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Article: ITGB1 Suppresses Autophagy Through Inhibiting The mTORC2/AKT Signaling Pathway In H9C2 Cells.

Zhou, Weiwei / Liu, Weizhe / Zhou, Dingyan / Li, Aiying

2022 Volume 77, Issue 5, Page(s) 137–140

Abstract: Cardiomyocyte autophagy is closely related to myocardial infarction and hypertrophy. To study the molecular mechanism of autophagy is helpful for the prevention and treatment of these diseases. As a cell surface receptor, the function of ITGB1 gene in ... ...

Abstract	Cardiomyocyte autophagy is closely related to myocardial infarction and hypertrophy. To study the molecular mechanism of autophagy is helpful for the prevention and treatment of these diseases. As a cell surface receptor, the function of ITGB1 gene in cardiomyocyte autophagy is not clear. The purpose of this research was to investigate the function and molecular mechanism of ITGB1 on autophagy. The autophagy-related marker proteins and signaling molecules were detected using western blot with knockdown and overexpression of ITGB1 in H9C2 cells. The results suggested that ITGB1 could inhibit autophagy and the mTORC2/Akt pathway molecules. To further investigate whether the effect of ITGB1 on autophagy might affect myocardial hypertrophy, we constructed AngII induced H9C2 cells and TAC induced rats models. The results showed that ITGB1 inhibited myocardial hypertrophy in both H9C2 cells and heart tissues of disease model. These data highlight the regulation mechanism on autophagy by ITGB1 and the potential usefulness of the gene as a potential target for preventing heart disease.
MeSH term(s)	Animals ; Autophagy ; Cardiomegaly/metabolism ; Mechanistic Target of Rapamycin Complex 2/metabolism ; Proto-Oncogene Proteins c-akt/metabolism ; Rats ; Signal Transduction
Chemical Substances	Mechanistic Target of Rapamycin Complex 2 (EC 2.7.11.1) ; Proto-Oncogene Proteins c-akt (EC 2.7.11.1)
Language	English
Publishing date	2022-06-02
Publishing country	Germany
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	208793-5
ISSN	0031-7144
ISSN	0031-7144
DOI	10.1691/ph.2022.2351
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Article ; Online: Mechanism of skin whitening through San-Bai decoction-induced tyrosinase inhibition and discovery of natural products targeting tyrosinase.

Li, Liyuan / Tang, Yiran / Li, Xin / Zhou, Tao / Song, Qiuhang / Li, Aiying

Medicine

2023 Volume 102, Issue 13, Page(s) e33420

Abstract: Melanin deposition is the main cause of skin darkening, which can lead to severe physical and psychological distress, necessitating the development of approaches for preserving skin health and fairness. Tyrosinase (TYR) is the rate-limiting enzyme in ... ...

Abstract	Melanin deposition is the main cause of skin darkening, which can lead to severe physical and psychological distress, necessitating the development of approaches for preserving skin health and fairness. Tyrosinase (TYR) is the rate-limiting enzyme in melanin synthesis, and its activity directly determines the degree of melanin accumulation in the skin, which in turn affects skin color. Currently, TYR inhibitors derived from natural products are widely used for skin whitening. San-Bai decoction (SBD) is effective for skin whitening and softening, but its mechanism of action, efficacy and high efficiency TYR inhibitors for skin whitening remain poorly understood. Here, we employed systems biology and network pharmacology to analyze the active compounds and targets of SBD, using the follow databases: TCMIP, TCMID, and BATMAN-TCM. Construct a molecular network centered on the regulation of TYR by SBD in skin whitening, using STRING database and cytoscape. Enrichment analysis using KOBAS database and ClusterProfiler. Virtual screening of candidate TYR inhibitors using Molecular Operating Environment software and Amber 18 software. SBD may act through tyrosine metabolism, melanogenesis, and other signaling pathways to regulate TYR activity and inhibit melanogenesis. We identified TYR and ESR1 as possible key targets for the whitening effect of SBD and screened out pentagalloylglucose, 1,3,6-tri-O-galloyl-beta-D-glucose, 1,2,4,6-tetragalloylglucose, and liquiritigenin 4',7-diglucoside as inhibitors of TYR, in addition to glycyrrhizic acid, pachymic acid methyl ester, nicotiflorin, gamma-sitosterol, and isoliensinine as inhibitors of ESR1. We also performed virtual drug screening of a library of natural small-molecule compounds (19,505 in total) and screened out lycopsamine, 2-phenylethyl b-D-glucopyranoside, and 6-beta-hydroxyhyoscyamine as inhibitors of TYR. We identified natural compounds with the potential for skin whitening through inhibition of TYR, thus advancing research on SBD and its applications.
MeSH term(s)	Humans ; Monophenol Monooxygenase/metabolism ; Monophenol Monooxygenase/pharmacology ; Melanins/metabolism ; Melanins/pharmacology ; Biological Products/pharmacology ; Skin/metabolism ; Skin Pigmentation
Chemical Substances	Monophenol Monooxygenase (EC 1.14.18.1) ; Melanins ; Biological Products
Language	English
Publishing date	2023-03-06
Publishing country	United States
Document type	Journal Article
ZDB-ID	80184-7
ISSN	1536-5964 ; 0025-7974
ISSN (online)	1536-5964
ISSN	0025-7974
DOI	10.1097/MD.0000000000033420
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Article ; Online: Endoscopic retrograde appendicitis therapy for giant periappendiceal abscess with intestinal obstruction.

