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Article ; Online: Exploring the immune escape mechanisms in gastric cancer patients based on the deep AI algorithms and single-cell sequencing analysis.

Chen, Wenli / Liu, Xiaohui / Wang, Houhong / Dai, Jingyou / Li, Changquan / Hao, Yanyan / Jiang, Dandan

Journal of cellular and molecular medicine

2024 Volume 28, Issue 10, Page(s) e18379

Abstract: Gastric cancer is a prevalent and deadly malignancy, and the response to immunotherapy varies among patients. This study aimed to develop a prognostic model for gastric cancer patients and investigate immune escape mechanisms using deep machine learning ... ...

Abstract	Gastric cancer is a prevalent and deadly malignancy, and the response to immunotherapy varies among patients. This study aimed to develop a prognostic model for gastric cancer patients and investigate immune escape mechanisms using deep machine learning and single-cell sequencing analysis. Data from public databases were analysed, and a prediction model was constructed using 101 algorithms. The high-AIDPS group, characterized by increased AIDPS expression, exhibited worse survival, genomic variations and immune cell infiltration. These patients also showed immunotherapy tolerance. Treatment strategies targeting the high-AIDPS group identified three potential drugs. Additionally, distinct cluster groups and upregulated AIDPS-associated genes were observed in gastric adenocarcinoma cell lines. Inhibition of GHRL expression suppressed cancer cell activity, inhibited M2 polarization in macrophages and reduced invasiveness. Overall, AIDPS plays a critical role in gastric cancer prognosis, genomic variations, immune cell infiltration and immunotherapy response, and targeting GHRL expression holds promise for personalized treatment. These findings contribute to improved clinical management in gastric cancer.
MeSH term(s)	Humans ; Stomach Neoplasms/genetics ; Stomach Neoplasms/immunology ; Stomach Neoplasms/pathology ; Single-Cell Analysis/methods ; Algorithms ; Gene Expression Regulation, Neoplastic ; Prognosis ; Tumor Escape/genetics ; Cell Line, Tumor ; Immunotherapy/methods ; Biomarkers, Tumor/genetics ; Machine Learning
Language	English
Publishing date	2024-05-16
Publishing country	England
Document type	Journal Article
ZDB-ID	2074559-X
ISSN	1582-4934 ; 1582-4934 ; 1582-1838
ISSN (online)	1582-4934
ISSN	1582-4934 ; 1582-1838
DOI	10.1111/jcmm.18379
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Article: Genome Sequence Resource of

Cao, Yi / Cai, Qiuyan / Li, Changquan / Song, Guanglong / Lu, Ning / Yang, Zhixiao

Plant disease

2023 Volume 107, Issue 6, Page(s) 1916–1919

MeSH term(s)	Nicotiana ; Nanopores ; Sequence Analysis, DNA ; Curvularia
Language	English
Publishing date	2023-05-22
Publishing country	United States
Document type	Journal Article
ZDB-ID	754182-x
ISSN	0191-2917
ISSN	0191-2917
DOI	10.1094/PDIS-09-22-2283-A
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Innovative Solid Slippery Coating: Uniting Mechanical Durability, Optical Transparency, Anti-Icing, and Anti-Graffiti Traits.

Shen, Jiayi / Ou, Junfei / Lei, Sheng / Hu, Yating / Wang, Fajun / Fang, Xinzuo / Li, Changquan / Li, Wen / Amirfazli, Alidad

Polymers

2023 Volume 15, Issue 19

Abstract: Slippery coatings, such as the slippery liquid-infused porous surface (SLIPS), have gained significant attention for their potential applications in anti-icing and anti-fouling. However, they lack durability when subjected to mechanical impact. In this ... ...

Abstract	Slippery coatings, such as the slippery liquid-infused porous surface (SLIPS), have gained significant attention for their potential applications in anti-icing and anti-fouling. However, they lack durability when subjected to mechanical impact. In this study, we have developed a robust slippery coating by blending polyurethane acrylate (PUA) with methyltriethoxysilane (MTES) and perfluoropolyether (PFPE) in the solvent of butyl acetate. The resulting mixture is homogeneous and allows for uniform coating on various substrates using a drop coating process followed by drying at 160 °C for 3 h. The cured coating exhibits excellent water repellency (contact angle of ~108° and sliding angle of ~8°), high transparency (average visible transmittance of ~90%), exceptional adherence to the substrate (5B rating according to ASTMD 3359), and remarkable hardness (4H on the pencil hardness scale). Moreover, the coating is quite flexible and can be folded without affecting its wettability. The robustness of the coating is evident in its ability to maintain a sliding angle below 25° even when subjected to abrasion, water jetting, high temperature, and UV irradiation. Due to its excellent nonwetting properties, the coating can be employed in anti-icing, anti-graffiti, and anti-sticking applications. It effectively reduces ice adhesion on aluminum substrates from approximately 217 kPa to 12 kPa. Even after 20 cycles of icing and de-icing, there is only a slight increase in ice adhesion, stabilizing at 40 kPa. The coating can resist graffiti for up to 400 cycles of writing with an oily marker pen and erasing with a tissue. Additionally, the coating allows for easy removal of 3M tape thereon without leaving any residue.
Language	English
Publishing date	2023-10-03
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2527146-5
ISSN	2073-4360 ; 2073-4360
ISSN (online)	2073-4360
ISSN	2073-4360
DOI	10.3390/polym15193983
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article: Unraveling the regulatory network of miRNA expression in Potato Y virus-infected of

