LIVIVO - Search results -

Search results

Result 1 - 10 of total 101

Search options

Article ; Online: Antibacterial activity of nonantibiotics is orthogonal to standard antibiotics.

Noto Guillen, Mariana / Li, Carmen / Rosener, Brittany / Mitchell, Amir

2024 Volume 384, Issue 6691, Page(s) 93–100

Abstract: Numerous nonantibiotic drugs have potent antibacterial activity and can adversely affect the human microbiome. The mechanistic underpinning of this toxicity remains largely unknown. We investigated the antibacterial activity of 200 drugs using genetic ... ...

Abstract	Numerous nonantibiotic drugs have potent antibacterial activity and can adversely affect the human microbiome. The mechanistic underpinning of this toxicity remains largely unknown. We investigated the antibacterial activity of 200 drugs using genetic screens with thousands of barcoded
MeSH term(s)	Humans ; Anti-Bacterial Agents/chemistry ; Anti-Bacterial Agents/classification ; Anti-Bacterial Agents/pharmacology ; Escherichia coli/drug effects ; Escherichia coli/genetics ; Inhibitory Concentration 50 ; Microbial Sensitivity Tests ; Microbiota/drug effects ; Microbiota/genetics
Chemical Substances	Anti-Bacterial Agents
Language	English
Publishing date	2024-03-14
Publishing country	United States
Document type	Journal Article
ZDB-ID	128410-1
ISSN	1095-9203 ; 0036-8075
ISSN (online)	1095-9203
ISSN	0036-8075
DOI	10.1126/science.adk7368
Database	MEDical Literature Analysis and Retrieval System OnLINE

In stock of ZB MED Cologne/Königswinter

Zs.A 27: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (1.OG) ab Jg. 2022: Lesesaal (EG)
Zs.MG 77: Show issues

Order via subito

This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

Details ▾
- See ZB MED holdings
- Order with fees

Article ; Online: An alternative path to oral tolerance.

Li, Carmen H / Kabak, Ekaterina / Eiwegger, Thomas

Allergy

2023 Volume 78, Issue 7, Page(s) 2058–2060

MeSH term(s)	Humans ; Food Hypersensitivity ; Dendritic Cells ; Immune Tolerance ; Allergens ; Administration, Oral ; T-Lymphocytes, Regulatory
Chemical Substances	Allergens
Language	English
Publishing date	2023-03-16
Publishing country	Denmark
Document type	News
ZDB-ID	391933-x
ISSN	1398-9995 ; 0105-4538
ISSN (online)	1398-9995
ISSN	0105-4538
DOI	10.1111/all.15701
Database	MEDical Literature Analysis and Retrieval System OnLINE

Full text online

Accessible to users with ZB MED library card

In stock of ZB MED Cologne/Königswinter

Uh III Zs.150: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular ab Jg. 2022: Lesesaal (EG)
Zs.MO 125: Show issues

Order via subito

Details ▾

Article ; Online: Physical Supporting Devices as Interventions to Reduce Muscular Load of Surgeons in the Operating Room.

Li, Carmen Jiayang / Zhang, Yao / Li, Yuandong / Zheng, Bin

Surgical innovation

2023 Volume 30, Issue 4, Page(s) 517–525

Abstract: Introduction: Heavy muscle load during operations, caused by static and awkward postures, contributes to the discomfort of surgeons, and imperils surgical quality. We reviewed the supporting devices available to assist surgeons in the operating room and ...

