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  1. Article: Agreement of intraocular pressure measurement with Corvis ST, non-contact tonometer, and Goldmann applanation tonometer in children with ocular hypertension and related factors.

    Li, Hou-Gang / Chen, Yan-Hui / Lin, Fang / Li, Si-Yu / Liu, Qing-Hua / Yin, Chun-Ge / Chen, Xi-Yue / Zhang, Xin-Jie / Qu, Yue / Hui, Yan-Nian

    International journal of ophthalmology

    2023  Volume 16, Issue 10, Page(s) 1601–1607

    Abstract: Aim: To access the agreement of intraocular pressure (IOP) values obtained from biomechanically corrected tonometer [Corvis ST (CST)], non-contact tonometer (NCT), and Goldmann applanation tonometer (GAT) in children with NCT measured-IOP (NCT-IOP) ... ...

    Abstract Aim: To access the agreement of intraocular pressure (IOP) values obtained from biomechanically corrected tonometer [Corvis ST (CST)], non-contact tonometer (NCT), and Goldmann applanation tonometer (GAT) in children with NCT measured-IOP (NCT-IOP) values of 22 mm Hg or more, and related factors.
    Methods: A total of 51 eyes with NCT-IOP≥22 mm Hg in children aged 7 to 14y were examined and IOP was measured by CST, NCT, and GAT. Based on GAT measured IOP (GAT-IOP), ocular hypertension (OHT) group (≥22 mm Hg, 24 eyes) and the non-OHT group (<22 mm Hg, 27 eyes) were defined. We compared the agreement of the three measurements,
    Results: Compared with the OHT group, thicker CCT, larger rim volume, and higher differences between NCT-IOP and GAT-IOP, were found in the non-OHT group. The differences between CST-IOP and GAT-IOP were lower than the differences between NCT-IOP and GAT-IOP in both groups. The mean differences in CST-IOP and GAT-IOP were 1.26 mm Hg (95% limit of agreement ranged from 0.1 to 2.41 mm Hg, OHT group) and 1.20 mm Hg (95% limit of agreement ranged from -0.5 to 3.00 mm Hg, non-OHT group), and the mean differences in NCT and GAT were 3.90 mm Hg (95% limit of agreement ranged from -0.19 to 9.70 mm Hg, OHT group) and 6.00 mm Hg (95% limit of agreement ranged from 1.50 to 10.50 mm Hg, non-OHT group). The differences between CST-IOP and GAT-IOP were not related to CCT, age, and AL in both groups; while the differences between NCT-IOP and GAT-IOP were related to CCT in the OHT group (
    Conclusion: The accuracy of NCT in the diagnosis of pediatric OHT is low. The agreement of CST-IOP and GAT-IOP was significantly higher in children with and without OHT than in those with NCT-IOP and GAT-IOP. Therefore, CST can be used as a good alternative for IOP measurement in children. The impacts of CCT and AL on NCT measurement need to be fully considered when managing childhood IOP.
    Language English
    Publishing date 2023-10-18
    Publishing country China
    Document type Journal Article
    ZDB-ID 2663246-9
    ISSN 2227-4898 ; 2222-3959
    ISSN (online) 2227-4898
    ISSN 2222-3959
    DOI 10.18240/ijo.2023.10.07
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Yu Gan Long Ameliorates Hepatic Fibrosis by Inhibiting PI3K/AKT, Ras/ERK and JAK1/STAT3 Signaling Pathways in CCl

    Li, Hou-Gang / You, Peng-Tao / Xia, Yu / Cai, Yu / Tu, Yi-Jun / Wang, Meng-Heng / Song, Wan-Ci / Quan, Tai-Min / Ren, Hui-Ying / Liu, Yan-Wen / Dan, Han-Xiong / Xu, Shi-Qing

    Current medical science

    2020  Volume 40, Issue 3, Page(s) 539–547

    Abstract: Yu Gan Long (YGL) is a Chinese traditional herbal formula which has been reported to attenuate liver fibrosis for many years and we have explored its anti-fibrotic mechanism through blocking transforming growth factor (TGF-β) in the previous study. But ... ...