Song, Hongping / Gao, Xinwen / Song, Liyun / Jiao, Yubing / Shen, Lili / Yang, Jinguang / Li, Changquan / Shang, Jun / Wang, Hui / Zhang, Songbai / Li, Ying

Frontiers in genetics

2024 Volume 14, Page(s) 1290466

Abstract: Potato virus Y (PVY) disease is a global problem that causes significant damage to crop quality and yield. As traditional chemical control methods are ineffective against PVY, it is crucial to explore new control strategies. MicroRNAs (miRNAs) play a ... ...

Abstract	Potato virus Y (PVY) disease is a global problem that causes significant damage to crop quality and yield. As traditional chemical control methods are ineffective against PVY, it is crucial to explore new control strategies. MicroRNAs (miRNAs) play a crucial role in plant and animal defense responses to biotic and abiotic stresses. These endogenous miRNAs act as a link between antiviral gene pathways and host immunity. Several miRNAs target plant immune genes and are involved in the virus infection process. In this study, we conducted small RNA sequencing and transcriptome sequencing on healthy and PVY-infected
Language	English
Publishing date	2024-01-08
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2606823-0
ISSN	1664-8021
ISSN	1664-8021
DOI	10.3389/fgene.2023.1290466
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Non-transgenic, PAMAM co-delivery DNA of interactive proteins NbCRVP and NbCalB endows Nicotiana benthamiana with a stronger antiviral effect to RNA viruses.

Song, Liyun / Zhang, Daoshun / Liu, Tianbo / Jiang, Changqing / Li, Bin / Li, Changquan / Shen, Lili / Li, Ying / Wang, Fenglong / Jiao, Yubing / Yang, Jinguang

Journal of nanobiotechnology

2024 Volume 22, Issue 1, Page(s) 23

Abstract: Background: Viral diseases continue to pose a major threat to the world's commercial crops. The in-depth exploration and efficient utilization of resistance proteins have become crucial strategies for their control. However, current delivery methods for ...

Abstract	Background: Viral diseases continue to pose a major threat to the world's commercial crops. The in-depth exploration and efficient utilization of resistance proteins have become crucial strategies for their control. However, current delivery methods for introducing foreign DNA suffer from host range limitations, low transformation efficiencies, tissue damage, or unavoidable DNA integration into the host genome. The nanocarriers provides a convenient channel for the DNA delivery and functional utilization of disease-resistant proteins. Results: In this research, we identified a cysteine-rich venom protein (NbCRVP) in Nicotiana benthamiana for the first time. Virus-induced gene silencing and transient overexpression clarified that NbCRVP could inhibit the infection of tobacco mosaic virus, potato virus Y, and cucumber mosaic virus, making it a broad-spectrum antiviral protein. Yeast two-hybrid assay, co-immunoprecipitation, and bimolecular fluorescence complementation revealed that calcium-dependent lipid-binding (CaLB domain) family protein (NbCalB) interacted with NbCRVP to assist NbCRVP playing a stronger antiviral effect. Here, we demonstrated for the first time the efficient co-delivery of DNA expressing NbCRVP and NbCalB into plants using poly(amidoamine) (PAMAM) nanocarriers, achieving stronger broad-spectrum antiviral effects. Conclusions: Our work presents a tool for species-independent transfer of two interacting protein DNA into plant cells in a specific ratio for enhanced antiviral effect without transgenic integration, which further demonstrated new strategies for nanocarrier-mediated DNA delivery of disease-resistant proteins.
MeSH term(s)	Nicotiana/genetics ; RNA Viruses ; Calcium ; DNA ; Antiviral Agents/pharmacology
Chemical Substances	Calcium (SY7Q814VUP) ; DNA (9007-49-2) ; Antiviral Agents
Language	English
Publishing date	2024-01-08
Publishing country	England
Document type	Journal Article
ZDB-ID	2100022-0
ISSN	1477-3155 ; 1477-3155
ISSN (online)	1477-3155
ISSN	1477-3155
DOI	10.1186/s12951-023-02252-z
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article: Preparation of ZnO Nanoparticle/Acrylic Resin Superhydrophobic Coating via Blending Method and Its Wear Resistance and Antibacterial Properties.

