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Article: Enhancing the Quality of Life for Peritoneal Dialysis Patients: A Study of Influencing Factors.

Bu, Zhihua / Li, Chunmei

Alternative therapies in health and medicine

2023 Volume 30, Issue 1, Page(s) 73–77

Abstract: Objective: The objective of this study was to examine the quality of life among peritoneal dialysis (PD) patients and identify the influencing factors.: Methods: The study was conducted between March 2021 and December 2021 at the Peritoneal Dialysis ... ...

Abstract	Objective: The objective of this study was to examine the quality of life among peritoneal dialysis (PD) patients and identify the influencing factors. Methods: The study was conducted between March 2021 and December 2021 at the Peritoneal Dialysis Center of the Second Hospital affiliated with Harbin Medical University. A total of 148 patients with end-stage renal disease (ESRD) undergoing PD were included. Demographic information, assessments of dialysis adequacy, biochemical evaluations, and the administration of the Self-Rating Anxiety Scale (SAS) and Self-Rating Depression Scale (SDS) were carried out. The study analyzed the factors influencing the quality of life of these dialysis patients using the Spearman correlation coefficient and multiple linear regression. Results: The KDQOL-36 score for PD patients was 69.78±15.62, with 15.6% experiencing anxiety and 59.7% reporting depression. Age (r = -0.209), residual renal creatinine clearance rate (residual Ccr, r=-0.261), SAS (r=-0.623), and SDS (r = -0.116) scores exhibited significant negative correlations with KDQOL-36 scores (P < .05), while serum albumin levels (r = 0.199) showed significant positive correlations with KDQOL-36 scores (P < .05). Advanced age, poor nutritional status, low serum albumin levels, reduced residual renal Ccr, and high SAS and SDS scores were identified as significant predictors of lower KDQOL-36 scores (P < .05). Conclusions: The psychological state, age, nutritional status, serum albumin levels, and residual renal function significantly impacted the quality of life of PD patients.
MeSH term(s)	Humans ; Quality of Life/psychology ; Peritoneal Dialysis/psychology ; Kidney ; Renal Dialysis ; Kidney Failure, Chronic/therapy ; Serum Albumin/analysis
Chemical Substances	Serum Albumin
Language	English
Publishing date	2023-10-04
Publishing country	United States
Document type	Journal Article
ZDB-ID	1225073-9
ISSN	1078-6791
ISSN	1078-6791
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Article ; Online: Carbon emission reduction effect of renewable energy technology innovation: a nonlinear investigation from China's city level.

Qu, Fang / Li, Chun-Mei

Environmental science and pollution research international

2023 Volume 30, Issue 43, Page(s) 98314–98337

Abstract: There has always been controversy over how renewable energy technologies can play a role in reducing carbon emissions. Based on the energy patent data and the economic data of 244 prefecture-level cities from 2007 to 2017 in China, we explore the carbon ... ...

Abstract	There has always been controversy over how renewable energy technologies can play a role in reducing carbon emissions. Based on the energy patent data and the economic data of 244 prefecture-level cities from 2007 to 2017 in China, we explore the carbon reduction effect of renewable energy technology and its mechanism from the perspective of energy production, conservation, and management. The two-way fixed effect, instrumental variable, spatial Durbin, and mediation effect models are employed to explore empirical results. We found that (1) the impact of renewable energy technologies on carbon emissions is nonlinear, with an inverted U shape. However, this inverted U-shaped relationship only exists locally in cities and there are uncertainties in adjacent cities, which indicates that cross-regional cooperation in renewable energy technology needs to be improved. (2) The mechanism analysis shows that industrial agglomeration and energy consumption scale are the channels that renewable energy technologies affect carbon emissions. Thus, the implicit carbon emissions generated by industrial agglomeration and the failure to green upgrade energy consumption are the main reasons for the inverted U-shaped relationship. (3) The carbon reduction effect of renewable energy technologies of conservation type takes effect first, and renewable energy technologies of production type do not reduce carbon emissions in non-eastern cities, which means that non-eastern cities are likely to become pollution havens. This study provides evidence for renewable energy technologies to achieve efficient carbon emission reduction and cross-regional technical cooperation.
MeSH term(s)	Cities ; Carbon ; China ; Renewable Energy ; Technology
Chemical Substances	Carbon (7440-44-0)
Language	English
Publishing date	2023-08-22
Publishing country	Germany
Document type	Journal Article
ZDB-ID	1178791-0
ISSN	1614-7499 ; 0944-1344
ISSN (online)	1614-7499
ISSN	0944-1344
DOI	10.1007/s11356-023-29245-7
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Article ; Online: Rapid purification of alkylamides from

Wang, Pengxiang / Zhang, Zhuoya / Li, Kaikai / Li, Chunmei

Analytical methods : advancing methods and applications

2024 Volume 16, Issue 8, Page(s) 1196–1205

Abstract: In the present study, an efficient and rapid method for the preparation of high-purity typical alkylamides ... ...

