surgery. The Medline ... ...

Abstract	Malnutrition is a risk-factor for adverse postoperative outcomes. This systematic review and meta-analysis evaluated the impact of post-discharge oral nutritional supplements (ONS) on outcomes in patients undergoing gastrointestinal surgery. The Medline and Embase databases were searched for randomised clinical trials in patients undergoing gastrointestinal surgery who had received ONS for at least two weeks after discharge from hospital. The primary endpoint was weight change. Secondary endpoints included quality of life, total lymphocyte count, total serum protein and serum albumin. Analysis was performed using RevMan5.4 software. Fourteen studies with 2480 participants (1249 ONS/1231 controls) were included. Pooling of results revealed that a reduction in postoperative weight loss in patients taking ONS, when compared with control: overall weighted mean difference (WMD) −1.69 kg, 95% CI −2.98 to −0.41, P = 0.01. Serum albumin concentration was increased in the ONS group: WMD = 1.06 g/L, 95% CI 0.04 to 2.07, P = 0.04. Haemoglobin was also increased: WMD = 2.91 g/L, 95% CI 0.58 to 5.25, P = 0.01. Total serum protein, total lymphocyte count, total cholesterol and quality of life did not differ between the groups. Patient compliance was relatively poor across the studies and there was variability in the composition of ONS, volume consumed and surgical procedures performed. There was a reduction in postoperative weight loss and an improvement in some biochemical parameters in patients receiving ONS after gastrointestinal surgery. Future RCTs with more consistent methodologies are needed to investigate the efficacy of ONS after discharge from hospital following gastrointestinal surgery.
Keywords	cholesterol ; clinical nutrition ; computer software ; gastrointestinal system ; hemoglobin ; hospitals ; lymphocyte count ; malnutrition ; meta-analysis ; patient compliance ; quality of life ; serum albumin ; surgery ; systematic review ; weight loss ; Post-discharge nutrition ; Oral nutritional supplements ; Postoperative outcomes ; Gastrointestinal surgery ; BWL ; CI ; EORTC ; ESPEN ; NICE ; ONS ; PRISMA ; RCT ; SI ; WMD
Language	English
Dates of publication	2023-0505
Publishing place	Elsevier Ltd
Document type	Article ; Online
Note	Pre-press version ; Use and reproduction
ZDB-ID	604812-2
ISSN	1532-1983 ; 0261-5614
ISSN (online)	1532-1983
ISSN	0261-5614
DOI	10.1016/j.clnu.2023.04.028
Database	NAL-Catalogue (AGRICOLA)

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Zs.A 1774: Show issues

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Article ; Online: Selective neural inhibition via photobiomodulation alleviates behavioral hypersensitivity associated with small sensory fiber activation.

Buzza, Andrew / Tapas, Kalista / Zhuo, Junqi / Anders, Juanita J / Lewis, Stephen J / Jenkins, Michael W / Moffitt, Michael

Lasers in surgery and medicine

2024 Volume 56, Issue 3, Page(s) 305–314

Abstract: Objective: Photobiomodulation at higher irradiances has great potential as a pain-alleviating method that selectively inhibits small diameter nerve fibers and corresponding sensory experiences, such as nociception and heat sensation. The longevity and ... ...

Abstract	Objective: Photobiomodulation at higher irradiances has great potential as a pain-alleviating method that selectively inhibits small diameter nerve fibers and corresponding sensory experiences, such as nociception and heat sensation. The longevity and magnitude of these effects as a function of laser irradiation parameters at the nerve was explored. Methods: In a rodent chronic pain model (spared nerve injury-SNI), light was applied directly at the sural nerve with four delivery schemes: two irradiance levels (7.64 and 2.55 W/cm Results: At emitter irradiances of 7.64 W/cm Conclusions: The data from this study support the use of direct PBM on nerves of interest to reduce sensitivities associated with small-diameter fiber activity.
MeSH term(s)	Humans ; Low-Level Light Therapy/methods ; Chronic Pain ; Nerve Tissue
Language	English
Publishing date	2024-01-30
Publishing country	United States
Document type	Journal Article
ZDB-ID	604493-1
ISSN	1096-9101 ; 0196-8092
ISSN (online)	1096-9101
ISSN	0196-8092
DOI	10.1002/lsm.23762
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Article: The Reducing Agent Dithiothreitol Modulates the Ventilatory Responses That Occur in Freely Moving Rats during and following a Hypoxic-Hypercapnic Challenge.

