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Article ; Online: Electrical Stimulation for Children with Cerebral Palsy: A Meta-analysis for Randomized Controlled Trials.

Liu, Yu / Li, Hongzhi

2023 Volume 54, Issue 6, Page(s) 381–387

Abstract: Background: Different types of electrical stimulation (ES) showed diverse effects on children with cerebral palsy (CP). Previous studies reported inconsistent results for effects of ES on children with CP. The present study aimed to conduct a meta- ... ...

Abstract	Background: Different types of electrical stimulation (ES) showed diverse effects on children with cerebral palsy (CP). Previous studies reported inconsistent results for effects of ES on children with CP. The present study aimed to conduct a meta-analysis to summarize these diverse results. Methods: We searched for studies exploring effects of ES on children with CP in databases (PubMed and Web of Science) from their inception until December 2022. Standard mean differences (SMDs) and 95% confidence intervals (CIs) were computed using STATA 12.0 software. Results: The meta-analysis included 19 randomized controlled trials (including 265 CP patients in test group and 263 CP patients in corresponding control group). The study showed an increased improvement in gross motor function, walking speed, step length, and daily living activities in ES group compared with corresponding control group with random effects models (gross motor function: SMD = 2.04, 95% CI = 1.43-2.65; walking speed: SMD = 3.71, 95% CI = 1.49-5.92; step length: SMD = 1.89, 95% CI = 0.65-3.13; daily living activities: SMD = 5.18, 95% CI = 3.04-7.31), whereas the study showed no significant difference in change of muscle strength between ES group and the corresponding control group with a random effects model (SMD = 0.42, 95% CI = -0.12 to 0.97). Conclusion: The study demonstrated that ES might be used as therapy to improve gross motor function, gait, and daily living activities in children with CP.
MeSH term(s)	Humans ; Child ; Cerebral Palsy/therapy ; Randomized Controlled Trials as Topic ; Activities of Daily Living ; Gait ; Walking Speed
Language	English
Publishing date	2023-04-26
Publishing country	Germany
Document type	Meta-Analysis ; Journal Article
ZDB-ID	573291-8
ISSN	1439-1899 ; 0174-304X
ISSN (online)	1439-1899
ISSN	0174-304X
DOI	10.1055/a-2081-1560
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Changes in oscillatory patterns of microstate sequence in patients with first-episode psychosis.

Zhou, Dong-Dong / Li, Hong-Zhi / Wang, Wo / Kuang, Li

Scientific data

2024 Volume 11, Issue 1, Page(s) 38

Abstract: We aimed to utilize chaos game representation (CGR) for the investigation of microstate sequences and explore its potential as neurobiomarkers for psychiatric disorders. We applied our proposed method to a public dataset including 82 patients with first- ... ...

Abstract	We aimed to utilize chaos game representation (CGR) for the investigation of microstate sequences and explore its potential as neurobiomarkers for psychiatric disorders. We applied our proposed method to a public dataset including 82 patients with first-episode psychosis (FEP) and 61 control subjects. Two time series were constructed: one using the microstate spacing distance in CGR and the other using complex numbers representing the microstate coordinates in CGR. Power spectral features of both time series and frequency matrix CGR (FCGR) were compared between groups and employed in a machine learning application. The four canonical microstates (A, B, C, and D) were identified using both shared and separate templates. Our results showed the microstate oscillatory pattern exhibited alterations in the FEP group. Using oscillatory features improved machine learning performance compared with classical features and FCGR. This study opens up new avenues for exploring the use of CGR in analyzing EEG microstate sequences. Features derived from microstate sequence CGR offer fine-grained neurobiomarkers for psychiatric disorders.
MeSH term(s)	Humans ; Machine Learning ; Patients ; Psychotic Disorders ; Time Factors
Language	English
Publishing date	2024-01-05
Publishing country	England
Document type	Journal Article
ZDB-ID	2775191-0
ISSN	2052-4463 ; 2052-4463
ISSN (online)	2052-4463
ISSN	2052-4463
DOI	10.1038/s41597-023-02892-8
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Analysis and Validation of Tyrosine Metabolism-related Prognostic Features for Liver Hepatocellular Carcinoma Therapy.

Cui, Zhongfeng / Liu, Chunli / Li, Hongzhi / Wang, Juan / Li, Guangming

Current medicinal chemistry

2024

Abstract: Aims: To explore tyrosine metabolism-related characteristics in liver hepatocellular carcinoma (LIHC) and to establish a risk signature for the prognostic prediction of LIHC. Novel prognostic signatures contribute to the mining of novel biomarkers, ... ...

