LIVIVO - The Search Portal for Life Sciences

zur deutschen Oberfläche wechseln
Back to previous search Search history
Advanced search

Your last searches

  1. AU="Li, Guo-Min"
  2. AU="Zhou, Hai-Feng"

Search results

Result 1 - 10 of total 133

Search options

  1. Article ; Online: DNA mismatch repair in cancer immunotherapy.

    Guan, Junhong / Li, Guo-Min

    NAR cancer

    2023  Volume 5, Issue 3, Page(s) zcad031

    Abstract: Tumors defective in DNA mismatch repair (dMMR) exhibit microsatellite instability (MSI). Currently, patients with dMMR tumors are benefitted from anti-PD-1/PDL1-based immune checkpoint inhibitor (ICI) therapy. Over the past several years, great progress ... ...

    Abstract Tumors defective in DNA mismatch repair (dMMR) exhibit microsatellite instability (MSI). Currently, patients with dMMR tumors are benefitted from anti-PD-1/PDL1-based immune checkpoint inhibitor (ICI) therapy. Over the past several years, great progress has been made in understanding the mechanisms by which dMMR tumors respond to ICI, including the identification of mutator phenotype-generated neoantigens, cytosolic DNA-mediated activation of the cGAS-STING pathway, type-I interferon signaling and high tumor-infiltration of lymphocytes in dMMR tumors. Although ICI therapy shows great clinical benefits, ∼50% of dMMR tumors are eventually not responsive. Here we review the discovery, development and molecular basis of dMMR-mediated immunotherapy, as well as tumor resistant problems and potential therapeutic interventions to overcome the resistance.
    Language English
    Publishing date 2023-06-13
    Publishing country England
    Document type Journal Article
    ISSN 2632-8674
    ISSN (online) 2632-8674
    DOI 10.1093/narcan/zcad031
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

    Inter-library loan at ZB MED

    Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

  2. Article: Heat shock protein DNAJA2 regulates transcription-coupled repair by triggering CSB degradation via chaperone-mediated autophagy.

    Huang, Yaping / Gu, Liya / Li, Guo-Min

    Cell discovery

    2023  Volume 9, Issue 1, Page(s) 107

    Abstract: Transcription-coupled nucleotide excision repair (TC-NER) is an important genome maintenance system that preferentially removes DNA lesions on the transcribed strand of actively transcribed genes, including non-coding genes. TC-NER involves lesion ... ...

    Abstract Transcription-coupled nucleotide excision repair (TC-NER) is an important genome maintenance system that preferentially removes DNA lesions on the transcribed strand of actively transcribed genes, including non-coding genes. TC-NER involves lesion recognition by the initiation complex consisting of RNA polymerase II (Pol II) and Cockayne syndrome group B (CSB), followed by NER-catalyzed lesion removal. However, the efficient lesion removal requires the initiation complex to yield the right of way to the excision machinery, and how this occurs in a timely manner is unknown. Here we show that heat shock protein DNAJA2 facilitates the HSC70 chaperone-mediated autophagy (CMA) to degrade CSB during TC-NER. DNAJA2 interacts with and enables HSC70 to recognize sumoylated CSB. This triggers the removal of both CSB and Pol II from the lesion site in a manner dependent on lysosome receptor LAMP2A. Defects in DNAJA2, HSC70 or LAMP2A abolish CSB degradation and block TC-NER. Our findings discover DNAJA2-mediated CMA as a critical regulator of TC-NER, implicating the DNAJA2-HSC70-CMA axis factors in genome maintenance.
    Language English
    Publishing date 2023-10-31
    Publishing country England
    Document type Journal Article
    ISSN 2056-5968
    ISSN 2056-5968
    DOI 10.1038/s41421-023-00601-8
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

    Inter-library loan at ZB MED

    Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

  3. Article: A special issue on new insights into genome maintenance.

    Li, Guo-Min

    Cell & bioscience

    2017  Volume 7, Page(s) 10

    Language English
    Publishing date 2017-01-31
    Publishing country England
    Document type Editorial
    ZDB-ID 2593367-X
    ISSN 2045-3701
    ISSN 2045-3701
    DOI 10.1186/s13578-017-0137-7
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  4. Article ; Online: Speech Emotion Recognition Based on Modified ReliefF.

    Li, Guo-Min / Liu, Na / Zhang, Jun-Ao

    Sensors (Basel, Switzerland)

    2022  Volume 22, Issue 21

    Abstract: As the key of human-computer natural interaction, the research of emotion recognition is of great significance to the development of computer intelligence. In view of the issue that the current emotional feature dimension is too high, which affects the ... ...

    Abstract As the key of human-computer natural interaction, the research of emotion recognition is of great significance to the development of computer intelligence. In view of the issue that the current emotional feature dimension is too high, which affects the classification performance, this paper proposes a modified ReliefF feature selection algorithm to screen out feature subsets with smaller dimensions and better performance from high-dimensional features to further improve the efficiency and accuracy of emotion recognition. In the modified algorithm, the selection range of random samples is adjusted; the correlation between features is measured by the maximum information coefficient, and the distance measurement method between samples is established based on the correlation. The experimental results on the eNTERFACE'05 and SAVEE speech emotional datasets show that the features filtered based on the modified algorithm significantly reduce the data dimensions and effectively improve the accuracy of emotion recognition.
    MeSH term(s) Humans ; Speech ; Algorithms ; Emotions
    Language English
    Publishing date 2022-10-25
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2052857-7
    ISSN 1424-8220 ; 1424-8220
    ISSN (online) 1424-8220
    ISSN 1424-8220
    DOI 10.3390/s22218152
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  5. Article: Correction to: DNA mismatch repair in the context of chromatin.

    Huang, Yaping / Li, Guo-Min

    Cell & bioscience

    2020  Volume 10, Page(s) 84

    Abstract: This corrects the article DOI: 10.1186/s13578-020-0379-7.]. ...

    Abstract [This corrects the article DOI: 10.1186/s13578-020-0379-7.].
    Language English
    Publishing date 2020-07-02
    Publishing country England
    Document type Published Erratum
    ZDB-ID 2593367-X
    ISSN 2045-3701
    ISSN 2045-3701
    DOI 10.1186/s13578-020-00447-7
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  6. Article: DNA mismatch repair in the context of chromatin.

    Huang, Yaping / Li, Guo-Min

    Cell & bioscience

    2020  Volume 10, Page(s) 10

    Abstract: DNA mismatch repair (MMR) maintains replication fidelity by correcting mispaired nucleotides incorporated by DNA polymerases. Defects in MMR lead to cancers characterized by microsatellite instability. Recently, chromatin mechanisms that regulate MMR ... ...

    Abstract DNA mismatch repair (MMR) maintains replication fidelity by correcting mispaired nucleotides incorporated by DNA polymerases. Defects in MMR lead to cancers characterized by microsatellite instability. Recently, chromatin mechanisms that regulate MMR have been discovered, which sheds new light on MMR deficiency and its role in tumorigenesis. This review summarizes these chromatin-level mechanisms that regulate MMR and their implications for tumor development.
    Language English
    Publishing date 2020-02-03
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 2593367-X
    ISSN 2045-3701
    ISSN 2045-3701
    DOI 10.1186/s13578-020-0379-7
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  7. Article ; Online: DNA mismatch repair in the chromatin context: Mechanisms and therapeutic potential.

    Huang, Yaping / Li, Guo-Min

    DNA repair

    2020  Volume 93, Page(s) 102918

    Abstract: DNA mismatch repair (MMR) maintains genomic stability primarily by correcting replication errors. Defects in MMR lead to cancers and cause resistance to many chemotherapeutic drugs. Emerging evidence reveals that MMR is coupled with replication and ... ...

    Abstract DNA mismatch repair (MMR) maintains genomic stability primarily by correcting replication errors. Defects in MMR lead to cancers and cause resistance to many chemotherapeutic drugs. Emerging evidence reveals that MMR is coupled with replication and precisely regulated in the context of chromatin; strikingly, tumors defective in MMR are highly responsive to immune checkpoint blockade therapy. As a tribute to Dr. Samuel Wilson for his many scientific contributions to the field of DNA repair and his leadership as Editor-in-Chief of the journal DNA Repair, we summarize recent developments in research on MMR at the chromatin level, its implications for tumorigenesis, and its therapeutic potential.
    MeSH term(s) Carcinogenesis ; Chromatin/metabolism ; DNA Damage ; DNA Mismatch Repair ; Humans ; Neoplasms/drug therapy ; Neoplasms/genetics
    Chemical Substances Chromatin
    Language English
    Publishing date 2020-10-21
    Publishing country Netherlands
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Review
    ZDB-ID 2071608-4
    ISSN 1568-7856 ; 1568-7864
    ISSN (online) 1568-7856
    ISSN 1568-7864
    DOI 10.1016/j.dnarep.2020.102918
    Database MEDical Literature Analysis and Retrieval System OnLINE

    Full text online

    More links

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Zs.A 5555: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  8. Article ; Online: Clamping down on mismatches.

    Li, Guo-Min

    eLife

    2016  Volume 5

    Abstract: A sliding clamp complex may help correct DNA replication errors by keeping track of which DNA strand is new and which is the template. ...

    Abstract A sliding clamp complex may help correct DNA replication errors by keeping track of which DNA strand is new and which is the template.
    MeSH term(s) Constriction ; DNA Mismatch Repair ; DNA Repair ; MutS DNA Mismatch-Binding Protein ; Proliferating Cell Nuclear Antigen/genetics
    Chemical Substances Proliferating Cell Nuclear Antigen ; MutS DNA Mismatch-Binding Protein (EC 3.6.1.3)
    Language English
    Publishing date 2016-07-12
    Publishing country England
    Document type Journal Article ; Comment
    ZDB-ID 2687154-3
    ISSN 2050-084X ; 2050-084X
    ISSN (online) 2050-084X
    ISSN 2050-084X
    DOI 10.7554/eLife.18365
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  9. Article ; Online: Celebrating the work of Nobel Laureate Paul Modrich.

    Li, Guo-Min

    Science China. Life sciences

    2016  Volume 59, Issue 1, Page(s) 93–96

    MeSH term(s) DNA Mismatch Repair ; History, 20th Century ; History, 21st Century ; Nobel Prize ; United States
    Language English
    Publishing date 2016-01
    Publishing country China
    Document type Biography ; Historical Article ; News ; Portraits ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
    ISSN 1869-1889
    ISSN (online) 1869-1889
    DOI 10.1007/s11427-015-4989-y
    Database MEDical Literature Analysis and Retrieval System OnLINE

    Full text online

    More links

    Kategorien

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

    Inter-library loan at ZB MED

    Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

  10. Article ; Online: A Personal Tribute to 2015 Nobel Laureate Paul Modrich.

    Li, Guo-Min

    DNA repair

    2016  Volume 37, Page(s) A14–21

    MeSH term(s) Bacteria/metabolism ; Biochemistry/history ; DNA/metabolism ; DNA Mismatch Repair ; Eukaryota/metabolism ; History, 20th Century ; History, 21st Century ; Humans ; Nobel Prize ; United States
    Chemical Substances DNA (9007-49-2)
    Language English
    Publishing date 2016-01
    Publishing country Netherlands
    Document type Biography ; Historical Article ; Journal Article ; Portraits ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
    ZDB-ID 2071608-4
    ISSN 1568-7856 ; 1568-7864
    ISSN (online) 1568-7856
    ISSN 1568-7864
    DOI 10.1016/j.dnarep.2015.12.005
    Database MEDical Literature Analysis and Retrieval System OnLINE

    Full text online

    More links

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Zs.A 5555: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

To top