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Article ; Online: Pharmacokinetic Analyses of a Lipid Nanoparticle-Encapsulated mRNA-Encoded Antibody against Rift Valley Fever Virus.

Wang, Shuo / Zhu, Ziling / Li, Jianmin

2024 Volume 21, Issue 3, Page(s) 1342–1352

Abstract: Rift Valley fever virus (RVFV) could cause an emergency illness characterized by fever, muscle pain, and even death in humans or ruminants. However, there are no approved antiviral drugs that prevent or treat RVFV infection. While therapeutic antibodies ... ...

Abstract	Rift Valley fever virus (RVFV) could cause an emergency illness characterized by fever, muscle pain, and even death in humans or ruminants. However, there are no approved antiviral drugs that prevent or treat RVFV infection. While therapeutic antibodies have shown promising potential for prevention or treatment in several studies, many studies are ongoing, especially in the field of infectious diseases. Among these studies, the mRNA-LNP platform shows great potential for application, following the COVID-19 pandemic. Previously, we have obtained a neutralizing antibody against RVFV, which was named A38 protein and verified to have a high binding and neutralization ability. In this study, we aimed to identify an effectively optimized sequence and expressed the prioritized mRNA-encoded antibody
MeSH term(s)	Animals ; Humans ; Rift Valley fever virus/genetics ; Rift Valley Fever/prevention & control ; Pandemics ; Antibodies, Viral ; Communicable Diseases ; Liposomes ; Nanoparticles
Chemical Substances	Lipid Nanoparticles ; Antibodies, Viral ; Liposomes
Language	English
Publishing date	2024-01-31
Publishing country	United States
Document type	Journal Article
ZDB-ID	2138405-8
ISSN	1543-8392 ; 1543-8384
ISSN (online)	1543-8392
ISSN	1543-8384
DOI	10.1021/acs.molpharmaceut.3c01016
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Zs.A 6250: Show issues

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Article ; Online: Core decompression combined with platelet-rich plasma-augmented bone grafting for femur head necrosis: a systematic review and meta-analysis.

Zhu, Bo / Li, Jianmin / Li, Xuejia / Feng, Shengyi / Li, Bo

International journal of surgery (London, England)

2024 Volume 110, Issue 3, Page(s) 1687–1698

Abstract: Background: The clinical potential of biologic augmentation in core decompression and bone grafting for femoral head necrosis is widely acknowledged, with platelet-rich plasma (PRP) being a frequently employed biologic adjunct. However, its clinical ... ...

Abstract	Background: The clinical potential of biologic augmentation in core decompression and bone grafting for femoral head necrosis is widely acknowledged, with platelet-rich plasma (PRP) being a frequently employed biologic adjunct. However, its clinical application is not standardized, and high-level evidence is lacking. This study aimed to evaluate the efficacy and safety of core decompression and bone grafting combined with PRP for femur head necrosis. Methods: Several databases were systematically retrieved for randomized controlled trials comparing core decompression and bone grafting combined with or without PRP. A systematic review and meta-analysis were conducted following the PRISMA 2020 and AMSTAR 2 guidelines. The study is registered with PROSPERO under the code CRD42022361007, and it is also listed in the research registry under the identification number reviewregistry1537. Results: Eleven studies with 642 participants (742 hips) were included. The pooled estimates revealed that when core decompression and bone grafting were combined with PRP, the Harris hip score (mean difference: 7.98; 95% CI: 5.77-10.20; P <0.001), visual analog scale (SMD: -0.68; 95% CI: -0.96 - -0.40; P <0.001) and the pain component of Harris hip score (SMD: 8.4; 95% CI: 4.12-12.68; P <0.001), and reduction of radiographic progression [risk ratio (RR): 0.40; 95% CI: 0.27-0.59; P <0.001] were superior to core decompression and bone grafting alone. Fewer patients with treatment failure (RR: 0.27; 95% CI: 0.14-0.52; P <0.001) and higher good-to-excellent results (RR: 1.48; 95% CI: 1.17-1.86; P <0.001) were observed in treatment groups than control groups. Meanwhile, the pooled analysis substantiated the superior safety profile of PRP (RR: 0.29; 95% CI: 0.11-0.77; P =0.01). Conclusions: The combination of core decompression and bone grafting with PRP is superior to the approach without PRP, demonstrating enhanced effectiveness in terms of function, pain relief, and radiographic progression. Additionally, it results in lower rates of treatment failure and adverse events. However, further high-quality RCTs are needed to evaluate their effectiveness due to methodological and implementation limitations observed in the existing evidence.
MeSH term(s)	Humans ; Femur Head Necrosis/diagnostic imaging ; Femur Head Necrosis/surgery ; Bone Transplantation ; Treatment Outcome ; Decompression, Surgical/methods ; Platelet-Rich Plasma ; Femur Head ; Pain/surgery ; Biological Products
Chemical Substances	Biological Products
Language	English
Publishing date	2024-03-01
Publishing country	United States
Document type	Meta-Analysis ; Systematic Review ; Journal Article
ZDB-ID	2212038-5
ISSN	1743-9159 ; 1743-9191
ISSN (online)	1743-9159
ISSN	1743-9191
DOI	10.1097/JS9.0000000000001028
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Zs.A 6502: Show issues

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Article ; Online: Simultaneous and Proportional Control of Wrist and Hand Movements Based on a Neural-Driven Musculoskeletal Model.

