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Article ; Online: Electrochemical nickel-catalyzed cross-coupling of glycosyl thiols with preactivated phenols and ketones.

Li, Fuxin / Liu, Hui / Xing, Wanyu / Zhang, Qingju / Wang, Liming

2024 Volume 22, Issue 18, Page(s) 3597–3601

Abstract: An efficient electrochemical nickel-catalyzed cross-coupling reaction has been reported here for the synthesis ... ...

Abstract	An efficient electrochemical nickel-catalyzed cross-coupling reaction has been reported here for the synthesis of
Language	English
Publishing date	2024-05-08
Publishing country	England
Document type	Journal Article
ZDB-ID	2097583-1
ISSN	1477-0539 ; 1477-0520
ISSN (online)	1477-0539
ISSN	1477-0520
DOI	10.1039/d4ob00442f
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: NopC/T/L Signal Crosstalk Gene

Zhu, Zikun / Yu, Tong / Li, Fuxin / Zhang, Yu / Liu, Chunyan / Chen, Qingshan / Xin, Dawei

International journal of molecular sciences

2023 Volume 24, Issue 22

Abstract: Symbiotic nodulation between leguminous plants and rhizobia is a critical biological interaction. The type III secretion system (T3SS) employed by rhizobia manipulates the host's nodulation signaling, analogous to mechanisms used by certain bacterial ... ...

Abstract	Symbiotic nodulation between leguminous plants and rhizobia is a critical biological interaction. The type III secretion system (T3SS) employed by rhizobia manipulates the host's nodulation signaling, analogous to mechanisms used by certain bacterial pathogens for effector protein delivery into host cells. This investigation explores the interactive signaling among type III effectors HH103Ω
MeSH term(s)	Fabaceae/genetics ; Glycine max/metabolism ; Sinorhizobium fredii/genetics ; Genes, Bacterial ; Signal Transduction ; Symbiosis/genetics ; Bacterial Proteins/metabolism
Chemical Substances	Bacterial Proteins
Language	English
Publishing date	2023-11-20
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2019364-6
ISSN	1422-0067 ; 1422-0067 ; 1661-6596
ISSN (online)	1422-0067
ISSN	1422-0067 ; 1661-6596
DOI	10.3390/ijms242216521
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: pH-responsive resveratrol-loaded ZIF-8 nanoparticles modified with tannic acid for promoting colon cancer cell apoptosis.

Sun, Xueqiang / Li, Fuxin / Yuan, Lingyan / Bing, Zhitong / Li, Xun / Yang, Kehu

Journal of biomedical materials research. Part B, Applied biomaterials

2023 Volume 112, Issue 1, Page(s) e35320

Abstract: Resveratrol (Res) is known for its potential in treating various types of cancers, with a particular advantage of causing minimal toxic side effects. However, its clinical application is constrained by challenges such as poor bioavailability, low water ... ...

Abstract	Resveratrol (Res) is known for its potential in treating various types of cancers, with a particular advantage of causing minimal toxic side effects. However, its clinical application is constrained by challenges such as poor bioavailability, low water solubility, and chemical instability in neutral and alkaline environments. In light of these limitations, we have developed a pH-responsive drug delivery nanoplatform, Res@ZIF-8/TA NPs, which exhibits good biocompatibility and shows promise for in vitro cancer therapy. Benefiting from the mild reaction conditions provided by zeolitic imidazolate frameworks (ZIFs), a "one-pot method" was used for drug synthesis and loading, resulting in a satisfactory loading capacity. Notably, Res@ZIF-8/TA NPs respond to acidic environments, leading to an improved drug release profile with a controlled release effect. Our cell-based experiments indicated that tannic acid (TA) modification enhances the biocompatibility of ZIFs. 3-(4,5)-dimethylthiahiazo (-z-y1)-3,5-di- phenytetrazoliumromide (MTT assay), Hoechst 33342/PI staining, cell scratch assay, Transwell and Reverse Transcription quantitative PCR (RT-qPCR) assays further demonstrated that Res@ZIF-8/TA NPs inhibited colon cancer cell migration and invasion, and promoted apoptosis of colon cancer cells, suggesting a therapeutic potential and demonstrating anti-cancer properties. In conclusion, the Res@ZIF-8/TA NPs pH-responsive drug delivery systems we developed may offer a promising avenue for cancer therapy. By addressing some of the challenges associated with Res-based treatments, this system could contribute to advancements in cancer therapeutics.
MeSH term(s)	Humans ; Doxorubicin/pharmacology ; Resveratrol/pharmacology ; Nanoparticles/chemistry ; Colonic Neoplasms/drug therapy ; Apoptosis ; Hydrogen-Ion Concentration ; Zeolites/pharmacology ; Zeolites/chemistry ; Polyphenols
Chemical Substances	Doxorubicin (80168379AG) ; Resveratrol (Q369O8926L) ; Tannic Acid ; Zeolites (1318-02-1) ; Polyphenols
Language	English
Publishing date	2023-09-13
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2099992-6
ISSN	1552-4981 ; 1552-4973 ; 0021-9304
ISSN (online)	1552-4981
ISSN	1552-4973 ; 0021-9304
DOI	10.1002/jbm.b.35320
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Identification, Pathogenicity, and Sensitivity to Fungicide of Colletotrichum Species That Causes Walnut Anthracnose in Beijing

