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Article ; Online: Universal DNA-Based Sensing Toolbox for Programming Cell Functions.

Ma, Pei-Qiang / Huang, Fu-Wen / Xie, Ya-Qi / Li, Hong-Rui / Li, Hua-Dong / Ye, Bang-Ce / Yin, Bin-Cheng

Journal of the American Chemical Society

2023 Volume 145, Issue 51, Page(s) 28224–28232

Abstract: By recombining natural cell signaling systems and further reprogramming cell functions, use of genetically engineered cells and bacteria as therapies is an innovative emerging concept. However, the inherent properties and structures of the natural signal ...

Abstract	By recombining natural cell signaling systems and further reprogramming cell functions, use of genetically engineered cells and bacteria as therapies is an innovative emerging concept. However, the inherent properties and structures of the natural signal sensing and response pathways constrain further development. We present a universal DNA-based sensing toolbox on the cell surface to endow new signal sensing abilities for cells, control cell states, and reprogram multiple cell functions. The sensing toolbox contains a triangular-prismatic-shaped DNA origami framework and a sensing core anchored inside the internal confined space to enhance the specificity and efficacy of the toolbox. As a proof of principle, the sensing toolbox uses the customizable sensing core with signal sensing switches and converters to recognize unconventional signal inputs, deliver functional components to cells, and then control cell responses, including specific tumor cell death, immune cell disinhibition and adhesion, and bacterial expression. This work expands the diversity of cell sensing signals and reprograms biological functions by constructing nanomechanical-natural hybrid cells, providing new strategies for engineering cells and bacteria in diagnosis and treatment applications.
MeSH term(s)	Signal Transduction ; DNA ; Genetic Engineering ; Bacteria/genetics ; Quorum Sensing
Chemical Substances	DNA (9007-49-2)
Language	English
Publishing date	2023-12-18
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	3155-0
ISSN	1520-5126 ; 0002-7863
ISSN (online)	1520-5126
ISSN	0002-7863
DOI	10.1021/jacs.3c11232
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Article: Effect of synthesis conditions on the non-uniformity of nanofiltration membrane pore size distribution

Zhang, Ting / Fu, Ruo-Yu / Wang, Kun-Peng / Gao, Ya-Wei / Li, Hong-Rui / Wang, Xiao-Mao / Xie, Yuefeng F. / Hou, Li'an

Journal of membrane science. 2022 Apr. 05, v. 647

2022

Abstract: The uniformity of membrane pore sizes, which is essentially determined by the membrane synthesis conditions, significantly affects the rejection performance of nanofiltration (NF) membranes. In this study, we applied two modeling methods, i.e., the DSPM ( ...

Abstract	The uniformity of membrane pore sizes, which is essentially determined by the membrane synthesis conditions, significantly affects the rejection performance of nanofiltration (NF) membranes. In this study, we applied two modeling methods, i.e., the DSPM (Donnan Steric Pore Model) and the log-normal distribution methods, for the determination of the average membrane pore size and pore size uniformity of lab-made NF membranes. The synthesis conditions included concentration of monomers (e.g., piperazine and trimesoyl chloride), (thermal) curing temperature and time, and activation solvent type and duration. Results showed that both high piperazine (PIP) concentration (≥0.5 wt%) and curing temperature (≥40 °C) could enhance the membrane pore size uniformity. Although the average membrane pore size calculated by the DSPM method was higher than that by the log-normal distribution method, they significantly correlated. It appears that the log-normal distribution method could more directly characterize membrane pore size uniformity. Obviously, the pore uniformity of NF membranes affected the rejection of small molecules, such as trace organic compounds. These insights provided a theoretical foundation for the characterization of membrane pore size distribution with more accuracy and the fabrication of membranes with higher pore size uniformity.
Keywords	lognormal distribution ; models ; nanofiltration ; piperazine ; porosity ; solvents ; temperature ; trimesoyl chloride
Language	English
Dates of publication	2022-0405
Publishing place	Elsevier B.V.
Document type	Article
ZDB-ID	194516-6
ISSN	0376-7388
ISSN	0376-7388
DOI	10.1016/j.memsci.2022.120304
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Article ; Online: Triterpenoid saponins from Psammosilene tunicoides and their antinociceptive activities.

