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Article: A tightly controlled gene induction system that contributes to the study of lethal gene function in

Li, Yongliang / Li, Guanwen / Deng, Xuliang

2023 Volume 15, Issue 1, Page(s) 2253675

Abstract: Effective control of gene expression is crucial for understanding gene function in both eukaryotic and prokaryotic cells. While several inducible gene expression systems have been reported ... ...

Abstract	Effective control of gene expression is crucial for understanding gene function in both eukaryotic and prokaryotic cells. While several inducible gene expression systems have been reported in
Language	English
Publishing date	2023-09-07
Publishing country	United States
Document type	Journal Article
ZDB-ID	2523919-3
ISSN	2000-2297
ISSN	2000-2297
DOI	10.1080/20002297.2023.2253675
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Article ; Online: Deubiquitinase OTUD6A Regulates Innate Immune Response via Targeting UBC13.

Li, Zhiwei / Li, Guanwen / Li, Yunfei / Luo, Yujie / Jiang, Yuhan / Zhang, Ziyu / Zhou, Ziyi / Liu, Shengde / Wu, Chen / You, Fuping

Viruses

2023 Volume 15, Issue 8

Abstract: OTUD6A is a deubiquitinase that plays crucial roles in various human diseases. However, the precise regulatory mechanism of OTUD6A remains unclear. In this study, we found that OTUD6A significantly inhibited the production of type I interferon. ... ...

Abstract	OTUD6A is a deubiquitinase that plays crucial roles in various human diseases. However, the precise regulatory mechanism of OTUD6A remains unclear. In this study, we found that OTUD6A significantly inhibited the production of type I interferon. Consistently, peritoneal macrophages and bone marrow-derived macrophages from
MeSH term(s)	Humans ; Animals ; Mice ; Immunity, Innate ; Macrophages ; Herpesvirus 1, Human ; Interferon Type I ; Deubiquitinating Enzymes
Chemical Substances	Interferon Type I ; Deubiquitinating Enzymes (EC 3.4.19.12)
Language	English
Publishing date	2023-08-18
Publishing country	Switzerland
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2516098-9
ISSN	1999-4915 ; 1999-4915
ISSN (online)	1999-4915
ISSN	1999-4915
DOI	10.3390/v15081761
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article: Impact of nitrogen addition on plant-soil-enzyme C–N–P stoichiometry and microbial nutrient limitation

Xu, Hongwei / Qu, Qing / Li, Guanwen / Liu, Guobin / Geissen, Violette / Ritsema, Coen J. / Xue, Sha

Soil biology & biochemistry. 2022 July, v. 170

2022

Abstract: Global atmospheric nitrogen deposition significantly affects the nutrient cycling and C–N–P stoichiometry in ecosystems. Herein, a global meta-analysis was conducted based on 898 pairwise observations to analyze the impact of nitrogen addition on plant- ... ...

Abstract	Global atmospheric nitrogen deposition significantly affects the nutrient cycling and C–N–P stoichiometry in ecosystems. Herein, a global meta-analysis was conducted based on 898 pairwise observations to analyze the impact of nitrogen addition on plant-soil-enzyme C–N–P stoichiometry and microbial nutrient limitation in different ecosystem types (cropland, grassland, and forest), nitrogen addition intensity (0–5, 5–10, and >10 g N m⁻² yr⁻¹) and duration (0–5, 5–10, and >10yr). Results showed that nitrogen addition significantly decreased plant C:N (shoot: 16.5%, root: 27.1%, litter: 16.5%), soil C:N (5.9%), enzyme C:P (1.2%), and enzyme N:P (5.1%), whereas significantly increased soil C:P (4.9%), enzyme C:N (7.1%), vector angle (4.4%), vector length (3.9%), and plant N:P (shoot: 24.1%, root: 23.8%, and litter: 13.5%). Furthermore, nitrogen addition mainly affected the enzyme C:N and vector length in grasslands. Additionally, the changes in C:N in plants, soil, and enzymes, and vector angle and length were higher at nitrogen addition intensity of >10 g N m⁻² yr⁻¹. The changes in C:N and C:P in plant and soil were higher at nitrogen addition duration of >10 yr. Finally, the N:P in shoot, soil and enzyme, and vector angle were strongly correlated with mean annual precipitation (MAP). In conclusion, nitrogen addition significantly reduced the C:N ratio in plants and soil and increased plant N:P, and microbial C and P limitation. These effects vary with the ecosystem type, MAP, and nitrogen addition intensity and duration. The results improve our understanding of the plant-soil-microbial nutrient cycling processes in terrestrial ecosystems under global nitrogen deposition.
Keywords	atmospheric precipitation ; carbon nitrogen ratio ; cropland ; enzymes ; forests ; grasslands ; meta-analysis ; nitrogen ; soil ; soil biology ; stoichiometry
Language	English
Dates of publication	2022-07
Publishing place	Elsevier Ltd
Document type	Article
ZDB-ID	280810-9
ISSN	0038-0717
ISSN	0038-0717
DOI	10.1016/j.soilbio.2022.108714
Database	NAL-Catalogue (AGRICOLA)

