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Article ; Online: Multi-Level Optimization for Data-Driven Camera-LiDAR Calibration in Data Collection Vehicles.

Jiang, Zijie / Cai, Zhongliang / Hui, Nian / Li, Bozhao

2023 Volume 23, Issue 21

Abstract: Accurately calibrating camera-LiDAR systems is crucial for achieving effective data fusion, particularly in data collection vehicles. Data-driven calibration methods have gained prominence over target-based methods due to their superior adaptability to ... ...

Abstract	Accurately calibrating camera-LiDAR systems is crucial for achieving effective data fusion, particularly in data collection vehicles. Data-driven calibration methods have gained prominence over target-based methods due to their superior adaptability to diverse environments. However, current data-driven calibration methods are susceptible to suboptimal initialization parameters, which can significantly impact the accuracy and efficiency of the calibration process. In response to these challenges, this paper proposes a novel general model for the camera-LiDAR calibration that abstracts away the technical details in existing methods, introduces an improved objective function that effectively mitigates the issue of suboptimal parameter initialization, and develops a multi-level parameter optimization algorithm that strikes a balance between accuracy and efficiency during iterative optimization. The experimental results demonstrate that the proposed method effectively mitigates the effects of suboptimal initial calibration parameters, achieving highly accurate and efficient calibration results. The suggested technique exhibits versatility and adaptability to accommodate various sensor configurations, making it a notable advancement in the field of camera-LiDAR calibration, with potential applications in diverse fields including autonomous driving, robotics, and computer vision.
Language	English
Publishing date	2023-11-01
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2052857-7
ISSN	1424-8220 ; 1424-8220
ISSN (online)	1424-8220
ISSN	1424-8220
DOI	10.3390/s23218889
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Article ; Online: A fractional derivative model for nuclides transport in heterogeneous fractured media.

Wang, Zhaoyang / Sun, HongGuang / Tang, Zhuochao / Li, Bozhao / Qian, Jiazhong / Zhang, Chuanzeng

Journal of contaminant hydrology

2023 Volume 259, Page(s) 104265

Abstract: Nuclide transport in fractured media involves the advection, dispersion, adsorption, etc. The dispersion and adsorption properties of the rock matrix have spatial variability, which results in an anomalous transport of nuclides. In this study, a time- ... ...

Abstract	Nuclide transport in fractured media involves the advection, dispersion, adsorption, etc. The dispersion and adsorption properties of the rock matrix have spatial variability, which results in an anomalous transport of nuclides. In this study, a time-fractional advection-diffusion equation (t-FADE) model is utilized to capture the sub-diffusion transport behavior with heavy-tail property, including the breakthrough curves (BTCs) of uranium and thorium transport in granite plates. Moreover, hydrodynamic dispersion of tritiated water, strontium and cesium in granite fractures are also studied. The results indicate that BTCs of nuclides transport in the granite fractures are unimodal and asymmetric. The decrease of the fractional order α reflects the stronger sub-diffusion. Furthermore, small initial velocity enhances sub-diffusion effect of nuclides and lengthens the breakout time of BTCs, which results in obvious heavy-tail phenomena. The analysis results demonstrate that the t-FADE model can accurately describe sub-diffusion behavior of nuclides transport. At last, the advantages of the t-FADE model in prediction and remediation of nuclides contamination are put forward.
MeSH term(s)	Models, Theoretical ; Water Movements ; Silicon Dioxide ; Diffusion
Chemical Substances	granite ; Silicon Dioxide (7631-86-9)
Language	English
Publishing date	2023-11-07
Publishing country	Netherlands
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	1494766-3
ISSN	1873-6009 ; 0169-7722
ISSN (online)	1873-6009
ISSN	0169-7722
DOI	10.1016/j.jconhyd.2023.104265
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Article ; Online: Tumor-Targeted Delivery of IL-2 by Fusing with a pH Low Insertion Peptide for Antitumor Immunotherapy.

Chu, Tianjiao / Cao, Bowei / Wang, Peina / Li, Bozhao / Ren, Jinna / Nie, Guangjun / Wei, Jingyan / Li, Suping

Bioconjugate chemistry

2023 Volume 34, Issue 10, Page(s) 1894–1901

Abstract: As a pleiotropic cytokine, interleukin-2 (IL-2) can effectively regulate lymphocyte proliferation, survival, and active antitumor immune responses in tumor microenvironments. Although the ability of IL-2 to boost immune responses was reported in cancer ... ...

