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  1. Article ; Online: Nonlinear dynamics of cavity optomechanical-thermal systems.

    Xu, Xiangming / Zhu, Huatao / Chen, Shuwen / Li, Feiyu / Zhang, Xin

    Optics express

    2024  Volume 32, Issue 5, Page(s) 7611–7621

    Abstract: Cavity optomechanics is concerned with the interaction between optical cavities and mechanical resonators. Here, we present systematic research on the dynamic behaviors of cavity optomechanical systems incorporating the influence of thermal nonlinearity. ...

    Abstract Cavity optomechanics is concerned with the interaction between optical cavities and mechanical resonators. Here, we present systematic research on the dynamic behaviors of cavity optomechanical systems incorporating the influence of thermal nonlinearity. A dimensionless theoretical model was established to describe the system and numerical simulations were performed to study the dynamic behaviors. We theoretically identify the staircase effect, which can abruptly alter the system parameters when adiabatically sweeping the pump laser frequency across the optical cavity resonance and driving the mechanical resonator into oscillation. Moreover, we found bistability effects in several detuning intervals when sweeping the laser forward and backward. Both effects are analyzed theoretically and the roots lie in the thermal instability between averaged cavity energy and laser detuning. Our study shows the dynamic behaviors in an optomechanical-thermal system and provides guidance in leveraging the systems for applications in optical frequency comb, phonon laser, etc.
    Language English
    Publishing date 2024-03-04
    Publishing country United States
    Document type Journal Article
    ZDB-ID 1491859-6
    ISSN 1094-4087 ; 1094-4087
    ISSN (online) 1094-4087
    ISSN 1094-4087
    DOI 10.1364/OE.515095
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Book ; Online: Rethinking PRL

    Li, Feiyu / Yang, Jun

    A Multiscale Progressively Residual Learning Network for Inverse Halftoning

    2023  

    Abstract: Image inverse halftoning is a classic image restoration task, aiming to recover continuous-tone images from halftone images with only bilevel pixels. Because the halftone images lose much of the original image content, inverse halftoning is a classic ill- ...

    Abstract Image inverse halftoning is a classic image restoration task, aiming to recover continuous-tone images from halftone images with only bilevel pixels. Because the halftone images lose much of the original image content, inverse halftoning is a classic ill-problem. Although existing inverse halftoning algorithms achieve good performance, their results lose image details and features. Therefore, it is still a challenge to recover high-quality continuous-tone images. In this paper, we propose an end-to-end multiscale progressively residual learning network (MSPRL), which has a UNet architecture and takes multiscale input images. To make full use of different input image information, we design a shallow feature extraction module to capture similar features between images of different scales. We systematically study the performance of different methods and compare them with our proposed method. In addition, we employ different training strategies to optimize the model, which is important for optimizing the training process and improving performance. Extensive experiments demonstrate that our MSPRL model obtains considerable performance gains in detail restoration.
    Keywords Computer Science - Computer Vision and Pattern Recognition ; Electrical Engineering and Systems Science - Image and Video Processing
    Subject code 006 ; 004
    Publishing date 2023-05-26
    Publishing country us
    Document type Book ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  3. Article ; Online: A Customized Biohybrid Presenting Cascade Responses to Tumor Microenvironment.

    Li, Feiyu / Zhu, Peipei / Zheng, Bingzhu / Lu, Zijie / Fang, Chao / Fu, Yike / Li, Xiang

    Advanced materials (Deerfield Beach, Fla.)

    2024  , Page(s) e2404901

    Abstract: Intrinsic characteristics of microorganisms, including non-specific metabolism sites, toxic byproducts, and uncontrolled proliferation constrain their exploitation in medical applications such as tumor therapy. Here, the authors report an engineered ... ...

    Abstract Intrinsic characteristics of microorganisms, including non-specific metabolism sites, toxic byproducts, and uncontrolled proliferation constrain their exploitation in medical applications such as tumor therapy. Here, the authors report an engineered biohybrid that can efficiently target cancerous sites through a pre-determined metabolic pathway to enable precise tumor ablation. In this system, DH5α Escherichia coli is engineered by the introduction of hypoxia-inducible promoters and lactate oxidase genes, and further surface-armored with iron-doped ZIF-8 nanoparticles. This bioengineered E. coli can produce and secrete lactate oxidase to reduce lactate concentration in response to hypoxic tumor microenvironment, as well as triggering immune activation. The peroxidase-like functionality of the nanoparticles extends the end product of the lactate metabolism, enabling the conversion of hydrogen peroxide (H
    Language English
    Publishing date 2024-05-09
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 1474949-X
    ISSN 1521-4095 ; 0935-9648
    ISSN (online) 1521-4095
    ISSN 0935-9648
    DOI 10.1002/adma.202404901
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Optical stealth communication based on quantum noise stream ciphered amplified spontaneous emission light.

