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Artikel: Quantitative Evaluation of Oxygen Extraction Fraction Changes in the Monkey Brain during Acute Stroke by Using Quantitative Susceptibility Mapping.

Meng, Yuguang / Li, Chun-Xia / Zhang, Xiaodong

2023 Band 13, Heft 4

Abstract: Background: The oxygen extraction fraction (OEF) indicates the brain's oxygen consumption and can be estimated by using the quantitative susceptibility mapping (QSM) MRI technique. Recent studies have suggested that OEF alteration following stroke is ... ...

Abstract	Background: The oxygen extraction fraction (OEF) indicates the brain's oxygen consumption and can be estimated by using the quantitative susceptibility mapping (QSM) MRI technique. Recent studies have suggested that OEF alteration following stroke is associated with the viability of at-risk tissue. In the present study, the temporal evolution of OEF in the monkey brain during acute stroke was investigated using QSM. Methods: Ischemic stroke was induced in adult rhesus monkeys (n = 8) with permanent middle cerebral artery occlusion (pMCAO) by using an interventional approach. Diffusion-, T2-, and T2-weighted images were conducted on day 0, day 2, and day 4 post-stroke using a clinical 3T scanner. Progressive changes in magnetic susceptibility and OEF, along with their correlations with the transverse relaxation rates and diffusion indices, were examined. Results:* The magnetic susceptibility and OEF in injured gray matter of the brain significantly increased during the hyperacute phase, and then decreased significantly on day 2 and day 4. Moreover, the temporal changes of OEF in gray matter were moderately correlated with mean diffusivity (MD) (r = 0.52; Conclusion: The preliminary results demonstrate that QSM-derived OEF is a robust approach to examine the progressive changes of gray matter in the ischemic brain from the hyperacute phase to the subacute phase of stroke. The changes of OEF in gray matter were more prominent than those in white matter following stroke insult. The findings suggest that QSM-derived OEF may provide complementary information for understanding the neuropathology of the brain tissue following stroke and predicting stroke outcomes.
Sprache	Englisch
Erscheinungsdatum	2023-04-13
Erscheinungsland	Switzerland
Dokumenttyp	Journal Article
ZDB-ID	2662250-6
ISSN	2075-1729
ISSN	2075-1729
DOI	10.3390/life13041008
Datenquelle	MEDical Literature Analysis and Retrieval System OnLINE

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Artikel: Improving delineation of the corticospinal tract in the monkey brain scanned with conventional DTI by using a compressed sensing based algorithm.

Meng, Yuguang / Li, Chun-Xia / Zhang, Xiaodong

Investigative magnetic resonance imaging

2022 Band 26, Heft 4, Seite(n) 265–274

Abstract: Background: The corticospinal tract (CST) is a major tract for motor function. It can be impaired by stroke. Its degeneration is associated with stroke outcome. Diffusion tensor imaging (DTI) tractography plays an important role in assessing fiber ... ...

Abstract	Background: The corticospinal tract (CST) is a major tract for motor function. It can be impaired by stroke. Its degeneration is associated with stroke outcome. Diffusion tensor imaging (DTI) tractography plays an important role in assessing fiber bundle integrity. However, it is limited in detecting crossing fibers in the brain. The crossing fiber angular resolution of intra-voxel structure (CFARI) algorithm shows potential to resolve complex fibers in the brain. The objective of the present study was to improve delineation of CST pathways in monkey brains scanned by conventional DTI. Methods: Healthy rhesus monkeys were scanned by diffusion MRI with 128 diffusion encoding directions to evaluate the CFARI algorithm. Four monkeys with ischemic occlusion were also scanned with DTI (b = 1000 s/mm Results: CFARI algorithm revealed substantially more fibers originated from the ventral premotor cortex in healthy and stroke monkey brains than DTI tractography. In addition, CFARI showed better sensitivity in detecting CST abnormality than DTI tractography following stroke. Conclusion: CFARI significantly improved delineation of the CST in the brain scanned by DTI with 30 gradient directions. It showed better sensitivity in detecting abnormity of the CST following stroke. Preliminary results suggest that CFARI could facilitate prediction of function outcomes after stroke.
Sprache	Englisch
Erscheinungsdatum	2022-12-31
Erscheinungsland	Korea (South)
Dokumenttyp	Journal Article
ISSN	2384-1095
ISSN	2384-1095
DOI	10.13104/imri.2022.26.4.265
Datenquelle	MEDical Literature Analysis and Retrieval System OnLINE

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Artikel ; Online: Longitudinal evaluation of the functional connectivity changes in the secondary somatosensory cortex (S2) of the monkey brain during acute stroke.

