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Article ; Online: A framework for identifying priority areas through integrated eco-environmental risk assessment for a holistic watershed management approach

Li, Hualin / Zhang, Shouhong / Zhang, Jianjun / Zhang, Wenlong / Song, Zhuoyuan / Yu, Peidan / Xie, Chenxin

Ecological Indicators. 2023 Feb., v. 146 p.109919-

2023

Abstract: Identifying priority management areas (PMAs) through assessing integrated eco-environmental risk (IER) of watersheds is vital for efficient integrated watershed management (IWM). However, there is a lack of effective tools to support IWM. A novel ... ...

Abstract	Identifying priority management areas (PMAs) through assessing integrated eco-environmental risk (IER) of watersheds is vital for efficient integrated watershed management (IWM). However, there is a lack of effective tools to support IWM. A novel framework, which couples the analytical network process with the mean-square deviation decision method to quantify reciprocal feedbacks between ecosystems and socio-economic systems for assessing IER, was developed to identify PMAs for IWM through a case study in the upper Beiyun River watershed, China. The results show that water pollution, water resources, soil loss, hazards (i.e., floods, debris flows, collapses, and landslides), and vegetation degradation are noticeable environmental problems in the watershed. Water pollution, floods, and vegetation degradation risks are high in the southeast plain areas and low in the northwest mountainous areas of the watershed, while the other eco-environmental risks are opposite that of the three risks. The soil loss is mainly dominated by negligible class with a mean of 10.87 (t·km⁻²·yr⁻¹). The weights of water pollution risk and socio-economic indicator for IER are 0.2906 and 0.1837, respectively. It indicates that water pollution control is crucial for IWM, and socio-economic systems have a significant impact on IER. The PMAs, which are identified as zones with extremely high IER values, account for 6.46 % (72.91 km²) of the watershed. They are centrally distributed in the southeastern areas with high risks of both water pollution and vegetation degradation caused by large population density. The framework provides an effective tool to assess IER and identify PMAs for IWM.
Keywords	case studies ; mountains ; pollution control ; population density ; risk ; risk assessment ; rivers ; socioeconomics ; soil erosion ; vegetation ; water pollution ; watershed management ; watersheds ; China ; Integrated watershed management ; Priority management areas ; Integrated eco-environmental risk assessment framework ; Risk zoning ; Socio-economic system
Language	English
Dates of publication	2023-02
Publishing place	Elsevier Ltd
Document type	Article ; Online
Note	Use and reproduction
ZDB-ID	2036774-0
ISSN	1872-7034 ; 1470-160X
ISSN (online)	1872-7034
ISSN	1470-160X
DOI	10.1016/j.ecolind.2023.109919
Database	NAL-Catalogue (AGRICOLA)

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Article: Populus euphratica Phenology and Its Response to Climate Change in the Upper Tarim River Basin, NW China

Li, Hualin / Feng, Jianzhong / Bai, Linyan / Zhang, Jianjun

Forests. 2021 Sept. 26, v. 12, no. 10

2021

Abstract: Quantifying the phenological variations of Populus euphratica Olivier (P. euphratica) resulting from climate change is vital for desert ecosystems. There has previously been great progress in the influence of climate change on vegetation phenology, but ... ...