Li, Qianlong / Liu, Tianyu / Li, Aiying / Liu, Jing / Jiang, Biao / Yang, Bo

Endoscopy

2023 Volume 55, Issue S 01, Page(s) E1116–E1117

MeSH term(s)	Humans ; Abscess ; Appendicitis/complications ; Appendicitis/diagnostic imaging ; Appendicitis/surgery ; Abdominal Abscess/diagnostic imaging ; Abdominal Abscess/etiology ; Abdominal Abscess/surgery ; Intestinal Obstruction/diagnostic imaging ; Intestinal Obstruction/etiology ; Intestinal Obstruction/surgery ; Appendectomy
Language	English
Publishing date	2023-10-06
Publishing country	Germany
Document type	Journal Article
ZDB-ID	80120-3
ISSN	1438-8812 ; 0013-726X
ISSN (online)	1438-8812
ISSN	0013-726X
DOI	10.1055/a-2173-7756
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Zs.A 669: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (1.OG) ab Jg. 2022: Lesesaal (EG)
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Article ; Online: Synthetic biology-inspired strategies and tools for engineering of microbial natural product biosynthetic pathways.

Alam, Khorshed / Hao, Jinfang / Zhang, Youming / Li, Aiying

Biotechnology advances

2021 Volume 49, Page(s) 107759

Abstract: Microbial-derived natural products (NPs) and their derivative products are of great importance and used widely in many fields, especially in pharmaceutical industries. However, there is an immediate need to establish innovative approaches, strategies, ... ...

Abstract	Microbial-derived natural products (NPs) and their derivative products are of great importance and used widely in many fields, especially in pharmaceutical industries. However, there is an immediate need to establish innovative approaches, strategies, and techniques to discover new NPs with novel or enhanced biological properties, due to the less productivity and higher cost on traditional drug discovery pipelines from natural bioresources. Revealing of untapped microbial cryptic biosynthetic gene clusters (BGCs) using DNA sequencing technology and bioinformatics tools makes genome mining possible for NP discovery from microorganisms. Meanwhile, new approaches and strategies in the area of synthetic biology offer great potentials for generation of new NPs by engineering or creating synthetic systems with improved and desired functions. Development of approaches, strategies and tools in synthetic biology can facilitate not only exploration and enhancement in supply, and also in the structural diversification of NPs. Here, we discussed recent advances in synthetic biology-inspired strategies, including bioinformatics and genetic engineering tools and approaches for identification, cloning, editing/refactoring of candidate biosynthetic pathways, construction of heterologous expression hosts, fitness optimization between target pathways and hosts and detection of NP production.
MeSH term(s)	Biological Products ; Biosynthetic Pathways/genetics ; Genetic Engineering ; Multigene Family/genetics ; Synthetic Biology
Chemical Substances	Biological Products
Language	English
Publishing date	2021-04-27
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't ; Review
ZDB-ID	47165-3
ISSN	1873-1899 ; 0734-9750
ISSN (online)	1873-1899
ISSN	0734-9750
DOI	10.1016/j.biotechadv.2021.107759
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Zs.A 3730: Show issues

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Article ; Online: Pleiotropic effects of ActVI-ORFA as an unusual regulatory factor identified in the biosynthetic pathway of actinorhodin in Streptomyces coelicolor.