Li, Changquan / Wang, Chen / Li, Ziang / Cao, Zhenjun / Xie, Yu / Xue, Mingshan / Zhao, Jinsheng

Materials (Basel, Switzerland)

2021 Volume 14, Issue 14

Abstract: Herein, a facile method for the preparation of an acrylic resin-based superhydrophobic coating is provided. Firstly, ZnO nanoparticles were modified with silane to obtain hydrophobic ZnO, which was then homogeneously blended with acrylic resin. ... ...

Abstract	Herein, a facile method for the preparation of an acrylic resin-based superhydrophobic coating is provided. Firstly, ZnO nanoparticles were modified with silane to obtain hydrophobic ZnO, which was then homogeneously blended with acrylic resin. Subsequently, the mixture was sprayed on an aluminum sheet to form a cured coating. The surface composition and morphology of the coating were characterized using X-ray diffraction (XRD), Fourier transform infrared spectroscopy (FTIR), and scanning electron microscopy (SEM). The hydrophobicity, wear resistance, and antibacterial properties of the prepared samples were tested. The optimized hydrophobicity was achieved with 10 wt% modification agent and resin-to-ZnO mass ratio of 1:4, exhibiting contact and sliding angles of 168.11° and 7.2°, respectively. Wear resistance was insufficient with a low resin content, while it grew with the increase in the resin content. However, when the resin content was excessively high, the hydrophobicity was reduced because the resin could wrap the modified ZnO nanoparticles and decrease the number of hydrophobic groups on the surface. Compared with the pure acrylic resin coating, the ZnO nanoparticle/acrylic resin superhydrophobic coating demonstrated a significant enhancement in the antibacterial properties.
Language	English
Publishing date	2021-07-06
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2487261-1
ISSN	1996-1944
ISSN	1996-1944
DOI	10.3390/ma14143775
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Article: Water and mildew proof SiO₂ & ZnO/silica sol superhydrophobic composite coating on a circuit board

Li, Ziang / Li, Changquan / Ou, Junfei / Fang, Xinzuo / Cong, Mengqi / Wang, Chen / Mao, Feifei / Mao, Tianci / Amirfazli, Alidad

RSC advances. 2021 June 21, v. 11, no. 35

2021

Abstract: In order to improve the waterproof and mildew resistance of electronic equipment, a superhydrophobic coating was prepared on a circuit board. First, hexadecyl trimethoxysilane was used to modify the nano silica and nano zinc oxide particles, and then the ...

Abstract	In order to improve the waterproof and mildew resistance of electronic equipment, a superhydrophobic coating was prepared on a circuit board. First, hexadecyl trimethoxysilane was used to modify the nano silica and nano zinc oxide particles, and then the modified nanoparticles were mixed with the silica sol. Then the superhydrophobic coating was prepared on the surface of the printed circuit board by a spraying process. The preparation technology and physical and chemical properties of the coating were studied. The contact angle of the final sample can reach 169.47°, the sliding angle can reach 1.2°, it has good acid and alkali corrosion resistance, resistance to NaCl, self-cleaning performance and antimildew performance.
Keywords	contact angle ; corrosion ; electronic equipment ; hydrophobicity ; mildews ; silica ; zinc oxide
Language	English
Dates of publication	2021-0621
Size	p. 21862-21869.
Publishing place	The Royal Society of Chemistry
Document type	Article
ISSN	2046-2069
DOI	10.1039/d1ra03140f
Database	NAL-Catalogue (AGRICOLA)

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Article ; Online: The polydopamine-enhanced superadhesion and fracture strength of honeycomb polyurethane porous membranes.

Xue, Mingshan / Zhou, Dan / Ji, Yuwei / Xie, Yu / Li, Changquan / Zhao, Jinsheng

RSC advances

2020 Volume 10, Issue 3, Page(s) 1639–1647

Abstract: The superhydrophobic properties of biological surfaces in nature have attracted extensive attention in scientific and industrial circles. Relative to the rolling superhydrophobic state of lotus leaves, the adhesive superhydrophobic state of geckos ... ...