Abstract	As a pleiotropic cytokine, interleukin-2 (IL-2) can effectively regulate lymphocyte proliferation, survival, and active antitumor immune responses in tumor microenvironments. Although the ability of IL-2 to boost immune responses was reported in cancer patients, its short circulating half-life and high toxicity hinder its broad and continual clinical application. Herein, we developed a novel tumor target agent by fusing pH low insertion peptides (pHLIP) with IL-2, forming the fusion protein pHLIP-IL2. Based on the low pH insertion property of pHLIP, the pHLIP-IL2 fusion protein could be selectively delivered to the acidic tumor microenvironments and then promote the proliferation of killer immune cells to elicit tumor regression. We found that pHLIP-IL2 fusion proteins can be significantly enriched in tumor tissues and can effectively reduce tumor size in diverse tumor models, including breast cancer and melanoma, without apparent adverse effects. These data suggest that the pHLIP-IL2 fusion protein may be a promising solution for the continual and extensive application of IL-2, and pHLIP-IL2 is a potential and valuable therapeutic drug for cancer patients with antitumor immunotherapy.
MeSH term(s)	Humans ; Cell Line, Tumor ; Hydrogen-Ion Concentration ; Immunotherapy ; Interleukin-2/administration & dosage ; Melanoma/drug therapy ; Tumor Microenvironment ; Drug Delivery Systems
Chemical Substances	Interleukin-2
Language	English
Publishing date	2023-10-03
Publishing country	United States
Document type	Journal Article
ZDB-ID	1024041-x
ISSN	1520-4812 ; 1043-1802
ISSN (online)	1520-4812
ISSN	1043-1802
DOI	10.1021/acs.bioconjchem.3c00401
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Article ; Online: The dynamic role of platelets in cancer progression and their therapeutic implications.

Li, Suping / Lu, Zefang / Wu, Suying / Chu, Tianjiao / Li, Bozhao / Qi, Feilong / Zhao, Yuliang / Nie, Guangjun

Nature reviews. Cancer

2023 Volume 24, Issue 1, Page(s) 72–87

Abstract: Systemic antiplatelet treatment represents a promising option to improve the therapeutic outcomes and therapeutic efficacy of chemotherapy and immunotherapy due to the critical contribution of platelets to tumour progression. However, until recently, ... ...

Abstract	Systemic antiplatelet treatment represents a promising option to improve the therapeutic outcomes and therapeutic efficacy of chemotherapy and immunotherapy due to the critical contribution of platelets to tumour progression. However, until recently, targeting platelets as a cancer therapeutic has been hampered by the elevated risk of haemorrhagic and thrombocytopenic (low platelet count) complications owing to the lack of specificity for tumour-associated platelets. Recent work has advanced our understanding of the molecular mechanisms responsible for the contribution of platelets to tumour progression and metastasis. This has led to the identification of the biological changes in platelets in the presence of tumours, the complex interactions between platelets and tumour cells during tumour progression, and the effects of platelets on antitumour therapeutic response. In this Review, we present a detailed picture of the dynamic roles of platelets in tumour development and progression as well as their use in diagnosis, prognosis and monitoring response to therapy. We also provide our view on how to overcome challenges faced by the development of precise antiplatelet strategies for safe and efficient clinical cancer therapy.
MeSH term(s)	Humans ; Neoplasms/pathology ; Blood Platelets/pathology ; Blood Platelets/physiology ; Immunotherapy
Language	English
Publishing date	2023-12-01
Publishing country	England
Document type	Journal Article ; Review
ZDB-ID	2062767-1
ISSN	1474-1768 ; 1474-175X
ISSN (online)	1474-1768
ISSN	1474-175X
DOI	10.1038/s41568-023-00639-6
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Article: Suitability of a novel camel (Camelus dromedarius) chymosin as a coagulant for Cheddar cheese manufacture

Li, Bozhao / Waldron, David S. / Drake, MaryAnne / Lyne, John / Kelly, Alan L. / McSweeney, Paul L.H.

International dairy journal. 2022 June, v. 129

2022

Abstract: Cheddar-type cheese was manufactured using fermentation-produced bovine chymosin (BC), fermentation-produced camel chymosin (CC) and a modified fermentation-produced camel chymosin (mCC) and ripened for 180 days. Only minor differences were found in ... ...