Li, Fuxin / Chen, Jiawen / Chen, Qian / Liu, Ziyi / Sun, Junyuan / Yan, Yitong / Zhang, Hanxing / Bi, Yang

Agronomy. 2023 Jan. 10, v. 13, no. 1

2023

Abstract: Walnuts (Juglans regia L.) are a major food crop in Beijing. Recently, walnut anthracnose has become a serious problem in walnut plantations of Beijing, and the diversity of pathogens that cause this disease is poorly understood, making targeted ... ...

Abstract	Walnuts (Juglans regia L.) are a major food crop in Beijing. Recently, walnut anthracnose has become a serious problem in walnut plantations of Beijing, and the diversity of pathogens that cause this disease is poorly understood, making targeted treatment difficult. This study investigated incidences of walnut anthracnose in seven districts of Beijing (Changping, Fangshan, Haidian, Huairou, Mentougou, Miyun and Pinggu). A total of 377 isolates of Colletotrichum spp. were obtained from walnut anthracnose infected leaves and fruits. Morphological observation and multigene phylogenetic analysis of the genes ACT, CAL, CHS-1, GAPDH, ITS and TUB2 revealed that the isolates consisted of six species, C. aenigma, C. fructicola, C. gloeosporioides, C. siamense, C. liaoningense and C. sojae. Among these, C. gloeosporioides was the dominant species, and, for the first time, C. liaoningense and C. sojae were found to cause anthracnose in walnuts. Sensitivity tests showed that prochloraz and SYP-14288 had the strongest inhibitory effect on mycelial growth. These findings have clarified the species that cause walnut anthracnose in these seven districts of Beijing, which provides a scientific basis for diagnosis and control of walnut anthracnose.
Keywords	Colletotrichum ; Juglans regia ; agronomy ; anthracnose ; dominant species ; food crops ; mycelium ; pathogenicity ; phylogeny ; prochloraz ; walnuts ; China
Language	English
Dates of publication	2023-0110
Publishing place	Multidisciplinary Digital Publishing Institute
Document type	Article ; Online
ZDB-ID	2607043-1
ISSN	2073-4395
ISSN	2073-4395
DOI	10.3390/agronomy13010214
Database	NAL-Catalogue (AGRICOLA)

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Article: A water-energy-food-carbon nexus optimization model for sustainable agricultural development in the Yellow River Basin under uncertainty

Ren, Hourui / Liu, Bin / Zhang, Zirui / Li, Fuxin / Pan, Ke / Zhou, Zhongli / Xu, Xiaoshuang

Applied energy. 2022 Nov. 15, v. 326

2022

Abstract: Water scarcity, limited land resources and global warming are the most challenging issues facing sustainable agricultural development, and modern agriculture requires efficient and environmentally friendly agricultural water and land management practices. ...

Abstract	Water scarcity, limited land resources and global warming are the most challenging issues facing sustainable agricultural development, and modern agriculture requires efficient and environmentally friendly agricultural water and land management practices. This paper proposes a water-energy-food-carbon nexus system optimization model, which aims to formulate a scientific and rational water and land resource allocation strategy for sustainable agricultural development to increase irrigation water productivity, reduce carbon emissions and enhance regional agriculture competitiveness. First, the carbon footprint life cycle assessment method was used to measure carbon sinks and carbon emissions across the ecosystem. Second, a multiobjective nonlinear programming model with the goal of maximizing irrigation water productivity, minimizing carbon emissions, and maximizing the competitiveness of low-carbon agriculture is established. Finally, an empirical study is performed in the Yellow River Basin, and an elitist nondominated sorting genetic algorithm is used to solve the model. The research results show that the water-energy-food-carbon nexus system optimization model based on uncertain conditions established in this paper, can maximize resource utilization efficiency and effectively measure the impact of regional agricultural production on the environment. It has reference significance for the realization of carbon neutrality in the region.
Keywords	agricultural development ; algorithms ; carbon ; carbon footprint ; ecosystems ; empirical research ; energy ; irrigation water ; land management ; life cycle assessment ; models ; resource allocation ; system optimization ; uncertainty ; water shortages ; watersheds ; Yellow River
Language	English
Dates of publication	2022-1115
Publishing place	Elsevier Ltd
Document type	Article
ZDB-ID	2000772-3
ISSN	0306-2619
ISSN	0306-2619
DOI	10.1016/j.apenergy.2022.120008
Database	NAL-Catalogue (AGRICOLA)

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Article: Medullary Thyroid Carcinoma With Elevated Serum CEA and Normal Serum Calcitonin After Surgery: A Case Report and Literature Review.

