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Article ; Online: Silencing BMAL1 promotes M1/M2 polarization through the LDHA/lactate axis to promote GBM sensitivity to bevacizumab.

Wang, Fan / Liao, Wenjun / Li, Caiyan / Zhu, Ling

2024 Volume 134, Page(s) 112187

Abstract: Objective: Glioblastoma (GBM) has poor clinical prognosis due to limited treatment options. In addition, the current treatment regimens for GBM may only slightly prolong patient survival. The aim of this study was to assess the role of BMAL1 in the ... ...

Abstract	Objective: Glioblastoma (GBM) has poor clinical prognosis due to limited treatment options. In addition, the current treatment regimens for GBM may only slightly prolong patient survival. The aim of this study was to assess the role of BMAL1 in the immune microenvironment and drug resistance of GBM. Methods: GBM cell lines with stable BMAL1 knockdown or LDHA overexpression were constructed, and functionally characterized by the CCK8, EdU incorporation, and transwell assays. In vivo GBM model was established in C57BL/6J mice. Flow cytometry, ELISA, immunofluorescence, and RT-qPCR were performed to detect macrophage polarization. Lactate production, pathological changes, and the expression of glycolytic proteins were analyzed by HE staining, immunohistochemistry, biochemical assays, and Western blotting. Results: BMAL1 silencing inhibited the malignant characteristics, lactate production, and expression of glycolytic proteins in GBM cells, and these changes were abrogated by overexpression of LDHA or exogenous lactate supplementation. Furthermore, BMAL1 knockdown induced M1 polarization of macrophages, and inhibited M2 polarization and angiogenesis in GBM cells in conditioned media. Overexpression of LDHA or presence of exogenous lactate inhibited BMAL1-induced M1 polarization and angiogenesis. Finally, BMAL1 silencing and bevacizumab synergistically inhibited glycolysis, angiogenesis and M2 polarization, and promoted M1 polarization in vivo, thereby suppressing GBM growth. Conclusion: BMAL1 silencing can sensitize GBM cells to bevacizumab by promoting M1/M2 polarization through the LDHA/lactate axis.
Language	English
Publishing date	2024-05-10
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	2043785-7
ISSN	1878-1705 ; 1567-5769
ISSN (online)	1878-1705
ISSN	1567-5769
DOI	10.1016/j.intimp.2024.112187
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Article ; Online: Hollow Zeolite Nanoreactor with Double Shells for Methanol Aromatization: Explicit Recognition on Catalytic Function of Inverse Elemental Zone and Shell-Cavity.

Ma, Qian / Fu, Tingjun / Wang, Zhuo / Li, Caiyan / Wu, Xueqing / Yang, Ning / Li, Zhong

Small (Weinheim an der Bergstrasse, Germany)

2024 , Page(s) e2308502

Abstract: Core@shell catalyst composited of dual aluminosilicate zeolite can effectively regulate the distribution of acid sites to control hydrocarbon conversion process for the stable formation of target product. However, the diffusion restriction reduces the ... ...

Abstract	Core@shell catalyst composited of dual aluminosilicate zeolite can effectively regulate the distribution of acid sites to control hydrocarbon conversion process for the stable formation of target product. However, the diffusion restriction reduces the accessibility of inner active sites and affects synergy between core and shell. Herein, hollow ZSM-5 zeolite nanoreactor with inverse aluminum distribution and double shells are prepared and employed for methanol aromatization. It is demonstrated that the intershell cavity alleviated the steric hindrance from zeolites channel and provided more paths and pore entrance for guest molecule. Correspondingly, olefin intermediates generated from methanol over the external shell are easier to adsorb at internal acid sites for further reactions. Importantly, the diffusion of generated aromatic macromolecules to the external surface is also promoted, which slows down the formation of internal coke, and ensures the use of internal acid sites for aromatization. The aromatics selectivity of the nanoreactor remained at 8% after 154 h, while that of solid core@shell catalyst decreased to 2% after 75 h. This finding promises broader insight to improve internal active site utilization of core@shell catalyst at the diffusion level and can be great aid in the flexible design of multifunctional nanoreactors to enhance the relay efficiency.
Language	English
Publishing date	2024-01-03
Publishing country	Germany
Document type	Journal Article
ZDB-ID	2168935-0
ISSN	1613-6829 ; 1613-6810
ISSN (online)	1613-6829
ISSN	1613-6810
DOI	10.1002/smll.202308502
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Article ; Online: The anti-lipopolysaccharide effect of glycine via fibroblastic cell culture from the embryonic calipash tissue of Chinese soft-shelled turtle Pelodiscus sinensis

Zhou, Beining / Song, Wei / Zhu, Leyan / Deng, Zilian / Qian, Guoying / Li, Caiyan

Aquaculture Reports. , p.101575-

2023 , Page(s) 101575–

Abstract: As a representative kind of soft-shelled turtles, Pelodiscus sinensis has soft apron termed calipash around its pliable carapace as the most distinctive trait, which is functionally important in turtle defense. It is of great significance to explore the ... ...

