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  1. Book ; Online: Frailty and Herbal Medicines- From Molecular Mechanisms to Clinical Efficacy

    Inui, Akio / Bo Li, Jiang / Ataka, Koji / Takahashi, Ryuji / Iizuka, Noiro

    2020  

    Keywords Medicine ; Dietetics & nutrition ; herbal medicine ; Kampo medicine ; Ninjin'yoeito ; frailty ; aging
    Size 1 electronic resource (325 pages)
    Publisher Frontiers Media SA
    Document type Book ; Online
    Note English ; Open Access
    HBZ-ID HT021230849
    ISBN 9782889637614 ; 2889637611
    Database ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

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  2. Book ; Thesis: Early risk of type 2 diabetes mellitus and insulin restistance

    Li, Jiang

    estimation and identification

    2008  

    Author's details by Jiang Li
    Subject code 616.4
    Language English
    Size 79, [48] S., graph. Darst., 30 cm
    Publishing country Germany
    Document type Book ; Thesis
    Thesis / German Habilitation thesis Dresden, Techn. Univ., Diss., 2009
    Note Enth. 8 Beitr. aus verschiedenen Zeitschr.
    HBZ-ID HT016474563
    Database Catalogue ZB MED Medicine, Health

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    Shelf markLoan statusLocation
    2010 E 2747 order for loan Magazin

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  3. Article ; Online: Eyelid Metastatic Renal Clear Cell Carcinoma Mimics Sebaceous Carcinoma.

    Xu, Mingpeng / Zhou, Chuandi / Li, Jiang

    Ophthalmology

    2024  

    Language English
    Publishing date 2024-03-18
    Publishing country United States
    Document type Journal Article
    ZDB-ID 392083-5
    ISSN 1549-4713 ; 0161-6420
    ISSN (online) 1549-4713
    ISSN 0161-6420
    DOI 10.1016/j.ophtha.2024.02.010
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Digital Circulating Tumor Cells Quantification.

    Wang, Jidong / Liu, Xiaolei / Li, Jiang / Chen, Wenwen

    Analytical chemistry

    2024  

    Abstract: Circulating tumor cells (CTCs) are an emerging but vital biomarker for cancer management. An efficient methodology for accurately quantifying CTCs remains challenging due to their rareness. Here, we develop a digital CTC detection strategy using ... ...

    Abstract Circulating tumor cells (CTCs) are an emerging but vital biomarker for cancer management. An efficient methodology for accurately quantifying CTCs remains challenging due to their rareness. Here, we develop a digital CTC detection strategy using partitioning instead of enrichment to quantify CTCs. By utilizing the characteristics of droplet microfluidics that can rapidly generate a large number of parallel independent reactors, combined with Poisson distribution, we realize the quantification of CTCs in the blood directly. The limit of detection of our digital CTCs quantification assay is five cells per 5 mL of whole blood. By simultaneously detecting multiple genetic mutations, our approach achieves highly sensitive and specific detection of CTCs in peripheral blood from NSCLC patients (AUC = 1). Our digital platform offers a potential approach and strategy for the quantification of CTCs, which could contribute to the advancement of cancer medical management.
    Language English
    Publishing date 2024-04-24
    Publishing country United States
    Document type Journal Article
    ZDB-ID 1508-8
    ISSN 1520-6882 ; 0003-2700
    ISSN (online) 1520-6882
    ISSN 0003-2700
    DOI 10.1021/acs.analchem.3c02769
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  5. Article ; Online: Efficient Massive MIMO Detection for M-QAM Symbols

    Zhi Quan / Jiyu Luo / Hailong Zhang / Li Jiang

    Entropy, Vol 25, Iss 391, p

    2023  Volume 391

    Abstract: Massive multiple-input multiple-output (MIMO) systems significantly outperform small-scale MIMO systems in terms of data rate, making them an enabling technology for next-generation wireless systems. However, the increased number of antennas increases ... ...

    Abstract Massive multiple-input multiple-output (MIMO) systems significantly outperform small-scale MIMO systems in terms of data rate, making them an enabling technology for next-generation wireless systems. However, the increased number of antennas increases the computational difficulty of data detection, necessitating more efficient detection techniques. This paper presents a detector based on joint deregularized and box-constrained dichotomous coordinate descent (BOXDCD) with iterations for rectangular m-ary quadrature amplitude modulation (M-QAM) symbols. Deregularization maximized the energy of the solution. With the box-constraint, the deregularization forces the solution to be close to the rectangular boundary set. The numerical results demonstrate that the proposed detector achieves a considerable performance gain compared to existing detection algorithms. The performance advantage increases with the system size and signal-to-noise ratio.
    Keywords box-constrained dichotomous coordinate descent ; massive MIMO ; negative diagonal loading regularization ; signal detection ; quadrature amplitude modulation ; Science ; Q ; Astrophysics ; QB460-466 ; Physics ; QC1-999
    Subject code 003
    Language English
    Publishing date 2023-02-01T00:00:00Z
    Publisher MDPI AG
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  6. Article ; Online: Advances in deciphering the interactions between viral proteins of influenza A virus and host cellular proteins

    Li Jiang / Hualan Chen / Chengjun Li

    Cell Insight, Vol 2, Iss 2, Pp 100079- (2023)

    2023  

    Abstract: Influenza A virus (IAV) poses a severe threat to the health of animals and humans. The genome of IAV consists of eight single-stranded negative-sense RNA segments, encoding ten essential proteins as well as certain accessory proteins. In the process of ... ...