Abstract	Quantifying the phenological variations of Populus euphratica Olivier (P. euphratica) resulting from climate change is vital for desert ecosystems. There has previously been great progress in the influence of climate change on vegetation phenology, but knowledge of the variations in P. euphratica phenology is lacking in extremely arid areas. In this study, a modified method was proposed to explore P. euphratica phenology and its response to climate change using 18-year Global Land Surface Satellite (GLASS) leaf area index (LAI) time series data (2000–2017) in the upper Tarim River basin. The start of the growing season (SOS), length of the growing season (LOS), and end of the growing season (EOS) were obtained with the dynamic threshold method from the reconstructed growth time series curve by using the Savitzky–Golay filtering method. The grey relational analysis (GRA) method was utilized to analyze the influence between the phenology and the key climatic periods and factors. Importantly, we also revealed the positive and negative effects between interannual climate factors and P. euphratica phenology using the canonical correlation analysis (CCA) method, and the interaction between the SOS in spring and EOS in autumn. The results revealed that trends of P. euphratica phenology (i.e., SOS, EOS, and LOS) were not significant during the period from 2000–2017. The spring temperature and sunshine duration (SD) controlled the SOS, and the EOS was mainly affected by the temperature and SD from June–November, although the impacts of average relative humidity (RH) and precipitation (PR) on the SOS and EOS cannot be overlooked. Global warming may lead to SOS advance and EOS delay, and the increase in SD and PR may lead to earlier SOS and later EOS. Runoff was found to be a more key factor for controlling P. euphratica phenology than PR in this region.
Keywords	Populus euphratica ; autumn ; leaf area index ; multivariate analysis ; phenology ; relative humidity ; runoff ; satellites ; solar radiation ; spring ; temperature ; time series analysis ; watersheds ; China
Language	English
Dates of publication	2021-0926
Publishing place	Multidisciplinary Digital Publishing Institute
Document type	Article
ZDB-ID	2527081-3
ISSN	1999-4907
ISSN	1999-4907
DOI	10.3390/f12101315
Database	NAL-Catalogue (AGRICOLA)

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Article: Dietary Cholesterol Supplements Disturb Copper Homeostasis in Multiple Organs in Rabbits: Aorta Copper Concentrations Negatively Correlate with the Severity of Atherosclerotic Lesions

Li, Hualin / Zhao, Lijun / Wang, Tao / James Kang, Y.

Biological trace element research. 2022 Jan., v. 200, no. 1

2022

Abstract: Dietary cholesterol causes atherosclerosis along with a reduction of copper concentrations in the atherosclerosis wall. This study was to determine the relationship between aorta copper concentrations and the severity of atherosclerotic lesions as well ... ...

Abstract	Dietary cholesterol causes atherosclerosis along with a reduction of copper concentrations in the atherosclerosis wall. This study was to determine the relationship between aorta copper concentrations and the severity of atherosclerotic lesions as well as copper homeostasis in multiple organs in cholesterol-fed rabbits. Male New Zealand white rabbits, 10-week-old and averaged 2.0 kg, were fed a diet containing 1% (w/w) cholesterol or the same diet without cholesterol as controls. Twelve weeks after the feeding, aortic atherosclerotic lesions, serum cholesterol, and multiple organ copper concentrations were measured. Compared to controls, rabbits fed cholesterol-supplemented diet displayed higher serum cholesterol levels and developed atherosclerosis. Copper concentrations in the cholesterol-fed rabbits were increased in the serum and kidney but decreased in the atherosclerosis wall and multiple organs, including heart, liver, spleen, and lung. Furthermore, aorta copper concentrations negatively correlated, respectively, with the severity of the atherosclerotic lesion (r = − 0.64, p = 0.01), the microscope atherosclerotic lesion area (r = − 0.60, p = 0.02), and the stenosis of the lumen (r = − 0.54, p = 0.04). Dietary cholesterol not only causes atherosclerosis but also disturbs copper homeostasis in multiple organ systems. The negative correlation between aorta copper concentrations and the severity of atherosclerotic lesions suggests a vicious cycle between copper reduction and the pathogenesis of atherosclerosis. These changes in copper homeostasis would be additive to atherosclerosis as a risk factor for cardiovascular disease in humans.
Keywords	aorta ; atherosclerosis ; blood serum ; cholesterol ; diet ; heart ; homeostasis ; kidneys ; liver ; lungs ; males ; pathogenesis ; research ; risk factors ; spleen
Language	English
Dates of publication	2022-01
Size	p. 164-171.
Publishing place	Springer US
Document type	Article
ZDB-ID	445336-0
ISSN	1559-0720 ; 0163-4984
ISSN (online)	1559-0720
ISSN	0163-4984
DOI	10.1007/s12011-021-02618-0
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Article: A framework to assess spatio-temporal variations of potential non-point source pollution risk for future land-use planning

Li, Hualin / Zhang, Jianjun / Zhang, Shouhong / Zhang, Wenlong / Zhang, Sunxun / Yu, Peidan / Song, Zhuoyuan

Ecological indicators. 2022 Apr., v. 137

2022

Abstract: Quantifying spatio-temporal variations of non-point source pollution (NSP) risk induced by land-use change provides insights into effective control of NSP through land-use optimization. However, there is a lack of efficient tools for assessing the ... ...

