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Article ; Online: Advances in eye banking and corneal tissue processing.

Li, Jennifer Y

2022 Volume 33, Issue 5, Page(s) 447–452

Abstract: Purpose of review: Eye bank processing of donor corneal tissue has helped to revolutionize and popularize newer corneal transplantation surgeries. In particular, Descemet stripping automated endothelial keratoplasty (DSAEK) and Descemet membrane ... ...

Abstract	Purpose of review: Eye bank processing of donor corneal tissue has helped to revolutionize and popularize newer corneal transplantation surgeries. In particular, Descemet stripping automated endothelial keratoplasty (DSAEK) and Descemet membrane endothelial keratoplasty (DMEK) have benefited from eye banks preparing donor corneal tissue in advance of the surgery. As a result of these eye banking advances, surgeons have been able to rapidly adopt these new techniques. Recent findings: This article reviews the techniques that are now being utilized to prepare donor tissue for endothelial keratoplasty (EK) with a focus on Ultrathin-DSAEK, prestamped, prestained, preloaded DMEK tissue, and advancements to improve the safety of donor corneal tissue. Summary: Collaborative efforts between surgeons and eye banks have been at the core of advances that have been made in EK over the past decade. Corneal surgery starts in the eye bank, and it is important for corneal surgeons to understand the process and appreciate the efforts that have been made to provide them with suitable and safe donor corneal tissue.
MeSH term(s)	Cornea/surgery ; Corneal Diseases/surgery ; Descemet Membrane/surgery ; Descemet Stripping Endothelial Keratoplasty/methods ; Endothelium, Corneal ; Eye Banks ; Humans ; Tissue Donors ; Visual Acuity
Language	English
Publishing date	2022-06-27
Publishing country	United States
Document type	Journal Article ; Review
ZDB-ID	1049383-9
ISSN	1531-7021 ; 1040-8738
ISSN (online)	1531-7021
ISSN	1040-8738
DOI	10.1097/ICU.0000000000000868
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Article ; Online: Strategies to Address Shortages of Intermediate-Term Cold Donor Corneal Storage Solution.

Li, Jennifer Y

Cornea

2022 Volume 41, Issue 12, Page(s) 1475–1476

MeSH term(s)	Humans ; Tissue Donors ; Organ Preservation Solutions ; Cornea ; Organ Preservation ; Cold Temperature
Chemical Substances	Organ Preservation Solutions
Language	English
Publishing date	2022-09-29
Publishing country	United States
Document type	Editorial
ZDB-ID	604826-2
ISSN	1536-4798 ; 0277-3740
ISSN (online)	1536-4798
ISSN	0277-3740
DOI	10.1097/ICO.0000000000003169
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Zs.A 1790: Show issues

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Article: Input-specific synaptic depression shapes temporal integration in mouse visual cortex.

Li, Jennifer Y / Glickfeld, Lindsey L

bioRxiv : the preprint server for biology

2023

Abstract: Efficient sensory processing requires the nervous system to adjust to ongoing features of the environment. In primary visual cortex (V1), neuronal activity strongly depends on recent stimulus history. Existing models can explain effects of prolonged ... ...

Abstract	Efficient sensory processing requires the nervous system to adjust to ongoing features of the environment. In primary visual cortex (V1), neuronal activity strongly depends on recent stimulus history. Existing models can explain effects of prolonged stimulus presentation, but remain insufficient for explaining effects observed after shorter durations commonly encountered under natural conditions. We investigated the mechanisms driving adaptation in response to brief (100 ms) stimuli in L2/3 V1 neurons by performing
Language	English
Publishing date	2023-02-01
Publishing country	United States
Document type	Preprint
DOI	10.1101/2023.01.30.526211
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Article ; Online: The role of eye banking with cell-based therapies.

Tran, Lillian T / Li, Jennifer Y

Current opinion in ophthalmology

2023 Volume 34, Issue 4, Page(s) 334–338

Abstract: Purpose of review: Cell-based therapies are an exciting new frontier in managing corneal diseases. The introduction of these novel therapies may provide new alternatives to corneal transplantation and decrease the dependence on donor corneal tissue. ... ...

