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  1. Article: Spermatocytic tumor: A rare case report.

    Hao, Mei-Ling / Li, Chun-Hui

    World journal of clinical cases

    2022  Volume 9, Issue 35, Page(s) 11115–11121

    Abstract: Background: Spermatocytic tumor is a rare, malignant neoplasm of the testes. Since the prognosis for this tumor type is favorable, accurate diagnosis and differentiation from other malignant testicular neoplasms (classic seminoma and lymphoma) are ... ...

    Abstract Background: Spermatocytic tumor is a rare, malignant neoplasm of the testes. Since the prognosis for this tumor type is favorable, accurate diagnosis and differentiation from other malignant testicular neoplasms (classic seminoma and lymphoma) are crucial. To add to the existing literature on the diagnosis of spermatocytic tumor, herein we report the detailed clinical and histopathologic findings for a case that we encountered.
    Case summary: A 60-year-old Chinese man presented with a solid mass in the right scrotum. The mass was surgically removed and spermatocytic tumor was diagnosed. On microscopy, the tumor cells displayed an unusual arrangement in lobules, presenting a pseudo-glandular appearance. To summarize and compare the diagnostic features of this tumor and those of the differential diagnoses, we report our case findings and those mentioned in the literature for various testicular tumors. Although imaging methods can detect masses early in development, their diagnostic capabilities are limited. Biopsy, histopathology, and immunohistochemistry are necessary for confirmatory diagnosis.
    Conclusion: It is important to identify and review the key diagnostic features of spermatocytic tumor.
    Language English
    Publishing date 2022-01-03
    Publishing country United States
    Document type Case Reports
    ISSN 2307-8960
    ISSN 2307-8960
    DOI 10.12998/wjcc.v9.i35.11115
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article: Forest fire risk zoning based on fuzzy logic and analytical network process.

    Ouyang, Yi-Yun / Su, Zhang-Wen / Li, Chun-Hui / Zeng, Ai-Cong / Guo, Fu-Tao

    Ying yong sheng tai xue bao = The journal of applied ecology

    2024  Volume 35, Issue 2, Page(s) 354–362

    Abstract: Forest fires have a significant impact on human life, property safety, and ecological environment. Deve-loping high-quality forest fire risk maps is beneficial for preventing forest fires, guiding resource allocation for firefighting, assisting in fire ... ...

    Title translation 基于模糊逻辑和网络层次分析法的森林火险区划.
    Abstract Forest fires have a significant impact on human life, property safety, and ecological environment. Deve-loping high-quality forest fire risk maps is beneficial for preventing forest fires, guiding resource allocation for firefighting, assisting in fire suppression efforts, and supporting decision-making. With a multi-criteria decision analysis (MCDA) method based on geographic information systems (GIS) and literature review, we assessed the main factors influencing the occurrences of forest fires in Youxi County, Fujian Province. We analyzed the importance of each fire risk factor using the analytic network process (ANP) and assigned weights, and evaluated the sub-standard weights using fuzzy logic assessment. Using ArcGIS aggregation functions, we generated a forest fire risk map and validated it with satellite fire points. The results showed that the areas classified as level 4 or higher fire risk accounted for a considerable proportion in Youxi County, and that the central and northern regions were at higher risk. The overall fire risk situation in the county was severe. The fuzzy ANP model demonstrated a high accuracy of 85.8%. The introduction of this novel MCDA method could effectively improve the accuracy of forest fire risk mapping at a small scale, providing a basis for early fire warning and the planning and allocation of firefighting resources.
    MeSH term(s) Humans ; Fires/prevention & control ; Forests ; Fuzzy Logic ; Geographic Information Systems ; Trees ; Wildfires/statistics & numerical data
    Language English
    Publishing date 2024-03-24
    Publishing country China
    Document type Journal Article ; Review
    ZDB-ID 2881809-X
    ISSN 1001-9332
    ISSN 1001-9332
    DOI 10.13287/j.1001-9332.202402.024
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Tracking the temporal dynamics of the face-like inversion effect as revealed by Chinese characters using magnetoencephalography.