Li, Yan-Hong / Bai, Xi-Shan / Yang, Xiu-Xia / Li, Yu-Xiao / Li, Hong-Rui / Wang, Zi-Liang / Wang, Wei / Tian, Kai / Huang, Xiang-Zhong

Phytochemistry

2023 Volume 214, Page(s) 113795

Abstract: Herein, five undescribed oleanane-type triterpenoid saponins, namely, psammosaponins A-E, along with nine known compounds, were isolated from the roots of Psammosilene tunicoides. Moreover, part of the ethanolic extract of P. tunicoides was acid- ... ...

Abstract	Herein, five undescribed oleanane-type triterpenoid saponins, namely, psammosaponins A-E, along with nine known compounds, were isolated from the roots of Psammosilene tunicoides. Moreover, part of the ethanolic extract of P. tunicoides was acid-hydrolyzed and three aglycones were isolated from the resulting hydrolysate. The structures of all compounds were established through extensive analysis involving 1D and 2D NMR experiments, HRESIMS measurements, chemical derivatization, and comparison of spectroscopic data with the values reported in the literature. In all, 10 of the isolated saponins and the three aglycones were evaluated in the acetic acid-induced writhing model for their antinociceptive activity. At a dose of 40 mg/kg, these compounds exhibited significant inhibitory effects on the mouse writhing response, with inhibitions ranging from 31.9% to 79.3%. In addition, the structure-activity relationships of the isolates were discussed. Among the isolates, quillaic acid 3-O-glucuronide and 16α-hydroxygypsogenic acid showed better antinociceptive activity with inhibitions of 79.3% and 73.7%, respectively. Both isolates also exhibited antinociceptive activities in hot plate and formalin tests on mice. Their antinociceptive mechanism was explored in lipopolysaccharide-stimulated RAW 264.7 cells. These isolates could significantly inhibit the production of nitric oxide and interleukin-6 and downregulate the expression levels of inducible NO synthase, COX-1, and COX-2.
Language	English
Publishing date	2023-07-23
Publishing country	England
Document type	Journal Article
ZDB-ID	208884-8
ISSN	1873-3700 ; 0031-9422
ISSN (online)	1873-3700
ISSN	0031-9422
DOI	10.1016/j.phytochem.2023.113795
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Article ; Online: A Bifunctional Catalyst for Green Ammonia Synthesis from Ubiquitous Air and Water.

Gao, Rui / Dai, Tian-Yi / Meng, Zhe / Sun, Xue-Feng / Liu, Dong-Xue / Shi, Miao-Miao / Li, Hong-Rui / Kang, Xia / Bi, Bo / Zhang, Yu-Tian / Xu, Tong-Wen / Yan, Jun-Min / Jiang, Qing

Advanced materials (Deerfield Beach, Fla.)

2023 Volume 35, Issue 41, Page(s) e2303455

Abstract: ... Ammonia ( ... ...

Abstract	Ammonia (NH
Language	English
Publishing date	2023-09-08
Publishing country	Germany
Document type	Journal Article
ZDB-ID	1474949-X
ISSN	1521-4095 ; 0935-9648
ISSN (online)	1521-4095
ISSN	0935-9648
DOI	10.1002/adma.202303455
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Article: Secondary metabolites isolated from Agrimonia pilosa Ledeb

Li, Hong-Rui / Li, Yu-Kui / Xiao, Jian / Yang, Cui / Jiang, Meng-Yuan / Tian, Kai / Wang, Wei / Li, Yan-Hong / Huang, Xiang-Zhong

Natural product research. 2021 Dec. 22, v. 36, no. 1

2021

Abstract: A pilot study on the ethanol extracts of Agrimonia pilosa found to have anti-α-glucosidase and anti-inflammatory activities. Subsequent chemical study afforded a new phenylethyl isocoumarin glycoside (1) and eight known compounds (2-9). The structure of ... ...

Abstract	A pilot study on the ethanol extracts of Agrimonia pilosa found to have anti-α-glucosidase and anti-inflammatory activities. Subsequent chemical study afforded a new phenylethyl isocoumarin glycoside (1) and eight known compounds (2-9). The structure of 1 was elucidated by comprehensive spectroscopic analysis and chemical transformations. All compounds showed modest α-glucosidase inhibitory activity (IC₅₀ values ranging from 36.8 to 210.7 μM), which was lower than that of the positive control acarbose (IC₅₀=301.9 μM). Those compounds except inactive compounds 3 and 6 showed weak anti-inflammatory activity.
Keywords	Agrimonia pilosa ; acarbose ; anti-inflammatory activity ; ethanol ; glycosides ; research ; secondary metabolites ; spectral analysis
Language	English
Dates of publication	2021-1222
Size	p. 263-270.
Publishing place	Taylor & Francis
Document type	Article
ZDB-ID	2185747-7
ISSN	1478-6427 ; 1478-6419
ISSN (online)	1478-6427
ISSN	1478-6419
DOI	10.1080/14786419.2020.1779263
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Article ; Online: Two new monoterpene esters from