Abstract	Purpose of review: Cell-based therapies are an exciting new frontier in managing corneal diseases. The introduction of these novel therapies may provide new alternatives to corneal transplantation and decrease the dependence on donor corneal tissue. These changes have the potential to significantly impact eye banking in the future. Recent findings: The current article reviews current research involving cell-based therapy for treating corneal disorders, including cultivated limbal stem cell transplantation, limbal mesenchymal stem cells for stromal regeneration, and the use of human-cultivated endothelial cells. We will look at barriers to the development and implementation of these therapies. Summary: As corneal surgery expands to include cell-based therapies; eye banks will need to redefine their role to support the everchanging landscape of corneal surgery and the decreased demand for corneal donor tissue.
MeSH term(s)	Humans ; Epithelium, Corneal ; Eye Banks ; Endothelial Cells ; Limbus Corneae ; Corneal Diseases/surgery ; Stem Cell Transplantation
Language	English
Publishing date	2023-04-25
Publishing country	United States
Document type	Review ; Journal Article
ZDB-ID	1049383-9
ISSN	1531-7021 ; 1040-8738
ISSN (online)	1531-7021
ISSN	1040-8738
DOI	10.1097/ICU.0000000000000962
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Article ; Online: Simultaneous Behavioral and Neuronal Imaging by Tracking Microscopy.

Robson, Drew N / Li, Jennifer M

Methods in molecular biology (Clifton, N.J.)

2023 Volume 2707, Page(s) 155–167

Abstract: Tracking microscopy enables whole-brain cellular resolution imaging in freely swimming animals. This technique enables both structural and functional imaging without immobilizing the animal, and greatly expands the range of the behaviors accessible to ... ...

Abstract	Tracking microscopy enables whole-brain cellular resolution imaging in freely swimming animals. This technique enables both structural and functional imaging without immobilizing the animal, and greatly expands the range of the behaviors accessible to neuroscientists. We use infrared imaging to track the target animal in a behavioral arena. Based on the predicted trajectory of the brain, we apply optimal control theory to a motorized stage system to cancel brain motion in three dimensions. We have combined this motion cancellation system with Differential Illumination Focal Filtering (DIFF), a form of structured illumination microscopy, which enables us to image the brain of a freely swimming larval zebrafish for over an hour. Here we describe the typical experimental procedure for data acquisition and processing using the tracking microscope.
MeSH term(s)	Animals ; Microscopy ; Zebrafish ; Brain ; Larva ; Lighting
Language	English
Publishing date	2023-09-04
Publishing country	United States
Document type	Journal Article
ISSN	1940-6029
ISSN (online)	1940-6029
DOI	10.1007/978-1-0716-3401-1_10
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Article ; Online: Input-specific synaptic depression shapes temporal integration in mouse visual cortex.

Li, Jennifer Y / Glickfeld, Lindsey L

Neuron

2023 Volume 111, Issue 20, Page(s) 3255–3269.e6

Abstract	Efficient sensory processing requires the nervous system to adjust to ongoing features of the environment. In primary visual cortex (V1), neuronal activity strongly depends on recent stimulus history. Existing models can explain effects of prolonged stimulus presentation but remain insufficient for explaining effects observed after shorter durations commonly encountered under natural conditions. We investigated the mechanisms driving adaptation in response to brief (100 ms) stimuli in L2/3 V1 neurons by performing in vivo whole-cell recordings to measure membrane potential and synaptic inputs. We find that rapid adaptation is generated by stimulus-specific suppression of excitatory and inhibitory synaptic inputs. Targeted optogenetic experiments reveal that these synaptic effects are due to input-specific short-term depression of transmission between layers 4 and 2/3. Thus, brief stimulus presentation engages a distinct adaptation mechanism from that previously reported in response to prolonged stimuli, enabling flexible control of sensory encoding across a wide range of timescales.
MeSH term(s)	Mice ; Animals ; Neurons/physiology ; Sensation ; Membrane Potentials ; Visual Cortex/physiology ; Synapses/physiology
Language	English
Publishing date	2023-08-04
Publishing country	United States
Document type	Journal Article ; Research Support, N.I.H., Extramural
ZDB-ID	808167-0
ISSN	1097-4199 ; 0896-6273
ISSN (online)	1097-4199
ISSN	0896-6273
DOI	10.1016/j.neuron.2023.07.003
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Zs.A 2496: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (2.OG) ab Jg. 2022: Lesesaal (EG)
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Article ; Online: Management of Oligometastatic and Locally Recurrent Urothelial Carcinoma.