Li, Chun-Xia / Tong, Frank / Kempf, Doty / Howell, Leonard / Zhang, Xiaodong

Current research in neurobiology

2023 Band 5, Seite(n) 100097

Abstract: Background: Somatosensory deficits are frequently seen in acute stroke patients and may recover over time and affect functional outcome. However, the underlying mechanism of function recovery remains poorly understood. In the present study, progressive ... ...

Abstract	Background: Somatosensory deficits are frequently seen in acute stroke patients and may recover over time and affect functional outcome. However, the underlying mechanism of function recovery remains poorly understood. In the present study, progressive function alteration of the secondary somatosensory cortex (S2) and its relationship with regional perfusion and neurological outcome were examined using a monkey model of stroke. Methods and materials: Rhesus monkeys (n = 4) were induced with permanent middle cerebral artery occlusion (pMCAo). Resting-state functional MRI, dynamic susceptibility contrast perfusion MRI, diffusion-weighted, T Results: Ischemic lesion was evidently seen in the MCA territory including S2 in each monkey. Relative FC of injured S2 regions decreased substantially following stroke. Spetzler scores dropped substantially at 24 h post stroke but slightly recovered from Day 2 to Day 4. Relative FC progressively increased from 6 to 48 and 96 h post stroke and correlated significantly with relative CBFand CBF/Tmax changes. Conclusion: The present study revealed the progressive alteration of function connectivity in S2 during acute stroke. The preliminary results suggested the function recovery might start couple days post occlusion and collateral circulation might play a key role in the recovery of somatosensory function after stroke insult. The relative function connectivity in S2 may provide additional information for prediction of functional outcome in stroke patients.
Sprache	Englisch
Erscheinungsdatum	2023-06-23
Erscheinungsland	Netherlands
Dokumenttyp	Journal Article
ISSN	2665-945X
ISSN (online)	2665-945X
DOI	10.1016/j.crneur.2023.100097
Datenquelle	MEDical Literature Analysis and Retrieval System OnLINE

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Artikel: Evaluation of multi-shell diffusion MRI acquisition strategy on quantitative analysis using multi-compartment models.

Li, Chun-Xia / Patel, Sudeep / Zhang, Xiaodong

Quantitative imaging in medicine and surgery

2020 Band 10, Heft 4, Seite(n) 824–834

Abstract: Background: Multi-compartment diffusion models such as Neurite Orientation Dispersion and Density Imaging (NODDI) have been increasingly used for diffusion MRI (dMRI) data processing in biomedical research. However, those models usually require multiple ...

Abstract	Background: Multi-compartment diffusion models such as Neurite Orientation Dispersion and Density Imaging (NODDI) have been increasingly used for diffusion MRI (dMRI) data processing in biomedical research. However, those models usually require multiple HARDI shells that may increase scanning duration substantially, and their application can be hindered in uncooperative patients (like infants) accordingly. Also, it is highly expected that the same dataset can be explored with multiple diffusion models for retrieving complementary information. Methods: Multiple gradient-encoding schemes which consisted of 4-6 shells, moderate b-values (bmax =1,500 or 2,000 s/mm Results: The maps of orientation dispersion index (ODI) and CSF were consistent across the 4-6 shell sampling schemes. However, the corresponding intra-cellular volume fraction (ICVF) maps showed reduced pixel counts [1,100±98 (80 directions) Conclusions: The present study reports a fast multi-shell dMRI data acquisition and processing strategy which allows for obtaining complementary information about microstructural alteration and inflammation from a single dMRI data set with both NODDI and DBSI models. The proposed approach may be particularly useful for characterizing the neurodegenerative disorders in uncooperative patients like children or acute stroke patients in which brain injury is associated with inflammation.
Sprache	Englisch
Erscheinungsdatum	2020-04-30
Erscheinungsland	China
Dokumenttyp	Journal Article
ZDB-ID	2653586-5
ISSN	2223-4306 ; 2223-4292
ISSN (online)	2223-4306
ISSN	2223-4292
DOI	10.21037/qims.2020.03.11
Datenquelle	MEDical Literature Analysis and Retrieval System OnLINE