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Article ; Online: Identification, Characterization and Antihypertensive Effect In Vivo of a Novel ACE-Inhibitory Heptapeptide from Defatted Areca Nut Kernel Globulin Hydrolysates.

Liu, Xing / Li, Guanwen / Wang, Huimin / Qin, Nan / Guo, Lili / Wang, Xiaomin / Shen, Sang

Molecules (Basel, Switzerland)

2021 Volume 26, Issue 11

Abstract: The areca ( ...

Abstract	The areca (
MeSH term(s)	Amino Acid Sequence/genetics ; Angiotensin-Converting Enzyme Inhibitors/chemistry ; Animals ; Antihypertensive Agents/chemistry ; Areca/metabolism ; Blood Pressure/drug effects ; Globulins/metabolism ; Globulins/pharmacology ; Hypertension/metabolism ; Male ; Molecular Docking Simulation/methods ; Nuts/metabolism ; Peptide Fragments/pharmacology ; Peptides/chemistry ; Peptidyl-Dipeptidase A/metabolism ; Protein Hydrolysates/chemistry ; Protein Hydrolysates/metabolism ; Rats ; Rats, Inbred SHR ; Tandem Mass Spectrometry/methods
Chemical Substances	Angiotensin-Converting Enzyme Inhibitors ; Antihypertensive Agents ; Globulins ; Peptide Fragments ; Peptides ; Protein Hydrolysates ; Peptidyl-Dipeptidase A (EC 3.4.15.1)
Language	English
Publishing date	2021-05-31
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	1413402-0
ISSN	1420-3049 ; 1431-5165 ; 1420-3049
ISSN (online)	1420-3049
ISSN	1431-5165 ; 1420-3049
DOI	10.3390/molecules26113308
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Book ; Online: Fine-grained Appearance Transfer with Diffusion Models

Ye, Yuteng / Li, Guanwen / Zhou, Hang / Jiale, Cai / Yu, Junqing / Luo, Yawei / Song, Zikai / Xing, Qilong / Zhang, Youjia / Yang, Wei

2023

Abstract: Image-to-image translation (I2I), and particularly its subfield of appearance transfer, which seeks to alter the visual appearance between images while maintaining structural coherence, presents formidable challenges. Despite significant advancements ... ...

Abstract	Image-to-image translation (I2I), and particularly its subfield of appearance transfer, which seeks to alter the visual appearance between images while maintaining structural coherence, presents formidable challenges. Despite significant advancements brought by diffusion models, achieving fine-grained transfer remains complex, particularly in terms of retaining detailed structural elements and ensuring information fidelity. This paper proposes an innovative framework designed to surmount these challenges by integrating various aspects of semantic matching, appearance transfer, and latent deviation. A pivotal aspect of our approach is the strategic use of the predicted $x_0$ space by diffusion models within the latent space of diffusion processes. This is identified as a crucial element for the precise and natural transfer of fine-grained details. Our framework exploits this space to accomplish semantic alignment between source and target images, facilitating mask-wise appearance transfer for improved feature acquisition. A significant advancement of our method is the seamless integration of these features into the latent space, enabling more nuanced latent deviations without necessitating extensive model retraining or fine-tuning. The effectiveness of our approach is demonstrated through extensive experiments, which showcase its ability to adeptly handle fine-grained appearance transfers across a wide range of categories and domains. We provide our code at https://github.com/babahui/Fine-grained-Appearance-Transfer Comment: 14 pages, 15 figures
Keywords	Computer Science - Computer Vision and Pattern Recognition
Subject code	004
Publishing date	2023-11-26
Publishing country	us
Document type	Book ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Effects of Microplastics on the Transport of Soil Dissolved Organic Matter in the Loess Plateau of China

Guo, Ziqi / Li, Peng / Yang, Xiaomei / Wang, Zhanhui / Wu, Yang / Li, Guanwen / Liu, Guobin / Ritsema, Coen / Geissen, Violette / Xue, Sha

Environmental Science & Technology

2023 Volume 57, Issue 48

Abstract: Microplastics (MPs) pollution and dissolved organic matter (DOM) affect soil quality and functions. However, the effect of MPs on DOM and underlying mechanisms have not been clarified, which poses a challenge to maintaining soil health. Under ... ...