Abstract	As a representative kind of soft-shelled turtles, Pelodiscus sinensis has soft apron termed calipash around its pliable carapace as the most distinctive trait, which is functionally important in turtle defense. It is of great significance to explore the physiological function of stress resistance and the possible regulation of anti-stress nutrition for the survival of aquaculture. To address this issue, a fibroblast cell line from the embryonic calipash tissue of P. sinensis (PSCF) was established from the perspective of ethics, repeatability, and convenience. Effect of glycine, the main amino acid component in calipash extracellular matrix, on the proliferation of PSCF treated with 160μg/mL lipopolysaccharide and the underlying mechanisms were also studied. The results showed that adding 100μg/mL glycine significantly improved the fibroblast survival, increased the mRNA levels of collagen biosynthesis genes, prolyl hydroxylase and collagen degradation genes, and inhibited reactive oxygen species (ROS) production. It suggested that glycine shows positive effects on the cell proliferation of PSCF, and could regulate the oxidative stress and collagen metabolism. To our knowledge, this report is the first to describe cell cultures established at specific calipash tissue-forming stages during the embryonic development in P. sinensis and to reveal the anti-stress effect of glycine in turtles. The results will contribute to the application of functional calipash tissue, or its manipulation by nutrition additives, such as glycine, to prevent or ameliorate stress in turtle industry.
Keywords	Pelodiscus sinensis ; amino acids ; aquaculture ; biosynthesis ; cell culture ; cell lines ; cell proliferation ; collagen ; embryogenesis ; ethics ; extracellular matrix ; fibroblasts ; industry ; lipopolysaccharides ; nutrition ; oxidative stress ; procollagen-proline dioxygenase ; reactive oxygen species ; stress tolerance ; turtles ; DCF ; DCFH-DA ; DMEM ; FBS ; FITC ; LPS ; MMP ; P4H ; PSCF ; ROS ; TIMP ; Glycine ; Lipopolysaccharide ; Calipash
Language	English
Publishing place	Elsevier B.V.
Document type	Article ; Online
Note	Pre-press version ; Use and reproduction
ZDB-ID	2835391-2
ISSN	2352-5134
ISSN	2352-5134
DOI	10.1016/j.aqrep.2023.101575
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Article ; Online: Induction of Hibernation and Changes in Physiological and Metabolic Indices in Pelodiscus sinensis

Lin, Runlan / Wu, Jiahao / You, Ziyi / Xu, Dongjie / Li, Caiyan / Wang, Wei / Qian, Guoying

Biology (Basel). 2023 May 15, v. 12, no. 5

2023

Abstract: Pelodiscus sinensis (P. sinensis) is a commonly cultivated turtle species with a habit of hibernation. To study the changes in histone expression and methylation of P. sinensis during hibernation induction, a model was established by artificial induction. ...

Abstract	Pelodiscus sinensis (P. sinensis) is a commonly cultivated turtle species with a habit of hibernation. To study the changes in histone expression and methylation of P. sinensis during hibernation induction, a model was established by artificial induction. Physiological and metabolic indices were measured, and the expression and localization of histone (H1, H2A, H2B, H3, and H4) and methylation-related genes (ASH2L, KMT2A, KMT2E, KDM1A, KDM1B, and KDM5A) were measured by quantitative PCR, immunohistochemistry, and Western blot analysis. The results indicated that the metabolism, antioxidation index, and relative expression of histone methyltransferase were significantly decreased (p < 0.05), whereas the activity and expression of histone demethyltransferase were significantly increased (p < 0.05). Although our results showed significant changes in physiological and gene expression after hibernation induction, we could not confirm that P. sinensis entered deep hibernation. Therefore, for the state after cooling-induced hibernation, cold torpor might be a more accurate description. The results indicate that the P. sinensis can enter cold torpor through artificial induction, and the expression of histones may promote gene transcription. Unlike histones expressed under normal conditions, histone methylation may activate gene transcription during hibernation induction. Western blot analysis revealed that the ASH2L and KDM5A proteins were differentially expressed in the testis at different months (p < 0.05), which may perform a role in regulating gene transcription. The immunohistochemical localization of ASH2L and KDM5A in spermatogonia and spermatozoa suggests that ASH2L and KDM5A may perform a role in mitosis and meiosis. In conclusion, this study is the first to report changes in histone-related genes in reptiles, which provides insight for further studies on the physiological metabolism and histone methylation regulation of P. sinensis during the hibernation induction and hibernation period.
Keywords	Pelodiscus sinensis ; Western blotting ; cold ; gene expression ; hibernation ; histones ; immunohistochemistry ; meiosis ; metabolism ; methylation ; methyltransferases ; mitosis ; models ; quantitative polymerase chain reaction ; spermatogonia ; testes ; transcription (genetics) ; turtles
Language	English
Dates of publication	2023-0515
Publishing place	Multidisciplinary Digital Publishing Institute
Document type	Article ; Online
ZDB-ID	2661517-4
ISSN	2079-7737
ISSN	2079-7737
DOI	10.3390/biology12050720
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Article ; Online: Protection and Damage Repair Mechanisms Contributed To the Survival of