Abstract	Cheddar-type cheese was manufactured using fermentation-produced bovine chymosin (BC), fermentation-produced camel chymosin (CC) and a modified fermentation-produced camel chymosin (mCC) and ripened for 180 days. Only minor differences were found in cheese composition and pH between the cheeses made with any of the chymosins studied. Proteolysis in cheese made with mCC was reduced compared with cheese made with BC or CC. Significantly higher instrumental and sensory hardness and significantly lower meltability were found in cheeses made using CC or mCC compared with cheese BC after 180 days of ripening. Descriptive sensory analysis results showed that cheese made with CC or mCC had less sulphur and barny flavour; the brothy flavour and bitter taste of cheese made with mCC were also lowest. In conclusion, the modified camel chymosin appears to be suitable for the manufacture of Cheddar cheese with modified functionalities.
Keywords	Camelus dromedarius ; Cheddar cheese ; bitterness ; camels ; cattle ; chymosin ; coagulants ; hardness ; manufacturing ; pH ; proteolysis ; sensory evaluation ; sulfur
Language	English
Dates of publication	2022-06
Publishing place	Elsevier Ltd
Document type	Article
ZDB-ID	1076400-8
ISSN	0958-6946
ISSN	0958-6946
DOI	10.1016/j.idairyj.2022.105346
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Article: Understanding preferences for and consumer behavior toward cheese among a cohort of young, educated, internationally mobile Chinese consumers

Ouyang, Hao / Li, Bozhao / McCarthy, Mary / Miao, Song / Kilcawley, Kieran / Fenelon, Mark / Kelly, Alan / Sheehan, Jeremiah J.

American Dairy Science Association Journal of dairy science. 2021 Dec., v. 104, no. 12

2021

Abstract: This study explores the experiences of a cohort of young, educated, internationally mobile Chinese consumers with cheese and other dairy products, and how these experiences shape their behavior toward cheese products. In total, 41 Chinese students ... ...

Abstract	This study explores the experiences of a cohort of young, educated, internationally mobile Chinese consumers with cheese and other dairy products, and how these experiences shape their behavior toward cheese products. In total, 41 Chinese students studying at an Irish university participated in 5 focus groups (n = 41, n = 7–10). Thematic analysis identified important factors that influence consumer behaviors regarding cheese products. Individuals' expectations toward cheese were embedded in their knowledge structures, which were constructed from previous experience. Participants had general positive expectations toward cheese due to associations with western-style foods and nostalgia; however, direct eating experience determined long-term behavior. When making a purchase decision, choice motives were weighed and negotiated to establish a fundamental driving factor for purchase. Perceived probability of choice motive fulfillment was important in determining purchase decisions, with many participants having low perceived ability to select cheese and limited motivation to engage with cheese due to limited perceived relevance of cheese to their daily food life. Individuals' innovativeness was an important factor that influences their openness to cheese products when moving beyond familiar foods. Opportunities exist such as using nostalgic cues as marketing tools to increase consumers' interest in cheese or combining cheese with Chinese food to increase perceived relevance of cheese to their daily food life. Providing information at point of purchase could reduce the disconnect between expectation and actual experience, and innovative cheese products may be developed to better fulfill important choice motives.
Keywords	cheeses ; consumer behavior ; dairy science ; motivation ; probability
Language	English
Dates of publication	2021-12
Size	p. 12415-12426.
Publishing place	Elsevier Inc.
Document type	Article
ZDB-ID	242499-x
ISSN	1525-3198 ; 0022-0302
ISSN (online)	1525-3198
ISSN	0022-0302
DOI	10.3168/jds.2021-20598
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Article ; Online: Monitoring circulating platelet activity to predict cancer-associated thrombosis.

Li, Bozhao / Lu, Zefang / Yang, Zhenlin / Zhang, Xiuping / Wang, Meiqi / Chu, Tianjiao / Wang, Peina / Qi, Feilong / Anderson, Greg J / Jiang, Ershuai / Song, Zhenchuan / Nie, Guangjun / Li, Suping

Cell reports methods

2023 Volume 3, Issue 7, Page(s) 100513

Abstract: A characteristic clinical complication in cancer patients is the frequent incidence of thrombotic events. Numerous studies have shown hyperactive/activated platelets to be a critical earlier trigger for cancer-associated thrombus formation. However, ... ...

