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Article ; Online: Simulation study of heat transfer characteristics of a biomimetic honeycomb CO2 gas cooler

Zhang Yujia / Wang Zhihua / Li Guichen / Wang Fenghao

E3S Web of Conferences, Vol 356, p

2022 Volume 02054

Abstract: CO2 air source heat pumps are widely used because of their advantages of energy saving, high efficiency and clean. Gas cooler is one of the key components of CO2 heat pump system, while its heat transfer effect will affect the energy efficiency of the ... ...

Abstract	CO2 air source heat pumps are widely used because of their advantages of energy saving, high efficiency and clean. Gas cooler is one of the key components of CO2 heat pump system, while its heat transfer effect will affect the energy efficiency of the whole system. In order to improve the heat transfer efficiency, a biomimetic honeycomb gas cooler is proposed in this paper, the steady-state simulation model of the biomimetic honeycomb gas cooler is established by using MATLAB software, and the reliability of the model is verified by literature data. In addition, the heat transfer performance of the biomimetic honeycomb gas cooler is compared with that of the tube-in-tube gas cooler. The results showed that, under the same working condition, compared with the tube-in-tube gas cooler, the outlet temperature of the biomimetic honeycomb gas cooler with 1st, 2nd and 3rd level increased by 9.7°C, 25.4°C and 27.3°C, and heat transfer can be increased by 55.5%, 205.4% and 220.6% respectively. This research is helpful to provide the reference for the design and optimization of this type of gas cooler, and is conducive to the popularization of CO2 air source heat pump.
Keywords	Environmental sciences ; GE1-350
Subject code	621
Language	English
Publishing date	2022-01-01T00:00:00Z
Publisher	EDP Sciences
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Multicomponent All-Carbon Cascade and Sequential Annulation: Construction of Functionalized Decalins.

Zhong, Yuan / Li, Guichen / Zhang, Dan / Hao, Long / Cai, Zhengjun

Organic letters

2023 Volume 25, Issue 22, Page(s) 4119–4123

Abstract: The decalin skeleton is found in numerous bioactive molecules. The present study describes a multicomponent all-carbon cascade and sequential annulation involving benzoylacetonitrile derivatives and 2-arylidene-1,3-indanediones that yields highly ... ...

Abstract	The decalin skeleton is found in numerous bioactive molecules. The present study describes a multicomponent all-carbon cascade and sequential annulation involving benzoylacetonitrile derivatives and 2-arylidene-1,3-indanediones that yields highly functionalized decalin derivatives. The reaction strategy consisted of a consecutive Michael/Michael/tautomerization/Michael/Aldol annulation sequence and involved organic amine catalysts, mild conditions, and high stereoselectivity. This strategy, using a one-pot approach, resulted in the construction of four C-C bonds and the formation of fused carbocyclic decalin derivatives.
MeSH term(s)	Molecular Structure ; Carbon ; Stereoisomerism ; Naphthalenes/chemistry
Chemical Substances	decalin (88451Q4XYF) ; Carbon (7440-44-0) ; Naphthalenes
Language	English
Publishing date	2023-05-31
Publishing country	United States
Document type	Journal Article
ISSN	1523-7052
ISSN (online)	1523-7052
DOI	10.1021/acs.orglett.3c01379
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Article ; Online: Personally tailored exercises for improving physical outcomes for older adults in the community: A systematic review.

Li, Guichen / Li, Xin / Chen, Li

Archives of gerontology and geriatrics

2022 Volume 101, Page(s) 104707

Abstract: Purpose: To identify the effects of personally tailored exercise programmes for improving physical outcomes amongst older people living in the community.: Methods: Four databases (the Cochrane Library, PubMed, EMBASE, and Web of Science) were ... ...