Li, Caiyan / Zhang, Xianyuan / Ye, Tong / Li, Xiaoyan / Wang, Gaohong

Microbiology spectrum

2022 Volume 10, Issue 6, Page(s) e0344022

Abstract: ... ...

Abstract	Chroococcidiopsis
MeSH term(s)	Carotenoids ; Cyanobacteria/genetics ; Indoles/metabolism ; Phenols/metabolism ; Photosystem II Protein Complex/genetics ; Photosystem II Protein Complex/metabolism ; Extreme Environments
Chemical Substances	Carotenoids (36-88-4) ; Indoles ; Phenols ; Photosystem II Protein Complex ; scytonemin (152075-98-4)
Language	English
Publishing date	2022-12-01
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2807133-5
ISSN	2165-0497 ; 2165-0497
ISSN (online)	2165-0497
ISSN	2165-0497
DOI	10.1128/spectrum.03440-22
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Article: Induction of Hibernation and Changes in Physiological and Metabolic Indices in

Lin, Runlan / Wu, Jiahao / You, Ziyi / Xu, Dongjie / Li, Caiyan / Wang, Wei / Qian, Guoying

Biology

2023 Volume 12, Issue 5

Abstract: Pelodiscus ... ...

Abstract	Pelodiscus sinensis
Language	English
Publishing date	2023-05-15
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2661517-4
ISSN	2079-7737
ISSN	2079-7737
DOI	10.3390/biology12050720
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Article ; Online: Total Glucosides of Paeony Ameliorate Myocardial Injury in Chronic Heart Failure Rats by Suppressing PARP-1.

Wei, Wenjuan / Li, Caiyan / Zhang, Baoyong / Huang, Deyun / Li, Zheming / Gao, Jiaer

Journal of cardiovascular translational research

2023 Volume 17, Issue 2, Page(s) 388–402

Abstract: Total glucosides of paeony (TGP) have a potential protective effect on chronic heart failure (CHF) rats, but the mechanism remains unclear. PARP inhibition prevents the decrease in myocardial contractility. Therefore, we aim to investigate the effects ... ...