    Zhu, Huatao / Liu, Zhanqi / Chen, Shuwen / Xu, Xiangming / Li, Feiyu

    Optics express

    2023  Volume 31, Issue 3, Page(s) 3595–3605

    Abstract: Amplified spontaneous emission (ASE) light is the most natural optical carrier to hide a message in the existing optical networks at photonic layer. To enhance the anti-intercept ability of the ASE-carried stealth channel, a novel optical stealth ... ...

    Abstract Amplified spontaneous emission (ASE) light is the most natural optical carrier to hide a message in the existing optical networks at photonic layer. To enhance the anti-intercept ability of the ASE-carried stealth channel, a novel optical stealth communication scheme based on quantum noise stream cipher is proposed. The ASE light is intensity modulated by the cipher-text according to Y-00 protocol, and then transmitted under public optical noise after power attenuation. The expression of quantum noise stream ciphered ASE signal is derived, and numerical simulation is carried out. A proof-of-concept experiment is set up to demonstrate the feasibility of the proposed scheme. The experiment results show that the quantum noise stream ciphered stealth signals can be transmitted over a 25 km single-mode fiber span error-free.
    Language English
    Publishing date 2023-01-30
    Publishing country United States
    Document type Journal Article
    ZDB-ID 1491859-6
    ISSN 1094-4087 ; 1094-4087
    ISSN (online) 1094-4087
    ISSN 1094-4087
    DOI 10.1364/OE.479353
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Remote Cognitive Adaptation Training During and After COVID-19.

    Velligan, Dawn / Lara, Frankie / Li, Feiyu

    Psychiatric services (Washington, D.C.)

    2022  Volume 73, Issue 12, Page(s) 1429

    MeSH term(s) Humans ; COVID-19 ; Cognitive Behavioral Therapy ; Psychotherapy ; Cognition
    Language English
    Publishing date 2022-10-05
    Publishing country United States
    Document type Journal Article
    ZDB-ID 1220173-x
    ISSN 1557-9700 ; 1075-2730
    ISSN (online) 1557-9700
    ISSN 1075-2730
    DOI 10.1176/appi.ps.20220441
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Short-term outcomes of perioperative glucocorticoid administration in patients undergoing liver surgery: a systematic review and meta-analysis of randomised controlled trials.

    Yan, Xiangyu / Huang, Songhan / Li, Feiyu / Jiang, Liyong / Jiang, Yong / Liu, Jun

    BMJ open

    2023  Volume 13, Issue 5, Page(s) e068969

    Abstract: Objective: The purpose of this systematic review and meta-analysis was to investigate whether glucocorticoid might be beneficial after hepatectomy.: Design: Systematic review and meta-analysis.: Data sources: PubMed, Embase, Cochrane Library and ... ...

    Abstract Objective: The purpose of this systematic review and meta-analysis was to investigate whether glucocorticoid might be beneficial after hepatectomy.
    Design: Systematic review and meta-analysis.
    Data sources: PubMed, Embase, Cochrane Library and Web of Science.
    Eligibility criteria: We included studies assessing the efficacy of perioperative glucocorticoid administration in patients undergoing liver surgery.
    Data extraction and synthesis: Four data bases were retrieved for all randomised controlled trials. We considered postoperative complications, hospital stay and postoperative chemistry evaluations as outcomes. Pooled effects of dichotomic variables were expressed as relative risk (RR) with a 95% CI. The mean difference was used for continuous variables and an inverse variance statistical method was adopted.
    Results: Fourteen studies with 1205 patients were included. Lower risk of overall complications was associated with glucocorticoid (RR, 0.77; 95% CI 0.64 to 0.92), while no difference was found in hospital stay (RR, 0.02; 95% CI -0.47 to 0.51). There were also improvements in postoperative chemistry evaluations including interleukin 6 on day 1 and 3, C reactive protein on day 1, 2 and 3, international normalised ratio on day 2, total bilirubin on day 1, 2, 3 and 5, albumin on day 1.
    Conclusion: Current evidence indicated that perioperative glucocorticoid administration for patients undergoing hepatectomy reduced the risk of overall complications with inhibited postoperative inflammatory response and improved postoperative liver function.
    Prospero registration number: CRD42022307533.
    MeSH term(s) Humans ; Glucocorticoids ; Postoperative Complications/prevention & control ; Liver/surgery ; Randomized Controlled Trials as Topic
    Chemical Substances Glucocorticoids
    Language English
    Publishing date 2023-05-11
    Publishing country England
    Document type Meta-Analysis ; Systematic Review ; Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2599832-8
    ISSN 2044-6055 ; 2044-6055
    ISSN (online) 2044-6055
    ISSN 2044-6055
    DOI 10.1136/bmjopen-2022-068969
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: A Pilot Study Examining Feasibility and Initial Efficacy of Remotely Delivered Cognitive Adaptation Training.

