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Article ; Online: Reply to addressing the need for bilateral carotid evaluation in doppler monitoring studies for enhanced CPR outcomes.

Wang, Shuo / Li, Chunsheng

2024 , Page(s) 110194

Language	English
Publishing date	2024-03-22
Publishing country	Ireland
Document type	Letter
ZDB-ID	189901-6
ISSN	1873-1570 ; 0300-9572
ISSN (online)	1873-1570
ISSN	0300-9572
DOI	10.1016/j.resuscitation.2024.110194
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Zs.A 1048: Show issues

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Article ; Online: Therapeutic Effects of Shenfu Injection in Shock.

Zhang, Ming-Qing / Li, Chun-Sheng

Chinese journal of integrative medicine

2023 Volume 29, Issue 12, Page(s) 1142–1146

Abstract: Shock is the clinical manifestation of acute circulatory failure, which results in inadequate utilization of cellular oxygen. It is a common condition with high mortality rates in intensive care units. The intravenous administration of Shenfu Injection ( ... ...

Abstract	Shock is the clinical manifestation of acute circulatory failure, which results in inadequate utilization of cellular oxygen. It is a common condition with high mortality rates in intensive care units. The intravenous administration of Shenfu Injection (SFI) may attenuate inflammation, regulate hemodynamics and oxygen metabolism; inhibit ischemia-reperfusion responses; and have adaptogenic and antiapoptotic effects. In this review, we have discussed the clinical applications and antishock pharmacological effects of SFI. Further in-depth and large-scale multicenter clinical studies are warranted to determine the therapeutic effects of SFI on shock.
MeSH term(s)	Humans ; Drugs, Chinese Herbal/pharmacology ; Drugs, Chinese Herbal/therapeutic use ; Shock/drug therapy ; Injections ; Oxygen ; Multicenter Studies as Topic
Chemical Substances	Shen-Fu ; Drugs, Chinese Herbal ; Oxygen (S88TT14065)
Language	English
Publishing date	2023-05-24
Publishing country	China
Document type	Journal Article ; Review
ZDB-ID	2171254-2
ISSN	1993-0402 ; 1672-0415
ISSN (online)	1993-0402
ISSN	1672-0415
DOI	10.1007/s11655-023-3631-2
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Zs.A 5823: Show issues

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Article: Localizing targets for neuromodulation in drug-resistant epilepsy using intracranial EEG and computational model.

Liu, Yang / Li, Chunsheng

Frontiers in physiology

2022 Volume 13, Page(s) 1015838

Abstract: Neuromodulation has emerged as a promising technique for the treatment of epilepsy. The target for neuromodulation is critical for the effectiveness of seizure control. About 30% of patients with drug-resistant epilepsy (DRE) fail to achieve seizure ... ...

Abstract	Neuromodulation has emerged as a promising technique for the treatment of epilepsy. The target for neuromodulation is critical for the effectiveness of seizure control. About 30% of patients with drug-resistant epilepsy (DRE) fail to achieve seizure freedom after surgical intervention. It is difficult to find effective brain targets for neuromodulation in these patients because brain regions are damaged during surgery. In this study, we propose a novel approach for localizing neuromodulatory targets, which uses intracranial EEG and multi-unit computational models to simulate the dynamic behavior of epileptic networks through external stimulation. First, we validate our method on a multivariate autoregressive model and compare nine different methods of constructing brain networks. Our results show that the directed transfer function with surrogate analysis achieves the best performance. Intracranial EEGs of 11 DRE patients are further analyzed. These patients all underwent surgery. In three seizure-free patients, the localized targets are concordant with the resected regions. For the eight patients without seizure-free outcome, the localized targets in three of them are outside the resected regions. Finally, we provide candidate targets for neuromodulation in these patients without seizure-free outcome based on virtual resected epileptic network. We demonstrate the ability of our approach to locate optimal targets for neuromodulation. We hope that our approach can provide a new tool for localizing patient-specific targets for neuromodulation therapy in DRE.
Language	English
Publishing date	2022-10-20
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2564217-0
ISSN	1664-042X
ISSN	1664-042X
DOI	10.3389/fphys.2022.1015838
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Article ; Online: A High-Resolution, Wide-Swath SAR Imaging System Based on Tandem SAR Satellites.