Chen, Li / Zhao, Ke / Li, Fuxin / He, Xianghui

Frontiers in oncology

2020 Volume 10, Page(s) 526716

Abstract: Background: Medullary thyroid carcinoma (MTC) is a relatively rare malignant tumor subtype originated the parafollicular C cells of the thyroid gland, producing tumor markers including calcitonin (Ctn), carcinoembryonic antigen (CEA), and chromogranin A. ...

Abstract	Background: Medullary thyroid carcinoma (MTC) is a relatively rare malignant tumor subtype originated the parafollicular C cells of the thyroid gland, producing tumor markers including calcitonin (Ctn), carcinoembryonic antigen (CEA), and chromogranin A. Preoperative serum Ctn and CEA value is important for assessing disease burden, postoperative serum Ctn and CEA can help to determine whether there are recurrence and distant metastasis. Case presentation: We report a rare case in which the CEA level continued to increase and the Ctn value was normal after total thyroidectomy and central lymph node dissection in a MTC patient. The patient was asymptomatic during one and half year follow-up until lateral lymph node metastasis was revealed. However, the CEA level raised again after lateral neck lymph node dissection and bone metastases were found by 18F-FDG PET-CT. Conclusion: This case reminded us the recurrence of MTC should be suspected for patients with simply elevated CEA after surgery for MTC. Differential diagnosis of other malignant tumors and timely lymph node biopsy is of great significance for management.
Language	English
Publishing date	2020-10-27
Publishing country	Switzerland
Document type	Case Reports
ZDB-ID	2649216-7
ISSN	2234-943X
ISSN	2234-943X
DOI	10.3389/fonc.2020.526716
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article: Identification of a Six Gene Prognosis Signature for Papillary Thyroid Cancer Using Multi-Omics Methods and Bioinformatics Analysis.

Ren, He / Liu, Xin / Li, Fuxin / He, Xianghui / Zhao, Na

Frontiers in oncology

2021 Volume 11, Page(s) 624421

Abstract: Papillary thyroid carcinoma (PTC) is the most common subtype of thyroid cancer. PTC is typically curable with an excellent survival rate; however, some patients experience disease recurrence or death. This study aimed to discover potential key genes and ... ...

Abstract	Papillary thyroid carcinoma (PTC) is the most common subtype of thyroid cancer. PTC is typically curable with an excellent survival rate; however, some patients experience disease recurrence or death. This study aimed to discover potential key genes and signaling pathways of PTC, which could provide new insights for thyroid lesions. Four GEO microarray datasets were integrated to screen for candidate genes involved in PTC progression. A total of 164 upregulated and 168 downregulated differentially expressed genes (DEGs) were screened. Gene Ontology/Kyoto Encyclopedia of Genes and Genomes were used in pathway enrichment analyses for DEGs. A protein-protein interaction network was then built and analyzed utilizing STRING and Cytoscape, followed by the identification of 13 hub genes by cytoHubba.
Language	English
Publishing date	2021-03-18
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2649216-7
ISSN	2234-943X
ISSN	2234-943X
DOI	10.3389/fonc.2021.624421
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: The complete chloroplast genome sequence of

Yu, Song / Kang, WenJuan / Yang, Fang / Li, FuXin

Mitochondrial DNA. Part B, Resources

2021 Volume 6, Issue 7, Page(s) 1873–1874

Abstract: Potentilla ... ...

Abstract	Potentilla glabra
Language	English
Publishing date	2021-06-07
Publishing country	England
Document type	Journal Article
ISSN	2380-2359
ISSN (online)	2380-2359
DOI	10.1080/23802359.2021.1934141
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Oxidative stress and expression of inflammatory factors in lung tissue of acute mountain sickness rats.

Pu, Xiaoyan / Li, Fuxin / Lin, Xue / Wang, Rong / Chen, Zhi

Molecular medicine reports

2021 Volume 25, Issue 2

Abstract: The aim of the present study was to investigate the changes in lung histomorphology and oxidative stress, as well as the expression of interleukin (IL)‑17C and other inflammatory factors during acute mountain sickness (AMS) in male Sprague‑Dawley rats ... ...