Abstract	Introduction: Heavy muscle load during operations, caused by static and awkward postures, contributes to the discomfort of surgeons, and imperils surgical quality. We reviewed the supporting devices available to assist surgeons in the operating room and anticipated that physical support devices would help reduce occupational injuries among surgeons and improve surgical performance. Methods: A systematic literature review was completed. Papers on supporting devices for intraoperative stress reduction were included. Supported body parts and the impact of these devices on the surgeons' performance were extracted from the 21 selected papers. Results: Among the 21 devices introduced, eleven targeted on the upper extremities, 5 targeted on the lower extremities, and 5 were ergonomic chairs. Nine devices were tested in the operating room, 10 in a lab setting with simulated tasks, and 2 were still in development. The data from 7 studies did not show a significant improvement in stress reduction or surgical quality. With 2 devices still in the development phase, the remaining 12 papers showed promising results. Discussion: Although some of the devices were still in testing, most of the research teams believed that physical supporting devices can be useful in reducing muscle load, relieving discomfort, and improving surgical performance intraoperatively.
MeSH term(s)	Humans ; Operating Rooms ; Surgeons ; Ergonomics/methods ; Upper Extremity ; Posture
Language	English
Publishing date	2023-04-04
Publishing country	United States
Document type	Systematic Review ; Journal Article ; Review
ZDB-ID	2182571-3
ISSN	1553-3514 ; 1553-3506
ISSN (online)	1553-3514
ISSN	1553-3506
DOI	10.1177/15533506231169067
Database	MEDical Literature Analysis and Retrieval System OnLINE

In stock of ZB MED Cologne/Königswinter

Zs.A 4269: Show issues

Location:
Je nach Verfügbarkeit (siehe Angabe bei Bestand)
bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
Jg. 1995 - 2021: Lesesall (2.OG)
ab Jg. 2022: Lesesaal (EG)

Order via subito

Details ▾
- See ZB MED holdings
- Order with fees

Article ; Online: Categorical Updating in a Bayesian Propensity Problem.

Dewitt, Stephen H / Adler, Nine / Li, Carmen / Stoilova, Ekaterina / Fenton, Norman E / Lagnado, David A

Cognitive science

2023 Volume 47, Issue 7, Page(s) e13313

Abstract: We present three experiments using a novel problem in which participants update their estimates of propensities when faced with an uncertain new instance. We examine this using two different causal structures (common cause/common effect) and two ... ...

Abstract	We present three experiments using a novel problem in which participants update their estimates of propensities when faced with an uncertain new instance. We examine this using two different causal structures (common cause/common effect) and two different scenarios (agent-based/mechanical). In the first, participants must update their estimate of the propensity for two warring nations to successfully explode missiles after being told of a new explosion on the border between both nations. In the second, participants must update their estimate of the accuracy of two early warning tests for cancer when they produce conflicting reports about a patient. Across both experiments, we find two modal responses, representing around one-third of participants each. In the first, "Categorical" response, participants update propensity estimates as if they were certain about the single event, for example, certain that one of the nations was responsible for the latest explosion, or certain about which of the two tests is correct. In the second, "No change" response, participants make no update to their propensity estimates at all. Across the three experiments, the theory is developed and tested that these two responses in fact have a single representation of the problem: because the actual outcome is binary (only one of the nations could have launched the missile; the patient either has cancer or not), these participants believe it is incorrect to update propensities in a graded manner. They therefore operate on a "certainty threshold" basis, whereby, if they are certain enough about the single event, they will make the "Categorical" response, and if they are below this threshold, they will make the "No change" response. Ramifications are considered for the "categorical" response in particular, as this approach produces a positive-feedback dynamic similar to that seen in the belief polarization/confirmation bias literature.
MeSH term(s)	Humans ; Bayes Theorem ; Uncertainty ; Bias ; Neoplasms
Language	English
Publishing date	2023-07-10
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2002940-8
ISSN	1551-6709 ; 0364-0213
ISSN (online)	1551-6709
ISSN	0364-0213
DOI	10.1111/cogs.13313
Database	MEDical Literature Analysis and Retrieval System OnLINE

Full text online

Accessible to users with ZB MED library card

Order via subito

Details ▾
- Full text online
- Order with fees

Article ; Online: Variable Assembly of EMRE and MCU Creates Functional Channels with Distinct Gatekeeping Profiles.

Payne, Riley / Li, Carmen / Foskett, J Kevin

iScience

2020 Volume 23, Issue 4, Page(s) 101037

Abstract: ... MCU is a ... ...