Li, Caiyun / Li, Le / Huang, Luyao / Li, Aiying

Microbiological research

2021 Volume 250, Page(s) 126792

Abstract: Regulatory networks play critical roles in controlling the the biosynthesis of natural products in Streptomyces. ActVI-ORFA, a regulatory factor encoded by the actinorhodin biosynthetic gene cluster (act cluster), positively controls the production of ... ...

Abstract	Regulatory networks play critical roles in controlling the the biosynthesis of natural products in Streptomyces. ActVI-ORFA, a regulatory factor encoded by the actinorhodin biosynthetic gene cluster (act cluster), positively controls the production of actinorhodin (ACT) in Streptomyces coelicolor, although its regulatory mechanism remains obscure. This study aimed to identify the regulatory targets of ActVI-ORFA. Deletion of ActVI-ORFA caused the differential expression of hundreds of proteins, as determined by two-dimensional electrophoresis and peptide mass fingerprinting analysis. qRT-PCR analysis of some genes encoding these differentially expressed proteins, including act genes and non-act genes, confirmed that ActVI-ORFA could control their transcriptional levels. In an electrophoretic mobility shift assay with a promoter region of a target gene located in the act cluster, no binding was detected, consistent with the lack of a recognizable DNA-binding domain in ActVI-ORFA. Overall, our findings suggest that ActVI-ORFA is a pleiotropic regulatory factor that controls multiple physiological pathways, including secondary metabolite production, probably via an indirect mode.
MeSH term(s)	Anthraquinones/metabolism ; Bacterial Proteins/genetics ; Biosynthetic Pathways/genetics ; DNA, Bacterial/genetics ; Electrophoretic Mobility Shift Assay ; Gene Expression Regulation, Bacterial/genetics ; Multigene Family ; Open Reading Frames ; Secondary Metabolism/genetics ; Secondary Metabolism/physiology ; Streptomyces coelicolor/genetics
Chemical Substances	Anthraquinones ; Bacterial Proteins ; DNA, Bacterial ; actinorhodin (G4HH387T6Z)
Language	English
Publishing date	2021-05-27
Publishing country	Germany
Document type	Journal Article
ZDB-ID	1189614-0
ISSN	1618-0623 ; 0944-5013
ISSN (online)	1618-0623
ISSN	0944-5013
DOI	10.1016/j.micres.2021.126792
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Article: Synthetic biology-inspired strategies and tools for engineering of microbial natural product biosynthetic pathways

Alam, Khorshed / Hao, Jinfang / Zhang, Youming / Li, Aiying

Biotechnology advances. 2021 July, Aug., v. 49

2021

Abstract	Microbial-derived natural products (NPs) and their derivative products are of great importance and used widely in many fields, especially in pharmaceutical industries. However, there is an immediate need to establish innovative approaches, strategies, and techniques to discover new NPs with novel or enhanced biological properties, due to the less productivity and higher cost on traditional drug discovery pipelines from natural bioresources. Revealing of untapped microbial cryptic biosynthetic gene clusters (BGCs) using DNA sequencing technology and bioinformatics tools makes genome mining possible for NP discovery from microorganisms. Meanwhile, new approaches and strategies in the area of synthetic biology offer great potentials for generation of new NPs by engineering or creating synthetic systems with improved and desired functions. Development of approaches, strategies and tools in synthetic biology can facilitate not only exploration and enhancement in supply, and also in the structural diversification of NPs. Here, we discussed recent advances in synthetic biology-inspired strategies, including bioinformatics and genetic engineering tools and approaches for identification, cloning, editing/refactoring of candidate biosynthetic pathways, construction of heterologous expression hosts, fitness optimization between target pathways and hosts and detection of NP production.
Keywords	DNA ; bioinformatics ; biosynthesis ; biotechnology ; drugs ; heterologous gene expression ; synthetic biology
Language	English
Dates of publication	2021-07
Publishing place	Elsevier Inc.
Document type	Article
Note	NAL-AP-2-clean
ZDB-ID	47165-3
ISSN	0734-9750
ISSN	0734-9750
DOI	10.1016/j.biotechadv.2021.107759
Database	NAL-Catalogue (AGRICOLA)

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Article: Covalent RGD–graphene–phthalocyanine nanocomposite for fluorescence imaging-guided dual active/passive tumor-targeted combinatorial phototherapy

Ouyang, Ancheng / Zhao, Dongmu / Wang, Xianglei / Zhang, Wei / Jiang, Tianyu / Li, Aiying / Liu, Wei

Journal of materials chemistry B. 2022 Jan. 5, v. 10, no. 2

2022

Abstract: Poor tumor selectivity, low stability and quenched fluorescence are the main challenges to be overcome for nanomedicine, and are mainly caused by the dissociation of the nanostructure and aggregation of chromophores in the biological environment. Herein, ...