    Abstract Influenza A virus (IAV) poses a severe threat to the health of animals and humans. The genome of IAV consists of eight single-stranded negative-sense RNA segments, encoding ten essential proteins as well as certain accessory proteins. In the process of virus replication, amino acid substitutions continuously accumulate, and genetic reassortment between virus strains readily occurs. Due to this high genetic variability, new viruses that threaten animal and human health can emerge at any time. Therefore, the study on IAV has always been a focus of veterinary medicine and public health. The replication, pathogenesis, and transmission of IAV involve intricate interplay between the virus and host. On one hand, the entire replication cycle of IAV relies on numerous proviral host proteins that effectively allow the virus to adapt to its host and support its replication. On the other hand, some host proteins play restricting roles at different stages of the viral replication cycle. The mechanisms of interaction between viral proteins and host cellular proteins are currently receiving particular interest in IAV research. In this review, we briefly summarize the current advances in our understanding of the mechanisms by which host proteins affect virus replication, pathogenesis, or transmission by interacting with viral proteins. Such information about the interplay between IAV and host proteins could provide insights into how IAV causes disease and spreads, and might help support the development of antiviral drugs or therapeutic approaches.
    Keywords Biology (General) ; QH301-705.5 ; Medicine (General) ; R5-920
    Subject code 570
    Language English
    Publishing date 2023-04-01T00:00:00Z
    Publisher Elsevier
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  7. Article ; Online: Ginkgolide B can alleviate spinal cord glymphatic system dysfunction and provide neuroprotection in painful diabetic neuropathy rats by inhibiting matrix metalloproteinase-9.

    Li, Jiang / Jia, Shuaiying / Song, Yuehan / Xu, Wenmei / Lin, Jingyan

    Neuropharmacology

    2024  Volume 250, Page(s) 109907

    Abstract: The glymphatic system plays a crucial role in maintaining optimal central nervous system (CNS) function by facilitating the removal of metabolic wastes. Aquaporin-4 (AQP4) protein, predominantly located on astrocyte end-feet, is a key pathway for ... ...

    Abstract The glymphatic system plays a crucial role in maintaining optimal central nervous system (CNS) function by facilitating the removal of metabolic wastes. Aquaporin-4 (AQP4) protein, predominantly located on astrocyte end-feet, is a key pathway for metabolic waste excretion. β-Dystroglycan (β-DG) can anchor AQP4 protein to the end-feet membrane of astrocytes and can be cleaved by matrix metalloproteinase (MMP)-9 protein. Studies have demonstrated that hyperglycemia upregulates MMP-9 expression in the nervous system, leading to neuropathic pain. Ginkgolide B (GB) exerts an inhibitory effect on the MMP-9 protein. In this study, we investigated whether inhibition of MMP-9-mediated β-DG cleavage by GB is involved in the regulation of AQP4 polarity within the glymphatic system in painful diabetic neuropathy (PDN) and exerts neuroprotective effects. The PDN model was established by injecting streptozotocin (STZ). Functional changes in the glymphatic system were observed using magnetic resonance imaging (MRI). The paw withdrawal threshold (PWT) was measured to assess mechanical allodynia. The protein expressions of MMP-9, β-DG, and AQP4 were detected by Western blotting and immunofluorescence. Our findings revealed significant decreases in the efficiency of contrast agent clearance within the spinal glymphatic system of the rats, accompanied by decreased PWT, increased MMP-9 protein expression, decreased β-DG protein expression, and loss of AQP4 polarity. Notably, GB treatment demonstrated the capacity to ameliorate spinal cord glymphatic function by modulating AQP4 polarity through MMP-9 inhibition, offering a promising therapeutic avenue for PDN.
    MeSH term(s) Rats ; Animals ; Glymphatic System/metabolism ; Matrix Metalloproteinase 9 ; Neuroprotection ; Diabetic Neuropathies/drug therapy ; Diabetic Neuropathies/metabolism ; Spinal Cord/metabolism ; Aquaporin 4/metabolism ; Diabetes Mellitus ; Lactones ; Ginkgolides
    Chemical Substances Matrix Metalloproteinase 9 (EC 3.4.24.35) ; ginkgolide B (DF149B9460) ; Aquaporin 4 ; Lactones ; Ginkgolides
    Language English
    Publishing date 2024-03-14
    Publishing country England
    Document type Journal Article
    ZDB-ID 218272-5
    ISSN 1873-7064 ; 0028-3908
    ISSN (online) 1873-7064
    ISSN 0028-3908
    DOI 10.1016/j.neuropharm.2024.109907
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: Effect of Maternal DEHP Exposure on Lipid Metabolism in Adult Male Rats and the Antagonistic Effect of Genistein.

