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Article ; Online: Realizing Scalable Nano-SiO 2 -Aerogel-Reinforced Composite Polymer Electrolytes with High Ionic Conductivity via Rheology-Tuning UV Polymerization

Mianrui Li / Shengguang Qi / Shulian Li / Li Du

Molecules, Vol 28, Iss 756, p

2023 Volume 756

Abstract: Polymer electrolytes for lithium metal batteries have aroused widespread interest because of their flexibility and excellent processability. However, the low ambient ionic conductivity and conventional fabrication process hinder their large-scale ... ...

Abstract	Polymer electrolytes for lithium metal batteries have aroused widespread interest because of their flexibility and excellent processability. However, the low ambient ionic conductivity and conventional fabrication process hinder their large-scale application. Herein, a novel polyethylene-oxide-based composite polymer electrolyte is designed and fabricated by introducing nano-SiO 2 aerogel as an inorganic filler. The Lewis acid–base interaction between SiO 2 and anions from Li salts facilitates the dissociation of Li + . Moreover, the SiO 2 interacts with ether oxygen (EO) groups, which weakens the interaction between Li + and EO groups. This synergistic effect produces more free Li + in the electrolyte. Additionally, the facile rheology-tuning UV polymerization method achieves continuous coating and has potential for scalable fabrication. The composite polymer electrolyte exhibits high ambient ionic conductivity (0.68 mS cm −1 ) and mechanical properties (e.g., the elastic modulus of 150 MPa). Stable lithium plating/stripping for 1400 h in Li//Li symmetrical cells at 0.1 mA cm −2 is achieved. Furthermore, LiFePO 4 //Li full cells deliver superior discharge capacity (153 mAh g −1 at 0.5 C) and cycling stability (with a retention rate of 92.3% at 0.5 C after 250 cycles) at ambient temperature. This work provides a promising strategy for polymer-based lithium metal batteries.
Keywords	composite polymer electrolytes ; nano-SiO 2 aerogel ; rheology tuning ; lithium metal batteries ; UV polymerization ; Organic chemistry ; QD241-441
Subject code	333
Language	English
Publishing date	2023-01-01T00:00:00Z
Publisher	MDPI AG
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: OIP5 Interacts with NCK2 to Mediate Human Spermatogonial Stem Cell Self-Renewal and Apoptosis through Cell Cyclins and Cycle Progression and Its Abnormality Is Correlated with Male Infertility

Yinghong Cui / Wei Chen / Li Du / Zuping He

Research, Vol

2023 Volume 6

Abstract: Spermatogonial stem cells (SSCs) have important applications in both reproduction and regenerative medicine. Nevertheless, specific genes and signaling transduction pathways in mediating fate decisions of human SSCs remain elusive. Here, we have ... ...

Abstract	Spermatogonial stem cells (SSCs) have important applications in both reproduction and regenerative medicine. Nevertheless, specific genes and signaling transduction pathways in mediating fate decisions of human SSCs remain elusive. Here, we have demonstrated for the first time that OIP5 (Opa interacting protein 5) controlled the self-renewal and apoptosis of human SSCs. RNA sequencing identified that NCK2 was a target for OIP5 in human SSCs, and interestingly, OIP5 could interact with NCK2 as shown by Co-IP (co-immunoprecipitation), IP-MS (mass spectrometry), and GST pulldown assays. NCK2 silencing decreased human SSC proliferation and DNA synthesis but enhanced their apoptosis. Notably, NCK2 knockdown reversed the influence of OIP5 overexpression on human SSCs. Moreover, OIP5 inhibition decreased the numbers of human SSCs at S and G2/M phases, while the levels of numerous cell cycle proteins, including cyclins A2, B1, D1, E1 and H, especially cyclin D1, were remarkably reduced. Significantly, whole-exome sequencing of 777 patients with nonobstructive azoospermia (NOA) revealed 54 single-nucleotide polymorphism mutations of the OIP5 gene (6.95%), while the level of OIP5 protein was obviously lower in testes of NOA patients compared to fertile men. Collectively, these results implicate that OIP5 interacts with NCK2 to modulate human SSC self-renewal and apoptosis via cell cyclins and cell cycle progression and that its mutation and/or lower expression is correlated with azoospermia. As such, this study offers novel insights into molecular mechanisms underlying the fate determinations of human SSCs and the pathogenesis of NOA, and it provides new targets for treating male infertility.
Keywords	Science ; Q
Subject code	572
Language	English
Publishing date	2023-01-01T00:00:00Z
Publisher	American Association for the Advancement of Science
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Accelerating

