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Article ; Online: Natural-orifice transluminal endoscopic surgery for gallstones: Is it ready for the prime time?

Li, Dongying

2022 Volume 46, Issue 4, Page(s) 1653

MeSH term(s)	Humans ; Gallstones/surgery ; Natural Orifice Endoscopic Surgery ; Operative Time
Language	English
Publishing date	2022-10-07
Publishing country	China
Document type	Letter
ZDB-ID	1068461-x
ISSN	0219-3108 ; 1015-9584
ISSN (online)	0219-3108
ISSN	1015-9584
DOI	10.1016/j.asjsur.2022.09.112
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Zs.B 2831: Show issues

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Article ; Online: Theoretical Insights on the Charge State and Bifunctional OER/ORR Electrocatalyst Activity in 4d-Transition-Metal-Doped g-C

Li, Dongying / Zhang, Aodi / Feng, Zhenzhen / Wang, Wentao

ACS applied materials & interfaces

2024 Volume 16, Issue 5, Page(s) 5779–5791

Abstract: Exploring efficient and stable electrocatalysts for the bifunctional oxygen evolution reaction (OER) and oxygen reduction reaction (ORR) is vital to developing renewable energy technologies. However, due to the substantial and intricate design space ... ...

Abstract	Exploring efficient and stable electrocatalysts for the bifunctional oxygen evolution reaction (OER) and oxygen reduction reaction (ORR) is vital to developing renewable energy technologies. However, due to the substantial and intricate design space associated with these bifunctional OER/ORR electrocatalysts, their development presents a formidable challenge, resulting in their cost-prohibitive nature in both experimental and computational studies. Herein, using the defect physics method, we systematically investigate the formation energies and bifunctional overpotential (η
Language	English
Publishing date	2024-01-25
Publishing country	United States
Document type	Journal Article
ISSN	1944-8252
ISSN (online)	1944-8252
DOI	10.1021/acsami.3c14995
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Article ; Online: A systematic review of the relationship between natural environments and physiological and mental health during different stages of the COVID-19 pandemic.

Yen, Min-Hsuan / Li, Dongying / Chiang, Yen-Cheng

The Science of the total environment

2024 Volume 923, Page(s) 171392

Abstract: COVID-19 has altered how individuals interact with natural environments. Numerous studies have investigated the effects of such environments on health. However, how natural environments influenced individuals' physiological and mental health during ... ...

Abstract	COVID-19 has altered how individuals interact with natural environments. Numerous studies have investigated the effects of such environments on health. However, how natural environments influenced individuals' physiological and mental health during various stages of the COVID-19 pandemic remains unclear. Therefore, we conducted this study to investigate the effects of natural environments on individuals' physiological and mental health during different stages of the pandemic; we also identified factors that mediated these effects. Overall, we evaluated the importance of natural environments during challenging times. This study adhered to the Preferred Reporting Items for Systematic Review and Meta-Analysis guidelines. The pandemic period was divided into three stages on the basis of severity: pandemic (March 2020 - February 2022), easing (February 2022-September 2022), and post-acute COVID pandemic (September 2022 - present). An initial pool of 3018 studies was narrowed down to a final sample of 73 studies. During the pandemic stage, individuals frequenting public green spaces exhibited improved well-being, reduced stress levels, and a sense of nature deprivation. Private green spaces played crucial roles in maintaining health during the pandemic stage. Highquality window views were associated with improved well-being and reduced depression. During the easing stage, the environmental quality of public green spaces influenced individuals' perceived safety and sense of belonging. And coastal areas were the preferred natural destinations in this stage. During the post-acute COVID pandemic stage, individuals acknowledged the importance of natural environments in maintaining physiological and mental health as they gradually returned to prepandemic normalcy. In conclusion, the COVID-19 pandemic highlighted humanity's reliance on nature. Therefore, sufficient urban spaces should be dedicated to preservation of natural environments to mitigate negative emotions arising from prolonged indoor stays.
MeSH term(s)	Humans ; Mental Health ; Pandemics ; COVID-19/epidemiology ; Environment ; Parks, Recreational
Language	English
Publishing date	2024-02-29
Publishing country	Netherlands
Document type	Systematic Review ; Journal Article ; Review
ZDB-ID	121506-1
ISSN	1879-1026 ; 0048-9697
ISSN (online)	1879-1026
ISSN	0048-9697
DOI	10.1016/j.scitotenv.2024.171392
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Article: Emergency Department Visits for Mental Disorders and the Built Environment: Residential Greenspace and Historical Redlining

Wang, Huaqing / Li, Dongying

Landscape and urban planning. 2022 Sept. 02,

2022

Abstract: The built environment has been increasingly shown to impact mental health. However, little is known about how and the extent to which exposure to greenspace in the residential environment is associated with emergency department visits for mental ... ...