Abstract	MCU is a Ca
Language	English
Publishing date	2020-04-10
Publishing country	United States
Document type	Journal Article
ISSN	2589-0042
ISSN (online)	2589-0042
DOI	10.1016/j.isci.2020.101037
Database	MEDical Literature Analysis and Retrieval System OnLINE

Order via subito

Inter-library loan at ZB MED

Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

Article: Air Pollution and Allergic Rhinitis: Role in Symptom Exacerbation and Strategies for Management.

Li, Carmen H / Sayeau, Kyle / Ellis, Anne K

Journal of asthma and allergy

2020 Volume 13, Page(s) 285–292

Abstract: This article reviews the current understanding of the role of air pollution in both the symptom exacerbation and rising prevalence of allergic rhinitis (AR) for the development of future AR therapeutics and management strategies. We discuss the ... ...

Abstract	This article reviews the current understanding of the role of air pollution in both the symptom exacerbation and rising prevalence of allergic rhinitis (AR) for the development of future AR therapeutics and management strategies. We discuss the epidemiological evidence for this relationship through birth cohort studies, the economic impact of AR, and the influence of air pollution through the lens of the exposome framework of allergic disease development. This is followed by a discussion on the influence of diesel exhaust and diesel exhaust particles (DEP) from motor vehicle emissions and their implication in the rising prevalence of allergic disease and allergic sensitization through triggering inflammatory signalling pathways that exacerbate AR symptoms. Finally, a summary is provided of clinical trials assessing the influence of air pollution on AR with a depiction of currently available therapies and management strategies. Future directions in the development of AR modalities given the air pollution-mediated symptom exacerbation are challenged with unfolding the complex gene-environment interaction product of heterogenous AR presentation.
Language	English
Publishing date	2020-08-26
Publishing country	New Zealand
Document type	Journal Article ; Review
ZDB-ID	2494877-9
ISSN	1178-6965
ISSN	1178-6965
DOI	10.2147/JAA.S237758
Database	MEDical Literature Analysis and Retrieval System OnLINE

Order via subito

Article ; Online: It is no skin off my nose: The relationship between the skin and allergic rhinitis.

Ho, Jessica S S / Li, Carmen H / Wang, Ami / Asai, Yuka

Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology

2021 Volume 127, Issue 2, Page(s) 176–182

Abstract: Objective: Evidence supports the relationship between the skin barrier and allergic conditions. This narrative review evaluates what role the cutaneous barrier may play in the pathogenesis, disease course, and management of allergic rhinitis (AR).: ... ...

Abstract	Objective: Evidence supports the relationship between the skin barrier and allergic conditions. This narrative review evaluates what role the cutaneous barrier may play in the pathogenesis, disease course, and management of allergic rhinitis (AR). Data sources: A literature review of the MEDLINE (PubMed), Embase, Cochrane, and SCOPUS Sciverse databases was conducted to identify available evidence. Reference lists of pertinent papers were searched using a snowball technique. Study selections: Papers published in English from all years until December 2020 were included. Papers that did not address the relationship between AR and the skin and hypothesis papers were excluded. Results: The cutaneous barrier shares histologic characteristics with the sinonasal epithelial barrier, which may explain commonalities between AR and atopic dermatitis. A disruption in the epithelial barrier could be a common pathway in the development of multiple allergic conditions. The skin is a common target for the treatment of AR. Available data that look at the relationship between the skin and AR often include other topics such as other atopic disorders and the role of the epithelial barrier. Increased understanding of how the cutaneous barrier affects AR may lead to new innovations in its management. Conclusion: The connection between the cutaneous barrier and AR holds possibilities for further investigation, and these may lead to a better understanding and future innovations for all atopic diseases.
MeSH term(s)	Asthma/immunology ; Asthma/pathology ; Dermatitis, Atopic/immunology ; Epithelium/physiology ; Humans ; Nose/pathology ; Rhinitis, Allergic/immunology ; Skin/pathology ; Tight Junctions/physiology
Language	English
Publishing date	2021-04-23
Publishing country	United States
Document type	Journal Article ; Review
ZDB-ID	1228189-x
ISSN	1534-4436 ; 0003-4738 ; 1081-1206
ISSN (online)	1534-4436
ISSN	0003-4738 ; 1081-1206
DOI	10.1016/j.anai.2021.04.018
Database	MEDical Literature Analysis and Retrieval System OnLINE

In stock of ZB MED Cologne/Königswinter

Uh III Zs.136: Show issues

Location:
Je nach Verfügbarkeit (siehe Angabe bei Bestand)
bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
ab Jg. 2022: Lesesaal (EG)

Order via subito

Details ▾
- See ZB MED holdings
- Order with fees

Article ; Online: Evolved bacterial resistance to the chemotherapy gemcitabine modulates its efficacy in co-cultured cancer cells.

