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  1. Article ; Online: Structural basis of the recognition of adeno-associated virus by the neurological system-related receptor carbonic anhydrase IV.

    Zhang, Ran / Liu, Yixiao / Yu, Fengxi / Xu, Guangxue / Li, Lili / Li, Baobin / Lou, Zhiyong

    PLoS pathogens

    2024  Volume 20, Issue 2, Page(s) e1011953

    Abstract: Carbonic anhydrase IV (Car4) is a newly identified receptor that allows adeno-associated virus (AAV) 9P31 to cross the blood-brain barrier and achieve efficient infection in the central nervous system (CNS) in mouse models. However, the molecular ... ...

    Abstract Carbonic anhydrase IV (Car4) is a newly identified receptor that allows adeno-associated virus (AAV) 9P31 to cross the blood-brain barrier and achieve efficient infection in the central nervous system (CNS) in mouse models. However, the molecular mechanism by which engineered AAV capsids with 7-mer insertion in the variable region (VR) VIII recognize these novel cellular receptors is unknown. Here we report the cryo-EM structures of AAV9P31 and its complex with Mus musculus Car4 at atomic resolution by utilizing the block-based reconstruction (BBR) method. The structures demonstrated that Car4 binds to the protrusions at 3-fold axes of the capsid. The inserted 7-mer extends into a hydrophobic region near the catalytic center of Car4 to form stable interactions. Mutagenesis studies also identified the key residues in Car4 responsible for the AAV9P31 interaction. These findings provide new insights into the novel receptor recognition mechanism of AAV generated by directed evolution and highlight the application of the BBR method to studying the virus-receptor molecular mechanism.
    MeSH term(s) Animals ; Mice ; Dependovirus/genetics ; Carbonic Anhydrase IV/analysis ; Carbonic Anhydrase IV/metabolism ; Capsid/metabolism ; Capsid Proteins/metabolism ; Blood-Brain Barrier/metabolism ; Genetic Vectors
    Chemical Substances Carbonic Anhydrase IV (EC 4.2.1.-) ; Capsid Proteins
    Language English
    Publishing date 2024-02-05
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2205412-1
    ISSN 1553-7374 ; 1553-7374
    ISSN (online) 1553-7374
    ISSN 1553-7374
    DOI 10.1371/journal.ppat.1011953
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article: Reliability and validity analysis of personality assessment model based on gait video.

    Wen, Yeye / Li, Baobin / Chen, Deyuan / Zhu, Tingshao

    Frontiers in behavioral neuroscience

    2022  Volume 16, Page(s) 901568

    Abstract: Personality affects an individual's academic achievements, occupational tendencies, marriage quality and physical health, so more convenient and objective personality assessment methods are needed. Gait is a natural, stable, and easy-to-observe body ... ...

    Abstract Personality affects an individual's academic achievements, occupational tendencies, marriage quality and physical health, so more convenient and objective personality assessment methods are needed. Gait is a natural, stable, and easy-to-observe body movement that is closely related to personality. The purpose of this paper is to propose a personality assessment model based on gait video and evaluate the reliability and validity of the multidimensional model. This study recruited 152 participants and used cameras to record their gait videos. Each participant completed a 44-item Big Five Inventory (BFI-44) assessment. We constructed diverse static and dynamic time-frequency features based on gait skeleton coordinates, interframe differences, distances between joints, angles between joints, and wavelet decomposition coefficient arrays. We established multidimensional personality trait assessment models through machine learning algorithms and evaluated the criterion validity, split-half reliability, convergent validity, and discriminant validity of these models. The results showed that the reliability and validity of the Gaussian process regression (GPR) and linear regression (LR) models were best. The mean values of their criterion validity were 0.478 and 0.508, respectively, and the mean values of their split-half reliability were all greater than 0.8. In the formed multitrait-multimethod matrix, these methods also had higher convergent and discriminative validity. The proposed approach shows that gait video can be effectively used to evaluate personality traits, providing a new idea for the formation of convenient and non-invasive personality assessment methods.
    Language English
    Publishing date 2022-08-02
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2452960-6
    ISSN 1662-5153
    ISSN 1662-5153
    DOI 10.3389/fnbeh.2022.901568
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  3. Article ; Online: Using gait videos to automatically assess anxiety.

