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Article: Targeted Isolation of Tsitsikammamines from the Antarctic Deep-Sea Sponge Latrunculia biformis by Molecular Networking and Anticancer Activity

li, Fengjie / Janussen, Dorte / Pérez-Victoria, Ignacio / Tasdemir, Deniz

Marine drugs, 16(8):268

2018

Abstract: The Antarctic deep-sea sponge Latrunculia (Latrunculia) biformis Kirkpatrick, 1908 (Class Demospongiae Sollas, Order Poecilosclerida Topsent, Latrunculiidae Topsent) was selected for chemical analyses due to its potent anticancer activity. Metabolomic ... ...

Institution	Senckenberg am Meer
Abstract	The Antarctic deep-sea sponge Latrunculia (Latrunculia) biformis Kirkpatrick, 1908 (Class Demospongiae Sollas, Order Poecilosclerida Topsent, Latrunculiidae Topsent) was selected for chemical analyses due to its potent anticancer activity. Metabolomic analysis of its crude extract by HRMS/MS-based molecular networking showed the presence of several clusters of pyrroloiminoquinone alkaloids, i.e., discorhabdin and epinardin-type brominated pyridopyrroloquinolines and tsitsikammamines, the non-brominated bis-pyrroloiminoquinones. Molecular networking approach combined with a bioactivity-guided isolation led to the targeted isolation of the known pyrroloiminoquinone tsitsikammamine A (1) and its new analog 16,17-dehydrotsitsikammamine A (2). The chemical structures of the compounds 1 and 2 were elucidated by spectroscopic analysis (one-dimensional (1D) and two-dimensional (2D) NMR, HR-ESIMS). Due to minute amounts, molecular modeling and docking was used to assess potential affinities to potential targets of the isolated compounds, including DNA intercalation, topoisomerase I-II, and indoleamine 2,3-dioxygenase enzymes. Tsitsikammamines represent a small class of pyrroloiminoquinone alkaloids that have only previously been reported from the South African sponge genus Tsitsikamma Samaai & Kelly and an Australian species of the sponge genus Zyzzya de Laubenfels. This is the first report of tsitsikammamines from the genus Latrunculia du Bocage and the successful application of molecular networking in the identification of comprehensive chemical inventory of L.biformis followed by targeted isolation of new molecules. This study highlights the high productivity of secondary metabolites of Latrunculia sponges and may shed new light on their biosynthetic origin and chemotaxonomy.
Keywords	Antarctica ; Latrunculia ; deep-sea ; molecular networking ; molecular docking ; marine sponge ; tsitsikammamine
Language	English
Document type	Article
Database	Repository for Life Sciences

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Article ; Online: Understanding microplastic aging driven by photosensitization of algal extracellular polymeric substances.

Li, Fengjie / Bai, Xue / Ji, Yetong / Kang, Mengen

Journal of hazardous materials

2024 Volume 469, Page(s) 133949

Abstract: The aging of microplastics (MPs) is extremely influenced by photochemically-produced reactive intermediates (PPRIs), which are mediated by natural photosensitive substances. Algal extracellular polymeric substances (EPS) can produce PPRIs when exposed to ...

Abstract	The aging of microplastics (MPs) is extremely influenced by photochemically-produced reactive intermediates (PPRIs), which are mediated by natural photosensitive substances. Algal extracellular polymeric substances (EPS) can produce PPRIs when exposed to sunlight. Nonetheless, the specific role of EPS in the aging process of MPs remains unclear. This work systematically explored the aging process of polystyrene (PS) MPs in the EPS secreted by Chlorella vulgaris under simulated sunlight irradiation. The results revealed that the existence of EPS accelerated the degradation of PS MPs into particles with sizes less than 1 µm, while also facilitating the formation of hydroxy groups on the surface. The release rate of dissolved organic matter (DOM) from PS MPs was elevated from 0.120 mg·L
MeSH term(s)	Microplastics ; Plastics ; Extracellular Polymeric Substance Matrix/chemistry ; Chlorella vulgaris ; Sunlight ; Polystyrenes ; Water Pollutants, Chemical/analysis ; Humic Substances/analysis
Chemical Substances	Microplastics ; Plastics ; Polystyrenes ; Water Pollutants, Chemical ; Humic Substances
Language	English
Publishing date	2024-03-02
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	1491302-1
ISSN	1873-3336 ; 0304-3894
ISSN (online)	1873-3336
ISSN	0304-3894
DOI	10.1016/j.jhazmat.2024.133949
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Article ; Online: Transcriptomic sequencing reveals that WNK2 promotes reactive oxygen species production in ovarian cancer cells

LI Fengjie / JIA Yongqin / WANG Yanzhou / DU Xiurong

陆军军医大学学报, Vol 45, Iss 2, Pp 130-

2023 Volume 138

Abstract: Objective To investigate the biological and metabolic roles of WNK2 in regulation of ovarian cancer based on transcriptome sequencing technology. Methods Ovarian cancer SKOV3 cells were divided into experimental group and control group, with 3 replicates ...

