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Article ; Online: Integrating wastewater and randomised prevalence survey data for national COVID surveillance.

Li, Guangquan / Diggle, Peter / Blangiardo, Marta

2024 Volume 14, Issue 1, Page(s) 5124

Abstract: During the COVID-19 pandemic, studies in a number of countries have shown how wastewater can be used as an efficient surveillance tool to detect outbreaks at much lower cost than traditional prevalence surveys. In this study, we consider the utilisation ... ...

Abstract	During the COVID-19 pandemic, studies in a number of countries have shown how wastewater can be used as an efficient surveillance tool to detect outbreaks at much lower cost than traditional prevalence surveys. In this study, we consider the utilisation of wastewater data in the post-pandemic setting, in which collection of health data via national randomised prevalence surveys will likely be run at a reduced scale; hence an affordable ongoing surveillance system will need to combine sparse prevalence data with non-traditional disease metrics such as wastewater measurements in order to estimate disease progression in a cost-effective manner. Here, we use data collected during the pandemic to model the dynamic relationship between spatially granular wastewater viral load and disease prevalence. We then use this relationship to nowcast local disease prevalence under the scenario that (i) spatially granular wastewater data continue to be collected; (ii) direct measurements of prevalence are only available at a coarser spatial resolution, for example at national or regional scale. The results from our cross-validation study demonstrate the added value of wastewater data in improving nowcast accuracy and reducing nowcast uncertainty. Our results also highlight the importance of incorporating prevalence data at a coarser spatial scale when nowcasting prevalence at fine spatial resolution, calling for the need to maintain some form of reduced-scale national prevalence surveys in non-epidemic periods. The model framework is disease-agnostic and could therefore be adapted to different diseases and incorporated into a multiplex surveillance system for early detection of emerging local outbreaks.
MeSH term(s)	Humans ; COVID-19/epidemiology ; Pandemics ; Prevalence ; Wastewater ; Benchmarking
Chemical Substances	Wastewater
Language	English
Publishing date	2024-03-01
Publishing country	England
Document type	Journal Article
ZDB-ID	2615211-3
ISSN	2045-2322 ; 2045-2322
ISSN (online)	2045-2322
ISSN	2045-2322
DOI	10.1038/s41598-024-55752-9
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Monochromatic Wave of Fluid Pressure in a Porous Rock

Li, Guangquan / Miao, Yifang / Mei, Yangming

Groundwater. 2023 , v. 61, no. 4 p.544-551

2023

Abstract: From the perspective of rock mechanics, transmission of fluid pressure that drives groundwater flow is not instantaneous; instead it is a slow compressional (P) wave in porous rocks saturated with a fluid. In this paper, the approach of monochromatic ... ...

Abstract	From the perspective of rock mechanics, transmission of fluid pressure that drives groundwater flow is not instantaneous; instead it is a slow compressional (P) wave in porous rocks saturated with a fluid. In this paper, the approach of monochromatic wave is used to analyze the slow P‐wave. Permeability is derived as a function of the frequency of the wave. The permeability appears to be a complex number which asymptotes to Darcy permeability at the low frequency end but tends to vanish at the high frequency end. With Biot theory, the permeability predicts phase velocity and the quality factor of the monochromatic wave. Using Berea sandstone as an illustrative example, the complex‐number permeability can yield a lower phase velocity (within frequency of 10⁵–10⁸ Hz) and a larger attenuation (for frequency above 10⁶ Hz) than Darcy permeability does. This study extends the recent research of the low‐frequency waves of fluid pressure to the regime of very high frequency.
Keywords	groundwater ; groundwater flow ; mechanics ; permeability ; sandstone
Language	English
Dates of publication	2023-07
Size	p. 544-551.
Publishing place	Blackwell Publishing Ltd
Document type	Article ; Online
Note	JOURNAL ARTICLE
ZDB-ID	246212-6
ISSN	1745-6584 ; 0017-467X
ISSN (online)	1745-6584
ISSN	0017-467X
DOI	10.1111/gwat.13267
Database	NAL-Catalogue (AGRICOLA)

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Article: Influence of Long-Chain Amylopectin on Physicochemical and External Digestion Properties of Glutinous Rice in Zongzi.