Abstract	Aims: To explore tyrosine metabolism-related characteristics in liver hepatocellular carcinoma (LIHC) and to establish a risk signature for the prognostic prediction of LIHC. Novel prognostic signatures contribute to the mining of novel biomarkers, which are essential for the construction of a precision medicine system for LIHC and the improvement of survival. Background: Tyrosine metabolism plays a critical role in the initiation and development of LIHC. Based on the tyrosine metabolism-related characteristics in LIHC, this study developed a risk signature to improve the prognostic prediction of patients with LIHC. Objective: To investigate the correlation between tyrosine metabolism and progression of LIHC and to develop a tyrosine metabolism-related prognostic model. Methods: Gene expression and clinicopathological information of LIHC were obtained from The Cancer Genome Atlas (TCGA) database. Distinct subtypes of LIHC were classified by performing consensus cluster analysis on the tyrosine metabolism-related genes. Univariate and Lasso Cox regression were used to develop a RiskScore prognosis model. Kaplan-Meier (KM) survival analysis with log-rank test and area under the curve (AUC) of receiver operating characteristic (ROC) were employed in the prognostic evaluation and prediction validation. Immune infiltration, tyrosine metabolism score, and pathway enrichment were evaluated using single-sample gene set enrichment analysis (ssGSEA). Finally, a nomogram model was developed with the RiskScore and other clinicopathological features. Results: Based on the tyrosine metabolism genes in the TCGA cohort, we identified 3 tyrosine metabolism-related subtypes showing significant prognostic differences. Four candidate genes selected from the common differentially expressed genes (DEGs) between the 3 subtypes were used to develop a RiskScore model, which could effectively divide LIHC patients into high- and lowrisk groups. In both the training and validation sets, high-risk patients tended to have worse overall survival, less active immunotherapy response, higher immune infiltration and clinical grade, and higher oxidative, fatty, and xenobiotic metabolism pathways. Multivariate analysis confirmed that the RiskScore was an independent indicator for the prognosis of LIHC. The results from pan-- cancer analysis also supported that the RiskScore had a strong prognostic performance in other cancers. The nomogram demonstrated that the RiskScore contributed the most to the prediction of LIHC prognosis. Conclusion: Our study developed a tyrosine metabolism-related risk model that performed well in survival prediction, showing the potential to serve as an independent prognostic predictor for LIHC treatment.
Language	English
Publishing date	2024-02-26
Publishing country	United Arab Emirates
Document type	Journal Article
ZDB-ID	1319315-6
ISSN	1875-533X ; 0929-8673
ISSN (online)	1875-533X
ISSN	0929-8673
DOI	10.2174/0109298673290101240223074545
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Article: Electrical Stimulation for Children with Cerebral Palsy: A Meta-analysis for Randomized Controlled Trials

Liu, Yu / Li, Hongzhi

Neuropediatrics

2023 Volume 54, Issue 06, Page(s) 381–387

Abstract	Background: Different types of electrical stimulation (ES) showed diverse effects on children with cerebral palsy (CP). Previous studies reported inconsistent results for effects of ES on children with CP. The present study aimed to conduct a meta-analysis to summarize these diverse results. Methods: We searched for studies exploring effects of ES on children with CP in databases (PubMed and Web of Science) from their inception until December 2022. Standard mean differences (SMDs) and 95% confidence intervals (CIs) were computed using STATA 12.0 software. Results: The meta-analysis included 19 randomized controlled trials (including 265 CP patients in test group and 263 CP patients in corresponding control group). The study showed an increased improvement in gross motor function, walking speed, step length, and daily living activities in ES group compared with corresponding control group with random effects models (gross motor function: SMD = 2.04, 95% CI = 1.43–2.65; walking speed: SMD = 3.71, 95% CI = 1.49–5.92; step length: SMD = 1.89, 95% CI = 0.65–3.13; daily living activities: SMD = 5.18, 95% CI = 3.04–7.31), whereas the study showed no significant difference in change of muscle strength between ES group and the corresponding control group with a random effects model (SMD = 0.42, 95% CI = −0.12 to 0.97). Conclusion: The study demonstrated that ES might be used as therapy to improve gross motor function, gait, and daily living activities in children with CP.
Keywords	cerebral palsy ; electrical stimulation ; functional electrical stimulation ; meta-analysis ; neuromuscular electrical stimulation
Language	English
Publishing date	2023-04-26
Publisher	Georg Thieme Verlag KG
Publishing place	Stuttgart ; New York
Document type	Article
ZDB-ID	573291-8
ISSN	1439-1899 ; 0174-304X
ISSN (online)	1439-1899
ISSN	0174-304X
DOI	10.1055/a-2081-1560
Database	Thieme publisher's database

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Zs.A 728: Show issues

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Jg. 1995 - 2021: Lesesall (1.OG)
ab Jg. 2022: Lesesaal (EG)

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Article ; Online: Lightweight Differentiated Transmission Based on Fuzzy and Random Modeling in Underwater Acoustic Sensor Networks.