Sayin, Serkan / Rosener, Brittany / Li, Carmen G / Ho, Bao / Ponomarova, Olga / Ward, Doyle V / Walhout, Albertha J M / Mitchell, Amir

eLife

2023 Volume 12

Abstract: Drug metabolism by the microbiome can influence anticancer treatment success. We previously suggested that chemotherapies with antimicrobial activity can select for adaptations in bacterial drug metabolism that can inadvertently influence the host's ... ...

Abstract	Drug metabolism by the microbiome can influence anticancer treatment success. We previously suggested that chemotherapies with antimicrobial activity can select for adaptations in bacterial drug metabolism that can inadvertently influence the host's chemoresistance. We demonstrated that evolved resistance against fluoropyrimidine chemotherapy lowered its efficacy in worms feeding on drug-evolved bacteria (Rosener et al., 2020). Here, we examine a model system that captures local interactions that can occur in the tumor microenvironment. Gammaproteobacteria-colonizing pancreatic tumors can degrade the nucleoside-analog chemotherapy gemcitabine and, in doing so, can increase the tumor's chemoresistance. Using a genetic screen in
MeSH term(s)	Humans ; Gemcitabine ; Deoxycytidine/pharmacology ; Deoxycytidine/therapeutic use ; Escherichia coli/genetics ; Antimetabolites, Antineoplastic/pharmacology ; Drug Resistance, Neoplasm ; Pancreatic Neoplasms/pathology ; Cell Line, Tumor ; Tumor Microenvironment
Chemical Substances	Gemcitabine ; Deoxycytidine (0W860991D6) ; Antimetabolites, Antineoplastic
Language	English
Publishing date	2023-02-03
Publishing country	England
Document type	Journal Article ; Research Support, N.I.H., Extramural
ZDB-ID	2687154-3
ISSN	2050-084X ; 2050-084X
ISSN (online)	2050-084X
ISSN	2050-084X
DOI	10.7554/eLife.83140
Database	MEDical Literature Analysis and Retrieval System OnLINE

Order via subito

Article ; Online: Multi-year seabed environmental baseline in deep-sea offshore oil prospective areas established using microbial biodiversity

Ferguson, Deidra K. / Li, Carmen / Chakraborty, Anirban / Gittins, Daniel A. / Fowler, Martin / Webb, Jamie / Campbell, Calvin / Morrison, Natasha / MacDonald, Adam / Hubert, Casey R.J.

Marine Pollution Bulletin. 2023, p.115308-

2023 , Page(s) 115308–

Abstract: Microorganisms are the ocean's first responders to marine pollution events, yet baseline studies rarely focus on microbial communities. Temporal and spatial microbial biodiversity baselines were established using bacterial 16S rRNA gene amplicon ... ...