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Artikel ; Online: MDM2-Mediated Ubiquitination of RXRβ Contributes to Mitochondrial Damage and Related Inflammation in Atherosclerosis.

Zeng, Yi / Cao, Ji / Li, Chun-Xia / Wang, Chun-Yan / Wu, Ruo-Man / Xu, Xiao-Le

International journal of molecular sciences

2022 Band 23, Heft 10

Abstract: A novel function of retinoid X receptor beta (RXRβ) in endothelial cells has been reported by us during the formation of atherosclerosis. Here, we extended the study to explore the cellular mechanisms of RXRβ protein stability regulation. In this study, ... ...

Abstract	A novel function of retinoid X receptor beta (RXRβ) in endothelial cells has been reported by us during the formation of atherosclerosis. Here, we extended the study to explore the cellular mechanisms of RXRβ protein stability regulation. In this study, we discovered that murine double minute-2 (MDM2) acts as an E3 ubiquitin ligase to target RXRβ for degradation. The result showed that MDM2 directly interacted with and regulated RXRβ protein stability. MDM2 promoted RXRβ poly-ubiquitination and degradation by proteasomes. Moreover, mutated MDM2 RING domain (C464A) or treatment with an MDM2 inhibitor targeting the RING domain of MDM2 lost the ability of MDM2 to regulate RXRβ protein expression and ubiquitination. Furthermore, treatment with MDM2 inhibitor alleviated oxidized low-density lipoprotein-induced mitochondrial damage, activation of TLR9/NF-κB and NLRP3/caspase-1 pathway and production of pro-inflammatory cytokines in endothelial cells. However, all these beneficial effects were reduced by the transfection of RXRβ siRNA. Moreover, pharmacological inhibition of MDM2 attenuated the development of atherosclerosis and reversed mitochondrial damage and related inflammation in the atherosclerotic process in LDLr
Mesh-Begriff(e)	Animals ; Atherosclerosis/genetics ; Endothelial Cells/metabolism ; Inflammation/genetics ; Mice ; Proto-Oncogene Proteins c-mdm2/genetics ; Proto-Oncogene Proteins c-mdm2/metabolism ; Tumor Suppressor Protein p53/metabolism ; Ubiquitination
Chemische Substanzen	Tumor Suppressor Protein p53 ; Proto-Oncogene Proteins c-mdm2 (EC 2.3.2.27)
Sprache	Englisch
Erscheinungsdatum	2022-05-21
Erscheinungsland	Switzerland
Dokumenttyp	Journal Article
ZDB-ID	2019364-6
ISSN	1422-0067 ; 1422-0067 ; 1661-6596
ISSN (online)	1422-0067
ISSN	1422-0067 ; 1661-6596
DOI	10.3390/ijms23105766
Datenquelle	MEDical Literature Analysis and Retrieval System OnLINE

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Artikel: Whole body MRI of the non-human primate using a clinical 3T scanner: initial experiences.

Li, Chun-Xia / Zhang, Xiaodong

Quantitative imaging in medicine and surgery

2017 Band 7, Heft 2, Seite(n) 267–275

Abstract: With the advent of parallel imaging MRI techniques, whole-body MRI is being increasingly used in clinical diagnosis. However, its application in preclinical research using large animals remains very limited. In the present study, the whole-body MRI ... ...