    Zhang, Yun Bo / Li, Jiang Li / Tian, Jie / Na, Xiao Lin

    Biomedical and environmental sciences : BES

    2024  Volume 37, Issue 3, Page(s) 315–319

    MeSH term(s) Humans ; Female ; Rats ; Animals ; Male ; Genistein/pharmacology ; Lipid Metabolism ; Diethylhexyl Phthalate/toxicity ; Maternal Exposure ; Prenatal Exposure Delayed Effects
    Chemical Substances Genistein (DH2M523P0H) ; Diethylhexyl Phthalate (C42K0PH13C)
    Language English
    Publishing date 2024-04-07
    Publishing country China
    Document type Letter
    ZDB-ID 645083-0
    ISSN 2214-0190 ; 0895-3988
    ISSN (online) 2214-0190
    ISSN 0895-3988
    DOI 10.3967/bes2024.034
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 2459: Show issues Location:
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  9. Article: Recent advances in the catalytic transfer hydrogenation of furfural to furfuryl alcohol over heterogeneous catalysts

    An, Zhidong / Li, Jiang

    Green chemistry. 2022 Mar. 7, v. 24, no. 5

    2022  

    Abstract: Catalytic transfer hydrogenation (CTH) has recently emerged as a highly attractive approach for achieving biomass-based hydrogenation due to its avoidance of high-pressure fossil-derived H₂ and potentially reduced process costs. As numerous studies ... ...

    Abstract Catalytic transfer hydrogenation (CTH) has recently emerged as a highly attractive approach for achieving biomass-based hydrogenation due to its avoidance of high-pressure fossil-derived H₂ and potentially reduced process costs. As numerous studies relating to the CTH of furfural (FF) have been reported recently, it is quite urgent to systematically review the recent advances, especially those in which excellent catalytic performance is achieved over simple solid acid–base catalysts. In this review, recent advances relating to the CTH of FF over heterogeneous catalysts, including metal catalysts and solid acid–base catalysts, are extensively summarized. Some potential research trends for the design of more effective catalysts and the realization of the practical industrial production of furfuryl alcohol (FFA) via CTH are also proposed. As acidic or basic sites always play an important role during biomass conversion, the great progress made in the area of CTH also provides great potential for other reactions, especially reductive functionalization.
    Keywords biomass ; catalytic activity ; furfural ; furfuryl alcohol ; green chemistry ; hydrogenation
    Language English
    Dates of publication 2022-0307
    Size p. 1780-1808.
    Publishing place The Royal Society of Chemistry
    Document type Article
    ZDB-ID 2006274-6
    ISSN 1463-9270 ; 1463-9262
    ISSN (online) 1463-9270
    ISSN 1463-9262
    DOI 10.1039/d1gc04440k
    Database NAL-Catalogue (AGRICOLA)

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  10. Article ; Online: Reconnoitering correlation between human papillomavirus infection-induced vaginal microecological abnormality and squamous intraepithelial lesion (SIL) progression

    Jiawei Li / Haihong Jin / Yongmei Sun / Chunhua Wang / Hongjuan Chen / Shan Gong / Li Jiang

    BMC Women's Health, Vol 24, Iss 1, Pp 1-

    2024  Volume 9

    Abstract: Abstract Objective This study aims to investigate the relationship between abnormal vaginal microecology and human papillomavirus (HPV) infection, as well as the squamous intraepithelial lesions (SIL) progression. Methods A total of 383 patients ... ...

    Abstract Abstract Objective This study aims to investigate the relationship between abnormal vaginal microecology and human papillomavirus (HPV) infection, as well as the squamous intraepithelial lesions (SIL) progression. Methods A total of 383 patients diagnosed with HPV infection in our hospital between March 2017 and February 2022 were selected as the experimental group. In addition, several volunteers (n = 898) who underwent physical examination during the same period were randomly selected as the control group. Subsequently, we conducted several investigations, such as HPV detection and gene typing, examined vaginal microecological imbalances, and performed cytological examinations to analyze the correlation between microecological changes, different types of HPV infection, and SIL progression. Results HPV detection primarily included single and high-risk types of HPV infections. Moreover, significant disparities in the vaginal microecological environment between patients with persistent HPV infection and the control group, as well as patients with low-grade and high-grade SIL (LSIL and HSIL), were observed. The regression analysis revealed a correlation between LSIL and microflora density, diversity, bacteriological vaginosis (BV), vulvovaginal candidiasis (VVC), trichomonas vaginalis (TV), sialidase, as well as Lactobacillus. In addition, we identified an association between HSIL and pH, flora density, diversity, BV, VVC, candida vaginitis (CV), leukocyte esterase, catalase, and Lactobacillus levels. Conclusion These findings revealed a significant association between abnormal vaginal microecology and both HPV infection and the SIL progression.
    Keywords Vaginal microecology ; High-risk human papillomavirus ; Low-risk human papillomavirus ; Low-grade squamous intraepithelial lesion ; High-grade squamous intraepithelial lesion ; Gynecology and obstetrics ; RG1-991 ; Public aspects of medicine ; RA1-1270
    Subject code 610
    Language English
    Publishing date 2024-01-01T00:00:00Z
    Publisher BMC
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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