Abstract	Quantifying spatio-temporal variations of non-point source pollution (NSP) risk induced by land-use change provides insights into effective control of NSP through land-use optimization. However, there is a lack of efficient tools for assessing the variations of NSP risk under various land-use change scenarios. In this study, a framework, which couples the modified potential non-point pollution indicator (PNPI) model with the future land-use simulation (FLUS) model, was developed and applied for assessing the spatio-temporal variations of NSP risk caused by both historical and possible future land-use change in a rapidly urbanized basin (i.e., the upper Beiyun River basin, Beijing) during 1980–2030. The PNPI model is tested with monitored water quality data with an accuracy ratio of 0.75, and the FLUS model can accurately simulate land-use change in the basin (Kappa coefficient = 0.74). Due to rapid urbanization, the area of extremely high-risk zones of NSP went up, even though the area of farmlands decreased, and the area of green spaces increased during 1980–2020. The spatio-temporal variations of NSP risk are different in 2020–2030 under different land-use change scenarios. The ecological security scenario will slow down the growth rate of NSP risk, however, the total area of the extremely high-risk and high-risk zones will increase by 40.17 km² in 2030 under the rapid urbanization scenario. Coupling the modified PNPI model with the FLUS model provides an efficient tool set to support future land-use planning for NSP control and to assess spatio-temporal variations of NSP risk caused by both historical and future land-use change in data-limited regions.
Keywords	basins ; land use change ; models ; nonpoint source pollution ; risk ; urbanization ; water quality ; watersheds ; China
Language	English
Dates of publication	2022-04
Publishing place	Elsevier Ltd
Document type	Article
ZDB-ID	2036774-0
ISSN	1872-7034 ; 1470-160X
ISSN (online)	1872-7034
ISSN	1470-160X
DOI	10.1016/j.ecolind.2022.108751
Database	NAL-Catalogue (AGRICOLA)

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Article: Toughness Behavior of SBR Acrylate Copolymer-Modified Pervious Concrete with Single-Sized Aggregates.

Zhao, Chaohua / Li, Hualin / Peng, Yi / Jia, Xiaoyao / Rahman, Ali

Materials (Basel, Switzerland)

2021 Volume 14, Issue 17

Abstract: Pervious concrete is an eco-efficient concrete but has problems regarding its mechanical performance and permeability balance. This research investigated the feasibility of using a combination of styrene-butadiene rubber (SBR) and acrylate polymer to ... ...

Abstract	Pervious concrete is an eco-efficient concrete but has problems regarding its mechanical performance and permeability balance. This research investigated the feasibility of using a combination of styrene-butadiene rubber (SBR) and acrylate polymer to improve the toughness of pervious concrete while keeping its permeability. Single-sized aggregate and no sand were considered in the concrete mixture. Acrylate polymers with different solid content, PH, density, and viscosity were emulsion copolymerized with an SBR polymer. Eleven scenarios with different mix proportions and 220 specimens for compressive strength, flexural strength, flexural stiffness, impact resistance, and fracture toughness tests were selected to evaluate the effects of the copolymer on the toughness of copolymer-modified pervious concrete (CMPC). The studies showed that (1) the influence trend of the copolymers generally varied according to different mechanical indexes; (2) XG-6001 acrylate polymer mainly and comprehensively enhanced the toughness of the CMPC; (3) it was difficult to increase the enhancing property of the XG-6001 acrylate polymer with the growth of its mix proportion; (4) the zero-sand pervious concrete with 90% SBR and 10% XG-6001 acrylate emulsion copolymerization proved to have relatively high toughness. The proposed CMPC holds promising application value in sustainability traffic road construction.
Language	English
Publishing date	2021-09-06
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2487261-1
ISSN	1996-1944
ISSN	1996-1944
DOI	10.3390/ma14175089
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article: Mechanical Performance of Single-Graded Copolymer-Modified Pervious Concrete in a Corrosive Environment.

