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  1. Article ; Online: Author response to: Comment on: Evaluation of a quality improvement intervention to reduce anastomotic leak following right colectomy (EAGLE): pragmatic, batched stepped-wedge, cluster-randomized trial in 64 countries.

    Li, Elizabeth / Morton, Dion

    The British journal of surgery

    2024  Volume 111, Issue 3

    MeSH term(s) Humans ; Anastomotic Leak/etiology ; Anastomotic Leak/prevention & control ; Quality Improvement ; Research Design ; Sample Size ; Colectomy/adverse effects
    Language English
    Publishing date 2024-03-18
    Publishing country England
    Document type Randomized Controlled Trial ; Journal Article
    ZDB-ID 2985-3
    ISSN 1365-2168 ; 0263-1202 ; 0007-1323 ; 1355-7688
    ISSN (online) 1365-2168
    ISSN 0263-1202 ; 0007-1323 ; 1355-7688
    DOI 10.1093/bjs/znae065
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Author response to: Collaborative research in surgery: a rising tide lifts all boats.

    Li, Elizabeth / Bhangu, Aneel

    The British journal of surgery

    2022  Volume 109, Issue 10, Page(s) e108

    Language English
    Publishing date 2022-05-09
    Publishing country England
    Document type Journal Article ; Comment
    ZDB-ID 2985-3
    ISSN 1365-2168 ; 0263-1202 ; 0007-1323 ; 1355-7688
    ISSN (online) 1365-2168
    ISSN 0263-1202 ; 0007-1323 ; 1355-7688
    DOI 10.1093/bjs/znac171
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Collaborative research in surgery: a rising tide lifts all boats.

    Li, Elizabeth / Bhangu, Aneel

    The British journal of surgery

    2022  Volume 109, Issue 7, Page(s) 576–577

    Language English
    Publishing date 2022-03-29
    Publishing country England
    Document type Journal Article
    ZDB-ID 2985-3
    ISSN 1365-2168 ; 0263-1202 ; 0007-1323 ; 1355-7688
    ISSN (online) 1365-2168
    ISSN 0263-1202 ; 0007-1323 ; 1355-7688
    DOI 10.1093/bjs/znac099
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Epistemic trust: a comprehensive review of empirical insights and implications for developmental psychopathology.

    Li, Elizabeth / Campbell, Chloe / Midgley, Nick / Luyten, Patrick

    Research in psychotherapy (Milano)

    2023  Volume 26, Issue 3

    Abstract: Originally rooted in philosophy and sociology, the concept of epistemic trust has recently transitioned to developmental psychopathology, illuminating social-cognitive processes in psychopathology. This narrative review synthesizes empirical evidence on ... ...

    Abstract Originally rooted in philosophy and sociology, the concept of epistemic trust has recently transitioned to developmental psychopathology, illuminating social-cognitive processes in psychopathology. This narrative review synthesizes empirical evidence on epistemic trust to inform future research. A literature search highlighted 3 areas: i) the development of selective trust in children; ii) epistemic trust in non-clinical adults; iii) its link to mental health. Young children demonstrate selective learning from reliable sources using epistemic cues. Empirical studies beyond childhood were greatly facilitated in the last 2 years with the introduction of the Epistemic Trust, Mistrust and Credulity Questionnaire, a self-report scale measuring epistemic stance. Cross-sectional studies pinpointed dysfunctional epistemic strategies as factors in mental health vulnerability, and some qualitative work offered initial evidence linking restored epistemic trust to effective psychotherapy. For future research, we propose focusing on 3 primary areas. First, empirical investigations in adolescent samples are needed, as adolescence seems to be a pivotal phase in the development of epistemic trust. Second, more experimental research is required to assess dysfunctional and functional epistemic stances and how they relate to vulnerability to mental health disorders. Finally, intervention studies should explore the dynamics of epistemic stances within and between therapy sessions and their impact on therapeutic outcomes.
    Language English
    Publishing date 2023-12-20
    Publishing country Italy
    Document type Journal Article
    ZDB-ID 2654235-3
    ISSN 2239-8031 ; 2239-8031
    ISSN (online) 2239-8031
    ISSN 2239-8031
    DOI 10.4081/ripppo.2023.704
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Optimizing Calcium Detection Methods in Animal Systems: A Sandbox for Synthetic Biology.

