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  1. Article: Identification of apple leaf disease via novel attention mechanism based convolutional neural network.

    Cheng, Hebin / Li, Heming

    Frontiers in plant science

    2023  Volume 14, Page(s) 1274231

    Abstract: Introduction: The identification of apple leaf diseases is crucial for apple production.: Methods: To assist farmers in promptly recognizing leaf diseases in apple trees, we propose a novel attention mechanism. Building upon this mechanism and ... ...

    Abstract Introduction: The identification of apple leaf diseases is crucial for apple production.
    Methods: To assist farmers in promptly recognizing leaf diseases in apple trees, we propose a novel attention mechanism. Building upon this mechanism and MobileNet v3, we introduce a new deep learning network.
    Results and discussion: Applying this network to our carefully curated dataset, we achieved an impressive accuracy of 98.7% in identifying apple leaf diseases, surpassing similar models such as EfficientNet-B0, ResNet-34, and DenseNet-121. Furthermore, the precision, recall, and f1-score of our model also outperform these models, while maintaining the advantages of fewer parameters and less computational consumption of the MobileNet network. Therefore, our model has the potential in other similar application scenarios and has broad prospects.
    Language English
    Publishing date 2023-10-18
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2613694-6
    ISSN 1664-462X
    ISSN 1664-462X
    DOI 10.3389/fpls.2023.1274231
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Teaching with social context in instructional video facilitates second language vocabulary learning

    Zhang, Zhicong / Li, Heming / Chau, Ka Yin

    Heliyon. 2023 Mar., v. 9, no. 3 p.e14540-

    2023  

    Abstract: Video lectures are becoming an important and accessible way for adults to learn a new second language (L2). Unlike face-to-face classroom teaching, teachers are more challenged by the asynchronous mode of video teaching. Finding more effective teaching ... ...

    Abstract Video lectures are becoming an important and accessible way for adults to learn a new second language (L2). Unlike face-to-face classroom teaching, teachers are more challenged by the asynchronous mode of video teaching. Finding more effective teaching methods is a great concern for teachers. The present study examined adults' second language (L2) vocabulary learning in a video-based social learning environment. Participants included 116 Chinese undergraduates. They learned German words through one of three pedagogical video lecture conditions: social-context (SC) condition, picture-phonics (PP) condition, and non-picture phonics (NPP) condition. We measured learners' learning performance, cognitive load, intrinsic motivation, and learning satisfaction. The results indicated that adult learners in the SC condition performed significantly better in word meaning retention, had significantly higher intrinsic motivation, and perceived significantly lower cognitive load as compared to the PP and NPP conditions. The implications are that teachers could use social learning pedagogy to create a better video-based learning environment for L2 adult learners for better learning performance.
    Keywords adults ; cognition ; motivation ; Instructional video ; Vocabulary learning ; Social context ; Second language ; Social L2 instruction
    Language English
    Dates of publication 2023-03
    Publishing place Elsevier Ltd
    Document type Article ; Online
    Note Use and reproduction
    ZDB-ID 2835763-2
    ISSN 2405-8440
    ISSN 2405-8440
    DOI 10.1016/j.heliyon.2023.e14540
    Database NAL-Catalogue (AGRICOLA)

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  3. Article: Multikinase inhibitor-based immunotherapy doublet for advanced hepatocellular carcinoma: its efficacy still needs to be determined.

    Li, Heming / Hao, Xiangjun / Han, Tao

    Hepatobiliary surgery and nutrition

    2023  Volume 12, Issue 3, Page(s) 468–471

    Language English
    Publishing date 2023-05-18
    Publishing country China (Republic : 1949- )
    Document type Journal Article
    ZDB-ID 2812398-0
    ISSN 2304-389X ; 2304-3881
    ISSN (online) 2304-389X
    ISSN 2304-3881
    DOI 10.21037/hbsn-23-58
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Perfluorooctanoic acid inhibits androgen biosynthesis in rat immature Leydig cells.

    Zhang, Dongxu / Hu, Jiasheng / Li, Heming

    Environmental toxicology

    2023  Volume 39, Issue 3, Page(s) 1700–1714

    Abstract: Perfluorooctanoic acid (PFOA) is a commonly used short-chain synthetic perfluoroalkyl agent. Immature Leydig cells (ILCs) are localized in the testis and responsible for androgen biosynthesis and metabolism. Although PFOA shows toxicity in the ... ...