    Li, Chun-Hui / Wang, Man-Ying / Kuo, Bo-Cheng

    Cerebral cortex (New York, N.Y. : 1991)

    2022  Volume 33, Issue 13, Page(s) 8496–8509

    Abstract: The neural basis of configural processing has been extensively studied by exploiting face inversion during recognition, and growing evidence has revealed that word inversion also involves changes in configuration. However, the neural dynamics of face- ... ...

    Abstract The neural basis of configural processing has been extensively studied by exploiting face inversion during recognition, and growing evidence has revealed that word inversion also involves changes in configuration. However, the neural dynamics of face-like inversion effects remain unclear. Here, we tracked the temporal dynamics of neural responses that were sensitive to inversion during Chinese character recognition as they occurred during face recognition using multivariate decoding and temporal generalization analyses. We recorded magnetoencephalography while participants performed a one-back task for faces, compound characters, and simple characters with upright and inverted orientations. We showed that the inversion effect (inverted versus upright) can be decoded at occipitotemporal sensors for all stimulus types over and across time points, with a stronger impact on faces and compound characters than on simple characters. The inversion effect occurred earlier and lasted longer for faces than for characters, and the effect was also stronger for compound characters than for simple characters. Finally, we demonstrated inversion effects in the event-related field for all stimulus types and identified their sources in the ventral occipitotemporal areas. Overall, this study provides novel evidence for the temporal dynamics of the face-like inversion effect occurring during Chinese character recognition.
    MeSH term(s) Humans ; Magnetoencephalography ; Pattern Recognition, Visual/physiology ; Photic Stimulation ; Face ; Facial Recognition/physiology
    Language English
    Publishing date 2022-08-16
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 1077450-6
    ISSN 1460-2199 ; 1047-3211
    ISSN (online) 1460-2199
    ISSN 1047-3211
    DOI 10.1093/cercor/bhad135
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Temporal expectation based on the duration variability modulates alpha oscillations during working memory retention.

    Chen, Fang-Wen / Li, Chun-Hui / Kuo, Bo-Cheng

    NeuroImage

    2022  Volume 265, Page(s) 119789

    Abstract: While maintaining information over a delay of time, working memory (WM) also allows individuals to prepare the mnemonic contents for prospective utilisation. However, it remains unclear whether the expectation of the time of WM test could modulate neural ...

    Abstract While maintaining information over a delay of time, working memory (WM) also allows individuals to prepare the mnemonic contents for prospective utilisation. However, it remains unclear whether the expectation of the time of WM test could modulate neural responses during the retention interval of WM and subsequent performance. Here, we investigated whether temporal expectations based on the variability of delay duration can modulate 9-13 Hz alpha oscillations during WM retention and whether the expectation-induced alpha activity was associated with WM performance. Participants performed a retro-cueing WM task with magnetoencephalography (MEG) (Experiment 1) and a standard WM task with electroencephalography (EEG) (Experiment 2). The expectation of the timing of the WM test was manipulated by the temporal structure of the tasks with small or large variability in the delay durations. We showed that alpha oscillations during retention interval and WM performance varied with duration variability in both of the MEG and EEG experiments. The novel finding was greater alpha-power attenuation over the left frontal and parietal regions during WM retention when the duration variability was small and the test onset was predictable, compared to when the duration variability was large and the test onset was less predictable. Importantly, we observed a positive relationship in variability difference between the response benefit and alpha-power attenuation in the left posterior parietal regions at both MEG-source and EEG-electrode levels. Finally, we confirmed the behavioural benefit when a condition with a fixed delay-duration was included in a behavioural experiment (Experiment 3). When conjoined, the delay duration enables individuals to anticipate when the relevant information would be put to work, and alpha oscillations track the anticipatory states during WM maintenance.
    MeSH term(s) Humans ; Memory, Short-Term/physiology ; Motivation ; Alpha Rhythm/physiology ; Prospective Studies ; Electroencephalography
    Language English
    Publishing date 2022-12-05
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 1147767-2
    ISSN 1095-9572 ; 1053-8119
    ISSN (online) 1095-9572
    ISSN 1053-8119
    DOI 10.1016/j.neuroimage.2022.119789
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article: Collision carcinoma of the rectum involving neuroendocrine carcinoma and adenocarcinoma: A case report.