Abstract	Total glucosides of paeony (TGP) have a potential protective effect on chronic heart failure (CHF) rats, but the mechanism remains unclear. PARP inhibition prevents the decrease in myocardial contractility. Therefore, we aim to investigate the effects and mechanisms of TGP on CHF and the role of PARP-1 in CHF. Left anterior descending ligation rats and adriamycin-treated H9C9 cells were used as CHF models, and captopril as a positive control for in vivo experiments. We found that TGP alleviated myocardial remodeling and improved cardiac morphology and function. TGP also reduced myocardial apoptosis and autophagy, decreased inflammatory factor release, and inhibited the PARP-1 and NF-κB proteins. Through cell transfection, we found that PAPR-1 knockdown inhibited NF-κB nuclear translocation. Additionally, TGP inhibited apoptosis, autophagy, and inflammation in CHF cells, while PARP-1 overexpression partially antagonized them. In conclusion, TGP has the potential to improve CHF and PARP-1 may be a potential target.
MeSH term(s)	Animals ; Heart Failure/physiopathology ; Heart Failure/drug therapy ; Heart Failure/metabolism ; Heart Failure/enzymology ; Heart Failure/pathology ; Poly (ADP-Ribose) Polymerase-1/metabolism ; Poly (ADP-Ribose) Polymerase-1/genetics ; Glucosides/pharmacology ; Apoptosis/drug effects ; Disease Models, Animal ; Male ; Chronic Disease ; Myocytes, Cardiac/drug effects ; Myocytes, Cardiac/pathology ; Myocytes, Cardiac/enzymology ; Myocytes, Cardiac/metabolism ; Rats, Sprague-Dawley ; Poly(ADP-ribose) Polymerase Inhibitors/pharmacology ; Cell Line ; Paeonia/chemistry ; Ventricular Function, Left/drug effects ; Autophagy/drug effects ; Signal Transduction/drug effects ; Inflammation Mediators/metabolism ; NF-kappa B/metabolism ; Ventricular Remodeling/drug effects ; Anti-Inflammatory Agents/pharmacology ; Rats ; Plant Extracts/pharmacology ; Plant Extracts/isolation & purification
Chemical Substances	Poly (ADP-Ribose) Polymerase-1 (EC 2.4.2.30) ; Glucosides ; Parp1 protein, rat (EC 2.4.2.30) ; Poly(ADP-ribose) Polymerase Inhibitors ; Inflammation Mediators ; NF-kappa B ; Anti-Inflammatory Agents ; Plant Extracts
Language	English
Publishing date	2023-10-13
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2422411-X
ISSN	1937-5395 ; 1937-5387
ISSN (online)	1937-5395
ISSN	1937-5387
DOI	10.1007/s12265-023-10440-3
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Article: Cell damage repair mechanism in a desert green algae Chlorella sp. against UV-B radiation

Wang, Bo / Ye, Tong / Li, Caiyan / Li, Xiaoyan / Chen, Lanzhou / Wang, Gaohong

Ecotoxicology and environmental safety. 2022 Sept. 01, v. 242

2022

Abstract: The protective ozone layer is continually depleting owing to an increase in the levels of solar UV-B radiation, which has harmful effects on organisms. Algae in desert soil can resist UV-B radiation, but most research on the radiation resistance of ... ...

Abstract	The protective ozone layer is continually depleting owing to an increase in the levels of solar UV-B radiation, which has harmful effects on organisms. Algae in desert soil can resist UV-B radiation, but most research on the radiation resistance of desert algae has focused on cyanobacteria. In this study, we found that desert green algae, Chlorella sp., could maintain high photosynthetic activity under UV-B stress. To examine the tolerance mechanism of the desert green algae photosystem, we observed the physiological and transcriptome-level responses of Chlorella sp. to high doses of UV-B radiation. The results showed that the reactive oxygen species (ROS) content first increased and then decreased, while the malondialdehyde (MDA) content revealed no notable lipid peroxidation during the UV-B exposure period. These results suggested that Chlorella sp. may have strong system characteristics for scavenging ROS. The antioxidant enzyme system showed efficient alternate coordination, which exhibited a protective effect against enhanced UV-B radiation. DNA damage and the chlorophyll and soluble protein contents had no significant changes in the early irradiation stage; UV-B radiation did not induce extracellular polysaccharides (EPS) synthesis. Transcriptomic data revealed that a strong photosynthetic system, efficient DNA repair, and changes in the expression of genes encoding ribosomal protein (which aid in protein synthesis and improve resistance) are responsible for the high UV-B tolerance characteristics of Chlorella sp. In contrast, EPS synthesis was not the main pathway for UV-B resistance. Our results revealed the potential cell damage repair mechanisms within Chlorella sp. that were associated with high intensity UV-B stress, thereby providing insights into the underlying regulatory adaptations of desert green algae.
Keywords	Chlorella ; DNA damage ; DNA repair ; antioxidant enzymes ; chlorophyll ; desert soils ; ecotoxicology ; exposure duration ; irradiation ; lipid peroxidation ; malondialdehyde ; ozonosphere ; photosynthesis ; polysaccharides ; protective effect ; protein synthesis ; radiation resistance ; reactive oxygen species ; ribosomal proteins ; transcriptomics
Language	English
Dates of publication	2022-0901
Publishing place	Elsevier Inc.
Document type	Article
ZDB-ID	436536-7
ISSN	1090-2414 ; 0147-6513
ISSN (online)	1090-2414
ISSN	0147-6513
DOI	10.1016/j.ecoenv.2022.113916
Database	NAL-Catalogue (AGRICOLA)

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Article ; Online: Cell damage repair mechanism in a desert green algae Chlorella sp. against UV-B radiation.