Liu, Michael A / Li, Jennifer W / Runcie, Karie

Current oncology reports

2024 Volume 26, Issue 5, Page(s) 496–503

Abstract: Purpose of review: To summarize and evaluate the literature on treatment approaches for oligometastatic and locally recurrent urothelial cancer.: Recent findings: There is no clear definition for oligometastatic urothelial cancers due to limited data. ...

Abstract	Purpose of review: To summarize and evaluate the literature on treatment approaches for oligometastatic and locally recurrent urothelial cancer. Recent findings: There is no clear definition for oligometastatic urothelial cancers due to limited data. Studies focusing on oligometastatic and locally recurrent urothelial cancer have been primarily retrospective. Treatment options include local therapy with surgery or radiation, and generalized systemic therapy such as chemotherapy or immunotherapy. Oligometastatic and locally recurrent urothelial cancers remain challenging to manage, and treatment requires an interdisciplinary approach. Systemic therapy is nearly always a component of current care in the form of chemotherapy, but the role of immunotherapy has not been explored. Consideration of surgical and radiation options may improve outcomes, and no studies have compared directly between the two localized treatment options. The development of new prognostic and predictive biomarkers may also enhance the treatment landscape in the future.
MeSH term(s)	Humans ; Neoplasm Recurrence, Local/therapy ; Neoplasm Recurrence, Local/pathology ; Urinary Bladder Neoplasms/therapy ; Urinary Bladder Neoplasms/pathology ; Carcinoma, Transitional Cell/therapy ; Carcinoma, Transitional Cell/pathology ; Carcinoma, Transitional Cell/secondary ; Neoplasm Metastasis ; Immunotherapy ; Combined Modality Therapy ; Urologic Neoplasms/pathology ; Urologic Neoplasms/therapy ; Prognosis
Language	English
Publishing date	2024-04-11
Publishing country	United States
Document type	Journal Article ; Review
ZDB-ID	2057359-5
ISSN	1534-6269 ; 1523-3790
ISSN (online)	1534-6269
ISSN	1523-3790
DOI	10.1007/s11912-024-01523-8
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Zs.A 5521: Show issues

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Article ; Online: Unmasking of subclinical keratoconus with Descemet membrane endothelial keratoplasty in Fuchs endothelial dystrophy.

Yung, Madeline / Li, Jennifer Y

Taiwan journal of ophthalmology

2022 Volume 13, Issue 1, Page(s) 110–113

Abstract: We report a case of Fuchs endothelial corneal dystrophy (FECD) with concurrent forme fruste keratoconus (KCN) that was unmasked with Descemet membrane endothelial keratoplasty (DMEK) in the right eye, but not with Descemet-stripping automated endothelial ...

Abstract	We report a case of Fuchs endothelial corneal dystrophy (FECD) with concurrent forme fruste keratoconus (KCN) that was unmasked with Descemet membrane endothelial keratoplasty (DMEK) in the right eye, but not with Descemet-stripping automated endothelial keratoplasty (DSAEK) in the left eye. The patient was a 65-year-old female with FECD who underwent uncomplicated combination cataract surgery and DMEK in the right eye. She subsequently developed intractable monocular diplopia associated with inferior displacement of the thinnest point of the cornea and subtle steepening noted on posterior corneal curvature on Scheimpflug tomography. The patient was diagnosed with forme fruste KCN. Altering the surgical plan to combine cataract surgery and DSAEK in the left eye successfully circumvented the development of symptomatic visual distortion. This is the first case providing comparable data from contralateral eyes in the same patient regarding the outcome of DMEK versus DSAEK in eyes with concurrent forme fruste KCN. DMEK appeared to unmask posterior corneal irregularities and resulted in visual distortion, whereas DSAEK did not. The additional stromal tissue in DSAEK grafts appears to help normalize alterations of the posterior corneal curvature and may be the preferred endothelial keratoplasty for patients with concurrent mild KCN.
Language	English
Publishing date	2022-12-15
Publishing country	India
Document type	Case Reports
ZDB-ID	2652841-1
ISSN	2211-5072 ; 2211-5072
ISSN (online)	2211-5072
ISSN	2211-5072
DOI	10.4103/2211-5056.363562
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Article ; Online: A dynamical systems view of neuroethology: Uncovering stateful computation in natural behaviors.

Robson, Drew N / Li, Jennifer M

Current opinion in neurobiology

2022 Volume 73, Page(s) 102517

Abstract: State-dependent computation is key to cognition in both biological and artificial systems. Alan Turing recognized the power of stateful computation when he created the Turing machine with theoretically infinite computational capacity in 1936. ... ...