Abstract	A characteristic clinical complication in cancer patients is the frequent incidence of thrombotic events. Numerous studies have shown hyperactive/activated platelets to be a critical earlier trigger for cancer-associated thrombus formation. However, there currently is no viable approach to monitor specific changes in tumor-associated platelet activity. Here, we describe a chromatograph-like microfluidic device that is highly sensitive to the activity status of peripheral circulating platelets in both tumor-bearing mice and clinical cancer patients. Our results show a strongly positive correlation between platelet activation status and tumor progression. Six-month follow-up data from advanced cancer patients reveal positive links between platelet activity level and thrombus occurrence rate, with a high predictive capacity of thrombotic events (AUC = 0.842). Our findings suggest that circulating platelet activity status determined by this microfluidic device exhibits sensitive, predictive potential for thrombotic events in cancer patients for directing well-timed antithrombosis treatment.
MeSH term(s)	Mice ; Animals ; Blood Platelets/pathology ; Platelet Activation/physiology ; Thrombosis/etiology ; Neoplasms/complications
Language	English
Publishing date	2023-06-27
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ISSN	2667-2375
ISSN (online)	2667-2375
DOI	10.1016/j.crmeth.2023.100513
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Article ; Online: Nanoparticle-Based Combination Therapy Enhances Fulvestrant Efficacy and Overcomes Tumor Resistance in ER-Positive Breast Cancer.

Li, Bozhao / Qi, Feilong / Zhu, Fei / Lu, Zefang / Wang, Meiqi / Chu, Tianjiao / Wu, Suying / Wei, Jingyan / Song, Zhenchuan / Sukumar, Saraswati / Zhang, Cheng / Xu, Jiangfei / Li, Suping / Nie, Guangjun

Cancer research

2023 Volume 83, Issue 17, Page(s) 2924–2937

Abstract: Nanoparticles (NP) spanning diverse materials and properties have the potential to encapsulate and to protect a wide range of therapeutic cargos to increase bioavailability, to prevent undesired degradation, and to mitigate toxicity. Fulvestrant, a ... ...

Abstract	Nanoparticles (NP) spanning diverse materials and properties have the potential to encapsulate and to protect a wide range of therapeutic cargos to increase bioavailability, to prevent undesired degradation, and to mitigate toxicity. Fulvestrant, a selective estrogen receptor degrader, is commonly used for treating patients with estrogen receptor (ER)-positive breast cancer, but its broad and continual application is limited by poor solubility, invasive muscle administration, and drug resistance. Here, we developed an active targeting motif-modified, intravenously injectable, hydrophilic NP that encapsulates fulvestrant to facilitate its delivery via the bloodstream to tumors, improving bioavailability and systemic tolerability. In addition, the NP was coloaded with abemaciclib, an inhibitor of cyclin-dependent kinases 4 and 6 (CDK4/6), to prevent the development of drug resistance associated with long-term fulvestrant treatment. Targeting peptide modifications on the NP surface assisted in the site-specific release of the drugs to ensure specific toxicity in the tumor tissues and to spare normal tissue. The NP formulation (PPFA-cRGD) exhibited efficient tumor cell killing in both in vitro organoid models and in vivo orthotopic ER-positive breast cancer models without apparent adverse effects, as verified in mouse and Bama miniature pig models. This NP-based therapeutic provides an opportunity for continual and extensive clinical application of fulvestrant, thus indicating its promise as a treatment option for patients with ER-positive breast cancer. Significance: A smart nanomedicine encapsulating fulvestrant to improve its half-life, bioavailability, and tumor-targeting and coloaded with CDK4/6 inhibitor abemaciclib to block resistance is a safe and effective therapy for ER-positive breast cancer.
MeSH term(s)	Animals ; Mice ; Swine ; Fulvestrant/pharmacology ; Fulvestrant/therapeutic use ; Receptors, Estrogen/metabolism ; Aminopyridines/pharmacology ; Neoplasms/drug therapy ; Drug Resistance, Neoplasm ; Cell Line, Tumor
Chemical Substances	Fulvestrant (22X328QOC4) ; abemaciclib (60UAB198HK) ; Receptors, Estrogen ; Aminopyridines
Language	English
Publishing date	2023-06-16
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	1432-1
ISSN	1538-7445 ; 0008-5472
ISSN (online)	1538-7445
ISSN	0008-5472
DOI	10.1158/0008-5472.CAN-22-3559
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Article: Evaluation of production of Cheddar cheese from micellar casein concentrate

Li, Bozhao / Waldron, David S / Tobin, John T / Subhir, Surabhi / Kelly, Alan L / McSweeney, Paul L.H

International dairy journal. 2020 Aug., v. 107

2020

Abstract: The production of Cheddar cheese using micellar casein concentrate (MCC), a novel milk ingredient powder with a high casein content (∼92%), was evaluated. Four types of Cheddar cheese were manufactured and ripened for 180 days from the following starting ...