Abstract	Purpose: To identify the effects of personally tailored exercise programmes for improving physical outcomes amongst older people living in the community. Methods: Four databases (the Cochrane Library, PubMed, EMBASE, and Web of Science) were searched (from inception until Jan 25th, 2022) for original articles. All studies were randomized controlled trials (RCTs) and quasi-experimental trials reporting the effects of personally tailored exercise programmes on physical outcomes. Two independent reviewers extracted trial data and assessed the risk of bias using the risk of bias tool recommended by the Cochrane Back Review Group and the Methodological Index for Non-Randomized Studies (MINORS). Results: Of the 7310 articles that were screened, 10 articles including 959 participants met the inclusion criteria. Nine of the included studies reported significant improvements in physical outcomes including balance, strength, mobility and physical activity, and disease symptoms. Meta-analysis was not conducted due to the heterogeneity of study designs and outcome measures. Conclusions: This study demonstrated that personally tailored exercises based on assessments of physical function may be a safe and effective approach to improve physical outcomes in older adults living in the community. However, personally tailored exercise has no advantage in improving exercise adherence or economic benefits, and thus, further high-quality RCTs with larger sample sizes and qualitative studies are needed to better understand the effectiveness of personally tailored exercise and the attitude of elderly individuals towards such exercise. Future research should consider not only physical functions but also psychological factors when developing personalized exercise programs.
MeSH term(s)	Aged ; Exercise ; Exercise Therapy ; Humans ; Qualitative Research ; Quality of Life
Language	English
Publishing date	2022-04-19
Publishing country	Netherlands
Document type	Journal Article ; Review ; Systematic Review ; Research Support, Non-U.S. Gov't
ZDB-ID	603162-6
ISSN	1872-6976 ; 0167-4943
ISSN (online)	1872-6976
ISSN	0167-4943
DOI	10.1016/j.archger.2022.104707
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Article ; Online: Effects of virtual reality-based interventions on the physical and mental health of older residents in long-term care facilities: A systematic review.

Li, Guichen / Li, Xin / Chen, Li

International journal of nursing studies

2022 Volume 136, Page(s) 104378

Abstract: Background: Older residents in long-term care facilities often experience physical and mental health problems along with vulnerability to psychological and social stressors. Due to the shortage of human resources, the application of virtual reality ... ...

Abstract	Background: Older residents in long-term care facilities often experience physical and mental health problems along with vulnerability to psychological and social stressors. Due to the shortage of human resources, the application of virtual reality technology may be a new way to promote healthy aging for older residents in long-term care facilities. Objectives: To identify the effects of virtual reality-based interventions for improving physical and mental health outcomes among older residents in long-term care facilities. Design: Systematic review. Methods: A systematic review was reported in accordance with the Preferred Reporting Items for Systematic Reviews and Meta-Analyses 2020 Statement. Four databases (the Cochrane Library, PubMed, EMBASE, and Web of Science) were searched from their inception until May 2022 for original articles. Randomized controlled trials (RCTs) and quasi-experimental trials reporting the effects of virtual reality-based interventions on physical and mental health outcomes were included. Two independent reviewers extracted trial data and assessed the risk of bias using the risk of bias tool recommended by the Cochrane Back Review Group and the Methodological Index for Non-Randomized Studies. Results: Of the 8511 articles that were screened, 30 articles including 1057 participants met the inclusion criteria. Many studies have investigated multiple outcomes. Eighteen of the twenty-five studies that assessed physical health-related outcomes (n = 18/25, 72%) reported positive intervention effects, and fourteen (n = 14/25, 56%) reported negative postintervention effects. Eight of the sixteen studies that assessed mental health-related outcomes (n = 8/16, 50%) reported positive intervention effects, while twelve (n = 12/16, 75%) reported negative intervention effects. Meta-analysis was not conducted due to the heterogeneity of the study designs and outcome measures. Conclusions: This study demonstrated that virtual reality-based interventions could be a safe and effective approach to improve the physical outcomes of older residents in long-term care facilities, but this evidence lacks certainty. The effectiveness of virtual reality-based interventions for mental health outcomes is uncertain. Virtual reality-based interventions have the potential to provide individualized, error-free self-training for older residents in long-term care facilities, but the usability for these residents requires further study. Future studies should use RCT designs and aim to include larger sample sizes and have longer intervention durations. Registration number: PROSPERO registration ID: CRD42022331917. Tweetable abstract: Virtual reality-based interventions are possibly effective for improving physical health of older residents in long-term care facilities.
Language	English
Publishing date	2022-10-10
Publishing country	England
Document type	Journal Article ; Review
ZDB-ID	80148-3
ISSN	1873-491X ; 0020-7489
ISSN (online)	1873-491X
ISSN	0020-7489
DOI	10.1016/j.ijnurstu.2022.104378
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Article ; Online: In Reply to the Letter to the Editor Regarding "Transient Acute Hydrocephalus After Spontaneous Intracranial Bleeding in Adults".