Abstract	In the present study, an efficient and rapid method for the preparation of high-purity typical alkylamides from
MeSH term(s)	Zanthoxylum/chemistry ; Hypesthesia ; Electronic Nose ; Chromatography, Liquid ; Amides
Chemical Substances	sanshool (504-97-2) ; Amides
Language	English
Publishing date	2024-02-22
Publishing country	England
Document type	Journal Article
ZDB-ID	2515210-5
ISSN	1759-9679 ; 1759-9660
ISSN (online)	1759-9679
ISSN	1759-9660
DOI	10.1039/d3ay02015k
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Article ; Online: Characterization of PDGF-Induced Subcellular Calcium Regulation through Calcium Channels in Airway Smooth Muscle Cells by FRET Biosensors.

Ouyang, Mingxing / Zhou, Binqian / Li, Chunmei / Deng, Linhong

Biosensors

2024 Volume 14, Issue 4

Abstract: The homeostasis of cellular calcium is fundamental for many physiological processes, while the calcium levels remain inhomogeneous within cells. During the onset of asthma, epithelial and inflammatory cells secrete platelet-derived growth factor (PDGF), ... ...

Abstract	The homeostasis of cellular calcium is fundamental for many physiological processes, while the calcium levels remain inhomogeneous within cells. During the onset of asthma, epithelial and inflammatory cells secrete platelet-derived growth factor (PDGF), inducing the proliferation and migration of airway smooth muscle (ASM) to the epidermal layer, narrowing the airway. The regulation of ASM cells by PDGF is closely related to the conduction of calcium signals. In this work, we generated subcellular-targeted FRET biosensors to investigate calcium regulation in the different compartments of ASM cells. A PDGF-induced cytoplasmic calcium [Ca
MeSH term(s)	Biosensing Techniques ; Platelet-Derived Growth Factor/pharmacology ; Platelet-Derived Growth Factor/metabolism ; Calcium/metabolism ; Myocytes, Smooth Muscle/metabolism ; Fluorescence Resonance Energy Transfer ; Humans ; Endoplasmic Reticulum/metabolism ; Calcium Channels/metabolism ; Calcium Signaling
Chemical Substances	Platelet-Derived Growth Factor ; Calcium (SY7Q814VUP) ; Calcium Channels
Language	English
Publishing date	2024-04-07
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2662125-3
ISSN	2079-6374 ; 2079-6374
ISSN (online)	2079-6374
ISSN	2079-6374
DOI	10.3390/bios14040179
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Article ; Online: Particulate matter in poultry house on poultry respiratory disease: A systematic review

Wang, Kai / Shen, Dan / Dai, Pengyuan / Li, Chunmei

Poultry Science 2023 Apr., v. 102, no. 4, p. 102556

2023 , Page(s) 102556

Abstract: Particulate matter (PM) is one of the essential environmental stressors for the poultry industry in the world. Given its large specific surface area, PM can adsorb and carry a variety of pollutants, including heavy metal ions, ammonia, and persistent ... ...