Li, Guangquan / Chen, Ling / Xu, Feifei / Liu, Fei / Chen, Maoshen / Zhong, Fang

Foods (Basel, Switzerland)

2024 Volume 13, Issue 6

Abstract: Zongzi, made from glutinous rice, is usually thought to stay in the stomach for a long time, causing many people to shy away. In our research, Zongzi was prepared from three indica glutinous rice samples, and three japonica glutinous rice samples were ... ...

Abstract	Zongzi, made from glutinous rice, is usually thought to stay in the stomach for a long time, causing many people to shy away. In our research, Zongzi was prepared from three indica glutinous rice samples, and three japonica glutinous rice samples were digested in vitro in a human gastric simulator (HGS). It was found that digestion performance in HGS (gastric emptying) was mainly related to the hardness and stickiness of texture properties, and surprisingly, the hardness and stickiness of Zongzi were positively correlated, which contradicts past perception. Through the extraction and analysis of the coated layer on the surface of glutinous rice grains in Zongzi, the main source of its stickiness was the entanglement between the long chains of leached amylopectin molecules. The hardness was also mainly due to the high proportion of long chains in its glutinous rice starch, which made it difficult to gelatinize. Studies suggested that stickiness gradually disappeared during digestion, while hardness had a longer impact on digestive performance. The indica glutinous rice Zongzi with a higher long-chain level showed a higher resistant-starch (RS) level and slow hydrolysis in the intestinal digestion stage. Therefore, the texture and digestibility of Zongzi can be adjusted by changing the molecular structure of glutinous rice starch.
Language	English
Publishing date	2024-03-07
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2704223-6
ISSN	2304-8158
ISSN	2304-8158
DOI	10.3390/foods13060820
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article: Diagnostic value of different urine tests for urinary tract infection: a systematic review and meta-analysis.

Xie, Rong / Li, Xinli / Li, Guangquan / Fu, Rong

Translational andrology and urology

2022 Volume 11, Issue 3, Page(s) 325–335

Abstract: Background: There are differences in specificity and sensitivity of different routine urine tests for urinary tract infection, so meta-analysis was used to compare the diagnostic value of various urine analysis and detection methods in urinary tract ... ...

Abstract	Background: There are differences in specificity and sensitivity of different routine urine tests for urinary tract infection, so meta-analysis was used to compare the diagnostic value of various urine analysis and detection methods in urinary tract infection, including bacterial culture, urine sediment microscopy, automated urinalysis, and routine urine dry chemical methods. Methods: The PubMed, Embase, Cochrane Library, SpringerLink, CNKI, and Wanfang databases were searched from inception to December 2021. Two system assessors independently screened the literature according to the inclusion and exclusion criteria. RevMan version 5.3 (the Cochrane Collaboration) and Meta-DiSc were used to calculate the combined sensitivity (Sen), specificity (Spe), positive likelihood ratio (LR+), negative likelihood ratio (LR-), and diagnostic ratio (DOR) of the diagnostic tests and draw summary receiver operating characteristic (SROC) curves. Results: A total of 14 documents were included according to the inclusion and exclusion criteria. There was a significant statistical difference between the urine sediment microscopy group and the urine normalization group in urine leucocyte detection (OR =2.15, 95% CI: 1.29-3.56, P=0.003, I Discussion: When examining red and white blood cells in urinary tract infection diagnosis, urine dry chemistry is superior to automated urinalysis in terms of area under the curve (AUC), Sen, Spe, etc. When examining urine bacteria, urine dry chemistry can be recommended for urine bacteria screening, with bacterial culture required for confirmation.
Language	English
Publishing date	2022-03-09
Publishing country	China
Document type	Journal Article
ZDB-ID	2851630-8
ISSN	2223-4691 ; 2223-4691 ; 2223-4683
ISSN (online)	2223-4691
ISSN	2223-4691 ; 2223-4683
DOI	10.21037/tau-22-65
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Article ; Online: Monochromatic Wave of Fluid Pressure in a Porous Rock.

Li, Guangquan / Miao, Yifang / Mei, Yangming

Ground water

2022 Volume 61, Issue 4, Page(s) 544–551

Abstract	From the perspective of rock mechanics, transmission of fluid pressure that drives groundwater flow is not instantaneous; instead it is a slow compressional (P) wave in porous rocks saturated with a fluid. In this paper, the approach of monochromatic wave is used to analyze the slow P-wave. Permeability is derived as a function of the frequency of the wave. The permeability appears to be a complex number which asymptotes to Darcy permeability at the low frequency end but tends to vanish at the high frequency end. With Biot theory, the permeability predicts phase velocity and the quality factor of the monochromatic wave. Using Berea sandstone as an illustrative example, the complex-number permeability can yield a lower phase velocity (within frequency of 10
MeSH term(s)	Groundwater ; Porosity ; Pressure ; Hydrology
Language	English
Publishing date	2022-10-27
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	246212-6
ISSN	1745-6584 ; 0017-467X
ISSN (online)	1745-6584
ISSN	0017-467X
DOI	10.1111/gwat.13267
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Step-like rising and falling of a breakthrough curve observed at a karst spring.