Hou, Kun / Li, Guichen

World neurosurgery

2020 Volume 140, Page(s) 419–420

MeSH term(s)	Adult ; Hemorrhage ; Humans ; Hydrocephalus/diagnostic imaging ; Hydrocephalus/surgery ; Intracranial Hemorrhages/diagnostic imaging
Language	English
Publishing date	2020-08-14
Publishing country	United States
Document type	Journal Article ; Comment
ZDB-ID	2534351-8
ISSN	1878-8769 ; 1878-8750
ISSN (online)	1878-8769
ISSN	1878-8750
DOI	10.1016/j.wneu.2020.05.051
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Zs.A 1159: Show issues

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Article ; Online: Efficacy of alginate-and chitosan-based scaffolds on the healing of diabetic skin wounds in animal experimental models and cell studies: A systematic review.

Cai, Hong / Li, Guichen

Wound repair and regeneration : official publication of the Wound Healing Society [and] the European Tissue Repair Society

2020 Volume 28, Issue 6, Page(s) 751–771

Abstract: This systematic literature review was aimed to investigate the use of cell culture and animal models to evaluate the efficacy of alginate-and chitosan-based scaffolds on diabetic wound healing. We electronically searched the articles published until July ...

Abstract	This systematic literature review was aimed to investigate the use of cell culture and animal models to evaluate the efficacy of alginate-and chitosan-based scaffolds on diabetic wound healing. We electronically searched the articles published until July 2019. The databases included five English databases such as PubMed, Web of Science, Embase, the Cochrane Library, CINAHL, and three Chinese databases like CNKI, WanFang Data, and VIP. The related articles were manually searched to identify studies that were not searched by electronic database searches. Twenty-nine studies met the inclusion criteria. We divided the results into three groups: chitosan, alginate, and a combination of chitosan and alginate. Chitosan-, alginate-, and a combination of chitosan and alginate-based scaffolds showed good intervention effects on wound healing. Chitosan-based scaffolds were effective in diabetic skin wound healing. The effects of alginate and the combination of chitosan-and alginate-based scaffolds on diabetic skin wounds still need more research. However, due to the heterogeneity of animal and cell preclinical trials and the validity of the statistical analysis used in these studies, it is necessary to conduct a thorough study using well-designed experiments to confirm these results. In addition, properly designed chitosan-and/or alginate-based scaffolds with thorough preclinical evaluations are required prior to clinical applications.
MeSH term(s)	Alginates/pharmacology ; Animals ; Biocompatible Materials/pharmacology ; Cells, Cultured ; Chitosan/pharmacology ; Diabetes Mellitus, Experimental ; Diabetic Foot/therapy ; Drug Combinations ; Tissue Scaffolds ; Wound Healing/drug effects
Chemical Substances	Alginates ; Biocompatible Materials ; Drug Combinations ; Chitosan (9012-76-4)
Language	English
Publishing date	2020-08-29
Publishing country	United States
Document type	Journal Article ; Systematic Review
ZDB-ID	1174873-4
ISSN	1524-475X ; 1067-1927
ISSN (online)	1524-475X
ISSN	1067-1927
DOI	10.1111/wrr.12857
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Zs.A 3890: Show issues

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Article ; Online: Author's response to "Comment on Qiu et al. (2022) 'Prevalence of cognitive frailty among community-dwelling older adults: A systematic review and meta-analysis'''.