    Velligan, Dawn I / Li, Feiyu / Sebastian, Veronica / Kennedy, Cory / Mintz, Jim

    Schizophrenia bulletin open

    2023  Volume 4, Issue 1, Page(s) sgad028

    Abstract: Cognitive Adaptation Training (CAT) is an evidence-based treatment that uses environmental supports including signs, text messages, checklists, smart pill containers, and the organization of belongings to bypass cognitive and motivational impairments and ...

    Abstract Cognitive Adaptation Training (CAT) is an evidence-based treatment that uses environmental supports including signs, text messages, checklists, smart pill containers, and the organization of belongings to bypass cognitive and motivational impairments and to cue adaptive behavior in the home or work environment. We developed and tested a remote version of CAT to make the treatment available more broadly. Because CAT is focused on working with the individual in their home environment to establish supports, CAT may not be as easy to translate into an effective virtual treatment as talk-therapies. Fifty-six members of managed care were assigned to or given their treatment preference for CAT or Remote CAT (R-CAT) for 6 months. In-person or virtual pill counts were conducted monthly and assessments of habit-formation, symptoms, functioning, and satisfaction were administered every 2 months by independent raters. Analyses using mixed models with repeated measures focused on pre-planned evaluations of within-group change. Adherence improved significantly in R-CAT, functioning improved significantly in CAT and both groups improved significantly on measures of habit-formation and symptoms across 6 months. Higher functioning individuals appeared to choose R-CAT. Satisfaction with treatment was very high in both groups. R-CAT appears to be a potentially effective treatment, particularly for medication follow-though. However, in contrast to decades of previous research, fewer than 20% of eligible Medicaid recipients agreed to participate in the study. This may have been due to recruitment during and immediately post-pandemic.
    Language English
    Publishing date 2023-10-01
    Publishing country United States
    Document type Journal Article
    ISSN 2632-7899
    ISSN (online) 2632-7899
    DOI 10.1093/schizbullopen/sgad028
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: Subnoise optical covert communication based on amplified spontaneous emission light.

    Liu, Zhanqi / Zhu, Huatao / Zhang, Xin / Chen, Shuwen / Xu, Xiangming / Li, Feiyu

    Optics express

    2023  Volume 31, Issue 24, Page(s) 40261–40269

    Abstract: Amplified spontaneous emission (ASE) light is a common noise in optical communication systems with optical amplification, and a suitable optical carrier for optical covert communication. To deeply covert the secure signal, an in-band subnoise optical ... ...

    Abstract Amplified spontaneous emission (ASE) light is a common noise in optical communication systems with optical amplification, and a suitable optical carrier for optical covert communication. To deeply covert the secure signal, an in-band subnoise optical covert communication scheme is proposed and demonstrated by a proof-of-concept experiment. The power spectral density of optical secure channel is 10 dB less than the optical noise in the public channel. The covert signal is hidden in both optical and electrical domain, and can be transmitted with error-free. The trade-off between covertness and availability is discussed.
    Language English
    Publishing date 2023-12-01
    Publishing country United States
    Document type Journal Article
    ZDB-ID 1491859-6
    ISSN 1094-4087 ; 1094-4087
    ISSN (online) 1094-4087
    ISSN 1094-4087
    DOI 10.1364/OE.505033
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: Hollow CoFe Nanozymes Integrated with Oncolytic Peptides Designed via Machine-Learning for Tumor Therapy.