Liu, Hong / Li, Guangquan

Journal of contaminant hydrology

2020 Volume 235, Page(s) 103726

Abstract: Spring breakthrough curves induced by conventional advection and dispersion often present a gentle (smooth) change of concentration with time. We investigated an electrical-conductivity breakthrough curve which originated from a chemical release into the ...

Abstract	Spring breakthrough curves induced by conventional advection and dispersion often present a gentle (smooth) change of concentration with time. We investigated an electrical-conductivity breakthrough curve which originated from a chemical release into the aquifer matrix and was measured in June 2007 at Qinglondong Spring, southwest China. The curve presented abrupt rising and falling limbs. Modeling efforts were focused on the migration of the contaminants from the conduit wall to the spring. The conduit production segment was defined to be the conduit section where the chemical plume entered the conduit from aquifer fractures. The first model assumed that the time variance of the plume front reaching the conduit wall was much shorter than transport time over the conduit production segment. The model yielded a decrease of spring discharge which was inconsistent with the observed increase with time. In the second model, the above assumption was relaxed, and wall contaminant flux was inverted as function of downstream distance and time. The observed abrupt rising and falling in the breakthrough curve were interpreted as: (1) Taylor dispersion was too small to identify for a short conduit; (2) seepage from the fractures to the conduit was monodirectional and diluting.
MeSH term(s)	China ; Groundwater ; Models, Theoretical ; Water Movements
Language	English
Publishing date	2020-09-29
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	1494766-3
ISSN	1873-6009 ; 0169-7722
ISSN (online)	1873-6009
ISSN	0169-7722
DOI	10.1016/j.jconhyd.2020.103726
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Article: Step-like rising and falling of a breakthrough curve observed at a karst spring

Liu, Hong / Li, Guangquan

Journal of contaminant hydrology. 2020 Nov., v. 235

2020

Abstract	Spring breakthrough curves induced by conventional advection and dispersion often present a gentle (smooth) change of concentration with time. We investigated an electrical-conductivity breakthrough curve which originated from a chemical release into the aquifer matrix and was measured in June 2007 at Qinglondong Spring, southwest China. The curve presented abrupt rising and falling limbs. Modeling efforts were focused on the migration of the contaminants from the conduit wall to the spring. The conduit production segment was defined to be the conduit section where the chemical plume entered the conduit from aquifer fractures. The first model assumed that the time variance of the plume front reaching the conduit wall was much shorter than transport time over the conduit production segment. The model yielded a decrease of spring discharge which was inconsistent with the observed increase with time. In the second model, the above assumption was relaxed, and wall contaminant flux was inverted as function of downstream distance and time. The observed abrupt rising and falling in the breakthrough curve were interpreted as: (1) Taylor dispersion was too small to identify for a short conduit; (2) seepage from the fractures to the conduit was monodirectional and diluting.
Keywords	advection ; aquifers ; electrical conductivity ; models ; pollution ; seepage ; spring ; springs (water) ; variance ; China
Language	English
Dates of publication	2020-11
Publishing place	Elsevier B.V.
Document type	Article
Note	NAL-AP-2-clean
ZDB-ID	1494766-3
ISSN	1873-6009 ; 0169-7722
ISSN (online)	1873-6009
ISSN	0169-7722
DOI	10.1016/j.jconhyd.2020.103726
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Article ; Online: Porous Organic Polymers-Supported Zeigler-Natta Catalysts for Preparing Highly Isotactic Polypropylene with Broad Molecular Weight Distribution.

Wang, Xiong / Wu, Dong / Mu, Xuemei / Kang, Wenqian / Li, Guangquan / Huang, Anping / Xie, Yuan

Polymers

2023 Volume 15, Issue 3

Abstract: Porous organic polymers (POPs) have attracted much attention in numerous areas, including catalysis, adsorption and separation. Herein, POP supported Ziegler-Natta catalysts were designed for preparation of isotactic polypropylene (iPP). The POPs-based ... ...

