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Article: Advances on the Synthesis of C-Aryl-glycosides Since 2019

Li, Jiagen / Jiang, Xuefeng

2024

Abstract: Aryl-glycosides represent a significant subclass of crucial glycosidic compounds, increasingly capturing the attention of pharmaceutical developers as bioelectronic motifs embedded within glycosides. Their outstanding resistance to enzymatic hydrolysis ... ...

Abstract	Aryl-glycosides represent a significant subclass of crucial glycosidic compounds, increasingly capturing the attention of pharmaceutical developers as bioelectronic motifs embedded within glycosides. Their outstanding resistance to enzymatic hydrolysis bestows a distinctive advantage in the field of drug development, particularly in therapeutic domains such as diabetes treatment, where pharmaceuticals based on the C -aryl-glycoside architecture manifest compelling therapeutic efficacy. As a result, researchers in the realm of synthetic chemistry have diligently explored and devised a plethora of streamlined and efficacious synthetic methodologies. This comprehensive account systematically delineates methodologies employed in recent years for the efficient synthesis of C -aryl-glycosides, offering insights into three primary directions: transition-metal catalysis, radical strategies, and metal-free catalysis processes. 1 Introduction 2 Glycosylation via Transition-Metal Catalytic Approaches 3 Glycosylation via Glycosyl Radical Approaches 4 Glycosylation via Metal-Free Catalytic Approaches 5 Conclusion and Outlook
Keywords	-aryl-glycosides ; glycosylation ; transition-metal catalysis ; glycosyl radical ; metal-free catalysis
Language	English
Publishing date	2024-03-07
Publisher	Georg Thieme Verlag KG
Publishing place	Stuttgart ; New York
Document type	Article
ZDB-ID	2042012-2
ISSN	1437-2096 ; 0936-5214
ISSN (online)	1437-2096
ISSN	0936-5214
DOI	10.1055/a-2283-0623
Database	Thieme publisher's database

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Article ; Online: Evaluating the effectiveness of dual dye combination of indocyanine green and carbon nanoparticles with parathyroid hormone test in preserving parathyroid gland during papillary thyroid cancer surgery: a single-center retrospective cohort study.

Chen, Yuliang / Zhang, Songze / Miao, Keyu / Li, Jiagen

Updates in surgery

2024

Abstract: Preserving the integrity of parathyroid glands is crucial in papillary thyroid cancer (PTC) surgery to avoid hypoparathyroidism. In recent years, two novel dyes, activated carbon nanoparticles (CNP) and indocyanine green (ICG), have been utilized to ... ...

Abstract	Preserving the integrity of parathyroid glands is crucial in papillary thyroid cancer (PTC) surgery to avoid hypoparathyroidism. In recent years, two novel dyes, activated carbon nanoparticles (CNP) and indocyanine green (ICG), have been utilized to assist in parathyroid gland identification. However, the use of CNP or ICG alone can result in extravasation of dye or excessive fluorescence of non-parathyroid tissue, which can affect the accuracy of surgical outcomes by yielding false negative or false positive results. Therefore, it is important to further optimize the application of these two dyes in surgery. We analyzed case files of 124 PTC patients who underwent routine total or near-total thyroidectomy with bilateral lymph node dissection in the central region at the Affiliated People's Hospital of Ningbo University from January to November 2022. The patients were randomly divided into three groups based on the type of intraoperative dye used. The CNP group (n = 38) received an intra-thyroidal injection of CNP dye. The ICG group (n = 42) used the ICG near-infrared fluorescence endoscopy system to show parathyroid fluorescence. The group that received a combined approach of ICG and CNP (n = 44) leveraged the advantages of both methods that allow for positive development of ICG and negative development of CNP to identify and preserve the parathyroid gland during operation. The parathyroid hormone detection reagent (PTH test method) was employed to verify the highly suspected parathyroid tissue in all three groups. We analyzed intraoperative data pertaining to intraoperative parathyroid identification, misexcision, number of autotransplantation, and postoperative hypoparathyroidism among the three groups. Compared with the ICG group and the CNP group, the combined group demonstrated more prominent advantages in identifying average the number of lower parathyroid glands (1.93 ± 0.26, p = 0.015), reducing the average numberrate of misexcision (0.45 ± 0.5, p = 0.004), and reducing the incidence of postoperative temporary hypothyroidism (3/44, p = 0.015). The combined use of ICG and CNP dual-dye with PTH test method appears to be more effective in both identifying and protecting parathyroid glands during PTC surgery.
Language	English
Publishing date	2024-03-20
Publishing country	Italy
Document type	Journal Article
ZDB-ID	2572692-4
ISSN	2038-3312 ; 2038-131X
ISSN (online)	2038-3312
ISSN	2038-131X
DOI	10.1007/s13304-024-01804-8
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Article ; Online: Entropy-Driven Phase Transition in Nanonucleation via Reciprocal Relations.