Li, Du / Liu, Zhen-Fei / Yang, Li

Journal of chemical theory and computation

2023 Volume 19, Issue 24, Page(s) 9435–9444

Abstract: ... ...

Abstract	The
Language	English
Publishing date	2023-12-07
Publishing country	United States
Document type	Journal Article
ISSN	1549-9626
ISSN (online)	1549-9626
DOI	10.1021/acs.jctc.3c01032
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: International Efforts and Next Steps to Advance COVID-19 Vaccines Research and Production in Low- and Middle-Income Countries

Li Du / Meng Wang / Vera Lúcia Raposo

Vaccines, Vol 10, Iss 42, p

2022 Volume 42

Abstract: Equitable and efficient distribution of COVID-19 vaccines continues to be a key issue in global health, and a targeted approach is needed to meet the World Health Organization’s world vaccination targets. Although some low- and middle-income countries ( ... ...

Abstract	Equitable and efficient distribution of COVID-19 vaccines continues to be a key issue in global health, and a targeted approach is needed to meet the World Health Organization’s world vaccination targets. Although some low- and middle-income countries (LMICs) are developing their own vaccines to address the distribution problem, legal and technical challenges have had a negative impact on productivity. This article explores relevant international legal instruments that can enable faster research and development of COVID-19 vaccines in LMICs, focusing on the role of biosafety standards, biological materials transfer, and key knowledge sharing. Our analysis has established that the potential of existing global health legal instruments has yet to be realized in order to close the productivity gap in LMICs and strengthen their vaccine manufacturing capacity. Additionally, mutual recognition of vaccine efficacy has become a new challenge for achieving global vaccination targets. We argue that the World Health Organization should continue its leading position by developing a more practical and targeted framework to help LMICs overcome challenges arising from technology transfer, knowledge sharing, and politics.
Keywords	LMICs ; COVID-19 vaccines ; global health law ; vaccine distribution ; vaccine equity ; global vaccine certificate ; Medicine ; R
Subject code	306
Language	English
Publishing date	2022-12-01T00:00:00Z
Publisher	MDPI AG
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: The Psychological Effects of Digital Companies’ Employees during the Phase of COVID-19 Pandemic Extracted from Online Employee Reviews

Zhuo-Ming Ren / Wen-Li Du / Xing-Zhang Wen

Sustainability, Vol 14, Iss 2609, p

2022 Volume 2609

Abstract: The ways people use words online can furnish psychological processes about their beliefs, fears, thinking patterns, and so on. Extracting from online employees’ reviews on the workplace community websites, we can quantify the psychological effects of ... ...

Abstract	The ways people use words online can furnish psychological processes about their beliefs, fears, thinking patterns, and so on. Extracting from online employees’ reviews on the workplace community websites, we can quantify the psychological effects of employees during the phase of the COVID-19 pandemic. We collect the anonymous employees’ reviews of Top 100 digital companies from the Glassdoor website which allows people to evaluate and review the companies they have worked for or are working for. Here, based on the data of numerical evaluations and textual reviews, we firstly use Z-score to investigate the psychological effects of employees in digital companies during the phase of COVID-19 pandemic. Next, we use a text analysis application called Linguistic Inquiry and Word Count (LIWC), which provides an efficient and effective method for studying the various emotional, cognitive, and structural components existing in individuals’ verbal and written speech samples, to mine these reviews to obtain changes in personal pronouns and 10 dimensions of psychological processes. Finally, we use Z-score to count on all aspects of drives and personal concerns in psychological processes.
Keywords	online employee reviews ; psychological effect ; digital company ; COVID-19 pandemic ; Environmental effects of industries and plants ; TD194-195 ; Renewable energy sources ; TJ807-830 ; Environmental sciences ; GE1-350
Subject code	650
Language	English
Publishing date	2022-02-01T00:00:00Z
Publisher	MDPI AG
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: The Circadian Clock Regulates the Expression of the Nuclear Factor Erythroid 2-Related Factor 2 in Acute Kidney Injury following Myocardial Ischemia-Reperfusion in Diabetic Rat

