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Article ; Online: Effects of Anthraquinones on Immune Responses and Inflammatory Diseases.

Xin, Dandan / Li, Huhu / Zhou, Shiyue / Zhong, Hao / Pu, Weiling

2022 Volume 27, Issue 12

Abstract: The anthraquinones (AQs) and derivatives are widely distributed in nature, including plants, fungi, and insects, with effects of anti-inflammation and anti-oxidation, antibacterial and antiviral, anti-osteoporosis, anti-tumor, etc. Inflammation, ... ...

Abstract	The anthraquinones (AQs) and derivatives are widely distributed in nature, including plants, fungi, and insects, with effects of anti-inflammation and anti-oxidation, antibacterial and antiviral, anti-osteoporosis, anti-tumor, etc. Inflammation, including acute and chronic, is a comprehensive response to foreign pathogens under a variety of physiological and pathological processes. AQs could attenuate symptoms and tissue damages through anti-inflammatory or immuno-modulatory effects. The review aims to provide a scientific summary of AQs on immune responses under different pathological conditions, such as digestive diseases, respiratory diseases, central nervous system diseases, etc. It is hoped that the present paper will provide ideas for future studies of the immuno-regulatory effect of AQs and the therapeutic potential for drug development and clinical use of AQs and derivatives.
MeSH term(s)	Allergens ; Anthraquinones/pharmacology ; Anti-Inflammatory Agents/pharmacology ; Anti-Inflammatory Agents/therapeutic use ; Immunity ; Oxidation-Reduction
Chemical Substances	Allergens ; Anthraquinones ; Anti-Inflammatory Agents
Language	English
Publishing date	2022-06-14
Publishing country	Switzerland
Document type	Journal Article ; Review
ZDB-ID	1413402-0
ISSN	1420-3049 ; 1431-5165 ; 1420-3049
ISSN (online)	1420-3049
ISSN	1431-5165 ; 1420-3049
DOI	10.3390/molecules27123831
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Article ; Online: Crosstalk between intestinal flora and human iron metabolism: the role in metabolic syndrome-related comorbidities and its potential clinical application.

Yan, Yijing / Zhang, Wenlan / Wang, Yulin / Yi, Chunmei / Yu, Bin / Pang, Xiaoli / Li, Kunyang / Li, HuHu / Dai, Yongna

Microbiological research

2024 Volume 282, Page(s) 127667

Abstract: The interaction of iron and intestinal flora, both of which play crucial roles in many physiologic processes, is involved in the development of Metabolic syndrome (MetS). MetS is a pathologic condition represented by insulin resistance, obesity, ... ...

Abstract	The interaction of iron and intestinal flora, both of which play crucial roles in many physiologic processes, is involved in the development of Metabolic syndrome (MetS). MetS is a pathologic condition represented by insulin resistance, obesity, dyslipidemia, and hypertension. MetS-related comorbidities including type 2 diabetes mellitus (T2DM), obesity, metabolism-related fatty liver (MAFLD), hypertension polycystic ovary syndrome (PCOS), and so forth. In this review, we examine the interplay between intestinal flora and human iron metabolism and its underlying mechanism in the pathogenesis of MetS-related comorbidities. The composition and metabolites of intestinal flora regulate the level of human iron by modulating intestinal iron absorption, the factors associated with iron metabolism. On the other hand, the iron level also affects the abundance, composition, and metabolism of intestinal flora. The crosstalk between these factors is of significant importance in human metabolism and exerts varying degrees of influence on the manifestation and progression of MetS-related comorbidities. The findings derived from these studies can enhance our comprehension of the interplay between intestinal flora and iron metabolism, and open up novel potential therapeutic approaches toward MetS-related comorbidities.
MeSH term(s)	Female ; Humans ; Metabolic Syndrome/complications ; Metabolic Syndrome/metabolism ; Diabetes Mellitus, Type 2/complications ; Diabetes Mellitus, Type 2/metabolism ; Gastrointestinal Microbiome ; Obesity/complications ; Obesity/metabolism ; Iron/metabolism ; Hypertension/complications
Chemical Substances	Iron (E1UOL152H7)
Language	English
Publishing date	2024-03-01
Publishing country	Germany
Document type	Journal Article ; Review
ZDB-ID	1189614-0
ISSN	1618-0623 ; 0944-5013
ISSN (online)	1618-0623
ISSN	0944-5013
DOI	10.1016/j.micres.2024.127667
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Article: Comprehensive analysis of m6A regulator-based methylation modification patterns characterized by distinct immune profiles in colon adenocarcinomas