Wang, Bo / Ye, Tong / Li, Caiyan / Li, Xiaoyan / Chen, Lanzhou / Wang, Gaohong

Ecotoxicology and environmental safety

2022 Volume 242, Page(s) 113916

Abstract	The protective ozone layer is continually depleting owing to an increase in the levels of solar UV-B radiation, which has harmful effects on organisms. Algae in desert soil can resist UV-B radiation, but most research on the radiation resistance of desert algae has focused on cyanobacteria. In this study, we found that desert green algae, Chlorella sp., could maintain high photosynthetic activity under UV-B stress. To examine the tolerance mechanism of the desert green algae photosystem, we observed the physiological and transcriptome-level responses of Chlorella sp. to high doses of UV-B radiation. The results showed that the reactive oxygen species (ROS) content first increased and then decreased, while the malondialdehyde (MDA) content revealed no notable lipid peroxidation during the UV-B exposure period. These results suggested that Chlorella sp. may have strong system characteristics for scavenging ROS. The antioxidant enzyme system showed efficient alternate coordination, which exhibited a protective effect against enhanced UV-B radiation. DNA damage and the chlorophyll and soluble protein contents had no significant changes in the early irradiation stage; UV-B radiation did not induce extracellular polysaccharides (EPS) synthesis. Transcriptomic data revealed that a strong photosynthetic system, efficient DNA repair, and changes in the expression of genes encoding ribosomal protein (which aid in protein synthesis and improve resistance) are responsible for the high UV-B tolerance characteristics of Chlorella sp. In contrast, EPS synthesis was not the main pathway for UV-B resistance. Our results revealed the potential cell damage repair mechanisms within Chlorella sp. that were associated with high intensity UV-B stress, thereby providing insights into the underlying regulatory adaptations of desert green algae.
MeSH term(s)	Chlorella/genetics ; Chlorella/metabolism ; Chlorophyll/metabolism ; Photosynthesis/radiation effects ; Plants/metabolism ; Reactive Oxygen Species/metabolism ; Ultraviolet Rays
Chemical Substances	Reactive Oxygen Species ; Chlorophyll (1406-65-1)
Language	English
Publishing date	2022-07-22
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	436536-7
ISSN	1090-2414 ; 0147-6513
ISSN (online)	1090-2414
ISSN	0147-6513
DOI	10.1016/j.ecoenv.2022.113916
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Article ; Online: Friend or foe: RIG- I like receptors and diseases.

Song, Jie / Li, Muyuan / Li, Caiyan / Liu, Ke / Zhu, Yaxi / Zhang, Huali

Autoimmunity reviews

2022 Volume 21, Issue 10, Page(s) 103161

Abstract: Retinoic acid-inducible gene I (RIG-I)-like receptors (RLRs), which are pivotal sensors of RNA virus invasions, mediate the transcriptional induction of genes encoding type I interferons (IFNs) and proinflammatory cytokines, successfully establishing ... ...

Abstract	Retinoic acid-inducible gene I (RIG-I)-like receptors (RLRs), which are pivotal sensors of RNA virus invasions, mediate the transcriptional induction of genes encoding type I interferons (IFNs) and proinflammatory cytokines, successfully establishing host antiviral immune response. A few excellent reviews have elaborated on the structural biology of RLRs and the antiviral mechanisms of RLR activation. In this review, we give a basic understanding of RLR biology and summarize recent findings of how RLR signaling cascade is strictly controlled by host regulatory mechanisms, which include RLR-interacting proteins, post-translational modifications and microRNAs (miRNAs). Furthermore, we pay particular attention to the relationship between RLRs and diseases, especially how RLRs participate in SARS-CoV-2, malaria or bacterial infections, how single-nucleotide polymorphisms (SNPs) or mutations in RLRs and antibodies against RLRs lead to autoinflammatory diseases and autoimmune diseases, and how RLRs are involved in anti-tumor immunity. These findings will provide insights and guidance for antiviral and immunomodulatory therapies targeting RLRs.
MeSH term(s)	Humans ; Antiviral Agents ; COVID-19/genetics ; Cytokines ; Immunity, Innate ; Interferon Type I ; MicroRNAs ; SARS-CoV-2 ; Tretinoin
Chemical Substances	Antiviral Agents ; Cytokines ; Interferon Type I ; MicroRNAs ; Tretinoin (5688UTC01R)
Language	English
Publishing date	2022-08-01
Publishing country	Netherlands
Document type	Journal Article ; Review
ZDB-ID	2144145-5
ISSN	1873-0183 ; 1568-9972
ISSN (online)	1873-0183
ISSN	1568-9972
DOI	10.1016/j.autrev.2022.103161
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