Abstract	Objective To investigate the biological and metabolic roles of WNK2 in regulation of ovarian cancer based on transcriptome sequencing technology. Methods Ovarian cancer SKOV3 cells were divided into experimental group and control group, with 3 replicates in each group.The expression of WNK2 was knocked down with transfection of siRNA targeting WNK2 in SKOV3 cells.Then the total RNA was extracted and prepared for transcriptome sequencing and bioinformatics analysis after 48 h of transfection.The differential genes between siNC and siWNK2 were screened out in the range of padj < 0.01, fold change >1, and FPKM >500 to obtain the genes under the regulation of WNK2.DisGeNET and disease ontology (DO) enrichment analysis was used to analyze the relationship of the diseases and differentially expressed genes (DEGs).GO enrichment analysis was adopted to analyze the cellular functions and metabolic processes in which the DEGs were enriched.Finally, RT-qPCR was used to examine whether the 10 differential proteins in the reactive oxygen species (ROS) pathway were regulated by WNK2.The influence of WNK2 overexpression and knockdown on the ROS metabolic process of ovarian cancer cells was determined. Results The DisGeNET and DO enrichment analysis showed the obtained DEGs were closely related with malignant tumors (P < 0.05).GO functional enrichment analysis showed the obtained DEGs were enriched in biological processes such as ROS metabolism, apoptosis signaling pathway, formation of ubiquitin ligase complex and mitochondrial membrane protein complex, growth factor binding, and transcription activator activity and so on (P < 0.05).Among these enriched pathways, ROS related pathways were the most numerous and significant (P < 0.001).The results of RT-qPCR indicated that the changes in 9 DEGs were consistent with the sequencing results after WNK2 was knocked down, and one gene (PDGFB) was contrary to the sequencing results, and one gene had no significant change between the 2 groups.Knockdown of WNK2 in SKOV3 ...
Keywords	ovarian cancer ; rna-seq ; ros metabolism ; go enrichment ; Medicine (General) ; R5-920
Language	Chinese
Publishing date	2023-01-01T00:00:00Z
Publisher	Editorial Office of Journal of Army Medical University
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Thesis ; Online: Investigations into Chemistry and Anticancer Activity of Deep-water Latrunculia sp. Sponges from Antarctica

Li, Fengjie

2020

Language	English
Publishing date	2020-01-29
Publishing country	de
Document type	Thesis ; Online
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Article ; Online: Bioinformatics identification of characteristic genes of cervical cancer via an artificial neural network.

Liu, Liping / Huang, Lingjun / Deng, Li / Li, Fengjie / Vannucci, Jacopo / Tang, Shuai / Wang, Yanzhou

Chinese clinical oncology

2024 Volume 13, Issue 1, Page(s) 4

Abstract: Background: Artificial neural networks (ANNs) have been extensively used in the field of medicine. The present hypothesis-free study sought to use an ANN to identify the characteristic genes of cervical cancer (CC).: Methods: RNA sequencing profiles ... ...

Abstract	Background: Artificial neural networks (ANNs) have been extensively used in the field of medicine. The present hypothesis-free study sought to use an ANN to identify the characteristic genes of cervical cancer (CC). Methods: RNA sequencing profiles were obtained from the GSE7410, GSE9750, GSE63514, and GSE52903 datasets. The differentially expressed genes (DEGs) were identified and compared between the normal and CC tissues. An ANN analysis was conducted to obtain the random-forest tree and to examine differences in gene filtering. A neural network model was established using the characteristic genes of CC, while the verification accuracy of the model was examined by Cox regression. The differences in the immune infiltrating cells between the normal cervical and CC tissues were compared by CIBERSORT (an analytical tool can provide an estimation of the abundances of member cell types in a mixed cell population). Results: Nine genes' characteristics for CC were identified: cyclin-dependent kinase inhibitor 2A (CDKN2A), chromosome 1 open reading frame 112 (C1orf112), helicase, lymphoid-specific (HELLS), mini-chromosome maintenance protein 5 (MCM5), mini-chromosome maintenance protein 2 (MCM2), kinetochore associated 1 (KNTC1), cysteine-rich secretory protein 3 (CRISP3), phytanoyl-CoA 2-hydroxylase interacting protein (PHYHIP), and cornulin (CRNN). Conclusions: ANN is a robust neural network model that can be used to potentially predict CC based on the gene score. It can provide novel insights into the pathogenesis and molecular mechanisms of CC.
MeSH term(s)	Female ; Humans ; Uterine Cervical Neoplasms/genetics ; Uterine Cervical Neoplasms/pathology ; Computational Biology ; Neural Networks, Computer
Language	English
Publishing date	2024-03-11
Publishing country	China
Document type	Journal Article
ZDB-ID	2828547-5
ISSN	2304-3873 ; 2304-3873
ISSN (online)	2304-3873
ISSN	2304-3873
DOI	10.21037/cco-23-139
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Article: Weathering of geotextiles under ultraviolet exposure: A neglected source of microfibers from coastal reclamation

Bai, Xue / Li, Fengjie / Ma, Lingyu / Li, Chang

Science of the total environment. 2022 Jan. 15, v. 804

2022

Abstract: Geotextiles are a group of polymeric materials widely used in coastal reclamation projects. However, long-term exposure to solar illumination deteriorates the performance of geotextiles, resulting in physicochemical changes and high risks of releasing ... ...

Abstract	Geotextiles are a group of polymeric materials widely used in coastal reclamation projects. However, long-term exposure to solar illumination deteriorates the performance of geotextiles, resulting in physicochemical changes and high risks of releasing microfibers. This study investigated the photoaging behavior of geotextiles and evaluated the capacity of geotextiles to release microfibers in coastal reclamation areas through a combination of field research and laboratory experiments. A field survey in the coastal reclamation area of Yancheng (China) confirmed that many geotextiles made from polyethylene terephthalate (PET) existed on the beach, which was accompanied by a high value of carbonyl index of 0.70–0.93. The results from laboratory experiments revealed that ultraviolet exposure activated the photooxidative process and promoted the breakdown of PET geotextiles. Data of scanning electron microscope and laser particle analyzer showed that, initially, particles with the size of less than 1 μm were generated on the surface of geotextiles, followed by fragments with sizes of 1–100 μm falling off with the passage of time. The number of particles on the surface was calculated using Image-Pro Plus software and the maximum particle density was found to be around 2.52 million particles·mm⁻². In addition, based upon the conversion of irradiance between the simulated solar and natural solar, it was roughly estimated that the annual emissions of PET geotextile fibers in coastal reclamation areas were 0.24–0.79 million tons all over the world. It is inferred that polymer-made geotextile is a significant source of microplastic pollution in reclamation zones of coastal areas.
Keywords	chronic exposure ; computer software ; environment ; geotextiles ; light intensity ; lighting ; microplastics ; photoaging ; photooxidation ; pollution ; polyethylene terephthalates ; surveys ; China
Language	English
Dates of publication	2022-0115
Publishing place	Elsevier B.V.
Document type	Article
ZDB-ID	121506-1
ISSN	1879-1026 ; 0048-9697
ISSN (online)	1879-1026
ISSN	0048-9697
DOI	10.1016/j.scitotenv.2021.150168
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Article ; Online: Bayesian estimation for the accuracy of three neuropsychological tests in detecting Alzheimer's disease and mild cognitive impairment: a retrospective analysis of the ADNI database.

Wang, Xiaonan / Li, Fengjie / Tian, Jiang / Gao, Qi / Zhu, Huiping

European journal of medical research

2023 Volume 28, Issue 1, Page(s) 427

Abstract: Background: The neuropathological confirmation serves as the gold standard for diagnosing Alzheimer's disease (AD), but it is usually not available to the living individuals. In addition, the gold standard for diagnosing Mild Cognitive Impairment (MCI) ... ...

Abstract	Background: The neuropathological confirmation serves as the gold standard for diagnosing Alzheimer's disease (AD), but it is usually not available to the living individuals. In addition, the gold standard for diagnosing Mild Cognitive Impairment (MCI) remains unclear yet. Neuropsychological testing, such as the Montreal Cognitive Assessment (MoCA), Mini-Mental State Examination (MMSE) and Alzheimer's Disease Assessment Scale-Cognitive Subscale (ADAS-cog), is commonly used tests in identifying AD and MCI, offering convenience, affordability, non-invasiveness, and accessibility in clinical settings. We aimed to accurately evaluate the discriminative ability of the three tests administrated at the same visit simultaneously in detecting AD and MCI due to AD in the absence of a gold standard. Methods: A total of 1289 participants aged over 65 were included from the baseline visits of Alzheimer's disease Neuroimaging Initiative. Bayesian latent class models, accounting for conditional dependence between MoCA and MMSE, were conducted to assess the diagnostic accuracy of the three tests for detecting AD and MCI. Results: In detecting AD, the ADAS-cog had the highest Youden's Index (0.829), followed by the MoCA(0.813) and MMSE(0.796). The ADAS-cog and MoCA showed similar sensitivity (0.922 vs 0.912) and specificity (0.907 vs 0.901), while the MMSE had lower sensitivity (0.874) and higher specificity (0.922). For MCI detection, the ADAS-cog had the highest Youden's Index (0.704) compared to the MoCA (0.614) and MMSE (0.478). The ADAS-cog exhibited the highest sensitivity, closely followed by the MoCA and MMSE (0.869 vs 0.845 vs 0.757), and the ADAS-cog also had good specificity (0.835 vs 0.769 vs 0.721). The estimated true prevalence of AD among individuals aged over 65 was 20.0%, and the estimated true prevalence of MCI due to AD was 24.8%. Conclusions: The findings suggest that the ADAS-cog and MoCA are reliable tools for detecting AD and MCI, while the MMSE may be less sensitive in detecting these conditions. A large underdiagnosis of the MCI and Alzheimer's population still remains in clinical screening.
MeSH term(s)	Humans ; Aged ; Alzheimer Disease/diagnosis ; Alzheimer Disease/epidemiology ; Alzheimer Disease/psychology ; Bayes Theorem ; Retrospective Studies ; Neuropsychological Tests ; Cognitive Dysfunction/diagnosis ; Cognitive Dysfunction/epidemiology ; Cognitive Dysfunction/psychology
Language	English
Publishing date	2023-10-12
Publishing country	England
Document type	Journal Article
ZDB-ID	1329381-3
ISSN	2047-783X ; 0949-2321
ISSN (online)	2047-783X
ISSN	0949-2321
DOI	10.1186/s40001-023-01265-6
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Article ; Online: Validation of heart failure algorithm for diagnosing heart failure with preserved ejection fraction: a meta-analysis.

Li, Shu / Zhu, Xiaomei / Zhang, Yunlong / Li, Fengjie / Guo, Shubin

ESC heart failure

2023 Volume 10, Issue 4, Page(s) 2225–2235

Abstract: The aim of the meta-analysis was to generate a more comprehensive understanding of the HFA-PEFF score in the diagnosis of heart failure with preserved ejection fraction (HFpEF) and to pose clues in the field of scientific and clinical practice. ... ...

Abstract	The aim of the meta-analysis was to generate a more comprehensive understanding of the HFA-PEFF score in the diagnosis of heart failure with preserved ejection fraction (HFpEF) and to pose clues in the field of scientific and clinical practice. Electronic databases of PubMed, Web of Science, Cochrane Library, and Embase were systematically searched. Studies investigating the use of the HFA-PEFF score to diagnose HFpEF were included. Pooled sensitivity, specificity, positive likelihood ratio (PLR) and negative Likelihood Ratio (NLR), diagnostic odds ratio (DOR), area under the curve of summary receiver operating characteristic, and superiority index were calculated. Five studies with 1521 participants were included in this meta-analysis. In the pooled analysis of the 'Rule-out' approach, the pooled sensitivity, specificity, PLR, NLR, and DOR were 0.98 (0.94, 1.00), 0.33 (0.08, 0.73), 1.5 (0.8, 2.5), 0.05 (0.02, 0.17), and 28 (6, 127). In the pooled analysis of the 'Rule-in' approach, the pooled sensitivity and specificity, PLR, NLR, and DOR were 0.69 (0.62, 0.75), 0.87 (0.64, 0.96), 5.5 (1.8, 16.9), 0.35 (0.30, 0.41), and 16 (5, 50). This meta-analysis indicates that the HFA-PEFF algorithm showed acceptable specificity and sensitivity for the diagnosis and exclusion of HFpEF. More relevant studies on the diagnostic validity of the HFA-PEFF score are needed in the future.
MeSH term(s)	Humans ; Heart Failure/diagnosis ; Stroke Volume ; Sensitivity and Specificity ; ROC Curve ; Algorithms
Language	English
Publishing date	2023-06-09
Publishing country	England
Document type	Systematic Review ; Meta-Analysis ; Journal Article ; Review ; Research Support, Non-U.S. Gov't
ZDB-ID	2814355-3
ISSN	2055-5822 ; 2055-5822
ISSN (online)	2055-5822
ISSN	2055-5822
DOI	10.1002/ehf2.14421
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Article ; Online: Analysis of WNK2 regulating cytoskeleton formation in ovarian cancer cells based on phosphorylation modification sequencing

LI Fengjie / JIA Yongqin / LIANG Zhen / HU Bin / HE Simin

Di-san junyi daxue xuebao, Vol 44, Iss 6, Pp 513-

2022 Volume 521

Abstract: Objective To analyze the biological processes regulated by protein kinase WNK2 in ovarian cancer cells based on protein phosphorylation modified mass spectrometry. Methods Ovarian cancer cell line SKOV3 was transfected with lentiviral vector to knockdown ...

Abstract	Objective To analyze the biological processes regulated by protein kinase WNK2 in ovarian cancer cells based on protein phosphorylation modified mass spectrometry. Methods Ovarian cancer cell line SKOV3 was transfected with lentiviral vector to knockdown WNK2 and the obtained cells were further screened by drug screening. Then the total protein was extracted for protein phosphorylation modification mass spectrometry analysis. Bioinformatics analysis was adopted to detect the phosphorylation changes before and after WNK2 knockdown, and differential proteins were screened out. Gene Ontology (GO) analysis and Kyoto Encyclopedia of Genes and Genomes (KEGG) analysis were employed to explore the functions of differentially phosphorylated proteins, and experiments were performed to verify the biological processes regulated by WNK2. Results Phosphorylation modified mass spectrometry indicated that WNK2 knockdown significantly decreased the phosphorylation of 745 proteins with 1 078 altered protein sites, and increased the phosphorylation of 328 proteins with 415 altered protein sites. KEGG and GO enrichment analyses showed WNK2 influences biological processes such as cytoskeleton organization, signal transduction, cell composition, and regulation of kinase activity. Phalloidin staining indicated after WNK2 knockdown resulted in broken and disordered cytoskeleton, while its overexpression promoted cytoskeleton remodeling. Conclusion WNK2 is involved in the cytoskeleton formation in ovarian cancer cells by regulating the phosphorylation of vimentin and other proteins.
Keywords	ovarian cancer ; wnk2 ; phosphorylation modification ; vimentin ; cytoskeleton ; Medicine (General) ; R5-920
Language	Chinese
Publishing date	2022-04-01T00:00:00Z
Publisher	Editorial Office of Journal of Third Military Medical University
Document type	Article ; Online
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Article ; Online: An inevitable but underestimated photoaging behavior of plastic waste in the aquatic environment: Critical role of nitrate.

Li, Fengjie / Zhai, Xue / Yao, Mingxuan / Bai, Xue

Environmental pollution (Barking, Essex : 1987)

2022 Volume 314, Page(s) 120307

Abstract: Photoaging is an important reaction for waste plastics in the aquatic environment and plays a key role in the lifetime of plastics. Nevertheless, when natural photosensitive substances such as nitrate participate in this process, the physiochemical ... ...

Abstract	Photoaging is an important reaction for waste plastics in the aquatic environment and plays a key role in the lifetime of plastics. Nevertheless, when natural photosensitive substances such as nitrate participate in this process, the physiochemical changes in plastics and the corresponding reaction mechanisms are not well-understood. In this work, the photochemical behavior of polyethylene terephthalate (PET) bottles in deionized water and nitrate solution was systematically investigated under ultraviolet (UV) irradiation. The analyses of the surface physicochemical properties of the photoaged PET bottles indicated that, after 20 days of photo-irradiation, the presence of nitrate reduced the contact angle from 69.8 ± 0.9° to 60.0 ± 0.3°, and increased the O/C ratio from 0.23 to 0.32, respectively. The leaching rate of dissolved organic carbon (DOC), which was 0.0193 mg g
MeSH term(s)	Plastics/chemistry ; Nitrates/chemistry ; Polyethylene Terephthalates/chemistry ; Skin Aging ; Water/chemistry ; Hydroxyl Radical ; Carbon ; Oxygen ; Peroxides
Chemical Substances	Plastics ; Nitrates ; Polyethylene Terephthalates ; Water (059QF0KO0R) ; Hydroxyl Radical (3352-57-6) ; Carbon (7440-44-0) ; Oxygen (S88TT14065) ; Peroxides
Language	English
Publishing date	2022-09-28
Publishing country	England
Document type	Journal Article
ZDB-ID	280652-6
ISSN	1873-6424 ; 0013-9327 ; 0269-7491
ISSN (online)	1873-6424
ISSN	0013-9327 ; 0269-7491
DOI	10.1016/j.envpol.2022.120307
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