    Abstract Yu Gan Long (YGL) is a Chinese traditional herbal formula which has been reported to attenuate liver fibrosis for many years and we have explored its anti-fibrotic mechanism through blocking transforming growth factor (TGF-β) in the previous study. But the mechanisms associated with platelet-derived growth factor (PDGF)-BB remain obscure. In this study, we further investigated the mechanism of YGL reducing carbon tetrachloride (CCl
    MeSH term(s) Animals ; Carbon Tetrachloride/pharmacology ; Cytokines/metabolism ; Disease Models, Animal ; Down-Regulation/drug effects ; Drugs, Chinese Herbal/pharmacology ; Hepatic Stellate Cells/drug effects ; Hepatic Stellate Cells/metabolism ; Inflammation/drug therapy ; Inflammation/metabolism ; Janus Kinase 1/metabolism ; Liver/drug effects ; Liver/metabolism ; Liver Cirrhosis/chemically induced ; Liver Cirrhosis/drug therapy ; Liver Cirrhosis/metabolism ; MAP Kinase Signaling System/drug effects ; Male ; Medicine, Chinese Traditional/methods ; Phosphatidylinositol 3-Kinases/metabolism ; Proto-Oncogene Proteins c-akt/metabolism ; Rats ; Rats, Sprague-Dawley ; STAT3 Transcription Factor/metabolism ; Signal Transduction/drug effects
    Chemical Substances Cytokines ; Drugs, Chinese Herbal ; STAT3 Transcription Factor ; Carbon Tetrachloride (CL2T97X0V0) ; Janus Kinase 1 (EC 2.7.10.2) ; Proto-Oncogene Proteins c-akt (EC 2.7.11.1)
    Language English
    Publishing date 2020-07-17
    Publishing country China
    Document type Journal Article
    ZDB-ID 2931065-9
    ISSN 2523-899X ; 2096-5230
    ISSN (online) 2523-899X
    ISSN 2096-5230
    DOI 10.1007/s11596-020-2211-3
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: A self-contrast approach to evaluate the inhibitory effect of chrysosplenetin, in the absence and presence of artemisinin, on the in vivo P-glycoprotein-mediated digoxin transport activity.

    Yang, Bei / Ma, Li-Ping / Ma, Wei / Wei, Shi-Jie / Ji, Hong-Yan / Li, Hou-Gang / Dang, Hong-Wan / Liu, Cheng / Wu, Xiu-Li / Chen, Jing

    Biomedical chromatography : BMC

    2016  Volume 30, Issue 10, Page(s) 1582–1590

    Abstract: In this study, we used a self-contrast method, which excluded the individual difference, to evaluate the inhibitory effect of chrysosplentin (CHR) in the presence or absence of artemisinin (ART) on the P-glycoprotein (P-gp) transport activity. A ... ...

    Abstract In this study, we used a self-contrast method, which excluded the individual difference, to evaluate the inhibitory effect of chrysosplentin (CHR) in the presence or absence of artemisinin (ART) on the P-glycoprotein (P-gp) transport activity. A sensitive and rapid UHPLC-MS/MS method was applied for quantification of digoxin, a P-gp-specific substrate, in rat plasma. A pharmacokinetic study was carried out: first after an oral administration of digoxin at a dose of 0.09 mg/kg (first period), followed by a 20-day wash-out, then after another administration of digoxin (second period). During the second period, test compounds were orally given three times per day for seven consecutive days. Results showed that the t1/2 of digoxin in all the groups had no significant difference between the first and second periods. The AUC0-24 , Cmax , tmax , and Clz /F of the negative control and ART alone groups showed no difference. However, the AUC0-24 and Cmax in the CHR alone, CHR-ART (1:2) and verapamil (positive control) groups showed 2.34-, 3.04-, 1.79-, and 1.81-, 1.99-, 2.06-fold increases along with 3.50-, 3.84- and 4.76-fold decreases for CLz /F, respectively. The tmax in the CHR-ART (1:2) group increased 3.73-fold. In conclusion, our self-contrast study suggested that CHR, especially when combined with ART in a ratio of 1:2, inhibited P-gp activity while ART alone has no effect. Copyright © 2016 John Wiley & Sons, Ltd.
    MeSH term(s) ATP Binding Cassette Transporter, Subfamily B, Member 1/metabolism ; Animals ; Area Under Curve ; Artemisinins/pharmacokinetics ; Artemisinins/pharmacology ; Biological Transport ; Chromatography, High Pressure Liquid ; Digoxin/administration & dosage ; Digoxin/metabolism ; Flavonoids/pharmacokinetics ; Flavonoids/pharmacology ; Male ; Rats ; Rats, Sprague-Dawley ; Reference Standards ; Tandem Mass Spectrometry
    Chemical Substances ATP Binding Cassette Transporter, Subfamily B, Member 1 ; Artemisinins ; Flavonoids ; chrysoplenetin ; Digoxin (73K4184T59) ; artemisinin (9RMU91N5K2)
    Language English
    Publishing date 2016-04-24
    Publishing country England
    Document type Journal Article ; Validation Study
    ZDB-ID 632848-9
    ISSN 1099-0801 ; 0269-3879
    ISSN (online) 1099-0801
    ISSN 0269-3879
    DOI 10.1002/bmc.3725
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: A new periplogenin cardenolide from the seeds of Antiaris toxicaria.

