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Article ; Online: Targeting the AKT/mTOR/p70S6K Pathway for Oligodendrocyte Differentiation and Myelin Regeneration in Neurological Disorders.

Ge, Chen / Li, Changwei

2023 Volume 20, Issue 4, Page(s) 453–463

Abstract: Background: The AKT/mTOR/p70S6K pathway has been shown to potentially promote spinal cord injury (SCI) repair in rats. However, its exact mechanism and beyond needs to be further explored.: Objective: This study aims to explore the AKT/mTOR/p70S6K ... ...

Abstract	Background: The AKT/mTOR/p70S6K pathway has been shown to potentially promote spinal cord injury (SCI) repair in rats. However, its exact mechanism and beyond needs to be further explored. Objective: This study aims to explore the AKT/mTOR/p70S6K pathway in oligodendrocyte precursor cell (OPC) differentiation, microglial polarization differentiation, and the role of these in myelin regeneration in vitro. Methods: The isolation, induction and characterization of rat primary neuronal stem cells, OPCs and oligodendrocytes were investigated with immunofluorescence and RT-qPCR. Then, the role of AKT/mTOR/p70S6K signaling was explored using western blotting and immunofluorescence, the effect on myelination was examined with OPC-dorsal root ganglion (DRG) neurons co-culture, and the influence of M1/M2 polarization status of microglia on myelin formation was also observed by adding M1/M2 supernatants into OPC-DRG neurons co-culture. Results: Activation of the AKT/mTOR/p70S6K pathway elevated the expression of oligodendrocyte differentiation markers, including MBP, PLP and MOG, which also promoted the colocalization of MBP and NFH in OPC-DRG neurons co-culture. More interestingly, stimulation of the AKT/mTOR/p70S6K pathway facilitated M2 polarization of rat microglia. M2 polarization of microglia enhanced OPC differentiation to oligodendrocytes and myelin formation. Conclusion: Our findings highlight the potential of targeting the AKT/mTOR/p70S6K pathway in promoting oligodendrocyte differentiation and myelin regeneration in neurological disorders such as SCI.
MeSH term(s)	Rats ; Animals ; Myelin Sheath/metabolism ; Proto-Oncogene Proteins c-akt/metabolism ; Ribosomal Protein S6 Kinases, 70-kDa/metabolism ; Ribosomal Protein S6 Kinases, 70-kDa/pharmacology ; Rats, Sprague-Dawley ; TOR Serine-Threonine Kinases/metabolism ; Oligodendroglia/metabolism ; Cell Differentiation ; Spinal Cord Injuries/metabolism
Chemical Substances	Proto-Oncogene Proteins c-akt (EC 2.7.11.1) ; Ribosomal Protein S6 Kinases, 70-kDa (EC 2.7.11.1) ; TOR Serine-Threonine Kinases (EC 2.7.11.1) ; mTOR protein, rat (EC 2.7.1.1)
Language	English
Publishing date	2023-10-11
Publishing country	United Arab Emirates
Document type	Journal Article
ZDB-ID	2296350-9
ISSN	1875-5739 ; 1567-2026
ISSN (online)	1875-5739
ISSN	1567-2026
DOI	10.2174/0115672026274954230919070115
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Article ; Online: Auxin synthesis promotes N metabolism and optimizes root structure enhancing N acquirement in maize (Zea mays L.).

Jiang, Na / Zou, Tong / Huang, Haitao / Li, Changwei / Xia, Yixiang / Yang, Lan

Planta

2024 Volume 259, Issue 2, Page(s) 46

Abstract: Main conclusion: Foliar NAA increases photosynthate supplied by enhancing photosynthesis, to strengthen root activity and provide a large sink for root carbohydrate accumulation, which is beneficial to acquire more nitrogen. The improvement of grain ... ...