    Abstract Perfluorooctanoic acid (PFOA) is a commonly used short-chain synthetic perfluoroalkyl agent. Immature Leydig cells (ILCs) are localized in the testis and responsible for androgen biosynthesis and metabolism. Although PFOA shows toxicity in the reproductive system, it is not clear if it disrupts the function of ILCs. In the present study, primary ILCs were isolated from 35-day-old rats and exposed to a range of PFOA concentrations (0, 0.01, 0.1, or 1 μM). It was determined that 0.1 or 1 μM PFOA reduced total androgen biosynthesis in ILCs. Specifically, 22R-hydroxycholesterol (22R), and pregnenolone (P5) mediated androgen biosynthesis were reduced by 0.1 μM PFOA. PFOA also selectively downregulated mRNA and protein expressions of steroidogenic enzymes including LHCGR, CYP11A1, 3β-HSD1, and NR5A1 at 0.01, 0.1, or 1 μM. Further analysis revealed that 0.1 μM PFOA inhibited CYP11A1 and 3β-HSD1 enzyme activities. However, PFOA did not significantly affect androgen metabolism and turnover under any of the conditions tested. And PFOA gavaging to 35-day-old rats at 5 or 10 mg/kg for 7 or 14 days also reduced serum androgen levels secreted by ILCs. Moreover, PFOA gavaging also downregulated the mRNA and protein expression levels of LHCGR, CYP11A1, 3β-HSD1, and NR5A1 in vivo. Taken together, these findings suggest that PFOA inhibits androgen biosynthesis in ILCs by selectively targeting key enzymes in the synthesis pathway.
    MeSH term(s) Male ; Rats ; Animals ; Leydig Cells/metabolism ; Androgens/metabolism ; Rats, Sprague-Dawley ; Cholesterol Side-Chain Cleavage Enzyme/metabolism ; Fluorocarbons/metabolism ; RNA, Messenger/metabolism ; Testosterone ; Caprylates
    Chemical Substances Androgens ; perfluorooctanoic acid (947VD76D3L) ; Cholesterol Side-Chain Cleavage Enzyme (EC 1.14.15.6) ; Fluorocarbons ; RNA, Messenger ; Testosterone (3XMK78S47O) ; Caprylates
    Language English
    Publishing date 2023-12-05
    Publishing country United States
    Document type Journal Article
    ZDB-ID 1463449-1
    ISSN 1522-7278 ; 1520-4081
    ISSN (online) 1522-7278
    ISSN 1520-4081
    DOI 10.1002/tox.24042
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Imidacloprid-induced lung injury in mice: Activation of the PI3K/AKT/NF-κB signaling pathway via TLR4 receptor engagement.

    Xie, Wen / Chen, Canrong / Li, Heming / Tu, Yuxin / Zhong, Yanhui / Lin, Zian / Cai, Zongwei

    The Science of the total environment

    2024  Volume 931, Page(s) 172910

    Abstract: Significant impairment of pulmonary function has been demonstrated through long-term exposure to neonicotinoid insecticides, such as imidacloprid (IMI). However, the underlying mechanisms of lung injury induced by IMI remain unclear. In this study, a ... ...

    Abstract Significant impairment of pulmonary function has been demonstrated through long-term exposure to neonicotinoid insecticides, such as imidacloprid (IMI). However, the underlying mechanisms of lung injury induced by IMI remain unclear. In this study, a mouse model of IMI-induced pulmonary injury was established, and the toxicity and lung damage were assessed through mouse body weight, organ index, hematological parameters, and histopathological analysis of lung tissues. Furthermore, metabolomics and transcriptomics techniques were employed to explore the mechanistic aspects. Results from the toxicity assessments indicated that mouse body weight was significantly reduced by IMI, organ index was disturbed, and hematological parameters were disrupted, resulting in pulmonary injury. The mechanistic experimental results indicate that the differences in metabolites and gene expression in mouse lungs could be altered by IMI. Validation of the results through combined analysis of metabolomics and transcriptomics revealed that the mechanism by which IMI induces lung injury in mice might be associated with the activation of the TLR4 receptor, thereby activating the PI3K/AKT/NF-κB signaling pathway to induce inflammation in mouse lungs. This study provided valuable insights into the mechanisms underlying IMI-induced pulmonary damage, potentially contributing to the development of safer pest control strategies. The knowledge gained served as a robust scientific foundation for the prevention and treatment of IMI-related pulmonary injuries.
    Language English
    Publishing date 2024-05-01
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 121506-1
    ISSN 1879-1026 ; 0048-9697
    ISSN (online) 1879-1026
    ISSN 0048-9697
    DOI 10.1016/j.scitotenv.2024.172910
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Super-hydrophilic sulfonate-modified covalent organic framework nanosheets for efficient separation and enrichment of glycopeptides.