Liu, Tao / Li, Huhu / Du, Gang / Ma, Jun / Shen, Junpeng / Zhao, Haoliang / Luo, Fei / Li, Huiyu

Gene. 2022 May 05, v. 821

2022

Abstract: Mounting evidences have indicated that RNA N⁶-methyladenosine (m⁶A) modification played important roles in tumor formation and growth. However, it is rarely reported that m⁶A modifications are involved in the immune regulation and tumor microenvironment ( ...

Abstract	Mounting evidences have indicated that RNA N⁶-methyladenosine (m⁶A) modification played important roles in tumor formation and growth. However, it is rarely reported that m⁶A modifications are involved in the immune regulation and tumor microenvironment (TME) formation. In this study, we aimed to investigate the correlation between m⁶A modifications and TME regulation of colon adenocarcinoma (COAD) by bioinformatic analysis. NMF algorithm was applied to carry out consensus molecular subtype analysis on 36 selected m⁶A regulators regarding methylation modification, to identify m⁶A modification patterns and characteristics of m⁶A related genes in colon adenocarcinoma (COAD). Further, the relative infiltration levels of different immune cell subsets were quantified by ssGSEA and CIBERSORT algorithms, and a m⁶Sig scoring scheme was constructed to predict the prognosis and evaluate the response to immunotherapy in the patients with COAD. Among 579 COAD samples, we identified three different m⁶A modification patterns which were related to different biological pathways and clinical outcomes. Then, a scoring scheme termed “m⁶Sig score” was developed based on m⁶A-related characteristic genes, and was utilized to score patients with COAD into groups. We found that COAD patients with lower m⁶Sig scores exhibited prolonged survival and potentiated immune infiltration, which were associated with higher tumor mutation load, lower PD-L1 expression, and higher mutation rates of SMG (such as TTN and KRAS). Moreover, analysis regarding evaluation of immune response revealed that the patients with lower m⁶Sig scores had higher Immunophenoscore. Collectively, our study provided in depth insight into the interactions between m⁶A modification and regulation of TME. In addition, the quantitative evaluation of m⁶A modification patterns in our results may have implications in further immunotherapy for individual COAD patients.
Keywords	RNA ; adenocarcinoma ; algorithms ; bioinformatics ; colon ; genes ; immune response ; immunotherapy ; methylation ; mutation ; prognosis ; quantitative analysis
Language	English
Dates of publication	2022-0505
Publishing place	Elsevier B.V.
Document type	Article
ZDB-ID	391792-7
ISSN	1879-0038 ; 0378-1119
ISSN (online)	1879-0038
ISSN	0378-1119
DOI	10.1016/j.gene.2022.146250
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Article ; Online: Apoptosis detection: a purpose-dependent approach selection.

Guo, Maojuan / Lu, Bin / Gan, Jiali / Wang, Shuangcui / Jiang, Xijuan / Li, Huhu

Cell cycle (Georgetown, Tex.)

2021 Volume 20, Issue 11, Page(s) 1033–1040

Abstract: Apoptosis is closely associated with many diseases. Detection of apoptosis can be achieved by morphology, biochemistry, molecular biology, immunology, and other techniques. However, as technologies are increasingly used for the detection of apoptosis, ... ...