Abstract	The production of Cheddar cheese using micellar casein concentrate (MCC), a novel milk ingredient powder with a high casein content (∼92%), was evaluated. Four types of Cheddar cheese were manufactured and ripened for 180 days from the following starting materials: standardised control milk (control), skim milk with cream (SC), reconstituted MCC with cream (MC) and reconstituted low-heat skim milk powder with cream (PC). Only minor differences were found in composition between treatments, but MC cheese showed higher levels of proteolysis compared with other treatments, linked to significantly higher plasmin and chymosin activities. No differences were observed in hardness between treatments (60, 120 and 180 days), but the springiness and cohesiveness of MC and PC cheeses were significantly higher than that of the control and SC cheeses at 60, 120 and 180 days. The use of casein-dominant dairy streams thus has the potential for production of Cheddar cheese with tailored functionality.
Keywords	Cheddar cheese ; casein ; chymosin ; cohesion ; cream ; dried skim milk ; hardness ; ingredients ; plasmin ; proteolysis ; skim milk
Language	English
Dates of publication	2020-08
Publishing place	Elsevier Ltd
Document type	Article
Note	NAL-AP-2-clean
ZDB-ID	1076400-8
ISSN	0958-6946
ISSN	0958-6946
DOI	10.1016/j.idairyj.2020.104711
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Article ; Online: Protective Effects and Mechanisms of Recombinant Human Glutathione Peroxidase 4 on Isoproterenol-Induced Myocardial Ischemia Injury.

Liu, Chang / Li, Bozhao / Yan, Qi / Niu, Shaopeng / Zhao, Yiding / Xiong, Changhao / Zhang, Tianjiao / Wei, Jingyan

Oxidative medicine and cellular longevity

2021 Volume 2021, Page(s) 6632813

Abstract: Ischemic heart disease (IHD) is a cardiovascular disease with high fatality rate, and its pathogenesis is closely related to oxidative stress. Reactive oxygen species (ROS) in oxidative stress can lead to myocardial ischemia (MI) injury in many ways. ... ...

Abstract	Ischemic heart disease (IHD) is a cardiovascular disease with high fatality rate, and its pathogenesis is closely related to oxidative stress. Reactive oxygen species (ROS) in oxidative stress can lead to myocardial ischemia (MI) injury in many ways. Therefore, the application of antioxidants may be an effective way to prevent IHD. In recent years, glutathione peroxidase 4 (GPx4) has received increasing attention due to its antioxidant effect. In a previous study, we used the new chimeric tRNA
MeSH term(s)	Animals ; Apoptosis/drug effects ; Biomarkers/blood ; Cell Line ; Disease Models, Animal ; Electrocardiography ; Humans ; Isoproterenol/toxicity ; Male ; Membrane Potential, Mitochondrial/drug effects ; Myocardial Infarction/chemically induced ; Myocardial Infarction/drug therapy ; Myocardial Infarction/metabolism ; Myocytes, Cardiac/cytology ; Myocytes, Cardiac/drug effects ; Myocytes, Cardiac/metabolism ; Oxidative Stress/drug effects ; Phospholipid Hydroperoxide Glutathione Peroxidase/genetics ; Phospholipid Hydroperoxide Glutathione Peroxidase/metabolism ; Phospholipid Hydroperoxide Glutathione Peroxidase/pharmacology ; Phospholipid Hydroperoxide Glutathione Peroxidase/therapeutic use ; Protective Agents/pharmacology ; Protective Agents/therapeutic use ; Rats ; Rats, Sprague-Dawley ; Reactive Oxygen Species/metabolism ; Recombinant Proteins/biosynthesis ; Recombinant Proteins/pharmacology ; Recombinant Proteins/therapeutic use ; Troponin T/blood
Chemical Substances	Biomarkers ; Protective Agents ; Reactive Oxygen Species ; Recombinant Proteins ; Troponin T ; Phospholipid Hydroperoxide Glutathione Peroxidase (EC 1.11.1.12) ; Isoproterenol (L628TT009W)
Language	English
Publishing date	2021-09-07
Publishing country	United States
Document type	Journal Article
ZDB-ID	2455981-7
ISSN	1942-0994 ; 1942-0994
ISSN (online)	1942-0994
ISSN	1942-0994
DOI	10.1155/2021/6632813
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