Abstract	Porous organic polymers (POPs) have attracted much attention in numerous areas, including catalysis, adsorption and separation. Herein, POP supported Ziegler-Natta catalysts were designed for preparation of isotactic polypropylene (iPP). The POPs-based Ziegler-Natta catalysts exhibited the characteristic of broad molecular weight distribution (MWD > 11) with or without adding an extra internal electron donor. The added internal electron donor 3-methyl-5-tert-butyl-1,2-phenylene dibenzoate (ID-2) used in cat-2 showed good propylene polymerization activity of 15.3 × 10
Language	English
Publishing date	2023-01-21
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2527146-5
ISSN	2073-4360 ; 2073-4360
ISSN (online)	2073-4360
ISSN	2073-4360
DOI	10.3390/polym15030555
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Article: The impact of replacing corn with elephant grass (

Liu, Yi / Wang, Xianze / Li, Guangquan / Gong, Shaoming / Yang, Yunzhou / Wang, Cui / Wang, Huiying / He, Daqian

Heliyon

2024 Volume 10, Issue 8, Page(s) e29784

Abstract: This study investigated the effects of partially replacing corn with elephant grass dry matter (air drass) on growth performance, serum parameters, carcass traits, and nutrient digestibility in geese. A total of 360 one-day-old Hortobágyi geese were ... ...

Abstract	This study investigated the effects of partially replacing corn with elephant grass dry matter (air drass) on growth performance, serum parameters, carcass traits, and nutrient digestibility in geese. A total of 360 one-day-old Hortobágyi geese were randomly divided into three groups: control (basic diet), 12 % elephant grass, and 24 % elephant grass. The geese were raised for 70 days. The results showed that compared to the control, 12 % elephant grass had no adverse effects on final body weight, feed/gain ratio, mortality, serum liver and kidney function markers. However, 24 % elephant grass significantly reduced the final body weight (
Language	English
Publishing date	2024-04-17
Publishing country	England
Document type	Journal Article
ZDB-ID	2835763-2
ISSN	2405-8440
ISSN	2405-8440
DOI	10.1016/j.heliyon.2024.e29784
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Article ; Online: Role of estrogen in treatment of female depression.

Sun, Qihan / Li, Guangquan / Zhao, Fangyi / Dong, Mengmeng / Xie, Wei / Liu, Qianqian / Yang, Wei / Cui, Ranji

Aging

2024 Volume 16, Issue 3, Page(s) 3021–3042

Abstract: Depression is a neurological disorder that profoundly affects human physical and mental health, resulting in various changes in the central nervous system. Despite several prominent hypotheses, such as the monoaminergic theory, hypothalamic-pituitary- ... ...

Abstract	Depression is a neurological disorder that profoundly affects human physical and mental health, resulting in various changes in the central nervous system. Despite several prominent hypotheses, such as the monoaminergic theory, hypothalamic-pituitary-adrenal (HPA) axis theory, neuroinflammation, and neuroplasticity, the current understanding of depression's pathogenesis remains incomplete. Importantly, depression is a gender-dimorphic disorder, with women exhibiting higher incidence rates than men. Given estrogen's pivotal role in the menstrual cycle, it is reasonable to postulate that its fluctuating levels could contribute to the pathogenesis of depression. Estrogen acts by binding to a diversity of receptors, which are widely distributed in the central nervous system. An abundance of research has established that estrogen and its receptors play a crucial role in depression, spanning pathogenesis and treatment. In this comprehensive review, we provide an in-depth analysis of the fundamental role of estrogen and its receptors in depression, with a focus on neuroinflammation, neuroendocrinology, and neuroplasticity. Furthermore, we discuss potential mechanisms underlying the therapeutic effects of estrogen in the treatment of depression, which may pave the way for new antidepressant drug development and alternative treatment options.
MeSH term(s)	Male ; Female ; Humans ; Depression/drug therapy ; Neuroinflammatory Diseases ; Estrogens/metabolism ; Hypothalamo-Hypophyseal System/metabolism ; Antidepressive Agents/pharmacology ; Antidepressive Agents/therapeutic use
Chemical Substances	Estrogens ; Antidepressive Agents
Language	English
Publishing date	2024-02-02
Publishing country	United States
Document type	Review ; Journal Article
ISSN	1945-4589
ISSN (online)	1945-4589
DOI	10.18632/aging.205507
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