Chong Dong / Cheng Zeng / Li Du / Qian Sun

BioMed Research International, Vol

2021 Volume 2021

Abstract: Cardiac surgery-associated acute kidney injury (AKI) is a serious and frequent complication with poor prognosis, and disruption in circadian rhythm shall adversely influence cardiovascular and renal functions via oxidative stress mechanisms. However, the ...

Abstract	Cardiac surgery-associated acute kidney injury (AKI) is a serious and frequent complication with poor prognosis, and disruption in circadian rhythm shall adversely influence cardiovascular and renal functions via oxidative stress mechanisms. However, the role of circadian clock genes (circadian locomotor output cycle kaput (CLOCK) and brain and muscle aryl hydrocarbon receptor nuclear translocator-like protein-1 (BMAL1)) and its interaction with nuclear factor erythroid 2-related factor 2 (Nrf2) in AKI following myocardial ischemia-reperfusion (MIR) in the diabetic rat has not yet been explored. In this study, rats were divided into the sham (S) group, MIR (M) group, diabetic (D) group, and diabetic+MIR (DM) group. At light (zeitgeber time (ZT) 0) and dark time points (ZT12), rat MIR model was established by occlusion of the left anterior descending coronary artery for 30 min followed by 2 -hour reperfusion, and then renal injury was evaluated. The renal histological changes in the DM group were significantly high compared to other groups; serum creatinine, blood urea nitrogen, and neutrophil gelatinase-associated lipocalin levels, as well as malondialdehyde and 8-iso-prostaglandin-F2α levels in renal tissues of M ZT12 and DM ZT12 subgroups, were significantly higher than those of M ZT0 and DM ZT0 subgroups, individually indicating increased oxidative stress at a dark cycle. Further, Nrf2 protein accumulated in a circadian manner with decreasing levels at night in the DM and M groups. In conclusion, renal injury following MIR was exacerbated in the diabetic rat at night through molecular mechanisms involving transcriptional control of the circadian clock on light-dark activation of Nrf2.
Keywords	Medicine ; R
Subject code	571
Language	English
Publishing date	2021-01-01T00:00:00Z
Publisher	Hindawi Limited
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Ultrasound-guided puncture drainage versus surgical incision drainage for deep neck space abscesses

Bo Li / Guo Chen / Li Du / Jianqiao Zheng / Wei Nie / Yongbo Zheng / Xibiao Yang / Weiyi Zhang

BMJ Open, Vol 14, Iss

a protocol for a systematic review with meta-analysis and trial sequential analysis

2024 Volume 1

Abstract: Introduction Deep neck space abscesses (DNAs) are serious surgical emergencies, associated with life-threatening complications. Surgical incision and drainage combined with antibiotics is the main treatment for DNAs, but drawbacks still exist. Ultrasound- ...