Abstract	Microorganisms are the ocean's first responders to marine pollution events, yet baseline studies rarely focus on microbial communities. Temporal and spatial microbial biodiversity baselines were established using bacterial 16S rRNA gene amplicon sequencing of seafloor sediments in a deep-water oil prospective area along the Scotian Slope off Canada's east coast sampled during 2015-2018. Bacterial diversity was generally similar in space and time, with members of the family Woeseiaceae detected consistently in >1 % relative abundance, similar to seabed sediments in other parts of the world. Anomalous biodiversity results at one site featured lower Woeseiaceae as well as higher levels of bacterial groups specifically associated with cold seeps such as Aminicenantes. This was unexpected given that site selection was based on sediment geochemistry not revealing any petroleum hydrocarbons in these locations. This finding highlights the sensitivity and specificity of microbial DNA sequencing in environmental monitoring. Microbiome assessments like this one represent an important strategy for incorporating microbial biodiversity as a new and useful metric for establishing robust environmental baselines that are necessary for understanding ecosystem responses to marine pollution.
Keywords	DNA ; biodiversity ; coasts ; cold ; ecosystems ; genes ; geochemistry ; marine pollution ; microbiome ; oils ; petroleum ; sediments ; space and time ; Canada ; DNA sequencing ; Environmental baselines ; Deep Sea ; Microbial biodiversity ; Offshore oil industry
Language	English
Publishing place	Elsevier Ltd
Document type	Article ; Online
Note	Pre-press version
ZDB-ID	2001296-2
ISSN	1879-3363 ; 0025-326X
ISSN (online)	1879-3363
ISSN	0025-326X
DOI	10.1016/j.marpolbul.2023.115308
Database	NAL-Catalogue (AGRICOLA)

Full text online

Accessible to users with ZB MED library card

Order via subito

Details ▾
- Full text online
- Order with fees

Article ; Online: Global epidemiology of asymptomatic colonisation of methicillin-resistant

Yang, Liuyue / Dharmaratne, Priyanga / Zhu, Chendi / Sapugahawatte, Dulmini Nanayakkara / Rahman, Nannur / Barua, Nilakshi / Li, Carmen / Kwok, Kin On / Luo, Mingjing / Liyanapathirana, Veranja / Ip, Margaret

Archives of disease in childhood

2024 Volume 109, Issue 4, Page(s) 267–274

Abstract: Objective: To estimate the global prevalence of asymptomatic colonisation, and determine the associated risk factors, antibiotic resistance and genotypes of methicillin-resistant : Design: Four bibliometric databases were searched for publications ... ...

Abstract	Objective: To estimate the global prevalence of asymptomatic colonisation, and determine the associated risk factors, antibiotic resistance and genotypes of methicillin-resistant Design: Four bibliometric databases were searched for publications between 2010 and 2022 according to the protocol registered in PROSPERO. Cross-sectional or cohort studies describing the prevalence of asymptomatic colonisation of Setting and studies: We included studies where children without respiratory tract infection or Staphylococcal infection were recruited from the community, children's institutions (ie, nurseries, kindergartens, daycare centres and preschools) and healthcare centre visits and assessed for asymptomatic colonisation with Main outcome measures: The pooled prevalence of asymptomatic colonisation of Results: In this systematic review and meta-analysis of 21 416 young children, the pooled global prevalence of asymptomatic Conclusion: This study provides evidence of increased MRSA colonisation globally among young children, underlining the critical role of asymptomatic carriers in MRSA transmission and the need for control measures. Prospero registration number: CRD 42022328385.
MeSH term(s)	Child ; Child, Preschool ; Humans ; Methicillin-Resistant Staphylococcus aureus/genetics ; Staphylococcus aureus ; Cross-Sectional Studies ; Staphylococcal Infections/epidemiology ; Nose ; Prevalence
Language	English
Publishing date	2024-03-19
Publishing country	England
Document type	Meta-Analysis ; Systematic Review ; Journal Article
ZDB-ID	524-1
ISSN	1468-2044 ; 0003-9888 ; 1359-2998
ISSN (online)	1468-2044
ISSN	0003-9888 ; 1359-2998
DOI	10.1136/archdischild-2023-326124
Database	MEDical Literature Analysis and Retrieval System OnLINE

In stock of ZB MED Cologne/Königswinter

Um IV Zs.106: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular ab Jg. 2022: Lesesaal (EG)
Zs.MA 3: Show issues

Order via subito

Details ▾
- See ZB MED holdings
- Order with fees

To top

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

Full text online

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

Full text online

More links

Kategorien

Order via subito

More links

Kategorien

Order via subito

Inter-library loan at ZB MED

More links

Kategorien

Order via subito

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

More links

Kategorien

Order via subito

Full text online

More links

Kategorien

Order via subito

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito