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Article: A Case Study of Gastric Adenocarcinoma and Squamous Cell Carcinoma of the Cervix.

Liu, Suqing / Li, Fengling / Cao, Qinghua / Li, Ning / Gao, Qian

2024 Volume 17, Page(s) 339–344

Abstract: Gastric adenocarcinoma (GAS) is a rare subtype of mucinous adenocarcinoma characterized by gastric differentiation and is unrelated to human papillomavirus (HPV) infection. This report discusses a 40-year-old female who presented with abdominal ... ...

Abstract	Gastric adenocarcinoma (GAS) is a rare subtype of mucinous adenocarcinoma characterized by gastric differentiation and is unrelated to human papillomavirus (HPV) infection. This report discusses a 40-year-old female who presented with abdominal distension accompanied by increased abdominal circumference. CT of the abdomen and pelvis showed a large 21.012.726.0 cm mass later diagnosed as GAS combined with squamous cell carcinoma on surgical pathology. Immunohistological staining of GAS was positive for CK7, MUC6, PAX-8 CEA, and P53 (wild type) and negative for CDX2, CK20, ER, PR, P16, and WT1. The proliferative index (Ki-67) was 20%. Immunohistochemical staining of squamous cell carcinoma was positive for P16 and P53 (wild type), and the proliferative index (Ki-67) was 90%. However, the pathogenesis and molecular mechanisms of GAS have not been fully elucidated. As more cases are identified and reported, additional targeted therapies can be developed and tested in these patients.
Language	English
Publishing date	2024-04-15
Publishing country	New Zealand
Document type	Case Reports
ZDB-ID	2495130-4
ISSN	1178-6930
ISSN	1178-6930
DOI	10.2147/OTT.S435811
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Article ; Online: RHPN1‑AS1 promotes ovarian carcinogenesis by sponging miR‑6884‑5p thus releasing TOP2A mRNA.

Cui, Shoubin / Li, Fengling

Oncology reports

2021 Volume 46, Issue 4

Abstract: Ovarian cancer, a severe lethal gynecological malignancy, is characterized by both high morbidity and mortality. Long noncoding RNAs (lncRNAs) have recently caused extensive concern due to their regulatory function in various human tumors. There are a ... ...

Abstract	Ovarian cancer, a severe lethal gynecological malignancy, is characterized by both high morbidity and mortality. Long noncoding RNAs (lncRNAs) have recently caused extensive concern due to their regulatory function in various human tumors. There are a mounting number of lncRNAs that are in extreme need of research, serving as biomarkers for diagnosis and therapy for ovarian cancer. In the present study, RT‑qPCR was employed to detect how Rhophilin Rho GTPase binding protein 1 antisense RNA1 (RHPN1‑AS1), miR‑6884‑5p and DNA topoisomerase IIα (TOP2A) are expressed in ovarian cancer tissues or cell lines. BrdU, MTT, colony formation and cell adhesion assays, caspase‑3 activity, flow cytometry and wound healing assay were employed to assess cell proliferation, viability, colony number, adhesion, apoptosis and migration in ovarian cancer, respectively. RHPN1‑AS1 was determined to be enriched in ovarian cancer tissues and cell lines. Silencing of RHPN1‑AS1 was reported to increase cell apoptosis and impair cell proliferation, viability, colony number, adhesion and migration
MeSH term(s)	Aged ; Apoptosis/genetics ; Biomarkers, Tumor/genetics ; Carcinogenesis/genetics ; Cell Adhesion/genetics ; Cell Line, Tumor ; Cell Movement/genetics ; Cell Proliferation/genetics ; DNA Topoisomerases, Type II/genetics ; Female ; Flow Cytometry ; Fluorescence ; Gene Expression Regulation, Neoplastic/genetics ; Humans ; MicroRNAs/genetics ; Middle Aged ; Ovarian Neoplasms/genetics ; Poly-ADP-Ribose Binding Proteins/genetics ; RNA, Long Noncoding/genetics
Chemical Substances	Biomarkers, Tumor ; MicroRNAs ; Poly-ADP-Ribose Binding Proteins ; RNA, Long Noncoding ; long noncoding RNA RHPN1-AS1, human ; DNA Topoisomerases, Type II (EC 5.99.1.3) ; TOP2A protein, human (EC 5.99.1.3)
Language	English
Publishing date	2021-08-20
Publishing country	Greece
Document type	Journal Article
ZDB-ID	1222484-4
ISSN	1791-2431 ; 1021-335X
ISSN (online)	1791-2431
ISSN	1021-335X
DOI	10.3892/or.2021.8172
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Zs.A 4213: Show issues

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Article ; Online: Identification of Autism Spectrum Disorder Using Topological Data Analysis.

Zhang, Xudong / Gao, Yaru / Zhang, Yunge / Li, Fengling / Li, Huanjie / Lei, Fengchun

Journal of imaging informatics in medicine

2024

Abstract: Autism spectrum disorder (ASD) is a pervasive brain development disease. Recently, the incidence rate of ASD has increased year by year and posed a great threat to the lives and families of individuals with ASD. Therefore, the study of ASD has become ... ...

Abstract	Autism spectrum disorder (ASD) is a pervasive brain development disease. Recently, the incidence rate of ASD has increased year by year and posed a great threat to the lives and families of individuals with ASD. Therefore, the study of ASD has become very important. A suitable feature representation that preserves the data intrinsic information and also reduces data complexity is very vital to the performance of established models. Topological data analysis (TDA) is an emerging and powerful mathematical tool for characterizing shapes and describing intrinsic information in complex data. In TDA, persistence barcodes or diagrams are usually regarded as visual representations of topological features of data. In this paper, the Regional Homogeneity (ReHo) data of subjects obtained from Autism Brain Imaging Data Exchange (ABIDE) database were used to extract features by using TDA. The average accuracy of cross validation on ABIDE I database was 95.6% that was higher than any other existing methods (the highest accuracy among existing methods was 93.59%). The average accuracy for sampling with the same resolutions with the ABIDE I on the ABIDE II database was 96.5% that was also higher than any other existing methods (the highest accuracy among existing methods was 75.17%).
Language	English
Publishing date	2024-02-13
Publishing country	Switzerland
Document type	Journal Article
ISSN	2948-2933
ISSN (online)	2948-2933
DOI	10.1007/s10278-024-01002-3
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Article ; Online: Kinetic characterization of human mRNA guanine-N7 methyltransferase.

Perveen, Sumera / Yazdi, Aliakbar Khalili / Hajian, Taraneh / Li, Fengling / Vedadi, Masoud

Scientific reports

2024 Volume 14, Issue 1, Page(s) 4509

Abstract: The 5'-mRNA-cap formation is a conserved process in protection of mRNA in eukaryotic cells, resulting in mRNA stability and efficient translation. In humans, two methyltransferases, RNA cap guanine-N7 methyltransferase (hRNMT) and cap-specific nucleoside- ...

Abstract	The 5'-mRNA-cap formation is a conserved process in protection of mRNA in eukaryotic cells, resulting in mRNA stability and efficient translation. In humans, two methyltransferases, RNA cap guanine-N7 methyltransferase (hRNMT) and cap-specific nucleoside-2'-O-methyltransferase 1 (hCMTr1) methylate the mRNA resulting in cap0 (N7mGpppN-RNA) and cap1 (N7mGpppN2'-Om-RNA) formation, respectively. Coronaviruses mimic this process by capping their RNA to evade human immune systems. The coronaviral nonstructural proteins, nsp14 and nsp10-nsp16, catalyze the same reactions as hRNMT and hCMTr1, respectively. These two viral enzymes are important targets for development of inhibitor-based antiviral therapeutics. However, assessing the selectivity of such inhibitors against human corresponding proteins is crucial. Human RNMTs have been implicated in proliferation of cancer cells and are also potential targets for development of anticancer therapeutics. Here, we report the development and optimization of a radiometric assay for hRNMT, full kinetic characterization of its activity, and optimization of the assay for high-throughput screening with a Z-factor of 0.79. This enables selectivity determination for a large number of hits from various screening of coronaviral methyltransferases, and also screening hRNMT for discovery of inhibitors and chemical probes that potentially could be used to further investigate the roles RNMTs play in cancers.
MeSH term(s)	Humans ; Coronavirus/genetics ; Coronavirus Infections ; Guanine/metabolism ; Methyltransferases/metabolism ; RNA Caps/metabolism ; RNA, Messenger/genetics ; RNA, Viral/genetics ; Viral Nonstructural Proteins/genetics
Chemical Substances	Guanine (5Z93L87A1R) ; Methyltransferases (EC 2.1.1.-) ; RNA Caps ; RNA, Messenger ; RNA, Viral ; Viral Nonstructural Proteins ; mRNA (guanine(N7))-methyltransferase (EC 2.1.1.56)
Language	English
Publishing date	2024-02-24
Publishing country	England
Document type	Journal Article
ZDB-ID	2615211-3
ISSN	2045-2322 ; 2045-2322
ISSN (online)	2045-2322
ISSN	2045-2322
DOI	10.1038/s41598-024-55184-5
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Article ; Online: Experimental investigation of the mechanical properties of mud shale under water-bearing conditions and its applications.