Jiang, Meng-Yuan / Pu, Xiao-Yun / Li, Wen-Ting / Liu, Juan / Zeng, Xiao-Li / Li, Hong-Rui / Bai, Xi-Shan / Hu, Lin / Huang, Xiang-Zhong

Natural product research

2022 Volume 38, Issue 7, Page(s) 1230–1237

Abstract: Two new monoterpene esters, illigerates H and I ( ...

Abstract	Two new monoterpene esters, illigerates H and I (
MeSH term(s)	alpha-Glucosidases ; Anti-Inflammatory Agents/pharmacology ; Esters ; Molecular Structure ; Monoterpenes/pharmacology ; Monoterpenes/chemistry
Chemical Substances	alpha-Glucosidases (EC 3.2.1.20) ; Anti-Inflammatory Agents ; Esters ; Monoterpenes ; actinodaphine (517-69-1)
Language	English
Publishing date	2022-10-26
Publishing country	England
Document type	Journal Article
ZDB-ID	2185747-7
ISSN	1478-6427 ; 1478-6419
ISSN (online)	1478-6427
ISSN	1478-6419
DOI	10.1080/14786419.2022.2137802
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Article ; Online: The combined analgesic, sedative, and anti-gastric cancer mechanisms of Tinospora sagittata var. yunnanensis (S. Y. Hu) H. S. Lo based on integrated ethnopharmacological data.

Wang, Qian-Qian / Sun, Qin-Rong / Ji, Xin-Ye / Tang, Yun / Zhang, Ke / Wang, Xiao-Qin / Li, Hong-Rui / Huang, Xiang-Zhong / Zhang, Bo

Journal of ethnopharmacology

2022 Volume 303, Page(s) 115990

Abstract: Ethnopharmacology relevance: As a Yi medicine for eliminating wind to relieve pain, Tinospora sagittata var. yunnanensis (S. Y. Hu) H. S. Lo (TSY) is widely used to treat sore throat, stomach pain, bone and muscle injuries, and tumors; however, the ... ...

Abstract	Ethnopharmacology relevance: As a Yi medicine for eliminating wind to relieve pain, Tinospora sagittata var. yunnanensis (S. Y. Hu) H. S. Lo (TSY) is widely used to treat sore throat, stomach pain, bone and muscle injuries, and tumors; however, the material basis and mechanism of action remain unclear. Aim of the study: This study aims to investigate the potential active compounds of TSY and related pharmacological mechanisms against gastric cancer using a multitarget strategy. Materials and methods: The main chemical components of TSY were collected through a literature review and database searches. The components were further screened for ADMET properties, and their targets were predicted using network pharmacology (admetSAR) and substructure-drug-target network-based inference (SDTNBI) approaches in silico. The pharmacological mechanism of action of TSY extract for pain relief, sedation, and anti-gastric cancer activities were identified via in vivo and in vitro biochemical analyses. Results: Here, 28 chemical components were identified, 7 active compounds were selected, and 75 targets of TSY extract were predicted. A compound-target-disease network topological approach revealed that the predicted targets are highly related to the digestive system and nervous system. Network pharmacology results suggested that the anti-gastric cancer activity of TSY was highly correlated with its analgesic and sedative targets and MAPK. In vivo experiments confirmed that TSY extract not only reduced the number of voluntary activities in the mouse model but also exhibited a synergistic effect on sodium pentobarbital-induced sleep, reduced the number of mice exhibiting writhing responses to acetic acid, and increased the hot plate pain threshold of mice. Thus, TSY extract exhibits good analgesic and sedative effects. The TSY extract inhibited HGC-27 cell proliferation and induced apoptosis by regulating apoptotic proteins (BAX, BCL-2 and BCL-XL) in vitro. Conclusions: TSY exhibits combined analgesic, sedative, and anti-gastric cancer activities.
Language	English
Publishing date	2022-12-09
Publishing country	Ireland
Document type	Journal Article
ZDB-ID	134511-4
ISSN	1872-7573 ; 0378-8741
ISSN (online)	1872-7573
ISSN	0378-8741
DOI	10.1016/j.jep.2022.115990
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Article ; Online: Keap1 as Target of Genistein on Nrf2 Signaling Pathway Antagonizing Aβ induced Oxidative Damage of Cerebrovascular Endothelial Cells.