    Zhao, Xing / Zhang, Gang / Li, Chun-Hui

    World journal of clinical cases

    2021  Volume 9, Issue 18, Page(s) 4789–4796

    Abstract: Background: Collision carcinoma is a rare histological pattern, and includes two or more different types of tumors coexisting in the same organ as one neoplasm. Different to the combined type, the two adjacent tumors of collision carcinoma are ... ...

    Abstract Background: Collision carcinoma is a rare histological pattern, and includes two or more different types of tumors coexisting in the same organ as one neoplasm. Different to the combined type, the two adjacent tumors of collision carcinoma are histologically distinct. Collision carcinoma may occur from any origin or organ, including the cecum, liver, cervix, thyroid, stomach, kidney, and esophagus. In the rectum, adenocarcinoma is the most common pathological type, the combined type is rare, and collision tumors are even rarer. To date, only a limited number of collision carcinoma cases originating from the rectum have been reported. Due to the scarcity of rectal collision carcinoma, more cases need to be reported to fully understand the clinico-pathological features and biological behavior of the tumor.
    Case summary: Here we report a 40-year-old female who presented with the chief complaints of persistent changes in bowel habits and hematochezia for 10 d. She underwent Miles' operation which revealed a collision carcinoma of the rectum, showing a "side by side" pattern, composed of a high grade neuroendocrine carcinoma, (small cell carcinoma) and moderately differentiated adenocarcinoma, based on its clinico-pathological features and biological behavior. The patient remained disease-free at 12 mo follow-up. We also focused on the related literature and expert opinion.
    Conclusion: Collision carcinoma is a rare tumor with ambiguous biological behavior. Greater attention should be paid to its clinico-pathologic diagnosis. Regular and adequate follow-up is essential to help rule out metastasis and assess the prognosis.
    Language English
    Publishing date 2021-07-03
    Publishing country United States
    Document type Case Reports
    ISSN 2307-8960
    ISSN 2307-8960
    DOI 10.12998/wjcc.v9.i18.4789
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article: Increased serum asprosin is correlated with diabetes mellitus-induced erectile dysfunction.

    Li, Chun-Hui / Zhao, Xue / Xu, Yi / Zhang, Fang / Li, Chun-Ting / Zhao, Si-Nan / Hao, Yong-Mei

    Diabetology & metabolic syndrome

    2024  Volume 16, Issue 1, Page(s) 91

    Abstract: Objective: Asprosin, a newly identified adipokine, is pathologically increased in type 2 diabetes. The aim of this study is to see whether serum asprosin concentrations are linked to diabetes mellitus-induced erectile dysfunction (DMED).: Methods: 90 ...