Abstract	Particulate matter (PM) is one of the essential environmental stressors for the poultry industry in the world. Given its large specific surface area, PM can adsorb and carry a variety of pollutants, including heavy metal ions, ammonia, and persistent organic pollutants such as pathogenic microorganisms. High concentrations of PM induce poultry respiratory inflammation and trigger various diseases. However, the pathogenic mechanism of PM in poultry houses on respiratory diseases has not been clarified due to its complexity and lack of accurate assays. In terms of pathogenesis, there are three ways to explain this phenomenon: Inhaled PM irritates the respiratory tract, decreases immune resistance, and causes a respiratory disease; respiratory tract irritation by compounds presents in PM; infections with pathogenic and non-pathogenic microorganisms attached to PM. The latter two modes of influence are more harmful. Specifically, PM can induce the respiratory disease through several toxic mechanisms, including ammonia ingestion and bioaccumulation, lung flora dysbiosis, oxidative stress, and metabolic disorders. Therefore, this review summarizes the characteristics of PM in the poultry house and the impact of poultry PM on respiratory disease and proposes potential pathogenic mechanisms.
Keywords	ammonia ; bioaccumulation ; dysbiosis ; flora ; heavy metals ; inflammation ; ingestion ; lungs ; oxidative stress ; particulates ; pathogenesis ; poultry ; poultry housing ; poultry industry ; respiratory tract diseases ; surface area ; systematic review ; toxicity ; poultry house ; particulate matter ; respiratory disease
Language	English
Dates of publication	2023-0203
Size	p. 102556
Publishing place	Elsevier Inc.
Document type	Article ; Online
Note	Pre-press version ; Use and reproduction
ZDB-ID	242586-5
ISSN	1525-3171 ; 0032-5791
ISSN (online)	1525-3171
ISSN	0032-5791
DOI	10.1016/j.psj.2023.102556
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Article: A new variant of Choledochal cyst-type VI: a rare case presentation and review of the literature.

Bai, Yufan / Li, Chunmei / Tang, Jihong / He, Min

Journal of surgical case reports

2023 Volume 2023, Issue 12, Page(s) rjad545

Abstract: A 53-year-old male patient with a previous diagnosis of dilatation of the common bile duct was admitted to the hospital due to recurrent episodes of vague epigastric pain over a 4-month period. After undergoing abdominal CT, MRI, MRCP, ERCP examinations, ...

Abstract	A 53-year-old male patient with a previous diagnosis of dilatation of the common bile duct was admitted to the hospital due to recurrent episodes of vague epigastric pain over a 4-month period. After undergoing abdominal CT, MRI, MRCP, ERCP examinations, together with joint diagnosis by the radiology department and the gastroscopy unit, the diagnosis of a cystic dilatation of the common bile duct was excluded, and to preliminarily diagnose as cystic lesion at the hepatoduodenum ligament. A nasobiliary tube was preset before the surgery, and it was found that the gallbladder, the cyst, and the common bile duct were connected in sequence during the surgery, leading to the definitive diagnosis of biliary cyst of the cystic duct. During the surgery, the anatomical position of the common bile duct was accurately identified, avoiding iatrogenic biliary injury and preserving the integrity of the common bile duct structure. The patient recovered and was discharged from the hospital on the 14th postoperative day. Cystic duct cysts are a relatively new and rare condition. This case demonstrates that clinical decision-making by a multidisciplinary team is of great significance for such diseases, and preoperative assessment of the anatomical relationship between cystic dilation lesions in the hepatic portal region and the biliary system and gallbladder is also crucial.
Language	English
Publishing date	2023-12-19
Publishing country	England
Document type	Case Reports
ZDB-ID	2580919-2
ISSN	2042-8812
ISSN	2042-8812
DOI	10.1093/jscr/rjad545
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Article: Evaluation of the relationship between left atrial strain and exercise tolerance in patients with hypertrophic cardiomyopathy by treadmill stress echocardiography.

Su, Ye / Li, Chunmei / Yin, Lixue

Frontiers in cardiovascular medicine

2023 Volume 10, Page(s) 1168514

Abstract: Objective: The aim of this study is to evaluate the left atrial strain (LAS) in patients with hypertrophic cardiomyopathy (HCM) by treadmill exercise stress echocardiography, combined with three-dimensional speckle tracking technology, for predicting ... ...

Abstract	Objective: The aim of this study is to evaluate the left atrial strain (LAS) in patients with hypertrophic cardiomyopathy (HCM) by treadmill exercise stress echocardiography, combined with three-dimensional speckle tracking technology, for predicting exercise tolerance. Methods: A total of 97 patients with HCM who underwent treadmill exercise stress echocardiography were recruited in Sichuan Provincial People's Hospital between January 2018 and January 2021, and 30 control subjects were selected to be included in the normal group. HCM patients with their metabolic equivalents (METS) ≤ 6.0 were included in the HCM-1 group, while those with METS > 6.0 were included in the HCM-2 group. The LAS and exercise tolerance were analyzed. The ultrasound parameters that could predict a decrease in exercise tolerance were screened, and a predictive model was constructed. Results: It was found that METS, Rest-LASr, Rest-LAScd, and Rest-LASct were significantly lower in HCM patients than those in normal controls. There was a significant difference in age, Target_HR, LVMI, LAVI, Conclusion: Left atrial reservoir strain (LASr) has the strongest association with METS ≤ 6.0. The LASr is an independent resting predictor of METS ≤ 6.0 and has a good performance record in predicting different subtypes of HCM. Compared with the traditional parameters, Peak-
Language	English
Publishing date	2023-05-15
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2781496-8
ISSN	2297-055X
ISSN	2297-055X
DOI	10.3389/fcvm.2023.1168514
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Article ; Online: Particulate matter in poultry house on poultry respiratory disease: a systematic review.