Fang, Xinxin / Feng, Hong / Li, Fengling / Wang, Hao

Scientific reports

2022 Volume 12, Issue 1, Page(s) 9486

Abstract: Mud shale, used in drilling engineering, is prone to hydration and expansion, resulting in creep deformation that leads to wellbore shrinkage and pipe sticking incidents. Studying the creep characteristics of mud shale is significant for designing a ... ...

Abstract	Mud shale, used in drilling engineering, is prone to hydration and expansion, resulting in creep deformation that leads to wellbore shrinkage and pipe sticking incidents. Studying the creep characteristics of mud shale is significant for designing a reasonable well structure and determining the lower limit of drilling fluid density. The influence of moisture content on rock strength and creep mechanical properties were studied using water absorption, uniaxial compression, and creep tests. Test results show that with an increase in the moisture content, the mud shale was damaged and softened; moreover, the elastic modulus decreased with increase in moisture content. Under the same load level, the instantaneous strain increased with increasing moisture content. Under different loading stresses, the creep of the rock had nonlinear characteristics, which could be divided into three different creep stages: attenuation, second, and accelerated creep. A new improved creep model based on the Nishihara model was established to describe the accelerated creep characteristics of mud shale under different moisture contents. The ageing degradation and water-bearing weakening effects were introduced. The Levenberg-Marquardt nonlinear least-squares method was applied to invert the creep parameters. The results show that the simulated creep curves, generated using the new creep model, conform to the experimental ones. The relationship between the drilling fluid density and wellbore shrinkage ratio can be defined using this model; it provides a reference for reasonably determining the drilling fluid density.
Language	English
Publishing date	2022-06-08
Publishing country	England
Document type	Journal Article
ZDB-ID	2615211-3
ISSN	2045-2322 ; 2045-2322
ISSN (online)	2045-2322
ISSN	2045-2322
DOI	10.1038/s41598-022-13476-8
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Article ; Online: Construction of Endometrial Carcinoma ceRNA Network and Screening of Key Genes Based on TCGA Database.

Song, Yuchun / Chu, Ping / Li, Pan / Li, Fengling

publication RETRACTED

Computational and mathematical methods in medicine

2022 Volume 2022, Page(s) 1418232

Abstract: Objective: Long noncoding RNA (lncRNA) has received more and more attention in human tumor research. This study is aimed at clarifying the regulatory network of lncRNAs-microRNAs- (miRNAs-) mRNAs and at determining the relevant targets in the ... ...