Abstract	Introduction Deep neck space abscesses (DNAs) are serious surgical emergencies, associated with life-threatening complications. Surgical incision and drainage combined with antibiotics is the main treatment for DNAs, but drawbacks still exist. Ultrasound-guided puncture drainage is an alternative treatment for some DNAs with limited clinical evidence. Hence, the optimal drainage technique for the treatment of DNAs remains unclear. Therefore, we will perform a protocol for a systematic review and meta-analysis to identify the efficacy of ultrasound-guided puncture drainage for DNAs.Methods and analysis PubMed, Ovid Medline, Cochrane Library, Embase, Web of Science, China National Knowledge Infrastructure, Wanfang database, VIP database and trial registry databases will be searched from inception to September 2023 to identify randomised controlled trials of patients diagnosed with DNAs accepting ultrasound-guided puncture drainage. The primary outcome will be the length of hospital stay. The secondary outcomes will be the cure rate, incidence of retreatment, complications and overall cost to the healthcare system. Fixed-effects or random-effects model will be used according to the statistical heterogeneity. Mean differences or standardised mean differences with 95% CIs for continuous data and risk ratio (RR) with 95% CIs for dichotomous data. The Cochrane risk-of-bias tool 2, Grading of Recommendations Assessment, Development and Evaluation (GRADE) and trial sequential analysis will be conducted to evaluate the evidence quality and control the random errors. Funnel plots and Egger’s regression test will be performed to evaluate publication bias.Ethics and dissemination Ethical approval was not required for this systematic review protocol. The results will be disseminated through peer-reviewed publications.PROSPERO registration number CRD42023441031.
Keywords	Medicine ; R
Language	English
Publishing date	2024-01-01T00:00:00Z
Publisher	BMJ Publishing Group
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: File processing security detection in multi-cloud environments

Xiaolu Zhang / Lei Cui / Wuqiang Shen / Jijun Zeng / Li Du / Haoyang He / Long Cheng

Journal of Cloud Computing: Advances, Systems and Applications, Vol 12, Iss 1, Pp 1-

a process mining approach

2023 Volume 10

Abstract: Abstract Cloud computing has gained popularity in recent years, but with its rise comes concerns about data security. Unauthorized access and attacks on cloud-based data, applications, and infrastructure are major challenges that must be addressed. While ...

Abstract	Abstract Cloud computing has gained popularity in recent years, but with its rise comes concerns about data security. Unauthorized access and attacks on cloud-based data, applications, and infrastructure are major challenges that must be addressed. While machine learning algorithms have improved intrusion detection systems in cloud data security, they often fail to consider the entire life cycle of file processing, making it difficult to detect certain issues, especially insider attacks. To address these limitations, this paper proposes a novel approach to analyzing data file processing in multi-cloud environments using process mining. By generating a complete file processing event log from a multi-cloud environment, the proposed approach enables detection from both control flow and performance perspectives, providing a deeper understanding of the underlying file processing in its full life cycle. Through our case study, we demonstrate the power and capabilities of process mining for file security detection and showcase its ability to provide further insights into file security in multi-cloud environments.
Keywords	Cloud file security ; Process mining ; Intrusion dection ; Process analysis ; Computer engineering. Computer hardware ; TK7885-7895 ; Electronic computers. Computer science ; QA75.5-76.95
Subject code	006
Language	English
Publishing date	2023-07-01T00:00:00Z
Publisher	SpringerOpen
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: MiR-379-5p Promotes Chondrocyte Proliferation via Inhibition of PI3K/Akt Pathway by Targeting YBX1 in Osteoarthritis.

Zhang, Hongjun / Zheng, Wendi / Li, Du / Zheng, Jia

Cartilage

2022 Volume 13, Issue 1, Page(s) 19476035221074024

Abstract: Objective: We evaluated the ability of miR-379-5p to influence the proliferation of osteoarthritis chondrocytes and elucidated the regulatory mechanism of miR-379-5p in osteoarthritis.: Methods: Real time polymerase chain reaction (RT- PCR) was used ... ...