Abstract	The aim of the present study was to investigate the changes in lung histomorphology and oxidative stress, as well as the expression of interleukin (IL)‑17C and other inflammatory factors during acute mountain sickness (AMS) in male Sprague‑Dawley rats and to explore the underlying mechanism. Rats were randomly divided into a control group (0 h) and three hypoxia stress groups, exposed to low‑pressure oxygen storage at a simulated altitude of 6,000 m for 24, 48 and 72 h, respectively. Morphological changes in lung tissue were observed by hematoxylin and eosin staining under light microscopy and transmission electron microscopy. The expression of inflammatory factors IL‑17C, nuclear factor‑κB (NF‑κB), IL‑1β, IL‑6 and tumor necrosis factor‑α (TNF‑α) in lung tissue was assessed by RNA sequencing and verified by reverse transcription‑quantitative PCR (RT‑qPCR) and western blotting (WB). Superoxide dismutase (SOD) and glutathione peroxidase (GSH‑Px) enzyme activity and malondialdehyde (MDA) expression were also measured. Experimental groups were compared to the control group following 24, 48 and 72 h of hypoxic stress. Lung tissue suffered from different degrees of injury, and the damage was the most severe after 48 h of hypoxic stress. RNA sequencing data from the lung tissue of rats from each group suggested that the expression of IL‑17C, NF‑κB, IL‑1β, IL‑6, and TNF‑α increased significantly after hypoxic stress. RT‑qPCR and WB demonstrated that the expression of IL‑17C and NF‑κB increased significantly after hypoxia lasting 48 and 72 h. IL‑1β expression increased significantly after hypoxia stress lasting 24 and 48 h, and the expressions of TNF‑α and IL‑6 increased significantly after hypoxia stress lasting 24, 48 and 72 h (P<0.01). The enzyme activity of SOD and GSH‑Px decreased significantly after lasting 24, 48 and 72 h of hypoxia (P<0.01), and MDA increased significantly after hypoxic stress lasting 48 and 72 h (P<0.01). In conclusion, under hypoxic stress, rats quickly initiate oxidative stress and immune responses. However, with prolonged hypoxic stress time, excessive oxidative stress can further stimulate the immune system
MeSH term(s)	Altitude Sickness/immunology ; Altitude Sickness/pathology ; Animals ; Disease Models, Animal ; Humans ; Inflammation Mediators/analysis ; Inflammation Mediators/metabolism ; Lung/immunology ; Lung/pathology ; Male ; Oxidative Stress/immunology ; RNA-Seq ; Rats ; Rats, Sprague-Dawley
Chemical Substances	Inflammation Mediators
Language	English
Publishing date	2021-12-16
Publishing country	Greece
Document type	Journal Article
ZDB-ID	2469505-1
ISSN	1791-3004 ; 1791-2997
ISSN (online)	1791-3004
ISSN	1791-2997
DOI	10.3892/mmr.2021.12565
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: From heatmaps to structured explanations of image classifiers

Li Fuxin / Zhongang Qi / Saeed Khorram / Vivswan Shitole / Prasad Tadepalli / Minsuk Kahng / Alan Fern

Applied AI Letters, Vol 2, Iss 4, Pp n/a-n/a (2021)

2021

Abstract: Abstract This paper summarizes our endeavors in the past few years in terms of explaining image classifiers, with the aim of including negative results and insights we have gained. The paper starts with describing the explainable neural network (XNN), ... ...

Abstract	Abstract This paper summarizes our endeavors in the past few years in terms of explaining image classifiers, with the aim of including negative results and insights we have gained. The paper starts with describing the explainable neural network (XNN), which attempts to extract and visualize several high‐level concepts purely from the deep network, without relying on human linguistic concepts. This helps users understand network classifications that are less intuitive and substantially improves user performance on a difficult fine‐grained classification task of discriminating among different species of seagulls. Realizing that an important missing piece is a reliable heatmap visualization tool, we have developed integrated‐gradient optimized saliency (I‐GOS) and iGOS++ utilizing integrated gradients to avoid local optima in heatmap generation, which improved the performance across all resolutions. During the development of those visualizations, we realized that for a significant number of images, the classifier has multiple different paths to reach a confident prediction. This has led to our recent development of structured attention graphs, an approach that utilizes beam search to locate multiple coarse heatmaps for a single image, and compactly visualizes a set of heatmaps by capturing how different combinations of image regions impact the confidence of a classifier. Through the research process, we have learned much about insights in building deep network explanations, the existence and frequency of multiple explanations, and various tricks of the trade that make explanations work. In this paper, we attempt to share those insights and opinions with the readers with the hope that some of them will be informative for future researchers on explainable deep learning.
Keywords	explanation of deep networks ; global explanations ; heatmap visualizations ; structured explanations ; Electronic computers. Computer science ; QA75.5-76.95
Subject code	006
Language	English
Publishing date	2021-12-01T00:00:00Z
Publisher	Wiley
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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