Liu, Rulin / Xu, Yao / Lu, Yihua / Li, Jiagen / Zhu, Xi

The journal of physical chemistry letters

2024 Volume 15, Issue 8, Page(s) 2111–2116

Abstract: Depletion forces, commonly modeled with rigid body assumptions, inadequately describe nanoparticle behavior. This study introduces the roles of Soret and Dufour effects in nanoparticle systems, focusing on mass and energy gradient interchange. The Dufour ...

Abstract	Depletion forces, commonly modeled with rigid body assumptions, inadequately describe nanoparticle behavior. This study introduces the roles of Soret and Dufour effects in nanoparticle systems, focusing on mass and energy gradient interchange. The Dufour effect drives energy flow through mass gradients, which implies the possibility of driving the energy flow near the nanoparticles to induce phase transitions via manipulating the monomer concentrations. Our experimental platform confirmed these theories, synthesizing HCP quantum dots from Au, Ag, Pd, and mixed halide perovskites under varied precursor concentrations. By analyzing energy flow and nucleation dynamics through the Dufour effect, we mapped phase transition thresholds, linking them to material entropy. This study provides insight into nanoparticle assembly and phase behavior, highlighting the significance of entropy in nucleation dynamics.
Language	English
Publishing date	2024-02-15
Publishing country	United States
Document type	Journal Article
ISSN	1948-7185
ISSN (online)	1948-7185
DOI	10.1021/acs.jpclett.4c00118
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Article: Clinical and Imaging Characteristics of Metastatic Orbital Tumours in North China.

Zhao, Yun / Yu, Shasha / Mu, Mengxia / Li, Jiagen / Li, Hongxun / Zhao, Hong

Journal of ophthalmology

2024 Volume 2024, Page(s) 3394425

Abstract: Purpose: This study was designed to review the primary sites, clinical manifestations, imaging features, treatments, and outcomes of 36 patients with orbital metastasis in North China.: Methods: This was a retrospective review of 36 patients with ... ...

Abstract	Purpose: This study was designed to review the primary sites, clinical manifestations, imaging features, treatments, and outcomes of 36 patients with orbital metastasis in North China. Methods: This was a retrospective review of 36 patients with orbital metastasis at Tianjin Eye Hospital between January 2010 and December 2020 in North China as well as a review of the literature. Results: Thirty-six patients were included in the study; 17 were male, and 19 were female, with an age range of 1-82 years (average 54.9 ± 19.8 years). All the tumours were unilateral. The mean duration from the onset of orbital signs to presentation at the hospital was 2.4 months (range 1-10 months). Breast carcinoma, gastrointestinal tract carcinoma, and lung carcinoma were the most common histological types. Proptosis, ocular pain, and diplopia were the most common clinical manifestations. The superior orbit was the most common quadrant involved. All patients received comprehensive therapy, including surgery, radiotherapy, or chemotherapy. The average follow-up time was 2.45 years (range 7 months to 5.5 years). Ten patients in this study died as a result of disseminated metastasis from the primary tumour. Conclusions: In North China, the most common primary cancer that metastasizes to the orbit is breast cancer, followed by gastrointestinal tract carcinoma and lung cancer. The increasing trend of orbital gastrointestinal tract metastases in North China in recent years is noteworthy. The survival rate of patients with orbital metastasis of neuroblastoma is low.
Language	English
Publishing date	2024-02-10
Publishing country	United States
Document type	Journal Article
ZDB-ID	2546525-9
ISSN	2090-0058 ; 2090-004X
ISSN (online)	2090-0058
ISSN	2090-004X
DOI	10.1155/2024/3394425
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article: Effects of Heating Treatment on the Physicochemical and Volatile Flavor Properties of Argentinian Shortfin Squid

Li, Jiagen / Li, Zhaoqi / Deng, Shanggui / Benjakul, Soottawat / Zhang, Bin / Huo, Jiancong

Foods (Basel, Switzerland)

2024 Volume 13, Issue 7

Abstract: In this study, the effect of different heating temperatures (80, 90, 100, and 121 °C) on the physicochemical and volatile flavor properties of fried mantles (Argentinian shortfin) was investigated. The squid mantles were soaked in a maltose syrup ... ...

Abstract	In this study, the effect of different heating temperatures (80, 90, 100, and 121 °C) on the physicochemical and volatile flavor properties of fried mantles (Argentinian shortfin) was investigated. The squid mantles were soaked in a maltose syrup solution (20%
Language	English
Publishing date	2024-03-27
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2704223-6
ISSN	2304-8158
ISSN	2304-8158
DOI	10.3390/foods13071025
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Article ; Online: Competition between ocean thermal structure and tropical cyclone characteristics modulates ocean environmental responses in the Yellow and Bohai Seas.