    Abstract Objective: Asprosin, a newly identified adipokine, is pathologically increased in type 2 diabetes. The aim of this study is to see whether serum asprosin concentrations are linked to diabetes mellitus-induced erectile dysfunction (DMED).
    Methods: 90 male patients with type 2 diabetes were included. According to the International Index of Erectile Function (IIEF-5) score, they were classified into two groups: 45 type 2 diabetes patients without erectile dysfunction (DM group) (IIEF-5 > 21),45 patients with diabetes induced erectile dysfunction (DMED group) (IIEF-5 ≤ 21)0.45 healthy male volunteers with normal blood glucose, IIEF-5 score > 21 points, and age matched with the DMED group were included as the control group. Anthropometric and biochemical variables were determined in all participants.
    Results: When compared to the controls, T2DM ( Type 2 Diabetes Mellitus)patients had higher serum asprosin levels. The DMED group had significantly higher serum asprosin than the T2DM groups(p < 0.001). After adjusting for multiple variables considered traditional risk factors for ED(erectile dysfunction), Asprosin can still be used as an independent risk factor for ED; The ROC(Receive Operating Characteristic Curve) indicates that asprosin has good sensitivity (97.8%) and specificity (62.2%) in predicting ED, with an area under the curve of 0.843.Correlation analysis shows that asprosin is negatively correlated with SOD(superoxide dismutase ) and positively correlated with MDA (malondialdehyde).
    Conclusion: Serum asprosin concentrations are increased in patients with DMED. Also, asprosin is correlated with oxidative stress indexes (MDA, SOD).
    Language English
    Publishing date 2024-04-24
    Publishing country England
    Document type Journal Article
    ZDB-ID 2518786-7
    ISSN 1758-5996
    ISSN 1758-5996
    DOI 10.1186/s13098-024-01333-9
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: The role of early cerebral edema and hematoma assessment in aneurysmal subarachnoid hemorrhage (a-SAH) in predicting structural brain abnormalities in cognitive impairments-- case controlled study.

    Wang, Ming-Dong / Fu, Qian-Hui / Ni, Andrew / Yuan, Yun-Peng / Li, Chun-Hui / Wang, Zhan-Xiang / Wang, Hong

    International journal of surgery (London, England)

    2024  

    Abstract: Background: Early assessment and management of cerebral edema and hematoma following aneurysmal subarachnoid hemorrhage (a-SAH) can significantly impact clinical cognitive outcomes. However, current clinical practices lack predictive models to identify ... ...

    Abstract Background: Early assessment and management of cerebral edema and hematoma following aneurysmal subarachnoid hemorrhage (a-SAH) can significantly impact clinical cognitive outcomes. However, current clinical practices lack predictive models to identify early structural brain abnormalities affecting cognition. To address this gap, we propose the development of a predictive model termed the a-SAH Early Brain Edema/Hematoma Compression Neural (Structural Brain) Networks Score System (SEBE-HCNNSS).
    Methods: In this study, 202 consecutive patients with spontaneous a-SAH underwent initial computed tomography (CT) or magnetic resonance imaging (MRI) scans within 24 hours of ictus with follow-up 2 months after discharge. Using logistic regression analysis (univariate and multivariate), we evaluated the association of clinically relevant factors and various traditional scale ratings with cognitive impairment (CI). Risk factors with the highest area under the curve (AUC) values were included in the multivariate analysis and least absolute shrinkage and selection operator (LASSO) analysis or Cox regression analysis.
    Results: A total of 177 patients were enrolled in the study, and 43 patients were classified with a high SEBE-HCNNSS grade (3 to 5). After a mean follow-up of 2 months, 121 individuals (68.36%) with a-SAH and 3 control subjects developed incident CI. The CT inter-observer reliability of the SEBE-HCNNSS scale was high, with a Kappa value of 1. Furthermore, ROC analysis identified the SEBE-HCNNSS scale (OR 3.322, 95% CI 2.312-7.237, P=0.00025) as an independent predictor of edema, CI, and unfavorable prognosis. These results were also replicated in a validation cohort.
    Conclusion: Overall, the SEBE-HCNNSS scale represents a simple assessment tool with promising predictive value for CI and clinical outcomes post-a-SAH. Our findings indicate its practical utility as a prognostic instrument for risk evaluation after a-SAH, potentially facilitating early intervention and treatment.
    Language English
    Publishing date 2024-03-05
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2212038-5
    ISSN 1743-9159 ; 1743-9191
    ISSN (online) 1743-9159
    ISSN 1743-9191
    DOI 10.1097/JS9.0000000000001244
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: PKM2 is a Novel Osteoporosis-Associated Protein in Chinese.