Sun, Liwei / Li, Chunsheng

Sensors (Basel, Switzerland)

2022 Volume 22, Issue 20

Abstract: For the spaceborne synthetic aperture radar (SAR), it is difficult to obtain high resolution and wide width at the same time. This paper proposes a novel imaging system based on tandem SAR satellites, where one obtains coarse resolution and wide swath by ...

Abstract	For the spaceborne synthetic aperture radar (SAR), it is difficult to obtain high resolution and wide width at the same time. This paper proposes a novel imaging system based on tandem SAR satellites, where one obtains coarse resolution and wide swath by the scanning mode, and the other obtains the undersampled echo from the same swath. The high resolution is achieved by associating the tandem SARs' echo and using the minimum-energy-based algorithm. Finally, a high-resolution wide-swath SAR system is designed, and its imaging performance is verified by simulated data and real airborne SAR data.
Language	English
Publishing date	2022-10-12
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2052857-7
ISSN	1424-8220 ; 1424-8220
ISSN (online)	1424-8220
ISSN	1424-8220
DOI	10.3390/s22207747
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Article: [Localization of epileptogenic zone based on reconstruction of dynamical epileptic network and virtual resection].

Huang, Baoqiang / Li, Chunsheng

Sheng wu yi xue gong cheng xue za zhi = Journal of biomedical engineering = Shengwu yixue gongchengxue zazhi

2022 Volume 39, Issue 6, Page(s) 1165–1172

Abstract: Drug-refractory epilepsy (DRE) may be treated by surgical intervention. Intracranial EEG has been widely used to localize the epileptogenic zone (EZ). Most studies of epileptic network focus on the features of EZ nodes, such as centrality and degrees. It ...

Abstract	Drug-refractory epilepsy (DRE) may be treated by surgical intervention. Intracranial EEG has been widely used to localize the epileptogenic zone (EZ). Most studies of epileptic network focus on the features of EZ nodes, such as centrality and degrees. It is difficult to apply those features to the treatment of individual patients. In this study, we proposed a spatial neighbor expansion approach for EZ localization based on a neural computational model and epileptic network reconstruction. The virtual resection method was also used to validate the effectiveness of our approach. The electrocorticography (ECoG) data from 11 patients with DRE were analyzed in this study. Both interictal data and surgical resection regions were used. The results showed that the rate of consistency between the localized regions and the surgical resections in patients with good outcomes was higher than that in patients with poor outcomes. The average deviation distance of the localized region for patients with good outcomes and poor outcomes were 15 mm and 36 mm, respectively. Outcome prediction showed that the patients with poor outcomes could be improved when the brain regions localized by the proposed approach were treated. This study provides a quantitative analysis tool for patient-specific measures for potential surgical treatment of epilepsy.
MeSH term(s)	Humans ; Epilepsy/surgery ; Brain/surgery ; Electrocorticography/methods ; Drug Resistant Epilepsy/surgery ; Brain Mapping/methods ; Electroencephalography/methods
Language	Chinese
Publishing date	2022-12-27
Publishing country	China
Document type	English Abstract ; Journal Article
ZDB-ID	2576847-5
ISSN	1001-5515
ISSN	1001-5515
DOI	10.7507/1001-5515.202205048
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Zs.A 6887: Show issues

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Article ; Online: Actinide Decorporation: A Review on Chelation Chemistry and Nanocarriers for Pulmonary Administration.

Lai, Edward P C / Li, Chunsheng

Radiation research

2022 Volume 198, Issue 4, Page(s) 430–443

Abstract: Chelation is considered the best method for detoxification by promoting excretion of actinides (Am, Np, Pu, Th, U) from the human body after internal contamination. Chemical agents that possess carboxylic acid or hydroxypyridinonate groups play a vital ... ...