Abstract	Main conclusion: Foliar NAA increases photosynthate supplied by enhancing photosynthesis, to strengthen root activity and provide a large sink for root carbohydrate accumulation, which is beneficial to acquire more nitrogen. The improvement of grain yield is an effective component in the food security. Auxin acts as a well-known plant hormone, plays an important role in maize growth and nutrient uptake. In this study, with maize variety Zhengdan 958 (ZD958) as material, the effects of auxin on nitrogen (N) uptake and assimilation of seedling maize were studied by hydroponic experiments. With water as the control, naphthalene acetic acid (NAA, 0.1 mmol/L) and aminoethoxyvinylglycine (AVG, 0.1 mmol/L, an auxin synthesis inhibitor) were used for foliar spraying. The results showed that NAA significantly improved photosynthetic rate and plant biomass by 58.6% and 91.7%, respectively, while the effect of AVG was opposite to that of NAA. At the same time, key enzymes activities related N assimilation in NAA leaves were significantly increased, and the activities of nitrate reductase (NR), glutamine synthetase (GS) and glutamate synthase (GOGAT) were increased by 32.3%, 22.9%, and 16.2% in new leaves. Furthermore, NAA treatment promoted underground growth. When compared with control, total root length, root surface area, root tip number, branch number and root activity were significantly increased by 37.8%, 22.2%, 35.1%, 28.8% and 21.2%. Root growth is beneficial to N capture in maize. Ultimately, the total N accumulation of NAA treatment was significantly increased by 74.5%, as compared to the control. In conclusion, NAA foliar spraying increased endogenous IAA content, and enhanced the activity of N assimilation-related enzymes and photosynthesis rate, in order to build a large sink for carbohydrate accumulation. In addition, NAA strengthened root activity and regulated root morphology and architecture, which facilitated further N uptake and plant growth.
MeSH term(s)	Zea mays ; Biological Transport ; Indoleacetic Acids ; Carbohydrates ; Nitrogen
Chemical Substances	Indoleacetic Acids ; Carbohydrates ; Nitrogen (N762921K75)
Language	English
Publishing date	2024-01-29
Publishing country	Germany
Document type	Journal Article
ZDB-ID	208909-9
ISSN	1432-2048 ; 0032-0935 ; 1866-2749
ISSN (online)	1432-2048
ISSN	0032-0935 ; 1866-2749
DOI	10.1007/s00425-023-04327-5
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Article ; Online: Effectively Controlled Structures of Si-C Composites from Rice Husk for Oxygen Evolution Catalyst.

Li, Changwei / Zhao, Xin / Gao, Min / Kong, Fangong / Chen, Honglei

Molecules (Basel, Switzerland)

2023 Volume 28, Issue 16

Abstract: This work explores a simple way to regulate the morphology and structure of biomass-based carbon and effectively utilize its internal functional groups as the substrate for the next energy materials. The unique randomly oriented and highly interconnected ...

Abstract	This work explores a simple way to regulate the morphology and structure of biomass-based carbon and effectively utilize its internal functional groups as the substrate for the next energy materials. The unique randomly oriented and highly interconnected cordyceps-like 3D structure of rice husk is formed by direct high-temperature carbonization, and the main component is SiC. The well-arranged cordyceps-like structure of SiC demonstrates a remarkable structural/chemical stability and a high rate of electron migration, and further could be used as a stable substrate for metal deposition and find application in the field of electrocatalysis. The oxygen evolution reaction catalyst (SiC-C@Fe
Language	English
Publishing date	2023-08-18
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	1413402-0
ISSN	1420-3049 ; 1431-5165 ; 1420-3049
ISSN (online)	1420-3049
ISSN	1431-5165 ; 1420-3049
DOI	10.3390/molecules28166117
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Article: Editorial: Genetic and proteomic biomarkers in solid tumor detection and treatment.

Li, Jitian / Chen, Apeng / Zhang, Ruowen / Li, Changwei / Zhou, Jianguo

Frontiers in genetics

2023 Volume 14, Page(s) 1200660

Language	English
Publishing date	2023-05-11
Publishing country	Switzerland
Document type	Editorial
ZDB-ID	2606823-0
ISSN	1664-8021
ISSN	1664-8021
DOI	10.3389/fgene.2023.1200660
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Article: Factors controlling carbonate slope failures: Insight from stratigraphic forward modelling

Liu, Jianliang / Liu, Keyu / Salles, Tristan / Li, Changwei

Earth-science reviews. 2022 Sept., v. 232

2022

Abstract: A carbonate slope links platform and basin-floor regions holding crucial information on the carbonate source-sink system of a vast ocean. There is a generally poor understanding of the entire process of carbonate slope deposition, failure, and subsequent ...