    Ji, Yin / Li, Heming / Dong, Jinghan / Lin, Jiashi / Lin, Zian

    Journal of chromatography. A

    2023  Volume 1699, Page(s) 464020

    Abstract: Highly efficient extraction of glycopeptides prior to mass spectrometry detection is extremely crucial for glycoproteomic research, especially in disease biomarker research. Reported here is the first time by applying two-dimensional (2D) covalent ... ...

    Abstract Highly efficient extraction of glycopeptides prior to mass spectrometry detection is extremely crucial for glycoproteomic research, especially in disease biomarker research. Reported here is the first time by applying two-dimensional (2D) covalent organic framework (COFs) nanosheets for highly efficient enrichment of glycopeptides. Particularly, by incorporating hydrophilic monomers through a bottom-up strategy, the 2D COF nanosheets (denoted as NUS-9) displayed an ultra-high graft density of sulfonic groups and super-hydrophilicity. In addition, because of the large surface area, low steric hindrance, high chemical stability, and abundant accessibility sites of 2D COF nanosheets, NUS-9 exhibited remarkable efficiency for glycopeptide enrichment, involving excellent detection sensitivity (0.01 fmol μL
    MeSH term(s) Humans ; Metal-Organic Frameworks/chemistry ; Glycopeptides/chemistry ; Mass Spectrometry ; Hydrophobic and Hydrophilic Interactions ; Horseradish Peroxidase/chemistry
    Chemical Substances Metal-Organic Frameworks ; Glycopeptides ; Horseradish Peroxidase (EC 1.11.1.-)
    Language English
    Publishing date 2023-04-23
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 1171488-8
    ISSN 1873-3778 ; 0021-9673
    ISSN (online) 1873-3778
    ISSN 0021-9673
    DOI 10.1016/j.chroma.2023.464020
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: Progress on the hippocampal circuits and functions based on sharp wave ripples.

    Xie, Boxu / Zhen, Zhihang / Guo, Ouyang / Li, Heming / Guo, Moran / Zhen, Junli

    Brain research bulletin

    2023  Volume 200, Page(s) 110695

    Abstract: Sharp wave ripples (SWRs) are high-frequency synchronization events generated by hippocampal neuronal circuits during various forms of learning and reactivated during memory consolidation and recall. There is mounting evidence that SWRs are essential for ...

    Abstract Sharp wave ripples (SWRs) are high-frequency synchronization events generated by hippocampal neuronal circuits during various forms of learning and reactivated during memory consolidation and recall. There is mounting evidence that SWRs are essential for storing spatial and social memories in rodents and short-term episodic memories in humans. Sharp wave ripples originate mainly from the hippocampal CA3 and subiculum, and can be transmitted to modulate neuronal activity in cortical and subcortical regions for long-term memory consolidation and behavioral guidance. Different hippocampal subregions have distinct functions in learning and memory. For instance, the dorsal CA1 is critical for spatial navigation, episodic memory, and learning, while the ventral CA1 and dorsal CA2 may work cooperatively to store and consolidate social memories. Here, we summarize recent studies demonstrating that SWRs are essential for the consolidation of spatial, episodic, and social memories in various hippocampal-cortical pathways, and review evidence that SWR dysregulation contributes to cognitive impairments in neurodegenerative and neurodevelopmental diseases.
    MeSH term(s) Humans ; Hippocampus/physiology ; Neurons ; Memory Consolidation ; Mental Recall ; Memory, Short-Term
    Language English
    Publishing date 2023-06-21
    Publishing country United States
    Document type Journal Article ; Review ; Research Support, Non-U.S. Gov't
    ZDB-ID 197620-5
    ISSN 1873-2747 ; 0361-9230
    ISSN (online) 1873-2747
    ISSN 0361-9230
    DOI 10.1016/j.brainresbull.2023.110695
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article: [UPLC-Q-TOF-MS-based metabolomics reveals mechanism of Morinda officinalis iridoid glycosides in treating rheumatoid arthritis and bone loss].