Wang, Xiuting / Li, Jiagen / Sun, Liang / Xu, Mengyuan / Liu, Haihua / Liu, Rui

Marine environmental research

2024 Volume 196, Page(s) 106444

Abstract: To study the environmental responses of tropical cyclones (TCs) in continental shelf regions, TCs passing over the Yellow Sea and Bohai Sea (YBS) during 2002-2020 were investigated, with a special focus on how competition between ocean thermal structure ... ...

Abstract	To study the environmental responses of tropical cyclones (TCs) in continental shelf regions, TCs passing over the Yellow Sea and Bohai Sea (YBS) during 2002-2020 were investigated, with a special focus on how competition between ocean thermal structure and TC characteristics modulates ocean surface changes. The spatial distributions of the climatic mixed layer depth (MLD), accumulated wind forcing power index (WPi), accumulated sea surface temperature (SST) changes and accumulated chlorophyll (Chl-a) changes in the YBS were calculated. The linear regressions indicate that both the TC-induced SST cooling and TC-induced Chl-a increase are correlated with the TC wind speed rather than the translation speed, especially when the TC forcing depth (Z
MeSH term(s)	Cyclonic Storms ; Temperature ; Oceans and Seas ; Chlorophyll ; Linear Models
Chemical Substances	Chlorophyll (1406-65-1)
Language	English
Publishing date	2024-03-10
Publishing country	England
Document type	Journal Article
ZDB-ID	1502505-6
ISSN	1879-0291 ; 0141-1136
ISSN (online)	1879-0291
ISSN	0141-1136
DOI	10.1016/j.marenvres.2024.106444
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Article: A SiO

Mei, Li / Yang, Yiting / Li, Jiagen / Shang, Shuyong / Fu, Xiaohong

International journal of analytical chemistry

2023 Volume 2023, Page(s) 6620613

Abstract: A novel enzyme-based biosensor for glucose detection is successfully developed using layer-by-layer assembly technology. The introduction of commercially available ... ...

Abstract	A novel enzyme-based biosensor for glucose detection is successfully developed using layer-by-layer assembly technology. The introduction of commercially available SiO
Language	English
Publishing date	2023-06-02
Publishing country	Egypt
Document type	Journal Article
ZDB-ID	2494714-3
ISSN	1687-8779 ; 1687-8760
ISSN (online)	1687-8779
ISSN	1687-8760
DOI	10.1155/2023/6620613
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article: Diastereoselective Synthesis of Thioglycosides via Pd-Catalyzed Allylic Rearrangement

Li, Jiagen / Wang, Ming / Jiang, Xuefeng

Organic letters. 2021 Nov. 16, v. 23, no. 23

2021

Abstract: Stereoselective glycosylation is challenging in carbohydrate chemistry. Herein, stereoselective thioglycosylation of glycals via palladium-catalyzed allylic rearrangement yields various substituents on α-isomer thioglycosides. Two comprehensive series of ...

Abstract	Stereoselective glycosylation is challenging in carbohydrate chemistry. Herein, stereoselective thioglycosylation of glycals via palladium-catalyzed allylic rearrangement yields various substituents on α-isomer thioglycosides. Two comprehensive series of aryl and benzyl thioglycosides were obtained via a combination of thiosulfates with glycals derived from glucose, arabinose, galactose, and rhamnose. Furthermore, diosgenyl α-l-rhamnoside and isoquercitrin achieved selectivity via stereospecific [2,3]-sigma rearrangements of α-sulfoxide-rhamnoside and α-sulfoxide-glucoside, respectively.
Keywords	arabinose ; diastereoselective synthesis ; galactose ; glucose ; glycosylation ; isoquercitrin ; rhamnose ; stereoselectivity ; stereospecificity ; thiosulfates
Language	English
Dates of publication	2021-1116
Size	p. 9053-9057.
Publishing place	American Chemical Society
Document type	Article
ISSN	1523-7052
DOI	10.1021/acs.orglett.1c03302
Database	NAL-Catalogue (AGRICOLA)

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Article ; Online: Predictors of impaired effectiveness of carbon nanoparticle-based central lymph node tracing in patients who underwent surgery for papillary thyroid cancer: A retrospective cohort study.

Chen, Ping-Ping / Zhang, Xing / Li, Jia-Gen / Chen, Gun

Medicine

2022 Volume 101, Issue 41, Page(s) e31257

Abstract: Carbon nanoparticles (CNs) are used in papillary thyroid cancer (PTC) surgery to facilitate central lymph node dissection (CLND) and protect the parathyroid glands (PGs). However, some cases develop hypoparathyroidism after using CNs. This cohort study ... ...