Abstract	Chelation is considered the best method for detoxification by promoting excretion of actinides (Am, Np, Pu, Th, U) from the human body after internal contamination. Chemical agents that possess carboxylic acid or hydroxypyridinonate groups play a vital role in actinide decorporation. In this review article, we provide considerable background details on the chelation chemistry of actinides with an aim to formulate better decorporation agents. Nanocarriers for pulmonary delivery represent an exciting prospect in the development of novel therapies for actinide decorporation that both reduce toxic side effects of the agent and improve its retention in the body. Recent studies have demonstrated the benefits of using a nebulizer or an inhaler to administer chelating agents for the decorporation of actinides. Effective chelation therapy with large groups of internally contaminated people can be a challenge unless both the agent and the nanocarrier are readily available from strategic national stockpiles for radiological or nuclear emergencies. Sunflower lecithin is particularly adept at alleviating the burden of administration when used to form liposomes as a nanocarrier for pulmonary delivery of diethylenetriamine-pentaacetic acid (DTPA) or hydroxypyridinone (HOPO). Better physiologically-based pharmacokinetic models must be developed for each agent in order to minimize the frequency of multiple doses that can overload the emergency response operations.
MeSH term(s)	Actinoid Series Elements ; Chelating Agents/pharmacology ; Humans ; Lecithins ; Liposomes ; Pentetic Acid/pharmacology ; Plutonium
Chemical Substances	Actinoid Series Elements ; Chelating Agents ; Lecithins ; Liposomes ; Plutonium (53023GN24M) ; Pentetic Acid (7A314HQM0I)
Language	English
Publishing date	2022-09-08
Publishing country	United States
Document type	Journal Article ; Review
ZDB-ID	80322-4
ISSN	1938-5404 ; 0033-7587
ISSN (online)	1938-5404
ISSN	0033-7587
DOI	10.1667/RADE-21-00004.1
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Ue I Zs.275: Show issues

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Article ; Online: Evaluation of hemorrhagic shock and fluid resuscitation in pigs using handless Doppler carotid artery ultrasound.

Zhao, Xiaoli / Yuan, Wei / Wang, Shuo / Wu, Junyuan / Li, Chunsheng

European journal of trauma and emergency surgery : official publication of the European Trauma Society

2024

Abstract: Objective: This study aimed to utilize a hemorrhagic shock pig model to compare two hemodynamic monitoring methods, pulse index continuous cardiac output (PiCCO) and spectral carotid artery Doppler ultrasound (CDU). Additionally, we sought to explore ... ...

Abstract	Objective: This study aimed to utilize a hemorrhagic shock pig model to compare two hemodynamic monitoring methods, pulse index continuous cardiac output (PiCCO) and spectral carotid artery Doppler ultrasound (CDU). Additionally, we sought to explore the feasibility of employing CDU as a non-invasive hemodynamic monitoring tool in the context of hemorrhagic shock and fluid resuscitation. Design: Animal experiments. Setting and subjects: Female pigs were selected, and hemorrhagic shock was induced by rapid bleeding through an arterial sheath. Interventions: Hemodynamic monitoring was conducted using both PiCCO and CDU during episodes of hemorrhagic shock and fluid resuscitation. Measurements and main results: Among the 10 female pigs studied, CDU measurements revealed a significant decrease in carotid velocity time integral (cVTI) compared to baseline values under shock conditions. During the resuscitation phase, after the mean arterial pressure (MAP) returned to its baseline level, there was no significant difference between cVTI and baseline values. A similar trend was observed for carotid peak velocity (cPV). The corrected flow time (FTc) exhibited a significant difference only at the time of shock compared to baseline values. In comparison to PiCCO, there was a significant correlation between cVTI and MAP (r = 0.616, P < 0.001), stroke volume (SV) (r = 0.821, P < 0.001), and cardiac index (CI) (r = 0.698, P < 0.001). The carotid Doppler shock index (cDSI) displayed negative correlations with MAP (r = - 0.593, P < 0.001), SV (r = - 0.761, P < 0.001), and CI (r = - 0.548, P < 0.001), while showing a positive correlation with the shock index (SI) (r = 0.647, P < 0.001). Conclusions: Compared to PiCCO, CDU monitoring can reliably reflect the volume status of hemorrhagic shock and fluid resuscitation. CDU offers the advantages of being non-invasive, providing real-time data, and being operationally straightforward. These characteristics make it a valuable tool for assessing and managing hemorrhagic shock, especially in resource-limited settings.
Language	English
Publishing date	2024-03-01
Publishing country	Germany
Document type	Journal Article
ZDB-ID	2275480-5
ISSN	1863-9941 ; 1863-9933
ISSN (online)	1863-9941
ISSN	1863-9933
DOI	10.1007/s00068-024-02481-3
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Zs.A 1221: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (1.OG) ab Jg. 2022: Lesesaal (EG)
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Article ; Online: The regulatory effects of serum catecholamines and endothelial cells in pig hemorrhagic shock and fluid resuscitation models.