Abstract	Microplastics (MPs) pollution and dissolved organic matter (DOM) affect soil quality and functions. However, the effect of MPs on DOM and underlying mechanisms have not been clarified, which poses a challenge to maintaining soil health. Under environmentally relevant conditions, we evaluated the major role of polypropylene particles at four micron-level sizes (20, 200, and 500 μm and mixed) in regulating changes in soil DOM content. We found that an increase in soil aeration by medium and high-intensity (>0.5%) MPs may reduce NH4+ leaching by accelerating soil nitrification. However, MPs have a positive effect on soil nutrient retention through the adsorption of PO43– (13.30–34.46%) and NH4+ (9.03–19.65%) and their leached dissolved organic carbon (MP-leached dissolved organic carbon, MP-DOC), thereby maintaining the dynamic balance of soil nutrients. The regulating ion (Ca2+) is also an important competitor in the MP-DOM adsorption system, and changes in its intensity are dynamically involved in the adsorption process. These findings can help predict the response of soil processes, especially nutrient cycling, to persistent anthropogenic stressors, improve risk management policies on MPs, and facilitate the protection of soil health and function, especially in future agricultural contexts.
Keywords	Life Science
Subject code	550
Language	English
Publishing country	nl
Document type	Article ; Online
ISSN	0013-936X
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Effects of Microplastics on the Transport of Soil Dissolved Organic Matter in the Loess Plateau of China.

Guo, Ziqi / Li, Peng / Yang, Xiaomei / Wang, Zhanhui / Wu, Yang / Li, Guanwen / Liu, Guobin / Ritsema, Coen J / Geissen, Violette / Xue, Sha

Environmental science & technology

2023 Volume 57, Issue 48, Page(s) 20138–20147

Abstract	Microplastics (MPs) pollution and dissolved organic matter (DOM) affect soil quality and functions. However, the effect of MPs on DOM and underlying mechanisms have not been clarified, which poses a challenge to maintaining soil health. Under environmentally relevant conditions, we evaluated the major role of polypropylene particles at four micron-level sizes (20, 200, and 500 μm and mixed) in regulating changes in soil DOM content. We found that an increase in soil aeration by medium and high-intensity (>0.5%) MPs may reduce NH
MeSH term(s)	Soil ; Microplastics ; Dissolved Organic Matter ; Plastics ; Carbon ; China
Chemical Substances	Soil ; Microplastics ; Dissolved Organic Matter ; Plastics ; Carbon (7440-44-0)
Language	English
Publishing date	2023-11-07
Publishing country	United States
Document type	Journal Article
ISSN	1520-5851
ISSN (online)	1520-5851
DOI	10.1021/acs.est.3c04023
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Article ; Online: Nuclear RNA homeostasis promotes systems-level coordination of cell fate and senescence.

Han, Xue / Xing, Linqing / Hong, Yantao / Zhang, Xuechun / Hao, Bo / Lu, J Yuyang / Huang, Mengyuan / Wang, Zuhui / Ma, Shaoqian / Zhan, Ge / Li, Tong / Hao, Xiaowen / Tao, Yibing / Li, Guanwen / Zhou, Shuqin / Zheng, Zheng / Shao, Wen / Zeng, Yitian / Ma, Dacheng /

Zhang, Wenhao / Xie, Zhen / Deng, Haiteng / Yan, Jiangwei / Deng, Wulan / Shen, Xiaohua

Cell stem cell

2024 Volume 31, Issue 5, Page(s) 694–716.e11

Abstract: Understanding cellular coordination remains a challenge despite knowledge of individual pathways. The RNA exosome, targeting a wide range of RNA substrates, is often downregulated in cellular senescence. Utilizing an auxin-inducible system, we observed ... ...