Abstract	A carbonate slope links platform and basin-floor regions holding crucial information on the carbonate source-sink system of a vast ocean. There is a generally poor understanding of the entire process of carbonate slope deposition, failure, and subsequent transportation and redeposition etc. due to the lack of field observation and adequate numerical modelling algorithms. Based on a comprehensive literature review on carbonate slope failures, a three-segment carbonate slope depositional model was conceptualized and simulated using a stratigraphic forward modelling (SFM) program. The model is capable of simulating carbonate slope failures in a) subaerial, b) shallow marine, and c) deep marine settings concurrently. The SFM program was employed to simulate the evolution of carbonate slope and the occurrence and distribution of mass transport deposits (MTDs) in a deeply buried upper Ediacaran carbonate succession in the central Sichuan Basin, China. The simulation results show that MTDs were mainly developed at the toe-of-slopes and in the center of the Ediacaran trough, offering a new potential play for future hydrocarbon exploration in the area. Several key factors controlling carbonate slope failures, including carbonate lithologies, carbonate growth rates, and frequencies and amplitudes of sea-level fluctuations, were quantitatively evaluated in both time and space domains. Simulations have confirmed that carbonate lithologies can notably affect the frequency and magnitude of slope failures and the development of MTDs, indicating that the higher the proportions of coarser and cemented sediments, the less frequent slope failures and the less the volume of the MTDs would be. The frequency of slope failures and the volume of the MTDs would increase with carbonate growth rates. Slope failures are more likely to be triggered by high-frequency sea-level fluctuations than by low-frequency sea-level changes. For a given sea-level change frequency, the magnitude of a single slope failure event and the total volume of associated MTDs are more likely to be more significant under a greenhouse climate, with a relatively smaller amplitude of sea-level changes, than under an icehouse climate.
Keywords	Ediacaran period ; basins ; carbonates ; climate ; greenhouse effect ; lithology ; mass transfer ; sea level ; transportation ; China
Language	English
Dates of publication	2022-09
Publishing place	Elsevier B.V.
Document type	Article
ZDB-ID	1792-9
ISSN	0012-8252
ISSN	0012-8252
DOI	10.1016/j.earscirev.2022.104108
Database	NAL-Catalogue (AGRICOLA)

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Article ; Online: Coronavirus Disease (COVID-19); Lessons Learnt from International Response and Advice to the Georgia Government.

Mawani, Minaz / Li, Changwei

Innovation (New York, N.Y.)

2020 Volume 1, Issue 2, Page(s) 100025

Abstract: This commentary presents an analysis of the containment and mitigation efforts by different countries against the recent COVID-19 pandemic. It was developed in response to the Georgia government's decision to relieve lock down restrictions. The article ... ...

Abstract	This commentary presents an analysis of the containment and mitigation efforts by different countries against the recent COVID-19 pandemic. It was developed in response to the Georgia government's decision to relieve lock down restrictions. The article also provides recommendations based on interventions that have been observed to be effective, which will guide decision making for not only Georgia but other states and countries that are currently struggling to manage this outbreak.
Language	English
Publishing date	2020-07-31
Publishing country	United States
Document type	News
ISSN	2666-6758
ISSN (online)	2666-6758
DOI	10.1016/j.xinn.2020.100025
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Article ; Online: What Can We Learn from Brazil's Health Care System?

Qi, Yanling / Li, Changwei

Innovation (New York, N.Y.)

2020 Volume 1, Issue 1, Page(s) 100002

Language	English
Publishing date	2020-04-29
Publishing country	United States
Document type	News
ISSN	2666-6758
ISSN (online)	2666-6758
DOI	10.1016/j.xinn.2020.04.002
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Article ; Online: Can additive carbon nanotubes reduce the PMMA fire risk?

Zhang, Ying / Ma, Chuyuan / Yang, Menglin / Yuan, Dachao / Tang, Kaixuan / Li, Changwei / Mao, Binbin

Fire Safety Journal. 2023 Apr., v. 136 p.103757-

2023

Abstract: The flammability and melt dripping illustrate polymer's fire risk. The high-efficiency thermal shielding effect of carbon nanotubes has been widely concerned to improve polymer's flame retardancy. However, the high thermal conductivity and wick effect of ...

Abstract	The flammability and melt dripping illustrate polymer's fire risk. The high-efficiency thermal shielding effect of carbon nanotubes has been widely concerned to improve polymer's flame retardancy. However, the high thermal conductivity and wick effect of carbon nanotubes may enhance heat and mass transfer to promote fire development. A series of experiments about ignition, heat release, horizontal flame spread and dripping behaviors were carried out to comprehensively analyze the fire risk of polymer composite including polymethyl methacrylate (PMMA) and multi-walled carbon nanotubes (MWCNTs). The results showed after the addition of MWCNTs, the limiting oxygen index (LOI) increased from 18% to 20%, the peak of heat release rate (PHRR) decreased from 548 kW/m² to 372 kW/m², and the flame spread rate (FSR) increased from 0.28 mm/s to 1.1 mm/s, respectively. These results indicate that MWCNTs decreased the ignition risk of PMMA and its heat generation, however, the fire growth rate increased sharply. That was due to the thermal shielding effect and the heat and mass transfer effect of the char layer, respectively. Therefore, the effects of MWCNTs addition on the fire risk of polymer composites need a comprehensive assessment of multiple factors including the fire growth risk.
Keywords	carbon nanotubes ; fire safety ; flammability ; heat ; mass transfer ; oxygen ; polymethylmethacrylate ; risk ; thermal conductivity ; Polymethyl methacrylate ; Fire risk ; Three-dimensional network char layer
Language	English
Dates of publication	2023-04
Publishing place	Elsevier Ltd
Document type	Article ; Online
ZDB-ID	1483569-1
ISSN	0379-7112
ISSN	0379-7112
DOI	10.1016/j.firesaf.2023.103757
Database	NAL-Catalogue (AGRICOLA)