Zhao, Chaohua / Jia, Xiaoyao / Yi, Zhijian / Li, Hualin / Peng, Yi

Materials (Basel, Switzerland)

2021 Volume 14, Issue 23

Abstract: Polymer-modified cement has found numerous applications due to its excellent tensile strength. When cement was modified with a single polymer, its tensile strength and performance marginally increased. However, when a small amount of the flexible polymer ...

Abstract	Polymer-modified cement has found numerous applications due to its excellent tensile strength. When cement was modified with a single polymer, its tensile strength and performance marginally increased. However, when a small amount of the flexible polymer latex was added to cement, the mechanical performance of cement considerably improved. In this study, single-graded copolymer-modified pervious concrete was prepared by mixing styrene-butadiene rubber (SBR) with different acrylate polymers, and its mechanical performance and durability were systematically studied through mechanical tests and theoretical analyses. The main findings are as follows: (1) When a waterborne emulsion was added, the freeze resistance of cement concrete increased, and its mass loss rate decreased. Cement concrete with two latexes had higher sulphate corrosion resistance and substantially lower dry shrinkage strain than ordinary cement concrete. (2) Through scanning electron microscopy, the microstructural changes in the cement binder, ordinary polymer-modified concrete, and the copolymer-modified cement concrete used in this study were observed, and the findings were compared with those reported in the literature. (3) Single-graded copolymer-modified pervious concrete exhibited excellent shrinkage performance. This study showed that single-graded copolymer-modified pervious concrete satisfied the performance requirements for use as a paving material for special cases.
Language	English
Publishing date	2021-11-29
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2487261-1
ISSN	1996-1944
ISSN	1996-1944
DOI	10.3390/ma14237304
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Dietary Cholesterol Supplements Disturb Copper Homeostasis in Multiple Organs in Rabbits: Aorta Copper Concentrations Negatively Correlate with the Severity of Atherosclerotic Lesions.

Li, Hualin / Zhao, Lijun / Wang, Tao / James Kang, Y

Biological trace element research

2021 Volume 200, Issue 1, Page(s) 164–171

Abstract	Dietary cholesterol causes atherosclerosis along with a reduction of copper concentrations in the atherosclerosis wall. This study was to determine the relationship between aorta copper concentrations and the severity of atherosclerotic lesions as well as copper homeostasis in multiple organs in cholesterol-fed rabbits. Male New Zealand white rabbits, 10-week-old and averaged 2.0 kg, were fed a diet containing 1% (w/w) cholesterol or the same diet without cholesterol as controls. Twelve weeks after the feeding, aortic atherosclerotic lesions, serum cholesterol, and multiple organ copper concentrations were measured. Compared to controls, rabbits fed cholesterol-supplemented diet displayed higher serum cholesterol levels and developed atherosclerosis. Copper concentrations in the cholesterol-fed rabbits were increased in the serum and kidney but decreased in the atherosclerosis wall and multiple organs, including heart, liver, spleen, and lung. Furthermore, aorta copper concentrations negatively correlated, respectively, with the severity of the atherosclerotic lesion (r = - 0.64, p = 0.01), the microscope atherosclerotic lesion area (r = - 0.60, p = 0.02), and the stenosis of the lumen (r = - 0.54, p = 0.04). Dietary cholesterol not only causes atherosclerosis but also disturbs copper homeostasis in multiple organ systems. The negative correlation between aorta copper concentrations and the severity of atherosclerotic lesions suggests a vicious cycle between copper reduction and the pathogenesis of atherosclerosis. These changes in copper homeostasis would be additive to atherosclerosis as a risk factor for cardiovascular disease in humans.
MeSH term(s)	Animals ; Aorta ; Atherosclerosis/chemically induced ; Cholesterol, Dietary ; Copper ; Homeostasis ; Male ; Rabbits
Chemical Substances	Cholesterol, Dietary ; Copper (789U1901C5)
Language	English
Publishing date	2021-03-04
Publishing country	United States
Document type	Journal Article
ZDB-ID	445336-0
ISSN	1559-0720 ; 0163-4984
ISSN (online)	1559-0720
ISSN	0163-4984
DOI	10.1007/s12011-021-02618-0
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Development of a Deep Learning Model for Diagnosing Lumbar Spinal Stenosis Based on CT Images.