Qiu, Yiming / Li, Guichen / Jia, Yong / Zheng, Lufang / Chen, Li

International journal of nursing studies

2022 Volume 127, Page(s) 104185

MeSH term(s)	Aged ; Cognition ; Frail Elderly ; Frailty/epidemiology ; Humans ; Independent Living ; Prevalence
Language	English
Publishing date	2022-01-25
Publishing country	England
Document type	Journal Article ; Comment
ZDB-ID	80148-3
ISSN	1873-491X ; 0020-7489
ISSN (online)	1873-491X
ISSN	0020-7489
DOI	10.1016/j.ijnurstu.2022.104185
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Article: Berberine-Albumin Nanoparticles: Preparation, Thermodynamic Study and Evaluation Their Protective Effects Against Oxidative Stress in Primary Neuronal Cells as a Model of Alzheimer's Disease.

Zhang, Yaohui / Wang, Lixiang / Li, Guichen / Gao, Jianyuan

Journal of biomedical nanotechnology

2021 Volume 17, Issue 6, Page(s) 1088–1097

Abstract: Berberine has shown an outstanding antioxidant activity, however the low bioavailability limits its applications in pharmaceutical platforms. Therefore, in this paper, after fabrication of the berberine-HSA nanoparticles by desolvation method, they were ... ...

Abstract	Berberine has shown an outstanding antioxidant activity, however the low bioavailability limits its applications in pharmaceutical platforms. Therefore, in this paper, after fabrication of the berberine-HSA nanoparticles by desolvation method, they were well characterized by TEM, SEM, DLS, and FTIR techniques. Afterwards the interaction of HSA and the berberine was evaluated by molecular docking analysis. Finally, the antioxidant activity of the berberine-HSA nanoparticles against H₂O₂-induced oxidative stress in cultured neurons as a model of AD was evaluated by cellular assays. The results showed that the prepared berberine-HSA nanoparticles have a spherical-shaped morphology with a size of around 100 nm and zeta potential value of -31.84 mV. The solubility value of nanoparticles was calculated to be 40.27%, with a berberine loading of 19.37%, berberine entrapment efficiency of 70.34%, and nanoparticles yield of 88.91%. Also, it was shown that the berberine is not significantly released from HSA nanoparticles within 24 hours. Afterwards, molecular docking investigation revealed that berberine spontaneously interacts with HSA through electrostatic interaction. Finally, cellular assays disclosed that the pretreatment of neuronal cultures with berberine-HSA nanoparticles decreased the H₂O₂-stimulated cytotoxicity and relevant morphological changes and enhanced the CAT activity. In conclusion, it can be indicated that the nanoformulation of the berberine can be used as a promising platform for inhibition of oxidative damage-induced Alzheimer's disease (AD).
MeSH term(s)	Albumins ; Alzheimer Disease/drug therapy ; Berberine/pharmacology ; Cells, Cultured ; Humans ; Hydrogen Peroxide ; Molecular Docking Simulation ; Nanoparticles ; Neurons/drug effects ; Oxidative Stress ; Thermodynamics
Chemical Substances	Albumins ; Berberine (0I8Y3P32UF) ; Hydrogen Peroxide (BBX060AN9V)
Language	English
Publishing date	2021-06-24
Publishing country	United States
Document type	Journal Article
ISSN	1550-7033
ISSN	1550-7033
DOI	10.1166/jbn.2021.2995
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Article ; Online: Mitochondrial translation factor EF4 regulates oxidative phosphorylation complexes and the production of ROS.

Li, Guichen / Qin, Yan

Free radical research

2019 Volume 52, Issue 11-12, Page(s) 1250–1255

Abstract: Mitochondrial translation system executes the biosynthesis of mitochondrial DNA encoded polypeptides that are the core subunits of oxidative phosphorylation complexes. Recently, we reported that elongation factor 4 (EF4) is a key quality control factor ... ...