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Article ; Online: A SERS Responsive DGT Sensing Device for

Lu, Yunshu / Li, Changwei / Wang, Yun / Wang, Ziyue / Liu, Chang / Fan, Hongtao / Sun, Ting

ACS sensors

2023 Volume 8, Issue 10, Page(s) 3762–3771

Abstract: Although diffusion gradient in the thin-film technique (DGT) is highly regarded in environmental analysis, the traditional DGT devices cannot serve as sensing devices ... ...

Abstract	Although diffusion gradient in the thin-film technique (DGT) is highly regarded in environmental analysis, the traditional DGT devices cannot serve as sensing devices but
MeSH term(s)	Swine ; Animals ; Gold/analysis ; Water Pollutants, Chemical/analysis ; Metal Nanoparticles ; Sulfadiazine ; Environmental Monitoring/methods
Chemical Substances	Gold (7440-57-5) ; Water Pollutants, Chemical ; Sulfadiazine (0N7609K889)
Language	English
Publishing date	2023-10-09
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ISSN	2379-3694
ISSN (online)	2379-3694
DOI	10.1021/acssensors.3c01169
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Article ; Online: Trends in the prevalence of metabolically healthy and unhealthy obesity in the US adult population: analysis of eight NHANES cross-sectional survey cycles, 1999-2014.

Wen, Yue / Liu, Tingting / Li, Shengxu / Gong, Renrong / Li, Changwei

BMJ open

2022 Volume 12, Issue 11, Page(s) e062651

Abstract: Objective: To exam the time trend of the prevalence of metabolically healthy obesity (MHO) in the US adult population.: Design: Eight cross-sectional survey cycles.: Setting: National Health and Nutrition Examination Survey (NHANES), 1999-2014.: ...

Abstract	Objective: To exam the time trend of the prevalence of metabolically healthy obesity (MHO) in the US adult population. Design: Eight cross-sectional survey cycles. Setting: National Health and Nutrition Examination Survey (NHANES), 1999-2014. Participants: 16 459 NHANES participants aged 20 years and older. Primary outcome measure: MHO was defined as central obesity (waist circumference ≥102 cm for men and ≥88 cm for women) without any of the following conditions: elevated levels of blood pressure (≥130/85 mm Hg), glucose (≥100 mg/dL) and triglycerides (≥150 mm/dL); reduced levels of high-density lipoprotein cholesterol (<40 mg/dL for men and <50 mg/dL for women) or any medication use for high cholesterol, hypertension or diabetes. Results: The prevalence of central obesity significantly increased from 45.2% in 1999-2000 to 56.7% in 2013-2014 (p=0.003). Over the same period, MHO prevalence among those with central obesity only slightly and non-significantly increased from 11.0% to 15.7% (p=0.38). However, MHO prevalence among women increased significantly (p=0.04) from 7.1% to 13.7%. Female gender, a younger age, being Hispanic and non-Hispanic black and high education (some college or above) were significantly (p<0.05) associated with higher prevalence of MHO. Conclusions: While the prevalence of central obesity in the US population has increased since 1999, the prevalence of MHO among those who are centrally obese remained fairly stable.
MeSH term(s)	Adult ; Male ; Female ; Humans ; Nutrition Surveys ; Cross-Sectional Studies ; Prevalence ; Obesity, Abdominal/epidemiology ; Obesity/epidemiology ; Obesity, Metabolically Benign ; Cholesterol, HDL
Chemical Substances	Cholesterol, HDL
Language	English
Publishing date	2022-11-30
Publishing country	England
Document type	Journal Article ; Research Support, N.I.H., Extramural
ZDB-ID	2599832-8
ISSN	2044-6055 ; 2044-6055
ISSN (online)	2044-6055
ISSN	2044-6055
DOI	10.1136/bmjopen-2022-062651
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