Abstract	The superhydrophobic properties of biological surfaces in nature have attracted extensive attention in scientific and industrial circles. Relative to the rolling superhydrophobic state of lotus leaves, the adhesive superhydrophobic state of geckos and
Language	English
Publishing date	2020-01-08
Publishing country	England
Document type	Journal Article
ISSN	2046-2069
ISSN (online)	2046-2069
DOI	10.1039/c9ra07887h
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Nanoparticle-dsRNA Treatment of Pollen and Root Systems of Diseased Plants Effectively Reduces the Rate of Tobacco Mosaic Virus in Contemporary Seeds.

Xu, Xiang / Jiao, Yubing / Shen, Lili / Li, Ying / Mei, Yunpeng / Yang, Wengang / Li, Changquan / Cao, Yi / Chen, Fenglei / Li, Bin / Yang, Jinguang

ACS applied materials & interfaces

2023 Volume 15, Issue 24, Page(s) 29052–29063

Abstract: Most crop viruses are carried and spread by seeds. Virus-infected seeds are seed-borne viral disease infections, and thus, reducing the rate of seed infection is an urgent problem in the seed-production industry. The objective of this study was to use ... ...

Abstract	Most crop viruses are carried and spread by seeds. Virus-infected seeds are seed-borne viral disease infections, and thus, reducing the rate of seed infection is an urgent problem in the seed-production industry. The objective of this study was to use nanoparticles (NPs) to directly deliver dsRNA into plants or pollen to initiate RNA interference (RNAi) to reduce viral carryover in seeds. Chitosan quaternary ammonium salt (HACC), complexed with dsRNAs, was selected for targeting the genes for the tobacco mosaic virus (TMV) coat protein (CP) and TMV RNA-dependent RNA polymerase (RdRP) to form HACC-dsRNA NPs. These NP-based dsRNAs were delivered to the plants using four different methods, including infiltration, spraying, root soaking, and pollen internalization. All four methods were able to reduce the seed-carrying rate of offspring seeds of the TMV-infected plants, with pollen internalization being the most effective in reducing the TMV-carrying rate from 95.1 to 61.1% in the control group. By measuring the plant uptake of fluorescence-labeled NPs and dsRNAs, the transportation of the HACC-dsRNA NPs into the plants was observed, and the uptake of dsRNA in combination with small RNA sequencing was further confirmed, resulting in the silencing of homologous RNA molecules during the topical application. The results demonstrated that the incidence of TMV infection was reduced by various degrees via RNAi induction without the need to develop transgenic plants. These results demonstrate the advantages of NP-based RNAi technology in breeding for disease resistance and developing a new strategy for virus-resistant breeding in plants.
MeSH term(s)	Tobacco Mosaic Virus/genetics ; Nicotiana/genetics ; RNA, Double-Stranded ; Seeds ; Pollen
Chemical Substances	RNA, Double-Stranded
Language	English
Publishing date	2023-06-06
Publishing country	United States
Document type	Journal Article
ISSN	1944-8252
ISSN (online)	1944-8252
DOI	10.1021/acsami.3c02798
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article: Novel All-Natural Material for Oil/Water Separation

Wang, Fajun / Lei, Sheng / Ou, Junfei / Li, Changquan / Li, Wen

Industrial & engineering chemistry process design and development. 2019 Jan. 15, v. 58, no. 5

2019

Abstract: Traditional oil/water separation materials were prepared with partial or all nonrenewable raw materials, which would not only increase resource consumption but also cause new environmental pollution after being abandoned. In this work, a superhydrophobic ...

Abstract	Traditional oil/water separation materials were prepared with partial or all nonrenewable raw materials, which would not only increase resource consumption but also cause new environmental pollution after being abandoned. In this work, a superhydrophobic and superoleophilic oil/water separation all-natural material was prepared using a simple and fast emulsion immersing method. The raw materials used including natural sponges and natural vegetable waxes, all of which are renewable. The as-prepared all-natural material can not only absorb various oils from water with high oil absorption capacity, fast oil absorption rate, and good recyclability but also achieve reuse of the absorbed oil by squeezing. In addition, the as-prepared all-natural material exhibits strong stability against cyclic compression, excellent resistance to corrosive aqueous solutions contacting, and organic solvents immersing. Furthermore, the surface wax coating can be easily recycled. This work provides a new method to prepare oil/water separation materials by using all-natural and renewable raw materials.
Keywords	absorption ; aqueous solutions ; coatings ; emulsions ; hydrophobicity ; oils ; pollution ; process design ; raw materials ; solvents ; vegetables ; waxes
Language	English
Dates of publication	2019-0115
Size	p. 1924-1931.
Publishing place	American Chemical Society
Document type	Article
ZDB-ID	1484436-9
ISSN	1520-5045 ; 0888-5885
ISSN (online)	1520-5045
ISSN	0888-5885
DOI	10.1021/acs.iecr.8b05535
Database	NAL-Catalogue (AGRICOLA)

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