Zhao, Xiaoli / Yuan, Wei / Wang, Shuo / Wu, Junyuan / Li, Chunsheng

Resuscitation plus

2024 Volume 18, Page(s) 100618

Abstract: Background: Acute blood loss not only leads to systemic compensatory response, but also the induced changes in vascular endothelial function.These pathological changes may have potential compensatory significance for maintaining organ perfusion and ... ...

Abstract	Background: Acute blood loss not only leads to systemic compensatory response, but also the induced changes in vascular endothelial function.These pathological changes may have potential compensatory significance for maintaining organ perfusion and fluid resuscitation. Objective: To understand trauma-induced endotheliopathy and their compensatory roles in acute hemorrhage, a porcine model of hemorrhagic shock (HS) was used to evaluate changes in vascular endothelial factors and catecholamine levels at different time points from shock to fluid resuscitation. Methods: HS was induced in female pigs by rapid bleeding via the arterial sheath. Hemodynamic monitoring was performed using a pulse index continuous cardiac output (PiCCO) system in HS and fluid resuscitation. Femoral vein blood samples were collected at baseline and 40% mean arterial pressure (MAP, shock), MAP recovery, and 30 min, 1 h, and 2 h after recovery. Serum levels of catecholamine and Angiopoietin-1 (Ang-1), Angiopoietin-2 (Ang-2), Tie-2, Eselectin, intracellular adhesion molecule-1 (ICAM-1), soluble thrombomodulin (sTM), and Syndecan-1 (SDC-1) were evaluated using enzyme-linked immunosorbent assay (ELISA). Results: Serum catecholamine levels were significantly higher in the shock than in the baseline state. Ang-1 and Ang-2 are endothelial growth factors secreted with distinct roles. Ang-1 stabilizes the endothelium and inhibits vascular leakage, and Ang-2 has the opposite effect. The ratio of Ang-2/Ang-1 was significantly higher in the shock state than in the baseline state; however, the Ang-1/Tie-2 ratio was comparable between the two states. This suggests that changes in vascular permeability may mainly depend on the upregulation of Ang-2 function. Serum levels of E-selectin, ICAM-1, sTM, and SDC-1 were significantly higher in the shock state than in the baseline state. After the MAP was restored to the baseline state, the levels of E-selectin, and SDC-1 remained higher compared with the baseline state until 1 h after MAP recovery. Conclusions: serum levels of catecholamines and vascular endothelial markers increased transiently under HS, promoting a compensatory response of the circulatory system to acute bleeding. This may be one of the potential theoretical basis for restrictive fluid resuscitation.
Language	English
Publishing date	2024-03-23
Publishing country	Netherlands
Document type	Journal Article
ISSN	2666-5204
ISSN (online)	2666-5204
DOI	10.1016/j.resplu.2024.100618
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Article ; Online: Improvement mechanism of volatile flavor in fermented tilapia surimi by cooperative fermentation of Pediococcus acidilactici and Latilactobacillus sakei: Quantization of microbial contribution through influence of genus.