    Xu, Qing / Li, Chun-Hui / Tang, Chang-Hua / Huang, Xiao-Li / Wu, Long-Fei / Zhou, Xu / Lei, Shu-Feng / Deng, Fei-Yan

    Endocrine research

    2024  Volume 49, Issue 2, Page(s) 92–105

    Abstract: Purpose:Osteoporosis is characterized by low bone mineral density (BMD) and high risk of osteoporotic fracture (OF). Peripheral blood monocytes (PBM) can differentiate into osteoclasts to resorb bone. This study was to identify PBM-expressed proteins ... ...

    Abstract Purpose:Osteoporosis is characterized by low bone mineral density (BMD) and high risk of osteoporotic fracture (OF). Peripheral blood monocytes (PBM) can differentiate into osteoclasts to resorb bone. This study was to identify PBM-expressed proteins significant for osteoporosis in Chinese Han elderly population (>65 years), and focused on two phenotypes of osteoporosis: low BMD and OF.
    Methods: Label-free quantitative proteomics was employed to profile PBM proteome and to identify differentially expressed proteins (DEPs) between OF (N=27) vs. non-fractured (NF, N=24) subjects and between low BMD (N=12) vs. high BMD (N=12) subjects in women. Western blotting (WB) was conducted to validate differential expression, and ELISA to evaluate translational value for secretory protein of interest.
    Results: We discovered 59 DEPs with fold change (FC)>1.3 (P<1×10-5), and validated the significant up-regulation of pyruvate kinase isozyme 2 (PKM2) with osteoporosis (P<0.001). PKM2 protein upregulation with OF was replicated with PBM in men (P=0.04). Plasma PKM2 protein level was significantly elevated with OF in an independent sample (N=100, FC=1.68, P=0.01). Pursuant functional assays showed that extracellular PKM2 protein supplement not only promoted monocyte trans-endothelial migration, growth, and osteoclast differentiation (marker gene expression), but also inhibited osteoblast growth, differentiation (ALP gene expression), and activity.
    Conclusion: The above findings suggest that PKM2 protein is a novel osteoporosis-associated functional protein in Chinese Han elderly population. It may serve as a risk biomarker and drug target for osteoporosis.
    MeSH term(s) Aged ; Aged, 80 and over ; Female ; Humans ; Male ; Bone Density ; Carrier Proteins/metabolism ; China ; East Asian People ; Monocytes/metabolism ; Osteoporosis ; Osteoporotic Fractures ; Pyruvate Kinase/metabolism
    Chemical Substances Carrier Proteins ; PKM2 protein, human (EC 2.7.1.40) ; Pyruvate Kinase (EC 2.7.1.40)
    Language English
    Publishing date 2024-01-30
    Publishing country England
    Document type Journal Article
    ZDB-ID 605823-1
    ISSN 1532-4206 ; 0743-5800
    ISSN (online) 1532-4206
    ISSN 0743-5800
    DOI 10.1080/07435800.2024.2310818
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: The effects of stimulus inversion on the neural representations of Chinese character and face recognition.

    Li, Chun-Hui / Wang, Man-Ying / Kuo, Bo-Cheng

    Neuropsychologia

    2021  Volume 164, Page(s) 108090

    Abstract: This study investigates whether stimulus inversion influences neural responses of Chinese character recognition similarly to its effect on face recognition in category-selective and object-related brain areas using functional magnetic resonance imaging. ... ...