Li, Kai-Yu / Weng, Jun-Jie / Li, Hua-Lin / Ye, Hao-Bo / Xiang, Jian-Wei / Tian, Nai-Feng

Spine

2023

Abstract: Study design: Retrospective study.: Objectives: This study aimed to develop an initial deep learning model based on CT scans for diagnosing lumbar spinal stenosis.: Summary of background data: MRI is commonly used for diagnosing lumbar spinal ... ...

Abstract	Study design: Retrospective study. Objectives: This study aimed to develop an initial deep learning model based on CT scans for diagnosing lumbar spinal stenosis. Summary of background data: MRI is commonly used for diagnosing lumbar spinal stenosis due to its high soft tissue resolution, but CT is more portable, cost-effective, and has wider regional coverage. Using deep learning models to improve the accuracy of CT diagnosis can effectively reduce missed diagnoses and misdiagnoses in clinical practice. Methods: Axial lumbar spine CT scans obtained between March 2022 and September 2023 were included. The dataset was divided into a training set (62.3%), a validation set (22.9%), and a control set (14.8%). All data were labeled by two spine surgeons using the widely accepted grading system for lumbar spinal stenosis. The training and validation sets were used to annotate the ROIs by the two spine surgeons. First, an ROI detection model and a CNN classifier were trained using the training set. After training, the model was preliminarily evaluated using a validation set. Finally, the performance of the deep learning model was evaluated on the control set, and a comparison was made between the model and classification performance of specialists with varying levels of experience. Results: The central stenosis grading accuracies of DL Model Version 1 and DL Model Version 2 were 88% and 83%, respectively. The lateral recess grading accuracies of DL Model Version 1 and DL Model Version 2 were 75% and 71%, respectively. Conclusions: Our preliminarily developed deep learning system for assessing the degree of lumbar spinal stenosis in CT, including the central canal and lateral recess, has shown similar accuracy to experienced specialist physicians. This holds great value for further development and clinical application.
Language	English
Publishing date	2023-12-19
Publishing country	United States
Document type	Journal Article
ZDB-ID	752024-4
ISSN	1528-1159 ; 0362-2436
ISSN (online)	1528-1159
ISSN	0362-2436
DOI	10.1097/BRS.0000000000004903
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Article: [Estimation and Critical Source Area Identification of Non-point Source Pollution Based on Improved Export Coefficient Models: A Case Study of the Upper Beiyun River Basin].

Li, Hua-Lin / Zhang, Shou-Hong / Yu, Pei-Dan / Song, Zhuo-Yuan / Xie, Chen-Xin / Zhang, Jian-Jun

Huan jing ke xue= Huanjing kexue

2023 Volume 44, Issue 11, Page(s) 6194–6204

Abstract: Non-point source pollution(NSP) poses a great threat to water ecosystem health. The quantitative estimation of spatial distribution characteristics and accurate identification of critical source areas(CSAs) of NSP are the basis for its efficient and ... ...