Abstract	Understanding cellular coordination remains a challenge despite knowledge of individual pathways. The RNA exosome, targeting a wide range of RNA substrates, is often downregulated in cellular senescence. Utilizing an auxin-inducible system, we observed that RNA exosome depletion in embryonic stem cells significantly affects the transcriptome and proteome, causing pluripotency loss and pre-senescence onset. Mechanistically, exosome depletion triggers acute nuclear RNA aggregation, disrupting nuclear RNA-protein equilibrium. This disturbance limits nuclear protein availability and hinders polymerase initiation and engagement, reducing gene transcription. Concurrently, it promptly disrupts nucleolar transcription, ribosomal processes, and nuclear exporting, resulting in a translational shutdown. Prolonged exosome depletion induces nuclear structural changes resembling senescent cells, including aberrant chromatin compaction, chromocenter disassembly, and intensified heterochromatic foci. These effects suggest that the dynamic turnover of nuclear RNA orchestrates crosstalk between essential processes to optimize cellular function. Disruptions in nuclear RNA homeostasis result in systemic functional decline, altering the cell state and promoting senescence.
MeSH term(s)	Cellular Senescence ; Homeostasis ; Animals ; RNA, Nuclear/metabolism ; Mice ; Cell Differentiation ; Cell Lineage ; Cell Nucleus/metabolism ; Transcriptome/genetics ; Humans
Chemical Substances	RNA, Nuclear
Language	English
Publishing date	2024-04-16
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2375354-7
ISSN	1875-9777 ; 1934-5909
ISSN (online)	1875-9777
ISSN	1934-5909
DOI	10.1016/j.stem.2024.03.015
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Impact of nitrogen addition on plant-soil-enzyme C–N–P stoichiometry and microbial nutrient limitation

Xu, Hongwei / Qu, Qing / Li, Guanwen / Liu, Guobin / Geissen, Violette / Ritsema, Coen J. / Xue, Sha

Soil Biology and Biochemistry

2022 Volume 170

Abstract	Global atmospheric nitrogen deposition significantly affects the nutrient cycling and C–N–P stoichiometry in ecosystems. Herein, a global meta-analysis was conducted based on 898 pairwise observations to analyze the impact of nitrogen addition on plant-soil-enzyme C–N–P stoichiometry and microbial nutrient limitation in different ecosystem types (cropland, grassland, and forest), nitrogen addition intensity (0–5, 5–10, and >10 g N m−2 yr−1) and duration (0–5, 5–10, and >10yr). Results showed that nitrogen addition significantly decreased plant C:N (shoot: 16.5%, root: 27.1%, litter: 16.5%), soil C:N (5.9%), enzyme C:P (1.2%), and enzyme N:P (5.1%), whereas significantly increased soil C:P (4.9%), enzyme C:N (7.1%), vector angle (4.4%), vector length (3.9%), and plant N:P (shoot: 24.1%, root: 23.8%, and litter: 13.5%). Furthermore, nitrogen addition mainly affected the enzyme C:N and vector length in grasslands. Additionally, the changes in C:N in plants, soil, and enzymes, and vector angle and length were higher at nitrogen addition intensity of >10 g N m−2 yr−1. The changes in C:N and C:P in plant and soil were higher at nitrogen addition duration of >10 yr. Finally, the N:P in shoot, soil and enzyme, and vector angle were strongly correlated with mean annual precipitation (MAP). In conclusion, nitrogen addition significantly reduced the C:N ratio in plants and soil and increased plant N:P, and microbial C and P limitation. These effects vary with the ecosystem type, MAP, and nitrogen addition intensity and duration. The results improve our understanding of the plant-soil-microbial nutrient cycling processes in terrestrial ecosystems under global nitrogen deposition.
Keywords	Ecological stoichiometry ; Meta-analysis ; Nitrogen deposition ; Plant-soil-microbial ; Soil chemistry ; Soil microbial activity
Language	English
Publishing country	nl
Document type	Article ; Online
ZDB-ID	280810-9
ISSN	0038-0717
ISSN	0038-0717
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Corrigendum to “Impact of nitrogen addition on plant-soil-enzyme C–N–P stoichiometry and microbial nutrient limitation”

Xu, Hongwei / Qu, Qing / Li, Guanwen / Liu, Guobin / Geissen, Violette / Ritsema, Coen J. / Xue, Sha

Soil Biology and Biochemistry

2022 Volume 174

Abstract: The authors regret Unfortunately, formula 2 had been published incorrectly as “[Formula presented] (2)”. The correct formula is “[Formula presented]”. The authors would like to apologise for any inconvenience caused. ...

Abstract	The authors regret Unfortunately, formula 2 had been published incorrectly as “[Formula presented] (2)”. The correct formula is “[Formula presented]”. The authors would like to apologise for any inconvenience caused.
Keywords	Life Science
Language	English
Publishing country	nl
Document type	Article ; Online
ZDB-ID	280810-9
ISSN	0038-0717
ISSN	0038-0717
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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