Abstract	Carbon nanoparticles (CNs) are used in papillary thyroid cancer (PTC) surgery to facilitate central lymph node dissection (CLND) and protect the parathyroid glands (PGs). However, some cases develop hypoparathyroidism after using CNs. This cohort study was undertaken to explore the predictors of the reduced effectiveness of CNs. Data on patients with PTC who underwent surgery wherein CNs were used during CLND were reviewed retrospectively. Patients who did not develop hypoparathyroidism and developed hypoparathyroidism were classified into Group A and B, respectively. Demographic and clinical characteristics were compared between the 2 groups. Univariate and multivariate logistic regression analysis were performed on related variables. The receiver operating characteristic curve was used to evaluate the predictors of the binary logistic model and the cutoff value of each predictor was obtained. A total of 265 patients were included. Compared with Group A, the patients in Group B had a higher body mass index (BMI) (P = .003), were more frequently associated with Hashimoto thyroiditis (HT) (P = .001), and tumors were larger in size (P = .026). Multivariate logistic regression analyses were performed on these variables and showed that HT (P = .001) and tumor size (P = .001) predicted the impaired role of CNs. CNs are not always useful in protecting PG function in patients who undergo CLND for PTC. In patients with coexisting HT (blood thyroid peroxidase antibody [TPOAb] level higher than 44.0 IU/mL or blood anti-thyroglobulin antibody [ATG] level higher than 125.0 IU/mL) or a tumor size exceeding 1.1 cm in diameter, the protective role of CNs may be impaired.
MeSH term(s)	Carbon ; Carcinoma, Papillary/complications ; Carcinoma, Papillary/surgery ; Cohort Studies ; Hashimoto Disease/complications ; Humans ; Hypoparathyroidism/surgery ; Iodide Peroxidase ; Lymph Node Excision ; Lymph Nodes/pathology ; Lymph Nodes/surgery ; Nanoparticles ; Retrospective Studies ; Thyroid Cancer, Papillary/complications ; Thyroid Cancer, Papillary/surgery ; Thyroid Neoplasms/pathology ; Thyroidectomy
Chemical Substances	Carbon (7440-44-0) ; Iodide Peroxidase (EC 1.11.1.8)
Language	English
Publishing date	2022-09-26
Publishing country	United States
Document type	Journal Article
ZDB-ID	80184-7
ISSN	1536-5964 ; 0025-7974
ISSN (online)	1536-5964
ISSN	0025-7974
DOI	10.1097/MD.0000000000031257
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Article ; Online: One-pot self-assembly fabrication of chitosan coated hollow sphere for pH/ glutathione dual responsive drug delivery.

Li, Jiagen / Li, Yaqi / Zhong, Zhanqiong / Fu, Xiaohong / Li, Zhonghui

Colloids and surfaces. B, Biointerfaces

2022 Volume 218, Page(s) 112773

Abstract: Chitosan-coated poly (methacrylic acid) (PMAA) hollow spheres with 64 ± 3% drug loading capacity and low drug leakage (7 ± 2%, 54 h) were prepared through a novel one-pot two-step self-assembly process. Site-specific doxorubicin (DOX) loading and ... ...

Abstract	Chitosan-coated poly (methacrylic acid) (PMAA) hollow spheres with 64 ± 3% drug loading capacity and low drug leakage (7 ± 2%, 54 h) were prepared through a novel one-pot two-step self-assembly process. Site-specific doxorubicin (DOX) loading and chitosan coating were achieved by electrostatic interaction to fulfill efficient drug loading and well-controlled drug release behavior. In vitro drug release profile revealed the pH and glutathione (GSH) dual responsive fast triggered drug release behavior, reaching 62 ± 3% during the first 10 h. And completely drug release could be achieved in 54 h. The high drug content and sensitive tumor microenvironment responsibility lead to similar anti-cancer efficiency with free doxorubicin in in vitro MTT assay. This self-assembly guided one-pot two-step fabrication process was proved to be an effective and convenient way to prepare the well-defined multi-layer structure and might be further employed in fabricating high-performance drug delivery systems.
MeSH term(s)	Chitosan/chemistry ; Doxorubicin/chemistry ; Doxorubicin/pharmacology ; Drug Carriers/chemistry ; Drug Delivery Systems ; Drug Liberation ; Glutathione ; Hydrogen-Ion Concentration ; Nanoparticles/chemistry
Chemical Substances	Drug Carriers ; Doxorubicin (80168379AG) ; Chitosan (9012-76-4) ; Glutathione (GAN16C9B8O)
Language	English
Publishing date	2022-08-13
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	1500523-9
ISSN	1873-4367 ; 0927-7765
ISSN (online)	1873-4367
ISSN	0927-7765
DOI	10.1016/j.colsurfb.2022.112773
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