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  1. Article: [

    Zhang, Lei / Wang, Jun-Yi / He, Xiang / Wu, Min / Li, Guo-Ping / Vincent, Kam-Wai-Wong

    Zhongguo yi xue ke xue yuan xue bao. Acta Academiae Medicinae Sinicae

    2024  Volume 46, Issue 1, Page(s) 1–10

    Abstract: Objective To investigate the impact ... ...

    Abstract Objective To investigate the impact of
    MeSH term(s) Humans ; Animals ; Mice ; Endothelial Cells ; Pseudomonas aeruginosa ; Calcium ; Pseudomonas Infections ; Transcription Factors ; Lung ; Pneumonia ; Lactates ; RNA, Messenger
    Chemical Substances Calcium (SY7Q814VUP) ; Transcription Factors ; Lactates ; RNA, Messenger
    Language Chinese
    Publishing date 2024-03-04
    Publishing country China
    Document type English Abstract ; Journal Article
    ZDB-ID 604853-5
    ISSN 1000-503X
    ISSN 1000-503X
    DOI 10.3881/j.issn.1000-503X.15831
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.B 2554: Show issues Location:
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  2. Article ; Online: Osthole, an ingredient from Cnidium monnieri, reduces the pyroptosis and apoptosis in bronchial epithelial cells

    Chen, Peng / Li, Qun / Su, Xian / Zhang, Zhen-Qi / Li, Guo-Ping

    Journal of Asian Natural Products Research. 2023 Oct. 3, v. 25, no. 10 p.999-1011

    2023  

    Abstract: Osthole is the prominent active ingredient isolated from Cnidium. The role of osthole in chronic obstructive pulmonary disease (COPD) was investigated herein. Bronchial epithelial 16HBE cells were exposed to cigarette smoke extract (CSE) to generate ... ...

    Abstract Osthole is the prominent active ingredient isolated from Cnidium. The role of osthole in chronic obstructive pulmonary disease (COPD) was investigated herein. Bronchial epithelial 16HBE cells were exposed to cigarette smoke extract (CSE) to generate injury models. The concentration of CSE had an inverse correlation with cell viability. Osthole suppressed inflammation, oxidative stress, apoptosis, and pyroptosis in 16HBE cells, along with a decrease in RIPK2 level. RIPK2 overexpression reversed the effects of osthole on the abovementioned aspects. This study found that the osthole could reduce RIPK2 level, inhibit pyroptosis, and alleviate the damage in 16HBE cells under CSE stimulation.
    Keywords Cnidium monnieri ; active ingredients ; cell viability ; cigarettes ; epithelium ; inflammation ; oxidative stress ; pyroptosis ; research ; respiratory tract diseases ; smoke ; Osthole ; RIPK2 ; COPD ; cigarette smoke extract
    Language English
    Dates of publication 2023-1003
    Size p. 999-1011.
    Publishing place Taylor & Francis
    Document type Article ; Online
    ZDB-ID 2077926-4
    ISSN 1477-2213 ; 1028-6020
    ISSN (online) 1477-2213
    ISSN 1028-6020
    DOI 10.1080/10286020.2023.2187381
    Database NAL-Catalogue (AGRICOLA)

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  3. Article ; Online: Osthole, an ingredient from

    Chen, Peng / Li, Qun / Su, Xian / Zhang, Zhen-Qi / Li, Guo-Ping

    Journal of Asian natural products research

    2023  Volume 25, Issue 10, Page(s) 999–1011

    Abstract: Osthole is the prominent active ingredient isolated ... ...

    Abstract Osthole is the prominent active ingredient isolated from
    MeSH term(s) Cnidium ; Pyroptosis ; Cell Line ; Apoptosis ; Nicotiana ; Epithelial Cells
    Chemical Substances osthol (XH1TI1759C)
    Language English
    Publishing date 2023-03-10
    Publishing country England
    Document type Journal Article
    ZDB-ID 2077926-4
    ISSN 1477-2213 ; 1028-6020
    ISSN (online) 1477-2213
    ISSN 1028-6020
    DOI 10.1080/10286020.2023.2187381
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Progress in Understanding the Functional Roles of Extracellular Vesicles in Reproduction.

    Han, Ting Ting / Li, Wei / Li, Guo Ping

    Biomedical and environmental sciences : BES

    2020  Volume 33, Issue 7, Page(s) 518–527

    MeSH term(s) Exosomes/physiology ; Female ; Genitalia, Female/physiology ; Genitalia, Male/physiology ; Humans ; Male ; Reproduction/physiology
    Language English
    Publishing date 2020-08-14
    Publishing country China
    Document type Journal Article ; Review
    ZDB-ID 645083-0
    ISSN 2214-0190 ; 0895-3988
    ISSN (online) 2214-0190
    ISSN 0895-3988
    DOI 10.3967/bes2020.068
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 2459: Show issues Location:
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  5. Article ; Online: Exosomal microRNA-15a from ACHN cells aggravates clear cell renal cell carcinoma via the BTG2/PI3K/AKT axis.

    Li, Dao-Yuan / Lin, Fei-Fei / Li, Guo-Ping / Zeng, Fan-Chang

    The Kaohsiung journal of medical sciences

    2021  Volume 37, Issue 11, Page(s) 973–982

    Abstract: Accumulating studies have indicated that exosomal microRNAs (miRNAs/miRs) can mediate clear cell renal cell carcinoma (ccRCC) at the early stage, but the mechanisms remain to be specified. Here, we investigated the mechanism of exosomal miR-15a in ccRCC. ...

    Abstract Accumulating studies have indicated that exosomal microRNAs (miRNAs/miRs) can mediate clear cell renal cell carcinoma (ccRCC) at the early stage, but the mechanisms remain to be specified. Here, we investigated the mechanism of exosomal miR-15a in ccRCC. After successful isolation of exosomes from RCC cells, we found that miR-15a was upregulated in ccRCC cells. Moreover, upregulation of miR-15a by pre-miR-15a promoted the proliferation, migration, invasion, and epithelial-mesenchymal transition of ccRCC cells. A luciferase assay revealed that B-cell translocation gene 2 (BTG2) was a target gene of miR-15a and negatively correlated with miR-15a expression. BTG2 was poorly expressed in ccRCC, which reduced the proliferation of ccRCC cells. In addition, overexpression of BTG2 could reverse the promotive effects of miR-15a on ccRCC. Furthermore, BTG2 reduced PI3K/AKT pathway activity. Our results collectively indicated that exosomal miR-15a from RCC cells accelerated cell viability by downregulating BTG2 and promoting the activity of the PI3K/AKT signaling pathway. We demonstrated a novel mechanism by which exosomal miR-15a exerted pro-proliferatory effects on ccRCC, highlighting the potential of exosomal miR-15a as a target for ccRCC prognosis.
    MeSH term(s) Base Pairing ; Base Sequence ; Carcinoma, Renal Cell/genetics ; Carcinoma, Renal Cell/metabolism ; Carcinoma, Renal Cell/pathology ; Cell Line, Tumor ; Cell Movement ; Cell Proliferation ; Epithelial-Mesenchymal Transition/genetics ; Exosomes/chemistry ; Exosomes/metabolism ; Gene Expression Regulation, Neoplastic ; Genes, Reporter ; Humans ; Immediate-Early Proteins/genetics ; Immediate-Early Proteins/metabolism ; Kidney Neoplasms/genetics ; Kidney Neoplasms/metabolism ; Kidney Neoplasms/pathology ; Luciferases/genetics ; Luciferases/metabolism ; MicroRNAs/genetics ; MicroRNAs/metabolism ; Neoplasm Invasiveness ; Neoplasm Staging ; Phosphatidylinositol 3-Kinases/genetics ; Phosphatidylinositol 3-Kinases/metabolism ; Proto-Oncogene Proteins c-akt/genetics ; Proto-Oncogene Proteins c-akt/metabolism ; Signal Transduction ; Tumor Suppressor Proteins/genetics ; Tumor Suppressor Proteins/metabolism
    Chemical Substances Immediate-Early Proteins ; MIRN15 microRNA, human ; MicroRNAs ; Tumor Suppressor Proteins ; BTG2 protein, human (141490-22-4) ; Luciferases (EC 1.13.12.-) ; Proto-Oncogene Proteins c-akt (EC 2.7.11.1)
    Language English
    Publishing date 2021-08-01
    Publishing country China (Republic : 1949- )
    Document type Journal Article
    ZDB-ID 639302-0
    ISSN 2410-8650 ; 0257-5655
    ISSN (online) 2410-8650
    ISSN 0257-5655
    DOI 10.1002/kjm2.12428
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article: [Efforts to promote the innovation and development of arthroscopic surgery of China].

    Li, Guo-Ping

    Zhonghua wai ke za zhi [Chinese journal of surgery

    2011  Volume 49, Issue 7, Page(s) 577

    MeSH term(s) Arthroscopy ; China ; Humans
    Language Chinese
    Publishing date 2011-07-01
    Publishing country China
    Document type Editorial
    ZDB-ID 604573-x
    ISSN 0529-5815
    ISSN 0529-5815
    DOI 10.3760/cma.j.issn.0529-5815.2011.07.001
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.B 2469: Show issues Location:
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    Zs.MO 218: Show issues

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  7. Article: Molecule characterization of chemosensory and metabolism-related genes in the proboscis of

    Tian, Cai-Hong / Liu, Xiao-Guang / Xu, Cun-Yi / Huang, Jian-Rong / Fu, Jun-Feng / Wang, Gen-Song / Zhang, Jun-Yi / Li, Guo-Ping / Yin, Xin-Ming / Feng, Hong-Qiang

    Frontiers in physiology

    2023  Volume 14, Page(s) 1287353

    Abstract: Introduction: ...

    Abstract Introduction:
    Language English
    Publishing date 2023-12-22
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2564217-0
    ISSN 1664-042X
    ISSN 1664-042X
    DOI 10.3389/fphys.2023.1287353
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: Combined transbronchoscopic needle aspiration (TBNA) and rapid on-site cytological evaluation (ROSE) for diagnosis of tuberculous mediastinal lymphadenitis: A case report.

    Dai, Xi / Niu, Bin / Yang, Xiao-Qiong / Li, Guo-Ping

    Medicine

    2018  Volume 97, Issue 37, Page(s) e11724

    Abstract: Introduction: The diagnosis of tuberculous mediastinal lymphadenitis remains a challenge, and the use of transbronchoscopic needle aspiration (TBNA) combined with rapid on-site cytological evaluation (ROSE) is still unclear. A case of tuberculous ... ...

    Abstract Introduction: The diagnosis of tuberculous mediastinal lymphadenitis remains a challenge, and the use of transbronchoscopic needle aspiration (TBNA) combined with rapid on-site cytological evaluation (ROSE) is still unclear. A case of tuberculous mediastinal lymphadenitis was illustrated to show the diagnostic value of TBNA and ROSE.
    Case presentation: In this case report, we presented a typical case of a 44-year-old male who underwent obvious odynophagia and mild symptom of dyspnea. One isolated mass positioned on posterior mediastinum was examined as positive discovery. Finally, he was diagnosed with tuberculous mediastinal lymphadenitis by using TBNA combined with ROSE and treated with anti-TB.
    Conclusions: TBNA is an efficacious and safe approach, which is worth popularizing for the clinical diagnosis of mediastinal masses. Meanwhile, ROSE is useful to reduce the numbers of needle passes during TBNA. We aimed to emphasize 2 key points in this case report. Firstly, a rare symptom of Tuberculosis in adults was supported by the patient. Secondly, TBNA combined with ROSE is useful for the diagnosis of tuberculous mediastinal lymphadenitis.
    MeSH term(s) Adult ; Biopsy, Needle ; Bronchoscopy/methods ; Humans ; Male ; Tuberculosis, Lymph Node/diagnosis ; Tuberculosis, Lymph Node/diagnostic imaging ; Tuberculosis, Lymph Node/pathology
    Language English
    Publishing date 2018-09-12
    Publishing country United States
    Document type Case Reports ; Journal Article
    ZDB-ID 80184-7
    ISSN 1536-5964 ; 0025-7974
    ISSN (online) 1536-5964
    ISSN 0025-7974
    DOI 10.1097/MD.0000000000011724
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Ua VI Zs.171: Show issues Location:
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  9. Article ; Online: Evaluated expression of CELSR3 in oral squamous cell carcinoma is associated with perineural invasion and poor prognosis.

    Zheng, Ke / Lan, Ting / Li, Guo-Ping / Huang, Li / Chen, Yu-Peng / Su, Bo-Hua / Zhang, Sheng / Zheng, Da-Li

    Oral surgery, oral medicine, oral pathology and oral radiology

    2021  Volume 133, Issue 5, Page(s) 564–573

    Abstract: Objective: The objective of this study was to evaluate CELSR3 expression and explore its potential mechanism in oral squamous cell carcinoma.: Study design: CELSR3 mRNA expression was analyzed using The Cancer Genome Atlas (TCGA) database. CELSR3 ... ...

    Abstract Objective: The objective of this study was to evaluate CELSR3 expression and explore its potential mechanism in oral squamous cell carcinoma.
    Study design: CELSR3 mRNA expression was analyzed using The Cancer Genome Atlas (TCGA) database. CELSR3 protein expression in 135 surgical oral squamous cell carcinoma specimens was observed by immunohistochemical staining. Staining results were used to investigate the association between CELSR3 expression and clinicopathologic characteristics and prognosis. Bioinformatics analyses were used to explore the potential mechanism of CELSR3 in head and neck squamous cell carcinoma.
    Results: CELSR3 mRNA expression was upregulated in patients with head and neck squamous cell carcinoma in the TCGA head and neck squamous cell carcinoma data set. Increased CELSR3 protein expression was associated with perineural invasion and poor clinical outcomes in patients with oral squamous cell carcinoma. Bioinformatics analyses revealed that CELSR3 is involvement in axonogenesis, neuron migration, and cell-cell adhesion, all of which are involved in the process of perineural invasion.
    Conclusion: CELSR3 may play a pro-oncogenic role in oral squamous cell carcinoma and can predict perineural invasion and poor survival. CELSR3 may be involved in oral squamous cell carcinoma progression by modulating perineural invasion.
    MeSH term(s) Cadherins ; Carcinoma, Squamous Cell/pathology ; Head and Neck Neoplasms ; Humans ; Mouth Neoplasms/genetics ; Mouth Neoplasms/pathology ; Neoplasm Invasiveness ; Prognosis ; RNA, Messenger/metabolism ; Receptors, Cell Surface ; Squamous Cell Carcinoma of Head and Neck
    Chemical Substances Cadherins ; Celsr3 protein, human ; RNA, Messenger ; Receptors, Cell Surface
    Language English
    Publishing date 2021-10-30
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2650843-6
    ISSN 2212-4411 ; 2212-4403
    ISSN (online) 2212-4411
    ISSN 2212-4403
    DOI 10.1016/j.oooo.2021.10.016
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article: Characterization of a supported ionic liquid membrane used for the removal of cyanide from wastewater.

    Xue, Juan Qin / Liu, Ni Na / Li, Guo Ping / Dang, Long Tao

    Water science and technology : a journal of the International Association on Water Pollution Research

    2017  Volume 76, Issue 11-12, Page(s) 3142–3149

    Abstract: This work evaluated the performance of ionic liquids (ILs) in supported liquid membranes in the removal of total cyanide from wastewater. Membranes were characterized by scanning electron microscopy and contact angle measurements to study the membrane ... ...

    Abstract This work evaluated the performance of ionic liquids (ILs) in supported liquid membranes in the removal of total cyanide from wastewater. Membranes were characterized by scanning electron microscopy and contact angle measurements to study the membrane morphology and wetting ability. In particular, the effects of operational parameters such as membrane immersion time, feed-phase concentration, and pH on cyanide removal were investigated. ILs are organic salts that are entirely composed of organic cations and either organic or inorganic anions. Since their vapor pressure is negligible, they can be handled easily; this characteristic gives rise to their 'green' nature. In this study, a hydrophobic IL, 1-butyl-3-methylimidazolium hexafluorophosphate ([Bmim]PF
    MeSH term(s) Cyanides/chemistry ; Hydrophobic and Hydrophilic Interactions ; Imidazoles/chemistry ; Ionic Liquids/chemistry ; Membranes, Artificial ; Waste Water/chemistry ; Water Pollutants, Chemical/chemistry
    Chemical Substances 1-butyl-3-methylimidazolium hexafluorophosphate ; Cyanides ; Imidazoles ; Ionic Liquids ; Membranes, Artificial ; Waste Water ; Water Pollutants, Chemical
    Language English
    Publishing date 2017-12
    Publishing country England
    Document type Journal Article
    ZDB-ID 764273-8
    ISSN 1996-9732 ; 0273-1223
    ISSN (online) 1996-9732
    ISSN 0273-1223
    DOI 10.2166/wst.2017.443
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Einzelsignatur: Show issues

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