Abstract	With the advent of parallel imaging MRI techniques, whole-body MRI is being increasingly used in clinical diagnosis. However, its application in preclinical research using large animals remains very limited. In the present study, the whole-body MRI techniques for adult macaque monkeys were explored using a conventional clinic 3T scanner. The T1, T2 anatomical images, and MR angiography of adult macaque whole bodies were illustrated. The preliminary results suggest whole-body MRI can be a robust tool to examine multiple organs of non-human primate (NHP) models from head to toe non-invasively and simultaneously using a conventional clinical setting. As NHPs are intensely used in biomedical research such as HIV/AIDS and vaccine discovery, whole body MRI techniques can have a wide range of applications in translational research using NHPs.
Sprache	Englisch
Erscheinungsdatum	2017-05-16
Erscheinungsland	China
Dokumenttyp	Journal Article
ZDB-ID	2653586-5
ISSN	2223-4306 ; 2223-4292
ISSN (online)	2223-4306
ISSN	2223-4292
DOI	10.21037/qims.2017.04.03
Datenquelle	MEDical Literature Analysis and Retrieval System OnLINE

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Artikel ; Online: Effects of Long-Duration Administration of 1% Isoflurane on Resting Cerebral Blood Flow and Default Mode Network in Macaque Monkeys.

Li, Chun-Xia / Zhang, Xiaodong

Brain connectivity

2017 Band 7, Heft 2, Seite(n) 98–105

Abstract: Isoflurane is an inhalational anesthetic that is widely used in medical procedures or biomedical research. The duration of anesthesia administration varies from minutes to hours. It is known that isoflurane has dose-dependent effects on brain ... ...

Abstract	Isoflurane is an inhalational anesthetic that is widely used in medical procedures or biomedical research. The duration of anesthesia administration varies from minutes to hours. It is known that isoflurane has dose-dependent effects on brain functionality and physiology, and long-duration anesthesia administration could cause neurocognitive decline in animals and humans. However, the duration effect of isoflurane on the brain physiology and functionality still remains poorly understood. In the present study, cerebral blood flow (CBF) and functional connectivity of adult rhesus monkeys (maintained with 1% isoflurane for 4 h) were examined by using magnetic resonance imaging. The results demonstrate that long-duration isoflurane exposure could result in CBF reduction in most brain areas and functional connectivity decrease in the dominant default-mode network. This study reveals the anesthetic duration effects in the central nervous system of anesthetized subjects and suggests that such duration effects should be considered in examining the brain function of anesthetized animals or humans with contemporary neuroimaging approaches.
Mesh-Begriff(e)	Anesthetics, Inhalation/pharmacology ; Animals ; Blood Pressure/drug effects ; Cerebral Cortex/diagnostic imaging ; Cerebral Cortex/drug effects ; Cerebrovascular Circulation/drug effects ; Cerebrovascular Circulation/physiology ; Dose-Response Relationship, Drug ; Female ; Heart Rate/drug effects ; Image Processing, Computer-Assisted ; Isoflurane/pharmacology ; Longitudinal Studies ; Macaca mulatta ; Magnetic Resonance Imaging ; Neural Pathways/blood supply ; Neural Pathways/diagnostic imaging ; Neural Pathways/drug effects ; Rest ; Time Factors
Chemische Substanzen	Anesthetics, Inhalation ; Isoflurane (CYS9AKD70P)
Sprache	Englisch
Erscheinungsdatum	2017-01-24
Erscheinungsland	United States
Dokumenttyp	Journal Article ; Research Support, N.I.H., Extramural
ZDB-ID	2609017-X
ISSN	2158-0022 ; 2158-0014
ISSN (online)	2158-0022
ISSN	2158-0014
DOI	10.1089/brain.2016.0445
Datenquelle	MEDical Literature Analysis and Retrieval System OnLINE

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Artikel ; Online: The reason and mechanism of propylene glycol alginate sodium sulfate (PSS) mediated allergic side effect.