Xi, Yuan-Di / Li, Xiao-Ying / Chi, Ya-Fei / Han, Jing / Li, Hong-Rui / Wang, Xian-Yun / Wang, Xuan / Li, Tian-Tian / Yu, Hui-Yan / Xiao, Rong

Current neurovascular research

2022 Volume 19, Issue 1, Page(s) 73–82

Abstract: Background: β-amyloid peptides (Aβ) induced oxidative damage contributes to the pathogenesis of neurodegenerative diseases, and the cerebrovascular system is more vulnerable to oxidative stress. Our earlier study showed a clue that Genistein (Gen) might ...

Abstract	Background: β-amyloid peptides (Aβ) induced oxidative damage contributes to the pathogenesis of neurodegenerative diseases, and the cerebrovascular system is more vulnerable to oxidative stress. Our earlier study showed a clue that Genistein (Gen) might activate the Nf-E2 related factor 2 (Nrf2) pathway to protect cerebrovascular cells from oxidative damage induced by Aβ, but the specific mechanisms and regulation targets are unclear. Objective: In this study, the anti-oxidative effects and the possible targets of Gen on regulating the Nrf2 pathway in bEnd.3 cells were investigated. Cells were divided into control, Aβ25-35, Gen, and Gen+Aβ25-35 groups. Methods: Cell viability, levels of malondialdehyde (MDA), Superoxide Dismutase (SOD) activity, and nitrotyrosine were evaluated. Moreover, mRNA and/or protein expressions of Nrf2 and kelchlike ECH-associated protein 1 (Keap1) were measured. Then we transfected Keap1 over-expressed plasmid into bEnd.3 cells and measured the protein expressions of Nrf2 pathway related factors. Results: Data showed that Gen could inhibit the over-production of MDA and nitrotyrosine and activate SOD activity. Furthermore, we discovered that Gen could up-regulate Nrf2 mRNA and protein expression while down-regulating Keap1 protein expression. The Keap1 over-expressed plasmid study revealed that the up-regulation of Nrf2 protein expression induced by Gen pretreatment could be blocked by transfection of Keap1 over-expressed plasmid, and the same results were observed in Nrf2 downstream factors. Conclusion: Gen could alleviate the cerebrovascular cells' oxidative damage induced by Aβ25-35 by regulating the Nrf2 pathway, and Keap1 might be one of the targets of Gen in activating the Nrf2 pathway.
MeSH term(s)	Animals ; Endothelial Cells/metabolism ; Genistein/pharmacology ; Kelch-Like ECH-Associated Protein 1/metabolism ; Mice ; NF-E2-Related Factor 2/genetics ; NF-E2-Related Factor 2/metabolism ; NF-E2-Related Factor 2/pharmacology ; Oxidative Stress ; RNA, Messenger/metabolism ; Signal Transduction ; Superoxide Dismutase/metabolism
Chemical Substances	Keap1 protein, mouse ; Kelch-Like ECH-Associated Protein 1 ; NF-E2-Related Factor 2 ; RNA, Messenger ; Genistein (DH2M523P0H) ; Superoxide Dismutase (EC 1.15.1.1)
Language	English
Publishing date	2022-04-06
Publishing country	United Arab Emirates
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2296350-9
ISSN	1875-5739 ; 1567-2026
ISSN (online)	1875-5739
ISSN	1567-2026
DOI	10.2174/1567202619666220406100320
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Article ; Online: Neoadjuvant nivolumab with or without platinum-doublet chemotherapy based on PD-L1 expression in resectable NSCLC (CTONG1804): a multicenter open-label phase II study.

Signal transduction and targeted therapy

2023 Volume 8, Issue 1, Page(s) 442

Abstract: This prospective multicenter phase II study evaluated the clinical efficacy of neoadjuvant nivolumab-exclusive (N) and nivolumab-chemotherapy (N/C) combinations based on PD-L1 expression. Eligible patients exhibited resectable clinical stage IIA-IIIB ( ... ...