Cao, Jiabao / Dou, Jinfeng / Liu, Jilong / Li, Hongzhi / Chen, Hao

Sensors (Basel, Switzerland)

2023 Volume 23, Issue 15

Abstract: Energy-efficient and reliable underwater acoustic communication attracts a lot of research due to special marine communication conditions with limited resources in underwater acoustic sensor networks (UASNs). In their final analysis, the existing studies ...

Abstract	Energy-efficient and reliable underwater acoustic communication attracts a lot of research due to special marine communication conditions with limited resources in underwater acoustic sensor networks (UASNs). In their final analysis, the existing studies focus on controlling redundant communication and route void that greatly influence UASNs' comprehensive performances. Most of them consider directional or omnidirectional transmission for partial optimization aspects, which still have many extra data loads and performance losses. This paper analyzes the main issue sources causing redundant communication in UASNs, and proposes a lightweight differentiated transmission to suppress extra communication to the greatest extent as well as balance energy consumption. First, the layered model employs layer ID to limit the scale of the data packet header, which does not need depth or location information. Second, the layered model, fuzzy-based model, random modeling and directional-omnidirectional differentiated transmission mode comb out the forwarders step by step to decrease needless duplicated forwarding. Third, forwarders are decided by local computation in nodes, which avoids exchanging controlling information among nodes. Simulation results show that our method can efficiently reduce the network load and improve the performance in terms of energy consumption balance, network lifetime, data conflict and network congestion, and data packet delivery ratio.
Language	English
Publishing date	2023-07-27
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2052857-7
ISSN	1424-8220 ; 1424-8220
ISSN (online)	1424-8220
ISSN	1424-8220
DOI	10.3390/s23156733
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: F-box protein 17 promotes glioma progression by regulating glycolysis pathway.

Deng, Chao / Li, Hongzhi / Li, Qingmin

Bioscience, biotechnology, and biochemistry

2022 Volume 86, Issue 4, Page(s) 455–463

Abstract: F-box protein 17 (FBXO17) is associated with high-grade glioma and acted as a promotor of glioma development. This study investigated the effect and underlying pathway of FBXO17 on glioma. The Cancer Genome Atlas database was applied to analyze FBXO17 ... ...

Abstract	F-box protein 17 (FBXO17) is associated with high-grade glioma and acted as a promotor of glioma development. This study investigated the effect and underlying pathway of FBXO17 on glioma. The Cancer Genome Atlas database was applied to analyze FBXO17 expression information in glioma. First, high FBXO17 expressions are associated with glioma and poor prognosis. Then, FBXO17 was upregulated in glioma cells. Meanwhile, knock-down of FBXO17 inhibited cell proliferation, migration, and invasion, but increased the cell apoptosis. Besides, knock-down of FBXO17 inhibited mitochondrial membrane potential and increased reactive oxygen species. Furthermore, knock-down of FBXO17 decreased level of adenosine triphosphate, glucose, lactate, GLUT1, HK2, PFKP, PKM2, and LDHA. In conclusion, FBXO17 was high expression in glioma, and FBXO17 regulates glioma by regulating glycolysis pathway, providing novel theoretical for the treatment of glioma.
MeSH term(s)	Apoptosis ; Cell Line, Tumor ; Cell Movement ; Cell Proliferation ; F-Box Proteins/genetics ; Gene Expression Regulation, Neoplastic ; Glioma/genetics ; Glioma/metabolism ; Glycolysis ; Humans
Chemical Substances	F-Box Proteins ; FBXO17 protein, human
Language	English
Publishing date	2022-03-02
Publishing country	England
Document type	Journal Article
ZDB-ID	1106450-x
ISSN	1347-6947 ; 0916-8451
ISSN (online)	1347-6947
ISSN	0916-8451
DOI	10.1093/bbb/zbac008
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Transduction of yeast NDI1 gene reduces the damages demonstrated by a rotenone-induced differentiated Parkinson's disease cell model

SHEN Luxi / XU Xuejing / YE Yifan / CHEN Zhuo / CHEN Lan / SHEN Yuqi / LI Hongzhi

Jichu yixue yu linchuang, Vol 43, Iss 10, Pp 1491-

2023 Volume 1497

Abstract: Objective To provide a basis for gene therapy of sporadic Parkinson's disease (PD) caused by mitochondrial complex Ⅰ dysfunction, yeast complex Ⅰ (expressed by internal NADH dehydrogenase,NDI1) was tested to replace human complex Ⅰ with functional ... ...