Abstract	Objective: Long noncoding RNA (lncRNA) has received more and more attention in human tumor research. This study is aimed at clarifying the regulatory network of lncRNAs-microRNAs- (miRNAs-) mRNAs and at determining the relevant targets in the development of endometrial cancers. Methods: Download the miRNA, mRNA, and lncRNA expression profile data of endometrial cancer patients from TCGA; use the "DESeq2" package of R software to identify the differential expression of miRNAs, mRNAs, and lncRNAs; construct a network of ceRNA; and perform gene ontology (GO) and Kyoto Encyclopedia of Gene and Genome (KEGG) pathway enrichment assessment on mRNAs in the network of ceRNA; string and Cytoscape 3.7.2 perform PPI assessment on target genes and TOP 10 hub gene screening; Cytoscape 3.7.2 computer program was employed for constructing the lncRNA-miRNA-TOP10 hub mRNA network diagram to determine the signal axis; StarBase database to verify the Top10 hub mRNA expression; the "survival" package in R computer program was implemented to analyze the survival rate of all genes on the lncRNA-miRNA-Top10 hub mRNA network diagram; RT-qPCR to verify the expression level of genes on the signal axis. Results: 1119 differential mRNAs, 14 differential lncRNAs, and 65 differential miRNAs were screened in TCGA; we constructed a ceRNA regulatory network composed of 5 DELs, 7 DEMs, and 90 DEGs; String combined with Cytoscape to screen out Top10 hub genes, namely: LEFTY1, LIN28A, LHX3, ST8SIA3, CEP55, FBXO32, DCN, ANGPTL1, ADRA1A, and KCNMA1; the StarBase database verification results show that ADRA1A, ANGPTL1, FBXO32, KCNMA1, and DCN are downregulated in endometrial cancer tissues; LEFTY1, LIN28A, LHX3, ST8SIA3, and CEP55 are upregulated in endometrial cancer; the constructed lncRNA-miRNA-hub Top10 mRNA network map identified CTD-2314B22, RP11-89 K21/hsa-miR-143, hsa-miR-424/LEFTY1, LIN28A, LHX3, ST8SIA3, and CEP55 signal axis; survival analysis results show that CTD-2314B22, RP11-89 K21, hsa-miR-96, hsa-miR-211, LHX3, ST8SIA3, and DCN are all related to survival; RT-qPCR results indicate CTD-2314B22, RP11-89 K21, LEFTY1, LIN28A, LHX3, ST8SIA3, and CEP55 are upregulated in endometrial cancer cells, and hsa-miR-143 and hsa-miR-424 are downregulated in endometrial cancer cells. Conclusion: From the perspective of the lncRNA-miRNA-mRNA network, our study identified CTD-2314B22, RP11-89 K21/hsa-miR-143, hsa-miR-424/LEFTY1, LIN28A, LHX3, ST8SIA3, and CEP55 signal axis, which can present considerably potent biomarkers and therapeutic targets for treating endometrial cancer.
MeSH term(s)	Cell Cycle Proteins/genetics ; Endometrial Neoplasms/genetics ; Female ; Gene Regulatory Networks ; Humans ; MicroRNAs/genetics ; MicroRNAs/metabolism ; RNA, Long Noncoding/genetics ; RNA, Long Noncoding/metabolism ; RNA, Messenger/genetics ; RNA, Messenger/metabolism
Chemical Substances	Cell Cycle Proteins ; Cep55 protein, human ; MicroRNAs ; RNA, Long Noncoding ; RNA, Messenger
Language	English
Publishing date	2022-07-04
Publishing country	United States
Document type	Journal Article ; Retracted Publication
ZDB-ID	2252430-7
ISSN	1748-6718 ; 1748-670X ; 1027-3662
ISSN (online)	1748-6718
ISSN	1748-670X ; 1027-3662
DOI	10.1155/2022/1418232
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Article ; Online: New prediction method of horizontal principal stress of deep tight reservoirs.

Fang, Xinxin / Zhang, Jianbin / Liu, Tao / Zhang, Zhen / Li, Fengling

Scientific reports

2022 Volume 12, Issue 1, Page(s) 12908

Abstract: As the tight reservoir of Lucaogou Formation in Jimsar sag is characterized as large burial depth and poor physical properties, hydraulic fracturing technology is greatly needed to increase the production. Firstly, based on elastic theory, the borehole ... ...

Abstract	As the tight reservoir of Lucaogou Formation in Jimsar sag is characterized as large burial depth and poor physical properties, hydraulic fracturing technology is greatly needed to increase the production. Firstly, based on elastic theory, the borehole displacement formula under stress is derived, then the borehole quasi-ellipse characteristic model is proposed, on this basis, the in-situ stress prediction model based on borehole deformation is constructed. Secondly, the force analysis of diamond bit during drilling is performed, and the continuous prediction formula of elastic modulus based on weight on bit (WOB) and torque parameters is derived. Combined with these two steps, a new model of continuous in-situ stress prediction based on borehole deformation and drilling parameters is established. Compared with the values measured by the acoustic emission method in the laboratory, the deviation between the predicted in-situ stress values and those measured by the acoustic emission method is less than 4%, which meets the accuracy requirements of the fracturing in the oil field. The prediction results show that the minimum horizontal principal stress of Lucaogou Formation is 51.1-62.7 MPa, and the maximum horizontal principal stress is 58.9-69.1 MPa, respectively. The maximum horizontal principal stress direction is NW-SE direction with an angle of about 159°. The results show that the fracture direction in the study area is in accordance with the present in-situ stress direction, which is beneficial to the secondary reconstruction of natural fractures and keeps good opening property of fractures. This study provides a theoretical basis for in-situ stress prediction and compressibility evaluation of tight reservoir.
Language	English
Publishing date	2022-07-28
Publishing country	England
Document type	Journal Article
ZDB-ID	2615211-3
ISSN	2045-2322 ; 2045-2322
ISSN (online)	2045-2322
ISSN	2045-2322
DOI	10.1038/s41598-022-16954-1
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Article ; Online: Tumor-Infiltrating Lymphocytes Improve Magee Equation-Based Prediction of Pathologic Complete Response in HR-Positive/HER2-Negative Breast Cancer.