Abstract	Objective: We evaluated the ability of miR-379-5p to influence the proliferation of osteoarthritis chondrocytes and elucidated the regulatory mechanism of miR-379-5p in osteoarthritis. Methods: Real time polymerase chain reaction (RT- PCR) was used to detect the expression of miR-379-5p and YBX1 in knee articular cartilages of human. Cell proliferation, inflammatory factors, extracellular matrix (ECM) degradation-associated proteins and proteins in PI3K/Akt pathway were assessed in rat primary chondrocytes treated with interleukin (IL)-1β or/and miR-379-5p mimics or miR-379-5p inhibitor via cell counting assay kit-8 (CCK-8), enzyme-linked immunosorbent assay (ELISA), immunofluorescence and Western blotting (WB). The target of miR-379-5p predicted by TargetScan and miRwalk software was verified by luciferase reporter assay. Safranin O-fast green staining, immunohistochemistry, and WB were performed to observe the effect of miR-379-5p agomir on development of osteoarthritis in rats. Results: MiR-379-5p was down-regulated in human osteoarthritic tissues and negatively correlated with YBX1 expression. High level of miR-379-5p in chondrocytes with IL-1β stimulated increased cell viability, the expression of proliferation-related protein and extracellular matrix (ECM)-related proteins collagen II and aggrecan. However, the expression of inflammatory factors and ECM-related proteins matrix metalloproteinases (MMP-1) and MMP-13 was decreased. Luciferase reporting assay verified the targeting relationship between miR-379-5p and YBX1. This function of miR-379-5p was exerted through PI3K/Akt pathway and could be blocked by the PI3K/Akt pathway inhibitor LY294002. MiR-379-5p agomir promoted the articular chondrocytes proliferation and alleviated cartilage degradation Conclusion: Our findings reveal that miR-379-5p can promote the articular chondrocytes proliferation in osteoarthritis (OA) by interacting with YBX1 and regulating PI3K/Akt pathway. Restoring miR-379-5p might be a future therapeutic strategy for OA.
MeSH term(s)	Animals ; Apoptosis ; Cartilage, Articular/metabolism ; Cell Proliferation ; Chondrocytes/metabolism ; DNA-Binding Proteins/metabolism ; MicroRNAs/genetics ; Osteoarthritis/metabolism ; Phosphatidylinositol 3-Kinases/metabolism ; Proto-Oncogene Proteins c-akt/metabolism ; Rats
Chemical Substances	DNA-Binding Proteins ; MIRN379 microRNA, rat ; MicroRNAs ; Ybx1 protein, rat ; Proto-Oncogene Proteins c-akt (EC 2.7.11.1)
Language	English
Publishing date	2022-03-08
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2515870-3
ISSN	1947-6043 ; 1947-6035
ISSN (online)	1947-6043
ISSN	1947-6035
DOI	10.1177/19476035221074024
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Book ; Online: Accelerating GW calculations of point defects with the defect-patched screening approximation

Li, Du / Liu, Zhen-Fei / Yang, Li

2023

Abstract: The GW approximation has been widely accepted as an ab initio tool for calculating defect levels with many-electron effect included. However, the GW simulation cost increases dramatically with the system size, and, unfortunately, large supercells are ... ...

Abstract	The GW approximation has been widely accepted as an ab initio tool for calculating defect levels with many-electron effect included. However, the GW simulation cost increases dramatically with the system size, and, unfortunately, large supercells are often required to model low-density defects that are experimentally relevant. In this work, we propose to accelerate GW calculations of point defects by reducing the simulation cost of the many-electron screening, which is the primary computational bottleneck. The random-phase approximation of many-electron screening is divided into two parts: one is the intrinsic screening, calculated using a unit cell of pristine structures, and the other is the defect-induced screening, calculated using the supercell within a small energy window. Depending on specific defects, one may only need to consider the intrinsic screening or include the defect contribution. This approach avoids the summation of many conductions states of supercells and significantly reduces the simulation time. We have applied it to calculating various point defects, including neutral and charged defects in two-dimensional and bulk systems with small or large bandgaps. The results consist with those from the direct GW simulations, and the agreements are further improved at the dilute-defect limit, which is experimentally relevant but extremely challenging for direct GW simulations. This defect-patched screening approach not only clarifies the roles of defects in many-electron screening but also paves the way to fast screen defect structures/materials for novel applications, including single-photon sources, quantum qubits, and quantum sensors. Comment: 32 pages, 6 figures
Keywords	Condensed Matter - Materials Science ; Condensed Matter - Mesoscale and Nanoscale Physics ; Physics - Computational Physics ; Quantum Physics
Subject code	530
Publishing date	2023-10-02
Publishing country	us
Document type	Book ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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