Abstract	This prospective multicenter phase II study evaluated the clinical efficacy of neoadjuvant nivolumab-exclusive (N) and nivolumab-chemotherapy (N/C) combinations based on PD-L1 expression. Eligible patients exhibited resectable clinical stage IIA-IIIB (AJCC 8th edition) NSCLC without EGFR/ALK alterations. Patients received either mono-nivolumab (N) or nivolumab + nab-paclitaxel+ carboplatin (N/C) for three cycles based on PD-L1 expression. The primary endpoint was the major pathological response (MPR). Key secondary endpoints included the pathologic complete response (pCR), objective response rate (ORR), and event-free survival (EFS). Baseline PD-L1 expression and perioperative circulating tumor DNA (ctDNA) status were correlated with pCR and EFS. Fifty-two patients were enrolled, with 46 undergoing surgeries. The MPR was 50.0% (26/52), with 25.0% (13/52) achieving pCR, and 16.7% and 66.7% for patients with PD-L1 ≥ 50% in N and N/C groups, respectively. Thirteen (25.0%) patients experienced grade 3 or higher immune-related adverse events during neoadjuvant treatment. Patients with post-neoadjuvant ctDNA negativity was more likely to have pCR (39.1%) compared with those remained positive (6.7%, odds ratio = 6.14, 95% CI 0.84-Inf, p = 0.077). With a median follow-up of 25.1 months, the 18-month EFS rate was 64.8% (95% CI 51.9-81.0%). For patients with ctDNA- vs. ctDNA + , the 18m-EFS rate was 93.8% vs 47.3% (HR, 0.15; 95% CI 0.04, 0.94; p = 0.005). Immunochemotherapy may serve as an optimal neoadjuvant treatment even for patients with PD-L1 expression ≥ 50%. ctDNA negativity following neoadjuvant treatment and surgery could help identify superior pathological and survival benefits, which requires further confirmation in a prospective clinical trial (NCT04015778).
MeSH term(s)	Humans ; Nivolumab/therapeutic use ; Neoadjuvant Therapy/adverse effects ; Platinum/therapeutic use ; B7-H1 Antigen/genetics ; Prospective Studies ; Carcinoma, Non-Small-Cell Lung/drug therapy ; Carcinoma, Non-Small-Cell Lung/genetics ; Carcinoma, Non-Small-Cell Lung/pathology ; Lung Neoplasms/drug therapy ; Lung Neoplasms/genetics ; Lung Neoplasms/pathology
Chemical Substances	Nivolumab (31YO63LBSN) ; Platinum (49DFR088MY) ; B7-H1 Antigen
Language	English
Publishing date	2023-12-06
Publishing country	England
Document type	Clinical Trial, Phase II ; Multicenter Study ; Journal Article
ZDB-ID	2886872-9
ISSN	2059-3635 ; 2095-9907
ISSN (online)	2059-3635
ISSN	2095-9907
DOI	10.1038/s41392-023-01700-4
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Article ; Online: Three new diterpenoids from Aralia dumetorum.

Li, Yan-Hong / Li, Hong-Rui / Yang, Chun-Tao / Tian, Kai / Yang, Cui / Sun, Jing-Xian / Wang, Wei / Huang, Xiang-Zhong

Journal of Asian natural products research

2019 Volume 21, Issue 4, Page(s) 308–315

Abstract: Three new diterpenoids, dumetoranes A (1) and B (2), melanocane B (3), together with four known ones including melanocane A (4), ent-15S,16-dihydroxypimar-8(14)-en-19-oic acid (5), ent-pimara-8(14),15-diene-19-oic acid (6), and ent-pimara-8(14),15-diene- ... ...

Abstract	Three new diterpenoids, dumetoranes A (1) and B (2), melanocane B (3), together with four known ones including melanocane A (4), ent-15S,16-dihydroxypimar-8(14)-en-19-oic acid (5), ent-pimara-8(14),15-diene-19-oic acid (6), and ent-pimara-8(14),15-diene-19-ol (7) were obtained from the ethanol extract of the roots of Aralia dumetorum. Their structure elucidation was achieved by the methods of spectroscopic HRMS, IR, NMR, and by comparison with literature. The cytotoxicities of compounds 1-3 and 5 were assayed by in vitro MTT methods.
MeSH term(s)	Aralia/chemistry ; Diterpenes/chemistry ; Diterpenes/isolation & purification ; Diterpenes/pharmacology ; Magnetic Resonance Spectroscopy ; Plant Roots/chemistry
Chemical Substances	Diterpenes
Language	English
Publishing date	2019-03-04
Publishing country	England
Document type	Journal Article
ZDB-ID	2077926-4
ISSN	1477-2213 ; 1028-6020
ISSN (online)	1477-2213
ISSN	1028-6020
DOI	10.1080/10286020.2019.1567503
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