Abstract	Poor tumor selectivity, low stability and quenched fluorescence are the main challenges to be overcome for nanomedicine, and are mainly caused by the dissociation of the nanostructure and aggregation of chromophores in the biological environment. Herein, covalently connected nanoparticles RGD–graphene–phthalocyanine (RGD–GO–SiPc) were constructed based on RGD peptide, silicon phthalocyanine (SiPc) and graphene oxide (GO) via a conjugation reaction for fluorescence imaging-guided cancer-targeted combinatorial phototherapy. The prepared RGD–GO–SiPc exhibited supreme biological stability, high-contrast fluorescence imaging, significantly enhanced NIR absorption, high photothermal conversion efficiency (25.6%), greatly improved cancer-targeting capability, and synergistic photodynamic (PDT) and photothermal therapy (PTT) efficacy along with low toxicity. Both in vitro and in vivo biological studies showed that RGD–GO–SiPc is a kind of promising multifunctional nanomedicine for fluorescence imaging-guided combined photothermal and photodynamic therapy with dual active/passive tumor-targeting properties.
Keywords	absorption ; chemical bonding ; dissociation ; fluorescence ; graphene oxide ; nanocomposites ; nanomedicine ; neoplasms ; peptides ; photochemotherapy ; photothermotherapy ; silicon ; toxicity
Language	English
Dates of publication	2022-0105
Size	p. 306-320.
Publishing place	The Royal Society of Chemistry
Document type	Article
ZDB-ID	2702241-9
ISSN	2050-7518 ; 2050-750X
ISSN (online)	2050-7518
ISSN	2050-750X
DOI	10.1039/d1tb02254g
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Article: Network pharmacology and computer-aided drug design to explored potential targets of Lianhua Qingwen and Qingfei Paidu decoction for COVID-19.

Li, Liyuan / Wang, Xiaoying / Guo, Xiao / Li, Yikun / Song, Qiuhang / Li, Aiying

Frontiers in pharmacology

2022 Volume 13, Page(s) 1013428

Abstract: Coronavirus disease 2019 (COVID-19) caused by SARS-CoV-2, has spread globally, affecting people's lives worldwide and hindering global development. Traditional Chinese Medicine (TCM) plays a unique role in preventing and treating COVID-19. Representative ...

Abstract	Coronavirus disease 2019 (COVID-19) caused by SARS-CoV-2, has spread globally, affecting people's lives worldwide and hindering global development. Traditional Chinese Medicine (TCM) plays a unique role in preventing and treating COVID-19. Representative prescriptions for the COVID-19 treatment, Lianhua Qingwen (LHQW) and Qingfei Paidu Decoction (QFPD), effectively alleviate COVID-19 symptoms, delaying its progression and preventing its occurrence. Despite the extensive similarity in their therapeutic effects, the mechanisms and advantages of LHQW and QFPD in in treating mild-to-moderate COVID-19 remain elusive. To characterize the mechanisms of LHQW and QFPD in treating COVID-19, we used integrated network pharmacology and system biology to compare the LHQW and QFPD components, active compounds and their targets in Homo sapiens. LHQW and QFPD comprise 196 and 310 active compounds, some of which have identical targets. These targets are enriched in pathways associated with inflammation, immunity, apoptosis, oxidative stress, etc. However, the two TCM formulas also have specific active compounds and targets. In LHQW, arctiin, corymbosin, and aloe-emodin target neurological disease-related genes (GRM1 and GRM5), whereas in QFPD, isofucosterol, baicalein, nobiletin, oroxylin A, epiberberine, and piperlonguminine target immunity- and inflammation-related genes (mTOR and PLA2G4A). Our findings indicate that LHQW may be suitable for treating mild-to-moderate COVID-19 with nervous system symptoms. Moreover, QFPD may effectively regulate oxidative stress damage and inflammatory symptoms induced by SARS-CoV-2. These findings may provide references for the clinical application of LHQW and QFPD.
Language	English
Publishing date	2022-09-23
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2587355-6
ISSN	1663-9812
ISSN	1663-9812
DOI	10.3389/fphar.2022.1013428
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Article ; Online: Diterpenoids from Streptomyces: Structures, Biosyntheses and Bioactivities.