Abstract	State-dependent computation is key to cognition in both biological and artificial systems. Alan Turing recognized the power of stateful computation when he created the Turing machine with theoretically infinite computational capacity in 1936. Independently, by 1950, ethologists such as Tinbergen and Lorenz also began to implicitly embed rudimentary forms of state-dependent computation to create qualitative models of internal drives and naturally occurring animal behaviors. Here, we reformulate core ethological concepts in explicitly dynamical systems terms for stateful computation. We examine, based on a wealth of recent neural data collected during complex innate behaviors across species, the neural dynamics that determine the temporal structure of internal states. We will also discuss the degree to which the brain can be hierarchically partitioned into nested dynamical systems and the need for a multi-dimensional state-space model of the neuromodulatory system that underlies motivational and affective states.
MeSH term(s)	Animals ; Behavior, Animal ; Brain ; Ethology ; Male
Language	English
Publishing date	2022-02-23
Publishing country	England
Document type	Journal Article ; Review ; Research Support, Non-U.S. Gov't
ZDB-ID	1078046-4
ISSN	1873-6882 ; 0959-4388
ISSN (online)	1873-6882
ISSN	0959-4388
DOI	10.1016/j.conb.2022.01.002
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Article ; Online: Ketamine ameliorates activity-based anorexia of adolescent female mice through changes in GluN2B-containing NMDA receptors at postsynaptic cytoplasmic locations of pyramidal neurons and interneurons of medial prefrontal cortex.

Li, Jennifer / Temizer, Rose / Chen, Yi-Wen / Aoki, Chiye

Brain structure & function

2024 Volume 229, Issue 2, Page(s) 323–348

Abstract: Anorexia nervosa (AN) is a mental illness with high rates of mortality and relapse, and no approved pharmacotherapy. Using the activity-based anorexia (ABA) model of AN, we previously showed that a single sub-anesthetic intraperitoneal injection of ... ...

Abstract	Anorexia nervosa (AN) is a mental illness with high rates of mortality and relapse, and no approved pharmacotherapy. Using the activity-based anorexia (ABA) model of AN, we previously showed that a single sub-anesthetic intraperitoneal injection of ketamine (30 mg/kg-KET, but not 3 mg/kg-KET), has an immediate and long-lasting effect of reducing anorexia-like behavior among adolescent female mice. We also showed previously that excitatory outflow from medial prefrontal cortex (mPFC) engages hunger-evoked hyperactivity, leading to the ABA condition of severe weight loss. Ketamine is known to target GluN2B-containing NMDARs (NR2B). Might synaptic plasticity involving NR2B in mPFC contribute to ketamine's ameliorative effects? We addressed this question through electron microscopic immunocytochemical quantification of GluN2B at excitatory synapses of pyramidal neurons (PN) and GABAergic interneurons (IN) in mPFC layer 1 of animals that underwent recovery from a second ABA induction (ABA2), 22 days after ketamine injection during the first ABA induction. The 30 mg/kg-KET evoked synaptic plasticity that differed for PN and IN, with changes revolving the cytoplasmic reserve pool of NR2B more than the postsynaptic membrane pool. Those individuals that suppressed hunger-evoked wheel running the most and increased food consumption during recovery from ABA2 the most showed the greatest increase of NR2B at PN and IN excitatory synapses. We hypothesize that 30 mg/kg-KET promotes long-lasting changes in the reserve cytoplasmic pool of NR2B that enables activity-dependent rapid strengthening of mPFC circuits underlying the more adaptive behavior of suppressed running and enhanced food consumption, in turn supporting better weight restoration.
MeSH term(s)	Mice ; Animals ; Female ; Ketamine/pharmacology ; Anorexia/drug therapy ; Receptors, N-Methyl-D-Aspartate/metabolism ; Motor Activity/physiology ; Pyramidal Cells/metabolism ; Interneurons/metabolism ; Prefrontal Cortex/metabolism
Chemical Substances	Ketamine (690G0D6V8H) ; Receptors, N-Methyl-D-Aspartate
Language	English
Publishing date	2024-01-03
Publishing country	Germany
Document type	Journal Article
ZDB-ID	2273162-3
ISSN	1863-2661 ; 1863-2653
ISSN (online)	1863-2661
ISSN	1863-2653
DOI	10.1007/s00429-023-02740-w
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