    Shen, Yi / Sun, Yi-Qi / Li, He-Ming / Zhang, Quan-Long / Zhao, Qi-Ming / Xu, Jin-Long / Qin, Lu-Ping / Zhang, Qiao-Yan

    Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica

    2024  Volume 49, Issue 2, Page(s) 453–460

    Abstract: This study aimed to investigate the therapeutic effects of Morinda officinalis iridoid glycosides(MOIG) on paw edema and bone loss of rheumatoid arthritis(RA) rats, and analyze its potential mechanism based on ultra-high performance liguid chromatography- ...

    Abstract This study aimed to investigate the therapeutic effects of Morinda officinalis iridoid glycosides(MOIG) on paw edema and bone loss of rheumatoid arthritis(RA) rats, and analyze its potential mechanism based on ultra-high performance liguid chromatography-guadrupole time-of-flight tandem mass spectrometry(UPLC-Q-TOF-MS) serum metabolomics. RA rats were established by injecting bovin type Ⅱ collagen. The collagen-induced arthritis(CIA) rats were administered drug by gavage for 8 weeks, the arthritic score were used to evaluate the severity of paw edem, serum bone metabolism biochemical parameters were measured by ELISA kits, Masson staining was used to observe the bone microstructure of the femur in CIA rats. UPLC-Q-TOF-MS was used to analyze the alteration of serum metabolite of CIA rats, principal component analysis(PCA) and partial least squares-discriminant analysis(PLS-DA) were used to screen the potential biomarkers, KEGG database analysis were used to construct related metabolic pathways. The results demonstrated that the arthritic score, serum levels of IL-6 and parameters related with bone metabolism including OCN, CTX-Ⅰ, DPD and TRAP were significantly increased, and the ratio of OPG and RANKL was significantly decreased, the microstructure of bone tissue and cartilage were destructed in CIA rats, while MOIG treatments could significantly reduce arthritis score, mitigate the paw edema, reverse the changes of serum biochemical indicators related with bone metabolism, and improve the microstructure of bone tissue and cartilage of CIA rats. The non-targeted metabolomics results showed that 24 altered metabolites were identified in serum of CIA rats; compared with normal group, 13 significantly altered metabolites related to RA were identified in serum of CIA rats, mainly involving alanine, aspartate and glutamate metabolism; compared with CIA model group, MOIG treatment reversed the alteration of 15 differential metabolites, mainly involving into alanine, aspartate and glutamate metabolism, D-glutamine and D-glutamate metabolism, taurine and hypotaurine metabolism, valine, leucine and isoleucine biosynthesis. Therefore, MOIG significantly alleviated paw edema, improved the destruction of microstructure of bone and cartilage in CIA rats maybe through involving into the regulation of amino acid metabolism.
    MeSH term(s) Rats ; Animals ; Iridoid Glycosides/chemistry ; Morinda/chemistry ; Chromatography, High Pressure Liquid ; Aspartic Acid ; Metabolomics ; Arthritis, Rheumatoid/drug therapy ; Edema ; Alanine/therapeutic use ; Glutamates/therapeutic use ; Biomarkers
    Chemical Substances Iridoid Glycosides ; Aspartic Acid (30KYC7MIAI) ; Alanine (OF5P57N2ZX) ; Glutamates ; Biomarkers
    Language Chinese
    Publishing date 2024-02-25
    Publishing country China
    Document type English Abstract ; Journal Article
    ZDB-ID 1004649-5
    ISSN 1001-5302 ; 0254-0029
    ISSN 1001-5302 ; 0254-0029
    DOI 10.19540/j.cnki.cjcmm.20230914.705
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: Crown Ether Copolymerized Polyimide Film: Enhanced Mechanical, Thermal Properties and Low Dielectric Constant under High Frequency.