Xue, Yi-Ting / Li, Shuang / Jiang, Xin-Yang / Xin, Meng / Li, Hai-Hua / Yu, Guang-Li / He, Xiao-Xi / Li, Chun-Xia

International journal of biological macromolecules

2023 Band 241, Seite(n) 124638

Abstract: Propylene glycol alginate sodium sulfate (PSS) is a heparinoid polysaccharide drug used in clinic for >30 years in China. But its allergy events happened from time to time and should not be ignored. Here, ammonium salt in PSS (PSS- ... ...

Abstract	Propylene glycol alginate sodium sulfate (PSS) is a heparinoid polysaccharide drug used in clinic for >30 years in China. But its allergy events happened from time to time and should not be ignored. Here, ammonium salt in PSS (PSS-NH
Mesh-Begriff(e)	Humans ; Alginates/pharmacology ; Polysaccharides/pharmacology ; Hypersensitivity/drug therapy ; Ammonium Compounds ; Mast Cells
Chemische Substanzen	propylene glycol alginate sodium sulfate ; Alginates ; Polysaccharides ; Ammonium Compounds
Sprache	Englisch
Erscheinungsdatum	2023-04-27
Erscheinungsland	Netherlands
Dokumenttyp	Journal Article
ZDB-ID	282732-3
ISSN	1879-0003 ; 0141-8130
ISSN (online)	1879-0003
ISSN	0141-8130
DOI	10.1016/j.ijbiomac.2023.124638
Datenquelle	MEDical Literature Analysis and Retrieval System OnLINE

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Artikel ; Online: Evaluation of prolonged administration of isoflurane on cerebral blood flow and default mode network in macaque monkeys anesthetized with different maintenance doses.

Li, Chun-Xia / Zhang, Xiaodong

Neuroscience letters

2017 Band 662, Seite(n) 402–408

Abstract: Object: Isoflurane is a commonly used volatile anesthetic agent in clinical anesthesia and biomedical research. Prior study suggested the cerebral blood flow (CBF) and default mode network (DMN) could be changed after prolonged administration of ... ...

Abstract	Object: Isoflurane is a commonly used volatile anesthetic agent in clinical anesthesia and biomedical research. Prior study suggested the cerebral blood flow (CBF) and default mode network (DMN) could be changed after prolonged administration of isoflurane. The normal maintenance doses of isoflurane may vary from light (∼0.75%) to deep (∼1.5 or 2%) anesthesia. However, it is not clear how the duration effects are affected by the altered doses. The present study is aimed to examine if the duration effects are affected when isoflurane concentration is altered within normal maintenance doses. Materials and methods: Adult rhesus monkeys (n=5, 8-12 years old, 8-10kg) were anesthetized and maintained at isoflurane levels 0.89±0.03%, 1.05±0.12%, or 1.19±0.08%. CBF and DMN of monkeys were examined using arterial spin-labeling perfusion and resting state functional MRI techniques. Results: the functional connectivity (FC) in the dominant DMN (posterior cingulate cortex (PCC) to anterior cingulated cortex (ACC) or media prefrontal cortex (MPFC)) decreased substantially and similarly during 4-h administration of isoflurane at any given maintenance dosage. CBF changes varied with isoflurane dosage. At the low dose (∼0.89%), CBF decreased in most brain regions. In contrast, no obvious changes was seen in those regions (except for the subcortex) when higher doses of isoflurane were applied. Conclusion: FC in DMN was reduced substantially during prolonged administration of isoflurane. The FC reduction was not varying significantly with maintenance doses of isoflurane but the duration effect on CBF was dose-dependent. Such duration effects of isoflurane administration on DMN and CBF should be considered in the interpretation of the outcome in related neuroimaging studies of anesthetized subjects.
Mesh-Begriff(e)	Anesthetics, Inhalation/administration & dosage ; Animals ; Brain/drug effects ; Cerebrovascular Circulation/drug effects ; Female ; Isoflurane/administration & dosage ; Macaca mulatta
Chemische Substanzen	Anesthetics, Inhalation ; Isoflurane (CYS9AKD70P)
Sprache	Englisch
Erscheinungsdatum	2017-10-18
Erscheinungsland	Ireland
Dokumenttyp	Journal Article
ZDB-ID	194929-9
ISSN	1872-7972 ; 0304-3940
ISSN (online)	1872-7972
ISSN	0304-3940
DOI	10.1016/j.neulet.2017.10.034
Datenquelle	MEDical Literature Analysis and Retrieval System OnLINE

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Artikel ; Online: Effects of alfaxalone on cerebral blood flow and intrinsic neural activity of rhesus monkeys: A comparison study with ketamine.