Abstract	The built environment has been increasingly shown to impact mental health. However, little is known about how and the extent to which exposure to greenspace in the residential environment is associated with emergency department visits for mental disorders. In addition, despite recent findings highlighting the links between historical discriminatory housing policies and health outcomes, no evidence is available regarding historical redlining and mental health. We aimed to investigate the extent to which the availability of greenspace in residential surroundings and historical redlining was associated with risks of mental disorder-related emergency department visits. In this cross-sectional, ecological study, we analyzed state-wide data on emergency room visits for mental health in all metropolitan areas in Texas between 2016 and 2019. Greenspace coverage was determined using the National Land Cover Database. Historical redlining was defined as the type C (definitely declining) or D (hazardous) designations according to the 1930s Home Owners’ Loan Corporation (HOLC) Security Maps. We fitted a conditional autoregressive spatial model with zero truncated negative binomial distribution to assess associations among emergency department visits, greenspace availability, and redlining, adjusted for risk and protective urban and social-demographic factors. We found that, with a 1% increase in greenspace coverage in a zip code area, emergency department visits due to mental health disorders were expected to decrease by a factor of 0.9984 (95% CI: 0.9971–0.9997). Meanwhile, a 1% increase of historically redlining zones was expected to lead to an increase in emergency department visits for mental health disorders by a factor of 1.0088 (95% CI: 1.0056–1.0120). Our findings support the notion that exposure to natural environments is linked to lower risks of emergency department visits for mental disorders. They also indicate that systematic segregation institutionalized by historical housing policies might be related to present-day mental health-related emergency department visits. This study offers novel insights into the built environmental correlates of mental health and provides planning and policy implications related to mental health and health equity promotion.
Keywords	binomial distribution ; databases ; ecological studies ; green infrastructure ; issues and policy ; land cover ; landscapes ; mental health ; models ; risk ; Texas
Language	English
Dates of publication	2022-0902
Publishing place	Elsevier B.V.
Document type	Article
Note	Pre-press version
ZDB-ID	742504-1
ISSN	1872-6062 ; 0169-2046
ISSN (online)	1872-6062
ISSN	0169-2046
DOI	10.1016/j.landurbplan.2022.104568
Database	NAL-Catalogue (AGRICOLA)

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Article: The spatial relationship between long-term vacant housing and non-communicable diseases in U.S. shrinking and growing metropolitan areas.

Zhu, Rui / Newman, Galen / Li, Dongying

Cities (London, England)

2023 Volume 145

Abstract: The rising prevalence of non-communicable diseases (NCDs) has led to increased attention on understanding how built environments affect NCD risks. However, there's a significant gap in the literature regarding the relationship between housing vacancy ... ...

Abstract	The rising prevalence of non-communicable diseases (NCDs) has led to increased attention on understanding how built environments affect NCD risks. However, there's a significant gap in the literature regarding the relationship between housing vacancy duration and NCDs in metropolitan areas with varying development rates. Our research addresses this gap by examining the association between housing vacancy duration and NCDs across all U.S. metropolitan areas, considering growing, shrinking, and fluctuating counties. We used a Multiscale Geographically Weighted Regression (MGWR) model to analyze this relationship, finding that longer-term vacant housing (over 3 years) is more positively associated with NCDs compared to short-term vacancies. We also discovered that this association is non-uniform across metropolitan counties, except for cancer and stroke outcomes. Shrinking counties in the Northeast are particularly affected, emphasizing the need for targeted public health interventions in these areas. This study underscores the importance of revitalizing vacant homes, especially those vacant for over 3 years, in both shrinking and growing regions to improve public health. Policymakers should adopt tailored strategies, engage public health experts, and invest in healthcare infrastructure to effectively address the health risks linked to vacant housing.
Language	English
Publishing date	2023-12-05
Publishing country	England
Document type	Journal Article
ISSN	0264-2751
ISSN	0264-2751
DOI	10.1016/j.cities.2023.104718
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Article: Risk prediction models for intracranial hemorrhage in acute ischemic stroke patients receiving intravenous alteplase treatment: a systematic review.

Hua, Yaqi / Yan, Chengkun / Zhou, Cheng / Zheng, Qingyu / Li, Dongying / Tu, Ping

Frontiers in neurology

2024 Volume 14, Page(s) 1224658

Abstract: Objectives: To identify and compare published models that use related factors to predict the risk of intracranial hemorrhage (ICH) in acute ischemic stroke patients receiving intravenous alteplase treatment.: Methods: Risk prediction models for ICH ... ...