Li, Fengling / Zhao, Yuanyuan / Wei, Yani / Xi, Yanfeng / Bu, Hong

American journal of clinical pathology

2022 Volume 158, Issue 2, Page(s) 291–299

Abstract: Objectives: Magee equation 3 (ME3) is predictive of the pathologic complete response (pCR) to neoadjuvant chemotherapy (NAC) in patients with hormone receptor (HR)-positive, human epidermal growth factor receptor 2 (HER2)-negative breast cancer but with ...

Abstract	Objectives: Magee equation 3 (ME3) is predictive of the pathologic complete response (pCR) to neoadjuvant chemotherapy (NAC) in patients with hormone receptor (HR)-positive, human epidermal growth factor receptor 2 (HER2)-negative breast cancer but with insufficient predictive performance. This study was designed to improve predictive ability by combining ME3 with additional clinicopathologic markers. Methods: We retrospectively enrolled 460 patients with HR-positive/HER2-negative breast cancer from 2 centers. We obtained baseline characteristics, the ME3 score, and the number of stromal tumor-infiltrating lymphocytes (sTILs). After performing a logistic regression analysis, a predictive nomogram was built and validated externally. Results: ME3 score (adjusted odds ratio [OR], 1.14 [95% confidence interval (CI), 1.10-1.17]; P < .001) and TILs (adjusted OR, 5.21 [95% CI, 3.33-8.14]; P < .001) were independently correlated with pCR. The nomogram (named ME3+) was established using ME3 and sTILs, and it demonstrated an area under the curve of 0.816 and 0.862 in internal and external validation, respectively, outperforming the ME3 score alone. sTILs and ME3 scores were also found to be positively correlated across the entire cohort (P < .001). Conclusions: The combination of sTILs and ME3 score potentially shows better performance for predicting pCR than ME3 alone. Larger validations are required for widespread application of ME3+ nomogram in NAC settings for HR-positive/HER2-negative breast cancer.
MeSH term(s)	Antineoplastic Combined Chemotherapy Protocols/therapeutic use ; Breast Neoplasms/pathology ; Female ; Humans ; Lymphocytes, Tumor-Infiltrating/pathology ; Neoadjuvant Therapy ; Nomograms ; Receptor, ErbB-2/genetics ; Receptor, ErbB-2/metabolism ; Retrospective Studies ; Treatment Outcome
Chemical Substances	Receptor, ErbB-2 (EC 2.7.10.1)
Language	English
Publishing date	2022-12-02
Publishing country	England
Document type	Journal Article
ZDB-ID	2944-0
ISSN	1943-7722 ; 0002-9173
ISSN (online)	1943-7722
ISSN	0002-9173
DOI	10.1093/ajcp/aqac041
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Article ; Online: Transcription factor ETV1-induced lncRNA MAFG-AS1 promotes migration, invasion, and epithelial-mesenchymal transition of pancreatic cancer cells by recruiting IGF2BP2 to stabilize ETV1 expression.

Weng, Hanqin / Feng, Weijian / Li, Fengling / Huang, Dong / Lin, Liangyi / Wang, Zaiguo

Growth factors (Chur, Switzerland)

2023 Volume 41, Issue 3, Page(s) 152–164

Abstract: We investigated the mechanism of ETS-translocation variant 1 (ETV1)/lncRNA-MAFG-AS1 in pancreatic cancer (PC). MAFG-AS1 and ETV1 levels in PC cell lines and HPNE cells were determined using reverse transcription quantitative polymerase chain reaction (RT- ...