Li, Chun-Xia / Kempf, Doty / Howell, Leonard / Zhang, Xiaodong

Magnetic resonance imaging

2020 Band 75, Seite(n) 134–140

Abstract: Objective: Alfaxalone has been used increasingly in biomedical research and veterinary medicine of large animals in recent years. However, its effects on the cerebral blood flow (CBF) physiology and intrinsic neuronal activity of anesthetized brains ... ...

Abstract	Objective: Alfaxalone has been used increasingly in biomedical research and veterinary medicine of large animals in recent years. However, its effects on the cerebral blood flow (CBF) physiology and intrinsic neuronal activity of anesthetized brains remain poorly understood. Methods: Four healthy adult rhesus monkeys were anesthetized initially with alfaxalone (0.125 mg/kg/min) or ketamine (1.6 mg/kg/min) for 50 min, then administrated with 0.8% isoflurane for 60 min. Heart rates, breathing beats, and blood pressures were continuously monitored. CBF data were collected using pseudo-continuous arterial spin-labeling (pCASL) MRI technique and rsfMRI data were collected using single-shot EPI sequence for each anesthetic. Results: Both the heart rates and mean arterial pressure (MAP) remained more stable during alfaxalone infusion than those during ketamine administration. Alfaxalone reduced CBF substantially compared to ketamine anesthesia (grey matter, 65 ± 22 vs. 179 ± 38 ml/100g/min, p<0.001; white matter, 14 ± 7 vs. 26 ± 6 ml/100g/min, p < 0.05); In addition, CBF increase was seen in all selected cortical and subcortical regions of alfaxalone-pretreated monkey brains during isoflurane exposure, very different from the findings in isoflurane-exposed monkeys pretreated with ketamine. Also, alfaxalone showed suppression effects on functional connectivity of the monkey brain similar to ketamine. Conclusion: Alfaxalone showed strong suppression effects on CBF of the monkey brain.The residual effect of alfaxalone on CBF of isoflurane-exposed brains was evident and monotonous in all the examined brain regions when used as induction agent for inhalational anesthesia. In particular, alfaxalone showed similar suppression effect on intrinsic neuronal activity of the brain in comparison with ketamine. These findings suggest alfaxalone can be a good alternative to veterinary anesthesia in neuroimaging examination of large animal models. However, its effects on CBF and functional connectivity should be considered.
Mesh-Begriff(e)	Anesthetics, Inhalation/administration & dosage ; Anesthetics, Inhalation/pharmacology ; Animals ; Brain/blood supply ; Brain/drug effects ; Brain/physiology ; Cerebrovascular Circulation/drug effects ; Heart Rate/drug effects ; Isoflurane/administration & dosage ; Isoflurane/pharmacology ; Ketamine/pharmacology ; Macaca mulatta ; Male ; Pregnanediones/administration & dosage ; Pregnanediones/pharmacology
Chemische Substanzen	Anesthetics, Inhalation ; Pregnanediones ; Ketamine (690G0D6V8H) ; alphaxalone (BD07M97B2A) ; Isoflurane (CYS9AKD70P)
Sprache	Englisch
Erscheinungsdatum	2020-10-27
Erscheinungsland	Netherlands
Dokumenttyp	Comparative Study ; Journal Article ; Research Support, N.I.H., Extramural
ZDB-ID	604885-7
ISSN	1873-5894 ; 0730-725X
ISSN (online)	1873-5894
ISSN	0730-725X
DOI	10.1016/j.mri.2020.10.011
Datenquelle	MEDical Literature Analysis and Retrieval System OnLINE

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