Abstract	Apoptosis is closely associated with many diseases. Detection of apoptosis can be achieved by morphology, biochemistry, molecular biology, immunology, and other techniques. However, as technologies are increasingly used for the detection of apoptosis, many researchers are confused about how to choose a suitable method to detect apoptosis. Selection of a suitable detection method for apoptosis will help clinical diagnosis and prevention of diseases. This article reviews the selection of optimal apoptosis-detection methods based on research purposes and technique principles.
MeSH term(s)	Animals ; Apoptosis/physiology ; Calcium/metabolism ; Cell Membrane/chemistry ; Cell Membrane/physiology ; Cell Nucleus/chemistry ; Cell Nucleus/physiology ; Cytoplasm/chemistry ; Cytoplasm/physiology ; Humans ; Microscopy, Fluorescence/methods ; Signal Transduction/physiology
Chemical Substances	Calcium (SY7Q814VUP)
Language	English
Publishing date	2021-05-18
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't ; Review
ZDB-ID	2146183-1
ISSN	1551-4005 ; 1538-4101 ; 1554-8627
ISSN (online)	1551-4005
ISSN	1538-4101 ; 1554-8627
DOI	10.1080/15384101.2021.1919830
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Zs.A 5881: Show issues

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Article ; Online: Focus on the role of mitochondria in NLRP3 inflammasome activation: A prospective target for the treatment of ischemic stroke (Review).

Zhang, Xiaolu / Zeng, Wenyun / Zhang, Yue / Yu, Qun / Zeng, Miao / Gan, Jiali / Zhang, Wenlan / Jiang, Xijuan / Li, Huhu

International journal of molecular medicine

2022 Volume 49, Issue 6

Abstract: Post‑ischemic neuroinflammation induced by the innate local immune response is a major pathophysiological feature of cerebral ischemic stroke, which remains the leading cause of mortality and disability worldwide. NLR family pyrin domain containing (NLRP) ...

Abstract	Post‑ischemic neuroinflammation induced by the innate local immune response is a major pathophysiological feature of cerebral ischemic stroke, which remains the leading cause of mortality and disability worldwide. NLR family pyrin domain containing (NLRP)3 inflammasome crucially mediates post‑ischemic inflammatory responses via its priming, activation and interleukin‑1β release during hypoxic‑ischemic brain damage. Mitochondrial dysfunctions are among the main hallmarks of several brain diseases, including ischemic stroke. In the present review, focus was addressed on the role of mitochondria in cerebral ischemic stroke while keeping NLRP3 inflammasome as a link. Under ischemia and hypoxia, mitochondria are capable of controlling NLRP3 inflammasome‑mediated neuroinflammation through mitochondrial released contents, mitochondrial localization and mitochondrial related proteins. Thus, inflammasome and mitochondria may be attractive targets to treat ischemic stroke as well as the several drugs that target the process of mitochondrial function to treat cerebral ischemic stroke. At present, certain drugs have already been studied in clinical trials.
MeSH term(s)	Humans ; Inflammasomes/metabolism ; Ischemic Stroke ; Mitochondria/metabolism ; NLR Family, Pyrin Domain-Containing 3 Protein/metabolism ; Prospective Studies ; Stroke/metabolism
Chemical Substances	Inflammasomes ; NLR Family, Pyrin Domain-Containing 3 Protein
Language	English
Publishing date	2022-04-08
Publishing country	Greece
Document type	Journal Article ; Review
ZDB-ID	1444428-8
ISSN	1791-244X ; 1107-3756
ISSN (online)	1791-244X
ISSN	1107-3756
DOI	10.3892/ijmm.2022.5130
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Article ; Online: Detection Rate and Prognosis of Lymph Nodes in Gastric Cancer Using Nano Carbon Combined with

Ma, Jun / Ren, Chongren / Du, Gang / Wang, Jinxi / Han, Zhenguo / Li, Huhu / Li, Huiyu / Xue, Liang

publication RETRACTED

Computational intelligence and neuroscience

2022 Volume 2022, Page(s) 4540176

Abstract: In this study, we are going to investigate the effect of nano carbon combined ... ...