    Abstract This study investigates whether stimulus inversion influences neural responses of Chinese character recognition similarly to its effect on face recognition in category-selective and object-related brain areas using functional magnetic resonance imaging. Participants performed a one-back matching task for simple (one radical) and compound (two radicals) Chinese characters and faces with upright and inverted orientations. Inverted stimuli produced slower response times with stronger activity within the fusiform gyrus (FG) than upright stimuli for faces and Chinese characters. While common inversion-related activation was identified in the left FG among stimulus types, we observed a significant inter-regional correlation between the left FG and the intraparietal sulcus for face inversion. Importantly, analyses of region-of-interest (ROI) multivariate pattern classification showed that classifiers trained on face inversion can decode the representations of character inversion in the character-selective ROI. However, this was not true for face inversion in face-selective ROIs when the classifiers were trained on characters. Similar activity patterns for character and face inversion were observed in the object-related ROIs. We also showed higher decoding accuracy for upright stimuli in the face-selective ROI than in the character-selective ROI but this was not true for inverted ones or when patterns were examined in the object-related ROIs. Together, our results support shared and distinct configural representations for character and face recognition in category-selective and object-related brain areas.
    MeSH term(s) China ; Face ; Facial Recognition ; Humans ; Pattern Recognition, Visual/physiology ; Photic Stimulation/methods
    Language English
    Publishing date 2021-11-18
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 207151-4
    ISSN 1873-3514 ; 0028-3932
    ISSN (online) 1873-3514
    ISSN 0028-3932
    DOI 10.1016/j.neuropsychologia.2021.108090
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: [microRNA-1 gene delivery mediated by exosomes suppresses CAL-27 cell proliferation].

    Wu, Bao-Qin / Li, Chun-Hui / Zhang, Meng-Lian / Nie, Min-Hai

    Hua xi kou qiang yi xue za zhi = Huaxi kouqiang yixue zazhi = West China journal of stomatology

    2021  Volume 39, Issue 2, Page(s) 136–142

    Abstract: Objectives: This study aims to construct endogenous exosomes abundantly loaded with miR-1 and investigate the role of exosome-mediated microRNA-1 (miR-1) delivery on CAL-27 cell proliferation.: Methods: Exosomes secreted by miR-1-overexpressing ... ...

    Abstract Objectives: This study aims to construct endogenous exosomes abundantly loaded with miR-1 and investigate the role of exosome-mediated microRNA-1 (miR-1) delivery on CAL-27 cell proliferation.
    Methods: Exosomes secreted by miR-1-overexpressing HEK293 cells (miR1-EXO) were purified via ultracentrifugation and subjected to transmission electron microscopy, nanoparticle analysis, Western blot analysis, and quantitative polymerase chain reaction (qPCR). CAL-27 cells were cocultured with exosomes secreted by HEK293 cells (CON-EXO) and miR1-EXO and equivalent phosphate buffer saline. The intracellular transport of exosomes was measured by using immunofluorescence, the expression of miR-1 and its target gene MET were investigated via qPCR, CAL-27 cell proliferation was measured through MTT assay, and cell cycle state was determined by applying flow cytometry.
    Results: Electron microscopy revealed that miR1-EXO and CON-EXO were spherical or cup-shaped with an average diameter of approximately 110 nm. The well-known exosome markers CD9, Tsg101, and Alix were enriched. The expression of miR-1 in miR1-EXO was higher than that in CON-EXO (285.80±14.33 vs 1.00±0.06,
    Conclusions: Exosomes secreted from miR1-EXO cells could load abundant miR-1. Exosomal miR-1 delivered into CAL-27 cells by using miR1-EXO suppressed the expression of MET mRNA and inhibited cell proliferation.
    MeSH term(s) Cell Cycle ; Cell Proliferation ; Exosomes ; HEK293 Cells ; Humans ; MicroRNAs
    Chemical Substances MIRN1 microRNA, human ; MicroRNAs
    Language Chinese
    Publishing date 2021-04-22
    Publishing country China
    Document type Journal Article
    ZDB-ID 1202342-5
    ISSN 2618-0456 ; 1000-1182
    ISSN (online) 2618-0456
    ISSN 1000-1182
    DOI 10.7518/hxkq.2021.02.003
    Database MEDical Literature Analysis and Retrieval System OnLINE

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