Li, Jianmin / Yue, Shizhuo / Pan, Lizhi

IEEE transactions on neural systems and rehabilitation engineering : a publication of the IEEE Engineering in Medicine and Biology Society

2023 Volume 31, Page(s) 3999–4007

Abstract: Human-machine interfaces (HMIs) based on electromyography (EMG) signals have been developed for simultaneous and proportional control (SPC) of multiple degrees of freedom (DoFs). The EMG-driven musculoskeletal model (MM) has been used in HMIs to predict ... ...

Abstract	Human-machine interfaces (HMIs) based on electromyography (EMG) signals have been developed for simultaneous and proportional control (SPC) of multiple degrees of freedom (DoFs). The EMG-driven musculoskeletal model (MM) has been used in HMIs to predict human movements in prosthetic and robotic control. However, the neural information extracted from surface EMG signals may be distorted due to their limitations. With the development of high density (HD) EMG decomposition, accurate neural drive signals can be extracted from surface EMG signals. In this study, a neural-driven MM was proposed to predict metacarpophalangeal (MCP) joint flexion/extension and wrist joint flexion/extension. Ten non-disabled subjects (male) were recruited and tested. Four 64-channel electrode grids were attached to four forearm muscles of each subject to record the HD EMG signals. The joint angles were recorded synchronously. The acquired HD EMG signals were decomposed to extract the motor unit (MU) discharge for estimating the neural drive, which was then used as the input to the MM to calculate the muscle activation and predict the joint movements. The Pearson's correlation coefficient (r) and the normalized root mean square error (NRMSE) between the predicted joint angles and the measured joint angles were calculated to quantify the estimation performance. Compared to the EMG-driven MM, the neural-driven MM attained higher r values and lower NRMSE values. Although the results were limited to an offline application and to a limited number of DoFs, they indicated that the neural-driven MM outperforms the EMG-driven MM in prediction accuracy and robustness. The proposed neural-driven MM for HMI can obtain more accurate neural commands and may have great potential for medical rehabilitation and robot control.
MeSH term(s)	Male ; Humans ; Wrist/physiology ; Hand/physiology ; Wrist Joint/physiology ; Electromyography/methods ; Muscle, Skeletal/physiology ; Movement/physiology
Language	English
Publishing date	2023-10-18
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	1166307-8
ISSN	1558-0210 ; 1063-6528 ; 1534-4320
ISSN (online)	1558-0210
ISSN	1063-6528 ; 1534-4320
DOI	10.1109/TNSRE.2023.3323347
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Zs.A 4726: Show issues

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Article: A 3D-printed patient-specific modular implants for pelvic reconstruction of bone tumors involving the sacroiliac joint.

Lv, Zhaorui / Li, Zhenfeng / Yang, Qiang / Li, Jianmin

Frontiers in bioengineering and biotechnology

2023 Volume 11, Page(s) 1233960

Abstract: Background: ...

Abstract	Background:
Language	English
Publishing date	2023-08-24
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2719493-0
ISSN	2296-4185
ISSN	2296-4185
DOI	10.3389/fbioe.2023.1233960
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Article ; Online: Eliciting tactile sensations in the hand through non-invasive proximal nerve stimulation: a feasibility study.

Pan, Lizhi / Ren, Zhihao / Zhu, Kun / Li, Jianmin

Medical & biological engineering & computing

2023 Volume 61, Issue 12, Page(s) 3225–3232

Abstract: Recently, non-invasive proximal nerve stimulation has been widely investigated to restore tactile sensations. It has been demonstrated that tactile sensations in the hand could be elicited by nerve stimulation on the upper arm. However, it is still ... ...

Abstract	Recently, non-invasive proximal nerve stimulation has been widely investigated to restore tactile sensations. It has been demonstrated that tactile sensations in the hand could be elicited by nerve stimulation on the upper arm. However, it is still unknown whether tactile sensations could be elicited by stimulation at a proximal location close to the neck. In this study, non-invasive proximal nerve stimulation tests were performed to elicit tactile sensations in the hand of subjects. Six Ag/AgCl gel electrodes (2 × 3) were placed on the supraclavicular fossa where the proximal parts of the brachial plexus nerves were located. Then, fifteen potential electrode pairs were tested to explore whether tactile sensations could be elicited by non-invasive proximal nerve stimulation. Eight able-bodied subjects (male) were recruited to participate in the test. The stimulated sensation regions in the hand and the sensory intensity were reported and recorded during the experiment. The results demonstrated that the tactile sensations in various regions in the hand could be elicited through non-invasive nerve stimulation at the proximal location close to the neck.
MeSH term(s)	Humans ; Male ; Feasibility Studies ; Hand/physiology ; Touch ; Arm ; Electric Stimulation
Language	English
Publishing date	2023-09-18
Publishing country	United States
Document type	Journal Article
ZDB-ID	282327-5
ISSN	1741-0444 ; 0025-696X ; 0140-0118
ISSN (online)	1741-0444
ISSN	0025-696X ; 0140-0118
DOI	10.1007/s11517-023-02923-x
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Zs.A 294: Show issues

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Article ; Online: Revealing the ammonia oxidation process and shortcut nitrification performance using nitrogen and oxygen isotope fractionation effect.