Abstract	In this study, we are going to investigate the effect of nano carbon combined with
MeSH term(s)	Humans ; Lymph Node Excision/methods ; Lymph Nodes/pathology ; Neoplasm Staging ; Retrospective Studies ; Stomach Neoplasms/diagnosis ; Stomach Neoplasms/surgery
Language	English
Publishing date	2022-08-23
Publishing country	United States
Document type	Journal Article ; Retracted Publication
ZDB-ID	2388208-6
ISSN	1687-5273 ; 1687-5273
ISSN (online)	1687-5273
ISSN	1687-5273
DOI	10.1155/2022/4540176
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Article ; Online: Comprehensive analysis of m

Liu, Tao / Li, Huhu / Du, Gang / Ma, Jun / Shen, Junpeng / Zhao, Haoliang / Luo, Fei / Li, Huiyu

Gene

2022 Volume 821, Page(s) 146250

Abstract: Mounting evidences have indicated that RNA ... ...

Abstract	Mounting evidences have indicated that RNA N
MeSH term(s)	Adenosine/analogs & derivatives ; Adenosine/metabolism ; Algorithms ; B7-H1 Antigen/genetics ; Colonic Neoplasms/drug therapy ; Colonic Neoplasms/genetics ; Colonic Neoplasms/immunology ; Computational Biology/methods ; Connectin/genetics ; DNA Methylation ; Databases, Genetic ; Gene Expression Regulation, Neoplastic ; Gene Regulatory Networks ; Humans ; Immunotherapy ; Prognosis ; Proto-Oncogene Proteins p21(ras)/genetics ; Survival Analysis ; Tumor Microenvironment
Chemical Substances	B7-H1 Antigen ; CD274 protein, human ; Connectin ; KRAS protein, human ; TTN protein, human ; N-methyladenosine (CLE6G00625) ; Proto-Oncogene Proteins p21(ras) (EC 3.6.5.2) ; Adenosine (K72T3FS567)
Language	English
Publishing date	2022-02-10
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	391792-7
ISSN	1879-0038 ; 0378-1119
ISSN (online)	1879-0038
ISSN	0378-1119
DOI	10.1016/j.gene.2022.146250
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Zs.A 1357: Show issues

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Article ; Online: Sodium Danshensu ameliorates cerebral ischemia/reperfusion injury by inhibiting CLIC4/NLRP3 inflammasome-mediated endothelial cell pyroptosis.

Zhang, Xiaolu / Yang, Qiuyue / Zhang, Ruifeng / Zhang, Yilin / Zeng, Wenyun / Yu, Qun / Zeng, Miao / Gan, Jiali / Li, Huhu / Yang, Lin / Gao, Qing / Jiang, Xijuan

BioFactors (Oxford, England)

2023 Volume 50, Issue 1, Page(s) 74–88

Abstract: Endothelial pyroptosis promotes cerebral ischemia/reperfusion injury (CIRI). Sodium Danshensu (SDSS) has been shown to attenuate CIRI and have anti-inflammatory properties in endothelial cells. However, the mechanism and effect of SDSS on alleviating ... ...

Abstract	Endothelial pyroptosis promotes cerebral ischemia/reperfusion injury (CIRI). Sodium Danshensu (SDSS) has been shown to attenuate CIRI and have anti-inflammatory properties in endothelial cells. However, the mechanism and effect of SDSS on alleviating endothelial pyroptosis after CIRI remains poorly understood. Thus, we aimed to investigate the efficacy and mechanism of SDSS in reducing endothelial pyroptosis. It has been shown that SDSS administration inhibited NLRP3 inflammasome-mediated pyroptosis. As demonstrated by protein microarrays, molecular docking, CETSA and ITDRF
MeSH term(s)	Humans ; Inflammasomes ; NLR Family, Pyrin Domain-Containing 3 Protein/genetics ; NLR Family, Pyrin Domain-Containing 3 Protein/metabolism ; Pyroptosis ; Endothelial Cells/metabolism ; Molecular Docking Simulation ; Reperfusion Injury/drug therapy ; Reperfusion Injury/genetics ; Reperfusion Injury/metabolism ; Brain Ischemia/drug therapy ; Brain Ischemia/genetics ; Chloride Channels/genetics ; Chloride Channels/pharmacology ; Lactates
Chemical Substances	Inflammasomes ; NLR Family, Pyrin Domain-Containing 3 Protein ; 3,4-dihydroxyphenyllactic acid (4GF33A5PAJ) ; CLIC4 protein, human ; Chloride Channels ; Lactates
Language	English
Publishing date	2023-07-17
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	59230-4
ISSN	1872-8081 ; 0951-6433
ISSN (online)	1872-8081
ISSN	0951-6433
DOI	10.1002/biof.1991
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Article ; Online: Jia-Wei-Kai-Xin-San Treatment Alleviated Mild Cognitive Impairment through Anti-Inflammatory and Antiapoptotic Mechanisms in SAMP8 Mice.