Gong, Kai / Yong, Daojing / Fu, Jun / Li, Aiying / Zhang, Youming / Li, Ruijuan

Chembiochem : a European journal of chemical biology

2022 Volume 23, Issue 17, Page(s) e202200231

Abstract: Bacteria, especially Streptomyces spp., have emerged as a rich source for natural diterpenoids with diverse structures and broad bioactivities. Here, we review diterpenoids biosynthesized by Streptomyces, with an emphasis on their structures, ... ...

Abstract	Bacteria, especially Streptomyces spp., have emerged as a rich source for natural diterpenoids with diverse structures and broad bioactivities. Here, we review diterpenoids biosynthesized by Streptomyces, with an emphasis on their structures, biosyntheses, and bioactivities. Although diterpenoids from Streptomyces are relatively rare compared to those from plants and fungi, their novel skeletons, biosyntheses and bioactivities present opportunities for discovering new drugs, enzyme mechanisms, and applications in biocatalysis and metabolic pathway engineering.
MeSH term(s)	Diterpenes/chemistry ; Fungi/metabolism ; Metabolic Engineering ; Metabolic Networks and Pathways ; Streptomyces
Chemical Substances	Diterpenes
Language	English
Publishing date	2022-06-20
Publishing country	Germany
Document type	Journal Article ; Review ; Research Support, Non-U.S. Gov't
ZDB-ID	2020469-3
ISSN	1439-7633 ; 1439-4227
ISSN (online)	1439-7633
ISSN	1439-4227
DOI	10.1002/cbic.202200231
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Article ; Online: Covalent RGD-graphene-phthalocyanine nanocomposite for fluorescence imaging-guided dual active/passive tumor-targeted combinatorial phototherapy.

Ouyang, Ancheng / Zhao, Dongmu / Wang, Xianglei / Zhang, Wei / Jiang, Tianyu / Li, Aiying / Liu, Wei

Journal of materials chemistry. B

2022 Volume 10, Issue 2, Page(s) 306–320

Abstract	Poor tumor selectivity, low stability and quenched fluorescence are the main challenges to be overcome for nanomedicine, and are mainly caused by the dissociation of the nanostructure and aggregation of chromophores in the biological environment. Herein, covalently connected nanoparticles RGD-graphene-phthalocyanine (RGD-GO-SiPc) were constructed based on RGD peptide, silicon phthalocyanine (SiPc) and graphene oxide (GO)
MeSH term(s)	Animals ; Antineoplastic Agents/chemistry ; Antineoplastic Agents/radiation effects ; Antineoplastic Agents/therapeutic use ; Cell Line, Tumor ; Female ; Fluorescent Dyes/chemistry ; Fluorescent Dyes/radiation effects ; Fluorescent Dyes/therapeutic use ; Graphite/chemistry ; Graphite/radiation effects ; Graphite/therapeutic use ; HEK293 Cells ; Humans ; Isoindoles/chemistry ; Isoindoles/radiation effects ; Isoindoles/therapeutic use ; Light ; Mice ; Nanocomposites/chemistry ; Nanocomposites/radiation effects ; Nanocomposites/therapeutic use ; Nanoparticles/chemistry ; Nanoparticles/radiation effects ; Nanoparticles/therapeutic use ; Neoplasms/diagnostic imaging ; Neoplasms/drug therapy ; Neoplasms/metabolism ; Oligopeptides/chemistry ; Optical Imaging ; Photochemotherapy ; Photosensitizing Agents/chemistry ; Photosensitizing Agents/radiation effects ; Photosensitizing Agents/therapeutic use ; Phototherapy ; Singlet Oxygen/metabolism
Chemical Substances	Antineoplastic Agents ; Fluorescent Dyes ; Isoindoles ; Oligopeptides ; Photosensitizing Agents ; graphene oxide ; Singlet Oxygen (17778-80-2) ; Graphite (7782-42-5) ; arginyl-glycyl-aspartic acid (78VO7F77PN) ; phthalocyanine (V5PUF4VLGY)
Language	English
Publishing date	2022-01-05
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2702241-9
ISSN	2050-7518 ; 2050-750X
ISSN (online)	2050-7518
ISSN	2050-750X
DOI	10.1039/d1tb02254g
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