Abstract	Objectives: To identify and compare published models that use related factors to predict the risk of intracranial hemorrhage (ICH) in acute ischemic stroke patients receiving intravenous alteplase treatment. Methods: Risk prediction models for ICH in acute ischemic stroke patients receiving intravenous alteplase treatment were collected from PubMed, Embase, Web of Science, and the Cochrane Library up to April 7, 2023. A meta-analysis was performed using Stata 13.0, and the included models were evaluated using the Prediction Model Risk of Bias Assessment Tool (PROBAST). Results: A total of 656 references were screened, resulting in 13 studies being included. Among these, one was a prospective cohort study. Ten studies used internal validation; five studies used external validation, with two of them using both. The area under the receiver operating characteristic (ROC) curve for subjects reported in the models ranged from 0.68 to 0.985. Common predictors in the prediction models include National Institutes of Health Stroke Scale (NIHSS) (OR = 1.17, 95% CI 1.09-1.25, Conclusion: This study systematically reviews available evidence on risk prediction models for ICH in acute ischemic stroke patients receiving intravenous alteplase treatment. Few models have been externally validated, while the majority demonstrate significant discriminative power.
Language	English
Publishing date	2024-01-05
Publishing country	Switzerland
Document type	Systematic Review
ZDB-ID	2564214-5
ISSN	1664-2295
ISSN	1664-2295
DOI	10.3389/fneur.2023.1224658
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Article ; Online: A framework enabling LLMs into regulatory environment for transparency and trustworthiness and its application to drug labeling document.

Wu, Leihong / Xu, Joshua / Thakkar, Shraddha / Gray, Magnus / Qu, Yanyan / Li, Dongying / Tong, Weida

Regulatory toxicology and pharmacology : RTP

2024 Volume 149, Page(s) 105613

Abstract: Regulatory agencies consistently deal with extensive document reviews, ranging from product submissions to both internal and external communications. Large Language Models (LLMs) like ChatGPT can be invaluable tools for these tasks, however present ... ...

Abstract	Regulatory agencies consistently deal with extensive document reviews, ranging from product submissions to both internal and external communications. Large Language Models (LLMs) like ChatGPT can be invaluable tools for these tasks, however present several challenges, particularly the proprietary information, combining customized function with specific review needs, and transparency and explainability of the model's output. Hence, a localized and customized solution is imperative. To tackle these challenges, we formulated a framework named askFDALabel on FDA drug labeling documents that is a crucial resource in the FDA drug review process. AskFDALabel operates within a secure IT environment and comprises two key modules: a semantic search and a Q&A/text-generation module. The Module S built on word embeddings to enable comprehensive semantic queries within labeling documents. The Module T utilizes a tuned LLM to generate responses based on references from Module S. As the result, our framework enabled small LLMs to perform comparably to ChatGPT with as a computationally inexpensive solution for regulatory application. To conclude, through AskFDALabel, we have showcased a pathway that harnesses LLMs to support agency operations within a secure environment, offering tailored functions for the needs of regulatory research.
MeSH term(s)	Drug Labeling/standards ; Drug Labeling/legislation & jurisprudence ; United States Food and Drug Administration/standards ; United States ; Humans
Language	English
Publishing date	2024-04-02
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	604672-1
ISSN	1096-0295 ; 0273-2300
ISSN (online)	1096-0295
ISSN	0273-2300
DOI	10.1016/j.yrtph.2024.105613
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Zs.A 1711: Show issues

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Article ; Online: Phenylglycine amphiphile-metal ion chiral supramolecular nanozymes for enantioselective catalysis.

Li, Dongying / Gao, Cong / Zhao, Cici / Sun, Qingqing / Xi, Zheng / Han, Jie / Guo, Rong

Chemical communications (Cambridge, England)

2024 Volume 60, Issue 34, Page(s) 4569–4572

Abstract: L/D-Phenylglycine amphiphiles and metal ions with peroxidase-like activity self-assembled into chiral nanoribbons, which act as efficient chiral supramolecular nanozymes for catalyzing the 3,4-dihydroxy-L/D-phenylalanine (L/D-DOPA) oxidation reactions. ... ...