    Wen, Yeye / Li, Baobin / Liu, Xiaoqian / Chen, Deyuan / Gao, Shaoshuai / Zhu, Tingshao

    Frontiers in public health

    2023  Volume 11, Page(s) 1082139

    Abstract: Background: In recent years, the number of people with anxiety disorders has increased worldwide. Methods for identifying anxiety through objective clues are not yet mature, and the reliability and validity of existing modeling methods have not been ... ...

    Abstract Background: In recent years, the number of people with anxiety disorders has increased worldwide. Methods for identifying anxiety through objective clues are not yet mature, and the reliability and validity of existing modeling methods have not been tested. The objective of this paper is to propose an automatic anxiety assessment model with good reliability and validity.
    Methods: This study collected 2D gait videos and Generalized Anxiety Disorder (GAD-7) scale data from 150 participants. We extracted static and dynamic time-domain features and frequency-domain features from the gait videos and used various machine learning approaches to build anxiety assessment models. We evaluated the reliability and validity of the models by comparing the influence of factors such as the frequency-domain feature construction method, training data size, time-frequency features, gender, and odd and even frame data on the model.
    Results: The results show that the number of wavelet decomposition layers has a significant impact on the frequency-domain feature modeling, while the size of the gait training data has little impact on the modeling effect. In this study, the time-frequency features contributed to the modeling, with the dynamic features contributing more than the static features. Our model predicts anxiety significantly better in women than in men (
    Conclusion: This study shows that anxiety assessment based on 2D gait video modeling is reliable and effective. Moreover, we provide a basis for the development of a real-time, convenient and non-invasive automatic anxiety assessment method.
    MeSH term(s) Humans ; Male ; Female ; Reproducibility of Results ; Gait ; Anxiety Disorders ; Anxiety ; Patient Health Questionnaire
    Language English
    Publishing date 2023-03-17
    Publishing country Switzerland
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2711781-9
    ISSN 2296-2565 ; 2296-2565
    ISSN (online) 2296-2565
    ISSN 2296-2565
    DOI 10.3389/fpubh.2023.1082139
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Structures of tweety homolog proteins TTYH2 and TTYH3 reveal a Ca

    Li, Baobin / Hoel, Christopher M / Brohawn, Stephen G

    Nature communications

    2021  Volume 12, Issue 1, Page(s) 6913

    Abstract: Tweety homologs (TTYHs) comprise a conserved family of transmembrane proteins found in eukaryotes with three members (TTYH1-3) in vertebrates. They are widely expressed in mammals including at high levels in the nervous system and have been implicated in ...

    Abstract Tweety homologs (TTYHs) comprise a conserved family of transmembrane proteins found in eukaryotes with three members (TTYH1-3) in vertebrates. They are widely expressed in mammals including at high levels in the nervous system and have been implicated in cancers and other diseases including epilepsy, chronic pain, and viral infections. TTYHs have been reported to form Ca
    MeSH term(s) Animals ; Anoctamins/chemistry ; Biological Transport ; Calcium/metabolism ; Cell Adhesion ; Cell Size ; Chloride Channels/chemistry ; Chloride Channels/genetics ; Chloride Channels/metabolism ; Chronic Pain ; Cryoelectron Microscopy ; Dimerization ; Eukaryota ; Hydrophobic and Hydrophilic Interactions ; Membrane Proteins/chemistry ; Membrane Proteins/genetics ; Membrane Proteins/metabolism ; Mice ; Receptor, EphB2 ; Signal Transduction
    Chemical Substances Anoctamins ; Chloride Channels ; Membrane Proteins ; TTYH3 protein, mouse ; Ttyh1 protein, mouse ; Ttyh2 protein, mouse ; EPHB2 protein, human (EC 2.7.10.1) ; Receptor, EphB2 (EC 2.7.10.1) ; Calcium (SY7Q814VUP)
    Language English
    Publishing date 2021-11-25
    Publishing country England
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
    ZDB-ID 2553671-0
    ISSN 2041-1723 ; 2041-1723
    ISSN (online) 2041-1723
    ISSN 2041-1723
    DOI 10.1038/s41467-021-27283-8
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Structural basis for pH gating of the two-pore domain K

    Li, Baobin / Rietmeijer, Robert A / Brohawn, Stephen G

    Nature

    2020  Volume 586, Issue 7829, Page(s) 457–462

    Abstract: TASK2 (also known as KCNK5) channels generate pH-gated leak-type ... ...