Wang, Kai / Shen, Dan / Dai, Pengyuan / Li, Chunmei

Poultry science

2023 Volume 102, Issue 4, Page(s) 102556

Abstract	Particulate matter (PM) is one of the essential environmental stressors for the poultry industry in the world. Given its large specific surface area, PM can adsorb and carry a variety of pollutants, including heavy metal ions, ammonia, and persistent organic pollutants such as pathogenic microorganisms. High concentrations of PM induce poultry respiratory inflammation and trigger various diseases. However, the pathogenic mechanism of PM in poultry houses on respiratory diseases has not been clarified due to its complexity and lack of accurate assays. In terms of pathogenesis, there are 3 ways to explain this phenomenon: Inhaled PM irritates the respiratory tract, decreases immune resistance, and causes a respiratory disease; respiratory tract irritation by compounds presents in PM; infections with pathogenic and non-pathogenic microorganisms attached to PM. The latter 2 modes of influence are more harmful. Specifically, PM can induce the respiratory disease through several toxic mechanisms, including ammonia ingestion and bioaccumulation, lung flora dysbiosis, oxidative stress, and metabolic disorders. Therefore, this review summarizes the characteristics of PM in the poultry house and the impact of poultry PM on respiratory disease and proposes potential pathogenic mechanisms.
MeSH term(s)	Animals ; Particulate Matter/adverse effects ; Particulate Matter/analysis ; Poultry ; Air Pollutants/analysis ; Ammonia/analysis ; Chickens ; Respiratory Tract Diseases/etiology ; Respiratory Tract Diseases/veterinary ; Inflammation/veterinary
Chemical Substances	Particulate Matter ; Air Pollutants ; Ammonia (7664-41-7)
Language	English
Publishing date	2023-02-03
Publishing country	England
Document type	Systematic Review ; Journal Article ; Review
ZDB-ID	242586-5
ISSN	1525-3171 ; 0032-5791
ISSN (online)	1525-3171
ISSN	0032-5791
DOI	10.1016/j.psj.2023.102556
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Article ; Online: High PAQR4 mRNA Expression May Play a Key Role in Prognosis of Kidney Renal Papillary Cell Carcinoma.

Liu, Chao / Cai, Weili / Tang, Peipei / Li, Chunmei

Annals of clinical and laboratory science

2023 Volume 53, Issue 5, Page(s) 701–711

Abstract: Objective: Kidney renal papillary cell carcinoma (KIRP) is the main subtype of renal cell carcinoma (RCC). The Progestin and AdipoQ Receptor Family Member 4 (PAQR4) has been found highly expressed in numerous cancers compared to normal tissues, but the ... ...