    Li, Feiyu / Xu, Bocheng / Lu, Zijie / Chen, Jiafei / Fu, Yike / Huang, Jie / Wang, Yizhen / Li, Xiang

    Small (Weinheim an der Bergstrasse, Germany)

    2024  , Page(s) e2311101

    Abstract: Developing novel substances to synergize with nanozymes is a challenging yet indispensable task to enable the nanozyme-based therapeutics to tackle individual variations in tumor physicochemical properties. The advancement of machine learning (ML) has ... ...

    Abstract Developing novel substances to synergize with nanozymes is a challenging yet indispensable task to enable the nanozyme-based therapeutics to tackle individual variations in tumor physicochemical properties. The advancement of machine learning (ML) has provided a useful tool to enhance the accuracy and efficiency in developing synergistic substances. In this study, ML models to mine low-cytotoxicity oncolytic peptides are applied. The filtering Pipeline is constructed using a traversal design and the Autogluon framework. Through the Pipeline, 37 novel peptides with high oncolytic activity against cancer cells and low cytotoxicity to normal cells are identified from a library of 25,740 sequences. Combining dataset testing with cytotoxicity experiments, an 80% accuracy rate is achieved, verifying the reliability of ML predictions. Peptide C2 is proven to possess membranolytic functions specifically for tumor cells as targeted by Pipeline. Then Peptide C2 with CoFe hollow hydroxide nanozyme (H-CF) to form the peptide/H-CF composite is integrated. The new composite exhibited acid-triggered membranolytic function and potent peroxidase-like (POD-like) activity, which induce ferroptosis to tumor cells and inhibits tumor growth. The study suggests that this novel ML-assisted design approach can offer an accurate and efficient paradigm for developing both oncolytic peptides and synergistic peptides for catalytic materials.
    Language English
    Publishing date 2024-01-17
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 2168935-0
    ISSN 1613-6829 ; 1613-6810
    ISSN (online) 1613-6829
    ISSN 1613-6810
    DOI 10.1002/smll.202311101
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: Expression and Characterization of Laccase Lac1 from Coriolopsis trogii Strain Mafic-2001 in Pichia pastoris and Its Degradation of Lignin.

    Bao, Chengling / Liu, Yajing / Li, Feiyu / Cao, Heng / Dong, Bing / Cao, Yunhe

    Applied biochemistry and biotechnology

    2023  Volume 195, Issue 10, Page(s) 6150–6167

    Abstract: The laccase gene (Lac1) was cloned from Coriolopsis trogii strain Mafic-2001. Full-length sequence of Lac1 containing 11 exons and 10 introns is composed of 2140 nucleotides (nts). mRNA of Lac1 encoded for a protein of 517 aa. Nucleotide sequence of the ... ...

    Abstract The laccase gene (Lac1) was cloned from Coriolopsis trogii strain Mafic-2001. Full-length sequence of Lac1 containing 11 exons and 10 introns is composed of 2140 nucleotides (nts). mRNA of Lac1 encoded for a protein of 517 aa. Nucleotide sequence of the laccase was optimized and expressed in Pichia pastoris X-33. SDS-PAGE analysis showed that the molecular weight of the purified recombinant laccase rLac1 was about 70 kDa. The optimum temperature and pH of rLac1 were 40 ℃ and 3.0, respectively. rLac1 showed high residual activity (90%) in the solutions after 1 h incubation at the pH ranging from 2.5 to 8.0. rLac1 maintained over 60% of laccase activity at the temperatures ranging from 20 to 60 °C, and kept higher than 50% of its activity at 40 °C for 2 h. The activity of rLac1 was promoted by Cu
    MeSH term(s) Laccase/metabolism ; Lignin/metabolism ; Cloning, Molecular ; Pichia/genetics ; Pichia/metabolism
    Chemical Substances Laccase (EC 1.10.3.2) ; Lignin (9005-53-2)
    Language English
    Publishing date 2023-02-27
    Publishing country United States
    Document type Journal Article
    ZDB-ID 392344-7
    ISSN 1559-0291 ; 0273-2289
    ISSN (online) 1559-0291
    ISSN 0273-2289
    DOI 10.1007/s12010-023-04390-4
    Database MEDical Literature Analysis and Retrieval System OnLINE

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