    Li, Elizabeth S / Saha, Margaret S

    Biomolecules

    2021  Volume 11, Issue 3

    Abstract: Since the 1970s, the emergence and expansion of novel methods for calcium ion ( ... ...

    Abstract Since the 1970s, the emergence and expansion of novel methods for calcium ion (Ca
    MeSH term(s) Animals ; Calcium/analysis ; Calcium Signaling/physiology ; Synthetic Biology/methods
    Chemical Substances Calcium (SY7Q814VUP)
    Language English
    Publishing date 2021-02-24
    Publishing country Switzerland
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Review
    ZDB-ID 2701262-1
    ISSN 2218-273X ; 2218-273X
    ISSN (online) 2218-273X
    ISSN 2218-273X
    DOI 10.3390/biom11030343
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  6. Article ; Online: A Bioinspired Synthesis of 1,4-Benzothiazines by Selective Addition of Sulfur Nucleophiles to

    Halloran, Matthew W / Li, Elizabeth / Esguerra, Kenneth Virgel N / Lumb, Jean-Philip

    The Journal of organic chemistry

    2023  Volume 88, Issue 4, Page(s) 2561–2569

    Abstract: Herein, we report a bioinspired approach to the synthesis of 1,4-benzothiazines by drawing inspiration from the biosynthesis of pheomelanin pigments (pheomelanogenesis). In this context, general conditions for the regioselective coupling reaction ... ...

    Abstract Herein, we report a bioinspired approach to the synthesis of 1,4-benzothiazines by drawing inspiration from the biosynthesis of pheomelanin pigments (pheomelanogenesis). In this context, general conditions for the regioselective coupling reaction between
    Language English
    Publishing date 2023-01-31
    Publishing country United States
    Document type Journal Article
    ZDB-ID 123490-0
    ISSN 1520-6904 ; 0022-3263
    ISSN (online) 1520-6904
    ISSN 0022-3263
    DOI 10.1021/acs.joc.2c02463
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    Zs.A 4473: Show issues Location:
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  7. Article ; Online: Factors Affecting the Decision to Initiate Dialysis: A National Survey of United States Nephrologists.

    Mathur, Vandana S / Wesson, Donald E / Li, Elizabeth / Tangri, Navdeep

    American journal of nephrology

    2022  Volume 53, Issue 10, Page(s) 722–729

    Abstract: Introduction: The percentage of patients initiating dialysis at an estimated glomerular filtration rate (eGFR) ≤9 mL/min/1.73 m2 decreased between 2000 and 2018 in the USA. Clinical practice guidelines recommend basing the decision to initiate dialysis ... ...

    Abstract Introduction: The percentage of patients initiating dialysis at an estimated glomerular filtration rate (eGFR) ≤9 mL/min/1.73 m2 decreased between 2000 and 2018 in the USA. Clinical practice guidelines recommend basing the decision to initiate dialysis primarily on uremic signs and symptoms rather than on a particular level of kidney function. However, what signs and symptoms currently practicing nephrologists consider "uremic," how they weigh eGFR and other factors in the decision to initiate dialysis have not been reported.
    Methods: The study was an online survey of 255 US nephrologists, conducted between August and October 2021.
    Results: Nearly half of respondents (49.8%) had an absolute lower eGFR (8.4 [95% CI: 7.6, 9.2] mL/min/1.73 m2) at which they would initiate dialysis in an asymptomatic patient. The top 5 symptoms that would trigger a recommendation to initiate dialysis were loss of appetite/nausea/vomiting (17%), low eGFR (10%), shortness of breath (10%), declining physical ability/function (9%), and generalized weakness (9%). Poor nutritional status and physical function decline were considered very important in the decision to initiate dialysis by 64% and 55% of respondents, respectively. Nephrologists surveyed significantly shortened the time to dialysis initiation in response to declining physical function in an otherwise asymptomatic (hypothetical) patient.
    Conclusions: Nearly half of nephrologists sometimes based their decision to initiate dialysis on eGFR alone. The eGFR threshold at which they did so was lower than has been examined in randomized controlled trials of dialysis initiation. Initiatives designed to safely delay dialysis through aggressive medical management could focus on modifiable factors that are the most important drivers of the decision to initiate dialysis.
    MeSH term(s) Humans ; United States ; Renal Dialysis ; Nephrologists ; Glomerular Filtration Rate ; Surveys and Questionnaires ; Cognition ; Kidney Failure, Chronic/therapy
    Language English
    Publishing date 2022-12-07
    Publishing country Switzerland
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 604540-6
    ISSN 1421-9670 ; 0250-8095
    ISSN (online) 1421-9670
    ISSN 0250-8095
    DOI 10.1159/000528167
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  8. Article ; Online: Effects of Veverimer in Older Adults With CKD and Metabolic Acidosis.