Abstract	Objective: Kidney renal papillary cell carcinoma (KIRP) is the main subtype of renal cell carcinoma (RCC). The Progestin and AdipoQ Receptor Family Member 4 (PAQR4) has been found highly expressed in numerous cancers compared to normal tissues, but the role of PAQR4 in KIRP is unclear. Methods: The expression levels of PAQR4 mRNA obtained from TCGA. Receiver operating characteristic (ROC) curves were used to evaluate the diagnostic value of PAQR4 expression in KIRP patients. Chi-square test was used to determine the correlation between clinical features and PAQR4 expression. Kaplan-Meier analysis and Cox analysis were used to determine the prognostic value of expression levels of PAQR4 in KIRP patients. Gene set enrichment analysis (GSEA) was also performed. The level of PAQR4 mRNA, protein expression and cell proliferation were analyzed through qRT-PCR, western blot and CCK-8 assay. Results: The expression levels of PAQR4 was significantly higher in KIRP tissues. Highly expressed PAQR4 mRNA was correlated with gender, clinical stage and overall survival. Multivariate analysis indicated that PAQR4 was an independent risk factor for patients with KIRP. GPCR ligand binding, signaling by Rho GTPases, DNA repair and PI3K-AKT signaling pathway were associated with aberrant PAQR4 expressions. Moreover, the expression levels of PAQR4 was upregulated in human KIRP and the inhibition of PAQR4 reduced cells proliferation. Conclusion: PAQR4 could be a potential diagnostic and prognostic biomarker in KIRP. The aberrant expression of this protein may trigger the alterations in the numerous signaling pathways, a process likely causing and accelerating the disease.
MeSH term(s)	Humans ; Carcinoma, Renal Cell/metabolism ; Kidney/pathology ; Kidney Neoplasms/pathology ; Ligands ; Phosphatidylinositol 3-Kinases ; Prognosis ; Receptors, G-Protein-Coupled ; RNA, Messenger/genetics
Chemical Substances	Ligands ; Phosphatidylinositol 3-Kinases (EC 2.7.1.-) ; Receptors, G-Protein-Coupled ; RNA, Messenger ; PAQR4 protein, human
Language	English
Publishing date	2023-11-09
Publishing country	United States
Document type	Journal Article
ZDB-ID	193092-8
ISSN	1550-8080 ; 0091-7370 ; 0095-8905
ISSN (online)	1550-8080
ISSN	0091-7370 ; 0095-8905
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Article ; Online: Therapeutic potential of amitriptyline for paraquat-induced pulmonary fibrosis: Involvement of caveolin-1-mediated anti-epithelial-mesenchymal transition and inhibition of apoptosis.

Chen, Jianshi / Jian, Xiangdong / Li, Chunmei / Cheng, Bihuang

Ecotoxicology and environmental safety

2023 Volume 254, Page(s) 114732

Abstract: Objective: Treatment of pulmonary fibrosis caused by paraquat (PQ) poisoning remains problematic. Amitriptyline (AMT) has multiple pharmacological effects. Here we investigated the anti-fibrotic effect of AMT on PQ-induced pulmonary fibrosis and its ... ...

Abstract	Objective: Treatment of pulmonary fibrosis caused by paraquat (PQ) poisoning remains problematic. Amitriptyline (AMT) has multiple pharmacological effects. Here we investigated the anti-fibrotic effect of AMT on PQ-induced pulmonary fibrosis and its possible mechanism. Methods: C57BL/6 mice were randomly divided into control, PQ, PQ + AMT and AMT groups. Histopathology of the lungs, blood gas analysis, and levels of hydroxyproline (HYP), transforming growth factor β1 (TGF-β1) and interleukin 17 (IL-17) were measured. The siRNA transfection inhibited caveolin-1 in A549 cells, which induced epithelial-mesenchymal transition (EMT) by PQ and followed intervention with AMT. E-cadherin, N-cadherin, α-smooth muscle actin (α-SMA) and caveolin-1 were studied by immunohistochemistry and western blot analysis. The apoptosis rate was measured by flow cytometry. Results: Compared with the PQ group, the PQ + AMT group displayed mild pathological changes in pulmonary fibrosis, lower HYP, IL-17 and TGF- β1 levels in lung, but high TGF- β1 in serum. Levels of N-cadherin and α-SMA in the lungs were significantly decreased, but caveolin-1 was increased, while SaO Conclusion: AMT inhibited PQ-induced EMT in A549 cells and improved lung histopathology and oxygenation in mice by up-regulating caveolin-1.
MeSH term(s)	Mice ; Animals ; Pulmonary Fibrosis/chemically induced ; Pulmonary Fibrosis/drug therapy ; Pulmonary Fibrosis/metabolism ; Paraquat/toxicity ; Amitriptyline/adverse effects ; Interleukin-17/metabolism ; Caveolin 1/genetics ; Caveolin 1/metabolism ; Caveolin 1/pharmacology ; Mice, Inbred C57BL ; Lung/metabolism ; Cadherins/genetics ; Cadherins/metabolism ; RNA, Small Interfering ; Apoptosis
Chemical Substances	Paraquat (PLG39H7695) ; Amitriptyline (1806D8D52K) ; Interleukin-17 ; Caveolin 1 ; Cadherins ; RNA, Small Interfering
Language	English
Publishing date	2023-03-08
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	436536-7
ISSN	1090-2414 ; 0147-6513
ISSN (online)	1090-2414
ISSN	0147-6513
DOI	10.1016/j.ecoenv.2023.114732
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