Zhang, Xiaolu / Sun, Yingxin / Yu, Qun / Zeng, Wenyun / Zhang, Yue / Zeng, Miao / Pang, Kexin / Yu, Yifei / Gan, Jiali / Li, Huhu / Yang, Lin / Jiang, Xijuan

Mediators of inflammation

2023 Volume 2023, Page(s) 7807302

Abstract: Background: Alleviating mild cognitive impairment (MCI) is crucial to delay the progression of Alzheimer's disease (AD). Jia-Wei-Kai-Xin-San (JWKXS) is applied for treating AD with MCI. However, the mechanism of JWKXS in the treatment of MCI is unclear. ...

Abstract	Background: Alleviating mild cognitive impairment (MCI) is crucial to delay the progression of Alzheimer's disease (AD). Jia-Wei-Kai-Xin-San (JWKXS) is applied for treating AD with MCI. However, the mechanism of JWKXS in the treatment of MCI is unclear. Thus, this study aimed to investigate the effect and mechanism of JWKXS in SAMP8 mice models of MCI. Methods: MCI models were established to examine learning and memory ability and explore the pathomechanisms in brain of SAMP8 mice at 4, 6, and 8 months. The mice were treated for 8 weeks and the effects of JWKXS on MCI were characterized through Morris water maze and HE/Nissl's/immunohistochemical staining. Its mechanism was predicted by the combination of UPLC-Q-TOF/MS and system pharmacology analysis, further verified with SAMP8 mice, BV2 microglial cells, and PC12 cells. Results: It was found that 4-month-old SAMP8 mice exhibited MCI. Two months of JWKXS treatment improved the learning and memory ability, alleviated the hippocampal tissue and neuron damage. Through network pharmacology, four key signaling pathways were found to be involved in treatment of MCI by JWKXS, including TLR4/NF- Conclusion: JWKXS treatment improved the learning and memory ability and conferred neuroprotective effects against MCI by inducing anti-inflammation and antiapoptosis.
MeSH term(s)	Rats ; Mice ; Animals ; Inflammasomes/metabolism ; NF-kappa B/metabolism ; NLR Family, Pyrin Domain-Containing 3 Protein/metabolism ; Toll-Like Receptor 4/metabolism ; Cognitive Dysfunction/drug therapy ; Alzheimer Disease/drug therapy ; Anti-Inflammatory Agents/therapeutic use
Chemical Substances	Kai-Xin-San ; Inflammasomes ; NF-kappa B ; NLR Family, Pyrin Domain-Containing 3 Protein ; Toll-Like Receptor 4 ; Anti-Inflammatory Agents
Language	English
Publishing date	2023-11-02
Publishing country	United States
Document type	Journal Article
ZDB-ID	1137605-3
ISSN	1466-1861 ; 0962-9351
ISSN (online)	1466-1861
ISSN	0962-9351
DOI	10.1155/2023/7807302
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Article: Zi Shen Wan Fang Attenuates Neuroinflammation and Cognitive Function

Shi, Jiangwei / Yin, Qingsheng / Zhang, Lin / Wu, Yu / Yi, Pengrong / Guo, Mengqing / Li, Huhu / Yuan, Liuyi / Wang, Zixuan / Zhuang, Pengwei / Zhang, Yanjun

Frontiers in pharmacology

2022 Volume 13, Page(s) 898360

Abstract: ... ...

Abstract	Background
Language	English
Publishing date	2022-07-15
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2587355-6
ISSN	1663-9812
ISSN	1663-9812
DOI	10.3389/fphar.2022.898360
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