Abstract	L/D-Phenylglycine amphiphiles and metal ions with peroxidase-like activity self-assembled into chiral nanoribbons, which act as efficient chiral supramolecular nanozymes for catalyzing the 3,4-dihydroxy-L/D-phenylalanine (L/D-DOPA) oxidation reactions. The catalytic efficiency and enantioselectivity are dominated by the chirality transfer and the synergistic effect between the metal ions and chiral nanoribbons.
Language	English
Publishing date	2024-04-23
Publishing country	England
Document type	Journal Article
ZDB-ID	1472881-3
ISSN	1364-548X ; 1359-7345 ; 0009-241X
ISSN (online)	1364-548X
ISSN	1359-7345 ; 0009-241X
DOI	10.1039/d4cc00637b
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Article ; Online: Dually Crosslinked Copper-Poly(tannic acid) Nanoparticles with Microenvironment-Responsiveness for Infected Wound Treatment.

Li, Dongying / Li, Jiarun / Wang, Siwei / Wang, Qinmei / Teng, Wei

Advanced healthcare materials

2023 Volume 12, Issue 17, Page(s) e2203063

Abstract: Reducing the burden of death due to wound infection is an urgent global public health priority. Metal-phenolic networks (MPNs) have received widespread attention in antimicrobial infections due to their facile synthesis process, excellent ... ...

Abstract	Reducing the burden of death due to wound infection is an urgent global public health priority. Metal-phenolic networks (MPNs) have received widespread attention in antimicrobial infections due to their facile synthesis process, excellent biocompatibility, and antimicrobial properties brought about by polyphenols and metal ions. However, typical therapeutic MPNs show rapid release of metal ions due to their poor solution stability, impeding long-acting efficacy in multiple wound healing stages. To address these issues, copper-poly (tannic acid) nanoparticles (Cu-PTA NPs): robust (dually crosslinked), microenvironment-responsive, antibacterial, antioxidative, and anti-inflammatory are prepared, which hierarchically modulate the infected wound healing process. Covalently polymerized via phenol-formaldehyde condensation and crosslinked with bioactive Cu
MeSH term(s)	Rats ; Animals ; Copper ; Nanoparticles ; Metals ; Polyphenols ; Anti-Bacterial Agents/pharmacology ; Anti-Bacterial Agents/therapeutic use ; Wound Infection/drug therapy ; Hydrogels
Chemical Substances	Copper (789U1901C5) ; Tannic Acid ; Metals ; Polyphenols ; Anti-Bacterial Agents ; Hydrogels
Language	English
Publishing date	2023-03-12
Publishing country	Germany
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2649576-4
ISSN	2192-2659 ; 2192-2640
ISSN (online)	2192-2659
ISSN	2192-2640
DOI	10.1002/adhm.202203063
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Article: Associations between vacant urban lands and public health outcomes in growing and shrinking cities.

Zhu, Rui / Newman, Galen / Li, Dongying / Song, Yang / Zou, Lei

Urban forestry & urban greening

2023 Volume 89

Abstract: Vacant urban land, although not officially designated as a green space, often exhibits a semi-wild natural state due to being left open to colonization by nature. Attention to the effects of vacant urban land on human health has increased due to both ... ...

Abstract	Vacant urban land, although not officially designated as a green space, often exhibits a semi-wild natural state due to being left open to colonization by nature. Attention to the effects of vacant urban land on human health has increased due to both rising urban vacancy rates and non-communicable diseases (NCDs). However, relationships between many vacant land characteristics (such as vegetation coverage, size, duration, and location) and NCDs have not been comprehensively examined, especially comparing shrinking (depopulating) and growing (populating) cities. This study evaluates St. Louis, MO (shrinking), and Los Angeles, CA (growing) to explore these relationships using ordinary least squares (OLS) interaction analysis with a moderator approach. Results show that associations between vacancy rate, duration, location, and NCDs differ significantly between city types. Vegetation coverage and size are associated with specific NCDs, but there are no differences between city types. Unlike the largely dilapidated vacant lands in the shrinking city, which tend to harm public health, vacant lots in the growing city were more functional green spaces that can, in some cases, even mitigate NCDs. Interestingly, In St. Louis, the shorter the average duration of the vacant land, the greater the risk of NCDs in a shrinking city. This is because vacant land can be contagious to nearby lots if not treated, leading to more newly emerged vacant lands and reducing the average duration of vacant land. In such cases, census tracts with the lower duration of vacant lands in St. Louis tend to be areas facing persistent environmental degradation and high public health threats. Regarding location, vacant lands near industrial areas were linked to negative health outcomes in the Los Angeles (growing), while those near single-family and commercial areas posed higher risks of NCDs in the St Louis (shrinking). The findings aid decision-making for land supply regulation and regeneration as well as urban green space management to promote human health and well-being.
Language	English
Publishing date	2023-10-26
Publishing country	Germany
Document type	Journal Article
ISSN	1618-8667
ISSN	1618-8667
DOI	10.1016/j.ufug.2023.128127
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