Article ; Online: The effect of dexamethasone on labor induction: a systematic review.
BMC pregnancy and childbirth
2021 Volume 21, Issue 1, Page(s) 563
Abstract: Background: To evaluate the effect of dexamethasone administration on the interval between initiation of labor induction and active phase of labor.: Methods: The databases including PubMed, Cochrane Library, Embase, Scopus and Web of Science were ... ...
Abstract | Background: To evaluate the effect of dexamethasone administration on the interval between initiation of labor induction and active phase of labor. Methods: The databases including PubMed, Cochrane Library, Embase, Scopus and Web of Science were searched for studies published up to June 27, 2021. Two types of articles were included: a) full-text articles published in English or any other languages, and b) Randomized Controlled Trials (RCTs). Participants were primi- or multigravida women with term or post-term pregnancy. The intervention group received parenteral or extra-amniotic dexamethasone whereas the control group received normal saline or no treatment before initiation of labor induction. All data were analyzed using Review Manager 5.3. Results: Seventeen studies involving 1879 patients were included in the meta-analysis. Administration of dexamethasone reduced the interval between the initiation of labor induction and the beginning of active phase by about 70 min [MD: - 1.17 (- 1.37, - 1.00); P < 0.00001]. Duration of the first stage of labor in the dexamethasone group was about 88 min shorter than that in the control. There were no maternal and fetal adverse effects. Conclusions: Dexamethasone could significantly reduce the length of induction-active phase interval, and length of the first stage of labor, with no difference in maternal or fetal adverse effects. |
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MeSH term(s) | Adolescent ; Adult ; Dexamethasone/therapeutic use ; Female ; Glucocorticoids/therapeutic use ; Humans ; Labor, Induced/methods ; Pregnancy ; Pregnancy Outcome ; Time ; Young Adult |
Chemical Substances | Glucocorticoids ; Dexamethasone (7S5I7G3JQL) |
Language | English |
Publishing date | 2021-08-17 |
Publishing country | England |
Document type | Journal Article ; Meta-Analysis ; Systematic Review |
ISSN | 1471-2393 |
ISSN (online) | 1471-2393 |
DOI | 10.1186/s12884-021-04010-1 |
Database | MEDical Literature Analysis and Retrieval System OnLINE |
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