    Wu, Xiu-Li / Wu, Yu-Ling / Li, Hou-Gang / Liu, He-Tao / Fu, Xue-Yan / Cui, Rui-Qin / Wang, Jian-Huan / Liu, Cheng / Chen, Jing

    Journal of Asian natural products research

    2014  Volume 16, Issue 4, Page(s) 418–421

    Abstract: A new periplogenin cardenolide, periplogulcoside (1), together with three known cardenolides, was isolated from the seeds of Antiaris toxicaria. The structure of the new compound was characterized as periplogenin-3-O-β-D-glucopyranosyl-(1 → 4)-β-D- ... ...

    Abstract A new periplogenin cardenolide, periplogulcoside (1), together with three known cardenolides, was isolated from the seeds of Antiaris toxicaria. The structure of the new compound was characterized as periplogenin-3-O-β-D-glucopyranosyl-(1 → 4)-β-D-glucopyranoside (1) by spectroscopic methods including 1D and 2D NMR, HR-TOF-MS, and CD spectrometry, and the known compounds were identified by comparison of their NMR and HR-TOF-MS data with those reported in the literature. Compound 1 showed significant cytotoxicity against Hela and HepG-2 cell lines.
    MeSH term(s) Antiaris/chemistry ; Antineoplastic Agents, Phytogenic/chemistry ; Antineoplastic Agents, Phytogenic/isolation & purification ; Antineoplastic Agents, Phytogenic/pharmacology ; Cardenolides/chemistry ; Cardenolides/isolation & purification ; Cardenolides/pharmacology ; Drug Screening Assays, Antitumor ; Drugs, Chinese Herbal/chemistry ; Drugs, Chinese Herbal/isolation & purification ; Drugs, Chinese Herbal/pharmacology ; HeLa Cells ; Hep G2 Cells ; Humans ; Molecular Structure ; Nuclear Magnetic Resonance, Biomolecular ; Plant Extracts/chemistry ; Seeds/chemistry
    Chemical Substances Antineoplastic Agents, Phytogenic ; Cardenolides ; Drugs, Chinese Herbal ; Plant Extracts ; periplogulcoside
    Language English
    Publishing date 2014
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2077926-4
    ISSN 1477-2213 ; 1028-6020
    ISSN (online) 1477-2213
    ISSN 1028-6020
    DOI 10.1080/10286020.2014.885506
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article: new periplogenin cardenolide from the seeds of Antiaris toxicaria

    Wu, Xiu-Li / Wu, Yu-Ling / Li, Hou-Gang / Liu, He-Tao / Fu, Xue-Yan / Cui, Rui-Qin / Wang, Jian-Huan / Liu, Cheng / Chen, Jing

    Journal of Asian natural products research

    Volume v. 16,, Issue no. 4

    Abstract: A new periplogenin cardenolide, periplogulcoside (1), together with three known cardenolides, was isolated from the seeds of Antiaris toxicaria . The structure of the new compound was characterized as periplogenin-3- O -β- d -glucopyranosyl-(1 → 4)-β- d - ...

    Abstract A new periplogenin cardenolide, periplogulcoside (1), together with three known cardenolides, was isolated from the seeds of Antiaris toxicaria . The structure of the new compound was characterized as periplogenin-3- O -β- d -glucopyranosyl-(1 → 4)-β- d -glucopyranoside (1) by spectroscopic methods including 1D and 2D NMR, HR-TOF-MS, and CD spectrometry, and the known compounds were identified by comparison of their NMR and HR-TOF-MS data with those reported in the literature. Compound 1 showed significant cytotoxicity against Hela and HepG-2 cell lines.
    Keywords seeds ; cytotoxicity ; nuclear magnetic resonance spectroscopy ; cardenolides
    Language English
    Document type Article
    ISSN 1477-2213
    Database AGRIS - International Information System for the Agricultural Sciences and Technology

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