    Abstract TASK2 (also known as KCNK5) channels generate pH-gated leak-type K
    MeSH term(s) Animals ; Cryoelectron Microscopy ; Hydrogen-Ion Concentration ; Ion Channel Gating ; Mice ; Models, Molecular ; Potassium/metabolism ; Potassium Channels, Tandem Pore Domain/chemistry ; Potassium Channels, Tandem Pore Domain/metabolism ; Potassium Channels, Tandem Pore Domain/ultrastructure ; Protein Domains ; Structure-Activity Relationship
    Chemical Substances Kcnk5 protein, mouse ; Potassium Channels, Tandem Pore Domain ; Potassium (RWP5GA015D)
    Language English
    Publishing date 2020-09-30
    Publishing country England
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
    ZDB-ID 120714-3
    ISSN 1476-4687 ; 0028-0836
    ISSN (online) 1476-4687
    ISSN 0028-0836
    DOI 10.1038/s41586-020-2770-2
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 26: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)
    Zs.MG 9: Show issues
    Zs.MO 244: Show issues

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  6. Article ; Online: Physical basis for distinct basal and mechanically gated activity of the human K

    Rietmeijer, Robert A / Sorum, Ben / Li, Baobin / Brohawn, Stephen G

    Neuron

    2021  Volume 109, Issue 18, Page(s) 2902–2913.e4

    Abstract: TRAAK is a mechanosensitive two-pore domain ... ...

    Abstract TRAAK is a mechanosensitive two-pore domain K
    MeSH term(s) Animals ; Female ; Humans ; Ion Channel Gating/physiology ; Mechanotransduction, Cellular/physiology ; Neurons/physiology ; Physical Stimulation/methods ; Potassium Channels/chemistry ; Potassium Channels/physiology ; Protein Structure, Secondary ; Protein Structure, Tertiary ; Saccharomycetales ; Xenopus laevis
    Chemical Substances KCNK4 protein, human ; Potassium Channels
    Language English
    Publishing date 2021-08-13
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
    ZDB-ID 808167-0
    ISSN 1097-4199 ; 0896-6273
    ISSN (online) 1097-4199
    ISSN 0896-6273
    DOI 10.1016/j.neuron.2021.07.009
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 2496: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)
    Zs.MG 92: Show issues

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  7. Article ; Online: Volatile Profiling and Transcriptome Sequencing Provide Insights into the Biosynthesis of α-Pinene and β-Pinene in

    Li, Yongquan / Gao, Yanfang / Deng, Lin / Lian, Huiming / Guo, Wei / Wu, Wei / Xue, Bine / Li, Baobin / Su, Yuzhen / Zhang, Hui

    Genes

    2023  Volume 14, Issue 1

    Abstract: Liquidambar ... ...

    Abstract Liquidambar formosana
    MeSH term(s) Transcriptome/genetics ; Liquidambar/chemistry ; Liquidambar/genetics ; Phylogeny ; Plant Leaves/physiology
    Chemical Substances beta-pinene (4MS8VHZ1HJ) ; alpha-pinene (JPF3YI7O34)
    Language English
    Publishing date 2023-01-06
    Publishing country Switzerland
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2527218-4
    ISSN 2073-4425 ; 2073-4425
    ISSN (online) 2073-4425
    ISSN 2073-4425
    DOI 10.3390/genes14010163
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: Volatile Profiling and Transcriptome Sequencing Provide Insights into the Biosynthesis of α-Pinene and β-Pinene in Liquidambar formosana Hance Leaves

    Li, Yongquan / Gao, Yanfang / Deng, Lin / Lian, Huiming / Guo, Wei / Wu, Wei / Xue, Bine / Li, Baobin / Su, Yuzhen / Zhang, Hui

    Genes (Basel). 2023 Jan. 06, v. 14, no. 1

    2023  

    Abstract: Liquidambar formosana Hance is a pinene-rich deciduous plant species in the Altingiaceae family that is used as a medicinal plant in China. However, the regulatory mechanisms underlying α-pinene and β-pinene biosynthesis in L. formosana leaves remain ... ...