    Tangri, Navdeep / Li, Elizabeth / Mathur, Vandana

    Kidney medicine

    2021  Volume 3, Issue 4, Page(s) 689–691

    Language English
    Publishing date 2021-06-23
    Publishing country United States
    Document type Journal Article
    ISSN 2590-0595
    ISSN (online) 2590-0595
    DOI 10.1016/j.xkme.2021.03.016
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  9. Article ; Online: Safety and Efficacy of Veverimer in Acidotic Patients With CKD and Heart Failure.

    Mathur, Vandana / Li, Elizabeth / Bushinsky, David A

    Kidney international reports

    2021  Volume 6, Issue 11, Page(s) 2908–2911

    Language English
    Publishing date 2021-08-23
    Publishing country United States
    Document type Journal Article
    ISSN 2468-0249
    ISSN (online) 2468-0249
    DOI 10.1016/j.ekir.2021.08.015
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  10. Article ; Online: Effects of veverimer on serum bicarbonate and physical function in diabetic patients with chronic kidney disease and metabolic acidosis: subgroup analysis from a randomized, controlled trial.

    Mathur, Vandana S / Li, Elizabeth / Wesson, Donald E

    Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association

    2021  Volume 37, Issue 7, Page(s) 1302–1309

    Abstract: Background: Metabolic acidosis is a complication of chronic kidney disease (CKD) that increases risk of CKD progression, and causes bone demineralization and muscle protein catabolism. Patients with diabetes are prone to metabolic acidosis and ... ...

    Abstract Background: Metabolic acidosis is a complication of chronic kidney disease (CKD) that increases risk of CKD progression, and causes bone demineralization and muscle protein catabolism. Patients with diabetes are prone to metabolic acidosis and functional limitations that decrease quality of life. Veverimer, an investigational, non-absorbed polymer that binds and removes gastrointestinal hydrochloric acid, is being developed as treatment for metabolic acidosis. This post hoc subgroup analysis evaluated effects of veverimer on metabolic acidosis and physical function among patients with diabetes.
    Methods: This was a Phase 3, multicenter, randomized, blinded, placebo-controlled trial in 196 patients with CKD (estimated glomerular filtration rate 20-40 mL/min/1.73 m2) and metabolic acidosis who were treated for up to 1 year with veverimer or placebo.
    Results: At Week 52, veverimer-treated patients with diabetes (n = 70), had a significantly greater increase in mean serum bicarbonate than the placebo group (n = 57) (4.4 versus 2.9 mmol/L, P < 0.05). Patient-reported limitations of physical function on the Kidney Disease and Quality of Life-Physical Function Domain (e.g. walking several blocks and climbing a flight of stairs) improved significantly in the veverimer versus placebo group (+12.5 versus +0.3, respectively, P < 0.001) as did objective physical performance on the repeated chair stand test (P < 0.0001).
    Conclusions: Few interventions for patients with diabetes and CKD have successfully improved quality of life or physical functioning. Our study demonstrated that veverimer effectively treated metabolic acidosis in patients with diabetes and CKD, and significantly improved how these patients felt and functioned.
    MeSH term(s) Acidosis/drug therapy ; Acidosis/etiology ; Bicarbonates ; Diabetes Mellitus/drug therapy ; Humans ; Polymers/pharmacology ; Polymers/therapeutic use ; Quality of Life ; Renal Insufficiency, Chronic ; Sodium Bicarbonate/therapeutic use
    Chemical Substances Bicarbonates ; Polymers ; veverimer ; Sodium Bicarbonate (8MDF5V39QO)
    Language English
    Publishing date 2021-07-08
    Publishing country England
    Document type Clinical Trial, Phase III ; Journal Article ; Multicenter Study ; Randomized Controlled Trial ; Research Support, Non-U.S. Gov't
    ZDB-ID 90594-x
    ISSN 1460-2385 ; 0931-0509
    ISSN (online) 1460-2385
    ISSN 0931-0509
    DOI 10.1093/ndt/gfab209
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