Abstract	Mitochondrial translation system executes the biosynthesis of mitochondrial DNA encoded polypeptides that are the core subunits of oxidative phosphorylation complexes. Recently, we reported that elongation factor 4 (EF4) is a key quality control factor in bacterial and mitochondrial translation regulating tRNA translocation and modulating cellular responses via a direct cross-talk with cytoplasmic translation machinery. Here, we made a brief review on mtEF4-regulated mitochondrial translation, respiratory chain biogenesis and the production of reactive oxygen species (ROS). We will discuss the influence of mtEF4 on the electron transport chain, especially at respiratory chain complex IV, which could result in cytochrome c peroxidase formation, electron leakage from electron transport chain and ROS increase.
MeSH term(s)	Animals ; Humans ; Mitochondria/metabolism ; Oxidative Phosphorylation ; Peptide Elongation Factors/metabolism ; Reactive Oxygen Species/metabolism
Chemical Substances	Peptide Elongation Factors ; Reactive Oxygen Species
Language	English
Publishing date	2019-01-29
Publishing country	England
Document type	Journal Article ; Review
ZDB-ID	1194130-3
ISSN	1029-2470 ; 1071-5762
ISSN (online)	1029-2470
ISSN	1071-5762
DOI	10.1080/10715762.2018.1479063
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Zs.A 2236: Show issues

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Article ; Online: Current diagnosis and treatment of acute pancreatitis in China: a real-world, multicenter study.

Sun, Chuandong / Li, Zhu / Shi, Zheng / Li, Guichen

BMC gastroenterology

2021 Volume 21, Issue 1, Page(s) 210

Abstract: Background: Efficacy of pancreatic enzyme inhibitors in acute pancreatitis (AP) is unclear in China.: Aims: We aimed to present the current status of AP and evaluate the efficacy of pancreatic enzyme inhibitors in a larger population in China.: ... ...

Abstract	Background: Efficacy of pancreatic enzyme inhibitors in acute pancreatitis (AP) is unclear in China. Aims: We aimed to present the current status of AP and evaluate the efficacy of pancreatic enzyme inhibitors in a larger population in China. Method: A retrospective, cross-sectional, real-world, multicenter analysis of a large dataset of patients presenting with AP from four hospitals of China over a two-year period was performed. Data were collected from the existing clinical records and the patients were grouped into medication group (somatostatin or octreotide or somatostatin and octreotide) and no medication group. Pair wise propensity score matching was performed for comparing somatostatin, octreotide and somatostatin/octreotide. The end points were incidence of disease complications, organ failure, hospitalization duration, and recovery time taken (hours) for serum amylase/serum lipase to normalcy. Results: A total of 3900 patients were recruited and 2775 patients were included for analysis. A total of 1100, 661, 676 and 338 patients received either somatostatin or octreotide or somatostatin and octreotide or no medication, respectively. The incidence of complications (7.6% vs 13.6%), organ failure (4.5% vs 7.4%), and the instances of entering ICU (9.3% vs 13.3%) were higher in unmedicated group. Complications at discharge (2.91 times), organ failure (2.53 times), and hospitalization stay were higher in octreotide-treated patients compared with somatostatin-treated patients. In comparison to the octreotide group, the serum amylase/lipase recovery time was shorter in the somatostatin group. Conclusion: This real-world study suggested that the use of pancreatic enzyme inhibitors was positively associated with greater clinical efficacy in AP patients and somatostatin might be more effective than octreotide in real-world settings in China.
MeSH term(s)	Acute Disease ; China/epidemiology ; Cross-Sectional Studies ; Humans ; Octreotide/therapeutic use ; Pancreatitis/diagnosis ; Pancreatitis/drug therapy ; Pancreatitis/epidemiology ; Retrospective Studies
Chemical Substances	Octreotide (RWM8CCW8GP)
Language	English
Publishing date	2021-05-08
Publishing country	England
Document type	Journal Article ; Multicenter Study
ZDB-ID	2041351-8
ISSN	1471-230X ; 1471-230X
ISSN (online)	1471-230X
ISSN	1471-230X
DOI	10.1186/s12876-021-01799-1
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