    Abstract Liquidambar formosana Hance is a pinene-rich deciduous plant species in the Altingiaceae family that is used as a medicinal plant in China. However, the regulatory mechanisms underlying α-pinene and β-pinene biosynthesis in L. formosana leaves remain unknown. Here, a joint analysis of the volatile compounds and transcriptomes of L. formosana leaves was performed to comprehensively explore the terpene synthase (TPS) that may participate in α-pinene and β-pinene biosynthesis. Headspace solid-phase microextraction (HS-SPME) and gas chromatography–mass spectrometry (GC–MS) jointly detected volatile L. formosana leaves. Trees with high and low levels of both α-pinene and β-pinene were defined as the H group and L group, respectively. RNA sequencing data revealed that DXR (1-deoxy-D-xylulose-5-phosphate reductoisomerase), HDS [(E)-4-hydroxy-3-methylbut-2-eny-l-diphosphate synthase], and TPS may be the major regulators of monoterpenoid biosynthesis. We identified three TPSs (LfTPS1, LfTPS2, and LfTPS3), which are highly homologous to α-pinene and β-pinene synthases of other species in phylogenetic analysis. Four TPS genes (LfTPS1, LfTPS2, LfTPS4, LfTPS5) may be critically involved in the biosynthesis and regulation of α-pinene and β-pinene in L. formosana. Bioinformatic and transcriptomic results were verified using quantitative real-time PCR. We identified LfTPS1, LfTPS2 as candidate genes for α-pinene and β-pinene biosynthesis that significantly improve the yield of beneficial terpenoids.
    Keywords Liquidambar formosana ; RNA ; bioinformatics ; biosynthesis ; gas chromatography-mass spectrometry ; headspace analysis ; medicinal plants ; monoterpenoids ; phylogeny ; quantitative polymerase chain reaction ; solid phase microextraction ; terpene synthases ; transcriptome ; transcriptomics ; China
    Language English
    Dates of publication 2023-0106
    Publishing place Multidisciplinary Digital Publishing Institute
    Document type Article ; Online
    ZDB-ID 2527218-4
    ISSN 2073-4425
    ISSN 2073-4425
    DOI 10.3390/genes14010163
    Database NAL-Catalogue (AGRICOLA)

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  9. Book ; Online: Coupling Chaotic System Based on Unit Transform and Its Applications in Image Encryption

    Hu, Guozhen / Li, Baobin

    2019  

    Abstract: Chaotic maps are very important for establishing chaos-based image encryption systems. This paper introduces a coupling chaotic system based on a certain unit transform, which can combine any two 1D chaotic maps to generate a new one with excellent ... ...

    Abstract Chaotic maps are very important for establishing chaos-based image encryption systems. This paper introduces a coupling chaotic system based on a certain unit transform, which can combine any two 1D chaotic maps to generate a new one with excellent performance. The chaotic behavior analysis has verified this coupling system's effectiveness and progress. In particular, we give a specific strategy about selecting an appropriate unit transform function to enhance chaos of generated maps. Besides, a new chaos based pseudo-random number generator, shorted as CBPRNG, is designed to improve the distribution of chaotic sequences. We give a mathematical illustration on the uniformity of CBPRNG, and test the randomness of it. Moreover, based on CBPRNG, an image encryption algorithm is introduced. Simulation results and security analysis indicate that the proposed image encryption scheme is competitive with some advanced existing methods.

    Comment: 41 pages, 15 figures
    Keywords Computer Science - Cryptography and Security ; Electrical Engineering and Systems Science - Image and Video Processing
    Subject code 515
    Publishing date 2019-09-18
    Publishing country us
    Document type Book ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

    Full text online

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  10. Article: Identifying Psychological Symptoms Based on Facial Movements.

    Wang, Xiaoyang / Wang, Yilin / Zhou, Mingjie / Li, Baobin / Liu, Xiaoqian / Zhu, Tingshao

    Frontiers in psychiatry

    2020  Volume 11, Page(s) 607890

    Abstract: Background: ...

    Abstract Background:
    Language English
    Publishing date 2020-12-15
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2564218-2
    ISSN 1664-0640
    ISSN 1664-0640
    DOI 10.3389/fpsyt.2020.607890
    Database MEDical Literature Analysis and Retrieval System OnLINE

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