Abstract	Objective To provide a basis for gene therapy of sporadic Parkinson's disease (PD) caused by mitochondrial complex Ⅰ dysfunction, yeast complex Ⅰ (expressed by internal NADH dehydrogenase,NDI1) was tested to replace human complex Ⅰ with functional defects. Methods The recombinant adeno-associated virus (rAAV-NDI1) infected the rotenone-induced differentiated cell model of PD. Three groups (DMSO+vector, rotenone+vector, rotenone+NDI1) were designed. The cytopathology and mitochondrial functions were examined by the methods of Western blot, immunofluorescence staining, measurement of oxygen consumption, ATP content and ROS, etc. Results Compared with rotenone+vector group, the rotenone+NDI1 group showed significantly improved cell morphology, increase in cell survival (P＜0.05), and decrease in level of pS129 α-synuclein and of whole-cell autophagy (P＜0.05, P＜0.001). Compared with rotenone+vector group, the rotenone+NDI1 group also displayed significant increase of complex Ⅰ-dependent oxygen consumption (P＜0.01), significant increase in total cellular ATP synthesis and mitochondrial oxidative phosphorylation-coupled ATP synthesis (P＜0.01),significant decrease in the level of mitochondrial ROS and mitochondrial mitophagy(P＜0.01, P＜0.001). Conclusions Yeast NDI1 can replace and compensate complex Ⅰ-related functional defects in rotenone-induced differentiated PD cell model, and can alleviate the damage of cytopathology and mitochondrial functions.
Keywords	yeast ndi1\|recombinant adeno-associated virus (raav)\|rotenone\|all-trans retinoic acid\|parkinson's disease ; Medicine ; R
Subject code	570
Language	Chinese
Publishing date	2023-10-01T00:00:00Z
Publisher	Institute of Basic Medical Sciences and Peking Union Medical College Hospital, Chinese Academy of Medical Sciences / Peking Union Medical College.
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Research status of engine emissions treated by nonthermal plasma

Zhang, Zongxi / Sui, Zhike / Song, Chuanzeng / Lu, Wenhao / Fan, Xiang / Li, Hongzhi / Wang, Pei

Environmental Technology & Innovation. 2023 Feb., v. 29 p.103007-

2023

Abstract: Emission from diesel engine has become one of the most important sources of air pollution, which has attracted the attention of countries all over the world. Many measures have been taken to reduce diesel engine emission. In recent years, nonthermal ... ...

Abstract	Emission from diesel engine has become one of the most important sources of air pollution, which has attracted the attention of countries all over the world. Many measures have been taken to reduce diesel engine emission. In recent years, nonthermal plasma (NTP) technology has been gradually applied to the field of engine emission treatment. In this research, the authors introduced the selection of NTP generator, parameter design and electric field intensity in discharge zone were analyzed in detail. The coupling mode of NTP and catalyst, and the loading mode of catalyst were compared. Combined with the relevant experimental research, the authors analyzed the mechanism of CO, HC, PM and volatile organic compounds (VOCs) treated by NTP. Finally, the authors proposed some suggestions for the development of NTP technology.
Keywords	air pollution ; catalysts ; diesel engines ; electric field ; environmental technology ; volatile organic compounds ; Nonthermal plasma ; Diesel engine emission ; Regeneration of DPF ; VOCs
Language	English
Dates of publication	2023-02
Publishing place	Elsevier B.V.
Document type	Article ; Online
Note	Use and reproduction
ISSN	2352-1864
DOI	10.1016/j.eti.2023.103007
Database	NAL-Catalogue (AGRICOLA)

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Article ; Online: Single-cell data revealed exhaustion of characteristic NK cell subpopulations and T cell subpopulations in hepatocellular carcinoma.

Cui, Zhongfeng / Li, Hongzhi / Liu, Chunli / Wang, Juan / Chen, Chunguang / Hu, Shanlei / Zhao, Xiaoli / Li, Guangming

Aging

2024 Volume 16, Issue 7, Page(s) 6550–6565

Abstract: Background: The treatment and prognosis of patients with advanced hepatocellular carcinoma (HCC) have been a major medical challenge. Unraveling the landscape of tumor immune infiltrating cells (TIICs) in the immune microenvironment of HCC is of great ... ...