    Li, Heming / Wang, Xinming / Ding, Ziyang / Gao, Weiguo / Liu, Yan / Ma, Ke / Hu, Zhizhi / Wang, Yongqi

    Polymers

    2024  Volume 16, Issue 9

    Abstract: Polymer materials with a low dielectric constant and low dielectric loss have the potential to be applied to high-frequency signal transmissions, such as mobile phone antennas and millimeter wave radars. Two types of diamines, 4,4'-diamino-p-tetraphenyl ( ...

    Abstract Polymer materials with a low dielectric constant and low dielectric loss have the potential to be applied to high-frequency signal transmissions, such as mobile phone antennas and millimeter wave radars. Two types of diamines, 4,4'-diamino-p-tetraphenyl (DPT) and crown ether diamine (CED), were prepared for ternary copolymerization with BPDA in this study. Cross-links with molecular chains were formed, increasing molecular chain distance by utilizing rings of CED. The MPI films exhibit a good thermal performance with the increase in CED addition, with Tg > 380 °C and CTE from -4 × 10
    Language English
    Publishing date 2024-04-24
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2527146-5
    ISSN 2073-4360 ; 2073-4360
    ISSN (online) 2073-4360
    ISSN 2073-4360
    DOI 10.3390/polym16091188
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: Fibrinogen-like protein 1 (FGL1): the next immune checkpoint target.

    Qian, Wenjing / Zhao, Mingfang / Wang, Ruoyu / Li, Heming

    Journal of hematology & oncology

    2021  Volume 14, Issue 1, Page(s) 147

    Abstract: Immune checkpoint therapy has achieved significant efficacy by blocking inhibitory pathways to release the function of T lymphocytes. In the clinic, anti-programmed cell death protein 1/programmed cell death ligand 1 (PD-1/PD-L1) monoclonal antibodies ( ... ...

    Abstract Immune checkpoint therapy has achieved significant efficacy by blocking inhibitory pathways to release the function of T lymphocytes. In the clinic, anti-programmed cell death protein 1/programmed cell death ligand 1 (PD-1/PD-L1) monoclonal antibodies (mAbs) have progressed to first-line monotherapies in certain tumor types. However, the efficacy of anti-PD-1/PD-L1 mAbs is still limited due to toxic side effects and de novo or adaptive resistance. Moreover, other immune checkpoint target and biomarkers for therapeutic response prediction are still lacking; as a biomarker, the PD-L1 (CD274, B7-H1) expression level is not as accurate as required. Hence, it is necessary to seek more representative predictive molecules and potential target molecules for immune checkpoint therapy. Fibrinogen-like protein 1 (FGL1) is a proliferation- and metabolism-related protein secreted by the liver. Multiple studies have confirmed that FGL1 is a newly emerging checkpoint ligand of lymphocyte activation gene 3 (LAG3), emphasizing the potential of targeting FGL1/LAG3 as the next generation of immune checkpoint therapy. In this review, we summarize the substantial regulation mechanisms of FGL1 in physiological and pathological conditions, especially tumor epithelial to mesenchymal transition, immune escape and immune checkpoint blockade resistance, to provide insights for targeting FGL1 in cancer treatment.
    MeSH term(s) Animals ; Antigens, CD/immunology ; Epithelial-Mesenchymal Transition/drug effects ; Fibrinogen/antagonists & inhibitors ; Fibrinogen/immunology ; Humans ; Immune Checkpoint Inhibitors/therapeutic use ; Immunotherapy/methods ; Molecular Targeted Therapy ; Neoplasms/drug therapy ; Neoplasms/immunology ; Tumor Escape/drug effects
    Chemical Substances Antigens, CD ; CD223 antigen ; FGL1 protein, human ; Immune Checkpoint Inhibitors ; Fibrinogen (9001-32-5)
    Language English
    Publishing date 2021-09-15
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 2429631-4
    ISSN 1756-8722 ; 1756-8722
    ISSN (online) 1756-8722
    ISSN 1756-8722
    DOI 10.1186/s13045-021-01161-8
    Database MEDical Literature Analysis and Retrieval System OnLINE

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