Li, Chunsheng / Chen, Shengjun / Huang, Hui / Li, Jun / Zhao, Yongqiang

Food chemistry

2024 Volume 449, Page(s) 139239

Abstract: Single starter can hardly improve the volatile flavor of fermented fish surimi. In this study, the changes of volatile compounds (VCs) and microbial composition during cooperative fermentation of Latilactobacillus sakei and Pediococcus acidilactici were ... ...

Abstract	Single starter can hardly improve the volatile flavor of fermented fish surimi. In this study, the changes of volatile compounds (VCs) and microbial composition during cooperative fermentation of Latilactobacillus sakei and Pediococcus acidilactici were studied by headspace solid-phase microextraction gas chromatography-mass spectrometry and 16S rRNA gene high-throughput sequencing. During cooperative fermentation, most VCs and the abundance of Latilactobacillus and Lactococcus significantly increased, while Pediococcus, Acinetobacter, and Macrococcus obviously decreased. After evaluation of correlation and abundance of each genus, Latilactobacillus and Lactococcus possessed the highest influence on the formation of volatile flavor during cooperative fermentation. Compared with the natural fermentation, cooperative fermentation with starters significantly enhanced most of pleasant core VCs (odor activity value≥1), but inhibited the production of trimethylamine and methanethiol, mainly resulting from the absolutely highest influence of Latilactobacillus. Cooperative fermentation of starters is an effective method to improve the volatile flavor in the fermented tilapia surimi.
Language	English
Publishing date	2024-04-03
Publishing country	England
Document type	Journal Article
ZDB-ID	243123-3
ISSN	1873-7072 ; 0308-8146
ISSN (online)	1873-7072
ISSN	0308-8146
DOI	10.1016/j.foodchem.2024.139239
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Article: Classifying epileptic phase-amplitude coupling in SEEG using complex-valued convolutional neural network.

Li, Chunsheng / Liu, Shiyue / Wang, Zeyu / Yuan, Guanqian

Frontiers in physiology

2023 Volume 13, Page(s) 1085530

Abstract: EEG phase-amplitude coupling (PAC), the amplitude of high-frequency oscillations modulated by the phase of low-frequency oscillations (LFOs), is a useful biomarker to localize epileptogenic tissue. It is commonly represented in a comodulogram of coupling ...

Abstract	EEG phase-amplitude coupling (PAC), the amplitude of high-frequency oscillations modulated by the phase of low-frequency oscillations (LFOs), is a useful biomarker to localize epileptogenic tissue. It is commonly represented in a comodulogram of coupling strength but without coupled phase information. The phase-amplitude coupling is also found in the normal brain, and it is difficult to discriminate pathological phase-amplitude couplings from normal ones. This study proposes a novel approach based on complex-valued phase-amplitude coupling (CV-PAC) for classifying epileptic phase-amplitude coupling. The CV-PAC combines both the coupling strengths and the coupled phases of low-frequency oscillations. The complex-valued convolutional neural network (CV-CNN) is then used to classify epileptic CV-PAC. Stereo-electroencephalography (SEEG) recordings from nine intractable epilepsy patients were analyzed. The leave-one-out cross-validation is performed, and the area-under-curve (AUC) value is used as the indicator of the performance of different measures. Our result shows that the area-under-curve value is .92 for classifying epileptic CV-PAC using CV-CNN. The area-under-curve value decreases to .89, .80, and .88 while using traditional convolutional neural networks, support vector machine, and random forest, respectively. The phases of delta (1-4 Hz) and alpha (8-10 Hz) bands are different between epileptic and normal CV-PAC. The phase information of CV-PAC is important for improving classification performance. The proposed approach of CV-PAC/CV-CNN promises to identify more accurate epileptic brain activities for potential surgical intervention.
Language	English
Publishing date	2023-01-05
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2564217-0
ISSN	1664-042X
ISSN	1664-042X
DOI	10.3389/fphys.2022.1085530
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