Abstract	Background: The treatment and prognosis of patients with advanced hepatocellular carcinoma (HCC) have been a major medical challenge. Unraveling the landscape of tumor immune infiltrating cells (TIICs) in the immune microenvironment of HCC is of great significance to probe the molecular mechanisms. Methods: Based on single-cell data of HCC, the cell landscape was revealed from the perspective of TIICs. Special cell subpopulations were determined by the expression levels of marker genes. Differential expression analysis was conducted. The activity of each subpopulation was determined based on the highly expressed genes. CTLA4+ T-cell subpopulations affecting the prognosis of HCC were determined based on survival analysis. A single-cell regulatory network inference and clustering analysis was also performed to determine the transcription factor regulatory networks in the CTLA4+ T cell subpopulations. Results: 10 cell types were identified and NK cells and T cells showed high abundance in tumor tissues. Two NK cells subpopulations were present, FGFBP2+ NK cells, B3GNT7+ NK cells. Four T cells subpopulations were present, LAG3+ T cells, CTLA4+ T cells, RCAN3+ T cells, and HPGDS+ Th2 cells. FGFBP2+ NK cells, and CTLA4+ T cells were the exhaustive subpopulation. High CTLA4+ T cells contributed to poor prognostic outcomes and promoted tumor progression. Finally, a network of transcription factors regulated by NR3C1, STAT1, and STAT3, which were activated, was present in CTLA4+ T cells. Conclusion: CTLA4+ T cell subsets in HCC exhibited functional exhaustion characteristics that probably inhibited T cell function through a transcription factor network dominated by NR3C1, STAT1, and STAT3.
MeSH term(s)	Humans ; Carcinoma, Hepatocellular/immunology ; Carcinoma, Hepatocellular/pathology ; Carcinoma, Hepatocellular/genetics ; Liver Neoplasms/immunology ; Liver Neoplasms/pathology ; Liver Neoplasms/genetics ; Single-Cell Analysis ; Killer Cells, Natural/immunology ; Killer Cells, Natural/metabolism ; Tumor Microenvironment/immunology ; CTLA-4 Antigen/metabolism ; CTLA-4 Antigen/genetics ; Lymphocytes, Tumor-Infiltrating/immunology ; Lymphocytes, Tumor-Infiltrating/metabolism ; Prognosis ; Gene Expression Regulation, Neoplastic ; T-Lymphocyte Subsets/immunology ; T-Lymphocyte Subsets/metabolism
Chemical Substances	CTLA-4 Antigen ; CTLA4 protein, human
Language	English
Publishing date	2024-04-05
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ISSN	1945-4589
ISSN (online)	1945-4589
DOI	10.18632/aging.205723
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Structure-specific nucleases in genome dynamics and strategies for targeting cancers.

Sun, Haitao / Luo, Megan / Zhou, Mian / Zheng, Li / Li, Hongzhi / Esworthy, R Steven / Shen, Binghui

Journal of molecular cell biology

2024

Abstract: Nucleases are a super family of enzymes that hydrolyze phosphodiester bonds present in genomes. They widely vary in substrates, causing differentiation in cleavage patterns and having a diversified role in maintaining genetic material. Through cellular ... ...

Abstract	Nucleases are a super family of enzymes that hydrolyze phosphodiester bonds present in genomes. They widely vary in substrates, causing differentiation in cleavage patterns and having a diversified role in maintaining genetic material. Through cellular evolution of prokaryotic to eukaryotic, nucleases become structure-specific in recognizing its own or foreign genomic DNA/RNA configurations as its substrates, including flaps, bubbles, and Holliday junctions. These special structural configurations are commonly found as intermediates in processes like DNA replication, repair, and recombination. The structure-specific nature and diversified functions make them essential to maintaining genome integrity and evolution in normal and cancer cells. In this article, we review their roles in various pathways, including Okazaki fragment maturation during DNA replication, end resection in homology-directed recombination repair of DNA double-strand breaks, DNA excision repair and apoptosis DNA fragmentation in response to exogeneous DNA damage, and HIV life cycle. As the nucleases serve as key points for the DNA dynamics, cellular apoptosis, and cancer cell survival pathways, we discuss the efforts in the field in developing the therapeutic regimens, taking advantage of recently available knowledge of their diversified structures and functions.
Language	English
Publishing date	2024-05-07
Publishing country	United States
Document type	Journal Article
ZDB-ID	2500949-7
ISSN	1759-4685 ; 1759-4685
ISSN (online)	1759-4685
ISSN	1759-4685
DOI	10.1093/jmcb/mjae019
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