Getsy, Paulina M / Coffee, Gregory A / May, Walter J / Baby, Santhosh M / Bates, James N / Lewis, Stephen J

Antioxidants (Basel, Switzerland)

2024 Volume 13, Issue 4

Abstract: The present study examined the hypothesis that changes in the oxidation-reduction state of thiol residues in functional proteins play a major role in the expression of the ventilatory responses in conscious rats that occur during a hypoxic-hypercapnic ( ... ...

Abstract	The present study examined the hypothesis that changes in the oxidation-reduction state of thiol residues in functional proteins play a major role in the expression of the ventilatory responses in conscious rats that occur during a hypoxic-hypercapnic (HH) gas challenge and upon return to room air. A HH gas challenge in vehicle-treated rats elicited robust and sustained increases in minute volume (via increases in frequency of breathing and tidal volume), peak inspiratory and expiratory flows, and inspiratory and expiratory drives while minimally affecting the non-eupneic breathing index (NEBI). The HH-induced increases in these parameters, except for frequency of breathing, were substantially diminished in rats pre-treated with the potent and lipophilic disulfide-reducing agent, L,D-dithiothreitol (100 µmol/kg, IV). The ventilatory responses that occurred upon return to room air were also substantially different in dithiothreitol-treated rats. In contrast, pre-treatment with a substantially higher dose (500 µmol/kg, IV) of the lipophilic congener of the monosulfide, N-acetyl-L-cysteine methyl ester (L-NACme), only minimally affected the expression of the above-mentioned ventilatory responses that occurred during the HH gas challenge or upon return to room air. The effectiveness of dithiothreitol suggests that the oxidation of thiol residues occurs during exposure to a HH gas challenge and that this process plays an essential role in allowing for the expression of the post-HH excitatory phase in breathing. However, this interpretation is contradicted by the lack of effects of L-NACme. This apparent conundrum may be explained by the disulfide structure affording unique functional properties to dithiothreitol in comparison to monosulfides. More specifically, the disulfide structure may give dithiothreitol the ability to alter the conformational state of functional proteins while transferring electrons. It is also possible that dithiothreitol is simply a more efficient reducing agent following systemic injection, although one interpretation of the data is that the effects of dithiothreitol are not due to its reducing ability.
Language	English
Publishing date	2024-04-22
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2704216-9
ISSN	2076-3921
ISSN	2076-3921
DOI	10.3390/antiox13040498
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Article ; Online: Surveying nonvisual arrestins reveals allosteric interactions between functional sites.

Seckler, James M / Robinson, Emily N / Lewis, Stephen J / Grossfield, Alan

Proteins

2022 Volume 91, Issue 1, Page(s) 99–107

Abstract: Arrestins are important scaffolding proteins that are expressed in all vertebrate animals. They regulate cell-signaling events upon binding to active G-protein coupled receptors (GPCR) and trigger endocytosis of active GPCRs. While many of the functional ...

Abstract	Arrestins are important scaffolding proteins that are expressed in all vertebrate animals. They regulate cell-signaling events upon binding to active G-protein coupled receptors (GPCR) and trigger endocytosis of active GPCRs. While many of the functional sites on arrestins have been characterized, the question of how these sites interact is unanswered. We used anisotropic network modeling (ANM) together with our covariance compliment techniques to survey all the available structures of the nonvisual arrestins to map how structural changes and protein-binding affect their structural dynamics. We found that activation and clathrin binding have a marked effect on arrestin dynamics, and that these dynamics changes are localized to a small number of distant functional sites. These sites include α-helix 1, the lariat loop, nuclear localization domain, and the C-domain β-sheets on the C-loop side. Our techniques suggest that clathrin binding and/or GPCR activation of arrestin perturb the dynamics of these sites independent of structural changes.
MeSH term(s)	Animals ; Arrestins/metabolism ; beta-Arrestins/metabolism ; Arrestin/metabolism ; Receptors, G-Protein-Coupled/metabolism ; Clathrin/metabolism
Chemical Substances	Arrestins ; beta-Arrestins ; Arrestin ; Receptors, G-Protein-Coupled ; Clathrin
Language	English
Publishing date	2022-08-27
Publishing country	United States
Document type	Journal Article ; Research Support, N.I.H., Extramural
ZDB-ID	806683-8
ISSN	1097-0134 ; 0887-3585
ISSN (online)	1097-0134
ISSN	0887-3585
DOI	10.1002/prot.26413
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