Abstract	We investigated the mechanism of ETS-translocation variant 1 (ETV1)/lncRNA-MAFG-AS1 in pancreatic cancer (PC). MAFG-AS1 and ETV1 levels in PC cell lines and HPNE cells were determined using reverse transcription quantitative polymerase chain reaction (RT-qPCR) and Western blotting (WB). After transfection with sh-MAFG-AS1, PC cell invasion, migration, proliferation, and epithelial-mesenchymal transition (EMT)-related proteins were measured by 5-ethynyl-2'-deoxyuridine (EdU), Transwell assay, and WB. The binding between ETV1 and MAFG-AS1 was studied using dual-luciferase assay and chromatin immunoprecipitation. The interactions between MAFG-AS1, IGF2BP2, and ETV1 were tested. Combined experiments were further performed using sh-MAFG-AS1 and pcDNA-ETV1 simultaneously. ETV1/MAFG-AS1 was highly expressed in PC cells. Blocking MAFG-AS1 inhibited the malignant behaviors of PC cells. ETV1 induced MAFG-AS1 transcription in PC cells. MAFG-AS1 stabilized ETV1 mRNA by recruiting IGF2BP2. ETV1 overexpression partially antagonized the suppression of silencing MAFG-AS1 on PC cells. ETV1-induced MAFG-AS1 stabilized the ETV1 expression by recruiting IGF2BP2 and promoted PC cell migration, invasion, proliferation, and EMT.
MeSH term(s)	Humans ; RNA, Long Noncoding/genetics ; RNA, Long Noncoding/metabolism ; Epithelial-Mesenchymal Transition/genetics ; Cell Proliferation/genetics ; Cell Line, Tumor ; Transcription Factors/genetics ; Transcription Factors/metabolism ; MicroRNAs/genetics ; Pancreatic Neoplasms/genetics ; Pancreatic Neoplasms/pathology ; Cell Movement/genetics ; Gene Expression Regulation, Neoplastic ; Repressor Proteins/genetics ; MafG Transcription Factor/genetics ; MafG Transcription Factor/metabolism ; RNA-Binding Proteins/genetics ; RNA-Binding Proteins/metabolism ; Pancreatic Neoplasms
Chemical Substances	RNA, Long Noncoding ; Transcription Factors ; MicroRNAs ; MAFG protein, human ; Repressor Proteins ; MafG Transcription Factor ; IGF2BP2 protein, human ; RNA-Binding Proteins ; ETV1 protein, human
Language	English
Publishing date	2023-07-10
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	1035755-5
ISSN	1029-2292 ; 0897-7194
ISSN (online)	1029-2292
ISSN	0897-7194
DOI	10.1080/08977194.2023.2227272
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Article ; Online: Comparison of kainate-induced seizures, cognitive impairment and hippocampal damage in male and female mice.

Li, Fengling / Liu, Lei

Life sciences

2019 Volume 232, Page(s) 116621

Abstract: Kainate (KA) mouse model induced by intraperitoneal injection has been widely used for epilepsy and neurodegeneration studies. KA elicits sustained epileptic activity in mouse brain revealed by recurrent behavioral seizures, deteriorative ... ...

Abstract	Kainate (KA) mouse model induced by intraperitoneal injection has been widely used for epilepsy and neurodegeneration studies. KA elicits sustained epileptic activity in mouse brain revealed by recurrent behavioral seizures, deteriorative neurodegeneration and various neurological deficits. However, to date, the vast majority of the studies used male mice only, and few studies on the comparison of brain injury between male and female mice in this model were reported. Epidemiological studies indicate that sex may affect the susceptibility to seizure response and neurodegeneration process. Therefore, this study focused on the effect of sex difference on KA-induced recurrent seizures and mortality, locomotor activity and cognitive impairment, and hippocampal neurodegeneration and reactive gliosis in mice. Our results showed that, compared to females, adult male mice exhibited worse performance in mortality rate, severity of epileptic seizures, and cognitive impairment indicated by novel object recognition task. Unexpectedly, post-KA male and female mice underwent similar decline and recovery of locomotor activity. KA-induced neurodegeneration in the whole hippocampus, particularly in CA1 and CA3 subregions, along with the deteriorative reactive gliosis in astrocytes and microglia, was more severe in males than that in females. These data provided the direct in vivo evidence that indicates the key role of sex difference in studies with KA mouse model, and this could be beneficial for optimizing the design of future studies.
MeSH term(s)	Animals ; Astrocytes/drug effects ; Cognitive Dysfunction/physiopathology ; Disease Models, Animal ; Epilepsy/chemically induced ; Female ; Gliosis/chemically induced ; Hippocampus/drug effects ; Kainic Acid/adverse effects ; Kainic Acid/metabolism ; Kainic Acid/pharmacology ; Male ; Mice ; Microglia/drug effects ; Neurons/drug effects ; Seizures/chemically induced ; Seizures/physiopathology ; Sex Factors
Chemical Substances	Kainic Acid (SIV03811UC)
Language	English
Publishing date	2019-06-30
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	3378-9
ISSN	1879-0631 ; 0024-3205
ISSN (online)	1879-0631
ISSN	0024-3205
DOI	10.1016/j.lfs.2019.116621
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