Abstract	Non-point source pollution(NSP) poses a great threat to water ecosystem health. The quantitative estimation of spatial distribution characteristics and accurate identification of critical source areas(CSAs) of NSP are the basis for its efficient and accurate control. The export coefficient model(ECM) has been widely used to assess NSP, but this model should be improved because it ignores pollutant loss in transport processes. In this study, the ECM, which refines the physical transport processes of pollutants through quantifying the loss rate of pollutants in runoff, sediment, and infiltration, was improved to assess NSP and identify CSAs. The simulation accuracy among Johnes ECM, frequent ECM, and improved ECM were analyzed, and the effects of the three models on the simulation results of both spatial distribution characteristics and CSAs were explored. The study showed that:① the simulation error of the improved ECM(-6.79%) was significantly lower than that of the Johnes ECM(50.44%) and the frequent ECM(-84.01%), and this improved ECM increased the simulation accuracy of NSP. ② The spatial distribution characteristics and CSAs of NSP obtained from Johnes, frequent, and improved ECMs were significantly different, and the simulation results of improved ECM were more consistent with the spatial characteristics of NSP in the watershed. The NSP was high in the southeast and low in the northwest of the basin, and the NSP mainly came from urban and cultivated land. ③ Based on the improved ECM, the CSAs of NSP in the basin were mainly distributed in Changping, Shahe, Shigezhuang, the north of Wenquan, and the west of Malianwa Street, accounting for 6.71% of the area. This study can provide an effective tool and scientific reference for the assessment and control of NSP in data-limited regions.
Language	Chinese
Publishing date	2023-11-16
Publishing country	China
Document type	English Abstract ; Journal Article
ISSN	0250-3301
ISSN	0250-3301
DOI	10.13227/j.hjkx.202211321
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Development and qualification of cell-based relative potency assay for a human respiratory syncytial virus (RSV) mRNA vaccine.

Li, Hualin Helen / Xu, Jenny / He, Li / Denny, Lynne Ireland / Rustandi, Richard R / Dornadula, Geethanjali / Fiorito, Brock / Zhang, Zhi-Qiang

Journal of pharmaceutical and biomedical analysis

2023 Volume 234, Page(s) 115523

Abstract: Respiratory syncytial virus (RSV) is a leading cause of severe lower respiratory tract infections worldwide. A safe and effective RSV vaccine has been an elusive goal but recent advances in vaccine technology have improved the likelihood that a vaccine ... ...

Abstract	Respiratory syncytial virus (RSV) is a leading cause of severe lower respiratory tract infections worldwide. A safe and effective RSV vaccine has been an elusive goal but recent advances in vaccine technology have improved the likelihood that a vaccine for the prevention of RSV could be licensed in near future. We have developed an RSV vaccine V171 consisting of four lipids and messenger ribonucleic acid (mRNA) encoding an engineered form of the RSV F protein stabilized in its prefusion conformation. The lipids form lipid nanoparticles (LNP) with mRNA encapsulated during process, which protects the mRNA from degradation and enables the mRNA to be delivered into mammalian cells. Once inside the cells, the mRNA then can be translated into RSV F protein and elicit both humoral and cellular immune responses. Preclinical results and Phase I clinical trial results indicate that this mRNA vaccine targeting RSV F protein is a promising RSV vaccine approach and should be further evaluated in clinical trials. We have developed a cell-based relative potency assay to support the Phase II development of this vaccine. Test articles and a reference standard are tested with serial dilutions in a 96-well plate pre-seeded with Hep G2 cells. Cells were incubated for 16-18 h after transfection and then permeabilized and stained with a human monoclonal antibody specific to RSV F protein, followed by a fluorophore-conjugated secondary antibody. The plate is then analyzed for percentage of transfected cells and relative potency of the test article is calculated by comparing its EC
MeSH term(s)	Animals ; Humans ; Respiratory Syncytial Virus, Human/genetics ; Respiratory Syncytial Virus Infections/prevention & control ; Antibodies, Neutralizing ; Antibodies, Viral ; Respiratory Syncytial Virus Vaccines/genetics ; RNA, Messenger/genetics ; Lipids ; Mammals/genetics ; mRNA Vaccines
Chemical Substances	Antibodies, Neutralizing ; Antibodies, Viral ; Respiratory Syncytial Virus Vaccines ; RNA, Messenger ; Lipids
Language	English
Publishing date	2023-06-11
Publishing country	England
Document type	Journal Article
ZDB-ID	604917-5
ISSN	1873-264X ; 0731-7085
ISSN (online)	1873-264X
ISSN	0731-7085
DOI	10.1016/j.jpba.2023.115523
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