Liu, Hong / Zeng, Wei / Zhan, Mengjia / Li, Jianmin

The Science of the total environment

2023 Volume 912, Page(s) 169322

Abstract: Natural abundance isotope fractionation properties have become the most effective way to explore nitrogen transformations of biological nitrogen removal from wastewater. The migration and transformation characteristics of N and O elements in the shortcut ...

Abstract	Natural abundance isotope fractionation properties have become the most effective way to explore nitrogen transformations of biological nitrogen removal from wastewater. The migration and transformation characteristics of N and O elements in the shortcut nitrification were analyzed using the N and O dual isotopic fractionation technique. The effects of dissolved oxygen (DO) and temperature changes on the performance of shortcut nitrification and isotopic fractionation were investigated. The fractionation characteristics of N and O elements during shortcut nitrification were explored by adjusting DO concentration (0.2-0.4, 1-1.2 and 3-4 mg/L) and temperature (33 ± 1 °C, 25 ± 1 °C and 18 ± 1 °C). Both δ
Language	English
Publishing date	2023-12-14
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	121506-1
ISSN	1879-1026 ; 0048-9697
ISSN (online)	1879-1026
ISSN	0048-9697
DOI	10.1016/j.scitotenv.2023.169322
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Zs.A 949: Show issues

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Article ; Online: A three evolutionary game model for driving mechanism of industry-university-research collaborative innovation in agricultural innovation ecosystems.

Hou, Xiaona / Gao, Xiangxiao / Yin, Shi / Li, Jianmin

PloS one

2023 Volume 18, Issue 8, Page(s) e0289408

Abstract: Based on the current state of China's agricultural industry, this article proposes an integrated framework for the agricultural innovation ecosystem in developing countries. Furthermore, a dynamic simulation model is constructed to analyze the game ... ...

Abstract	Based on the current state of China's agricultural industry, this article proposes an integrated framework for the agricultural innovation ecosystem in developing countries. Furthermore, a dynamic simulation model is constructed to analyze the game process and factors influencing the agricultural innovation ecosystem. The results indicate that industry-university-research collaboration serves as the main source of innovation within the agricultural innovation ecosystem, playing a central role in its development. The willingness to participate, cost of participation, and establishment of default fees by governments, agro-related enterprises, universities, and research institutions have significant implications for the evolution of collaborative innovation within agricultural innovation ecosystems. In order to promote the evolution of the system, agriculture-related enterprises, universities, and research institutions should establish more effective reward and punishment mechanisms, as well as cost control mechanisms. Governments should set reasonable regulatory costs and incentive intervals to actively foster a collaborative innovation atmosphere. The innovation points of this paper are as follows: extending the theory of innovation ecosystems to agriculture, particularly in developing countries characterized by imbalanced and insufficient development. A game model is also constructed to represent the collaborative innovation evolution among government, agriculture-related enterprises, universities, and research institutions, with the government as the endogenous variable. Through numerical simulation, the dynamic evolution process of collaborative innovation within the agricultural innovation ecosystem is revealed. This research enriches and expands upon innovation ecosystem theory, providing guidance for the of innovation ecology in agriculture through mathematical models in developing countries. This, in turn, promotes the convergence of symbiotic, shared, and-creation development.
MeSH term(s)	Humans ; Ecosystem ; Universities ; Agriculture ; Ecology ; Models, Theoretical ; Government ; China ; Game Theory
Language	English
Publishing date	2023-08-03
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2267670-3
ISSN	1932-6203 ; 1932-6203
ISSN (online)	1932-6203
ISSN	1932-6203
DOI	10.1371/journal.pone.0289408
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Article ; Online: Primary epithelioid trophoblastic tumor of the lung: A case report.

Zhang, Qiongying / Sun, Wenwen / Zhang, Zhen / Li, Jianmin

Indian journal of pathology & microbiology

2023

Abstract: Abstract: Primary epithelioid trophoblastic tumor (ETT) of the lung is exceedingly rare. Only about three cases have been reported in Pubmed and worldwide literature. We presented a case of multiple primary ETT of the lung occurring in a 33-year-old ... ...

Abstract	Abstract: Primary epithelioid trophoblastic tumor (ETT) of the lung is exceedingly rare. Only about three cases have been reported in Pubmed and worldwide literature. We presented a case of multiple primary ETT of the lung occurring in a 33-year-old Chinese female patient. Comprehensive physical examinations revealed no evidence of a primary lesion on the uterus or cervix uteri. Microscopic examination of the tumor demonstrated ETT of the lung, which was confirmed by immunohistochemical staining and declining level of beta-human choriogonadotropin (β-HCG) after the operation. Our case revealed that the ETT can occur in the lung and should be considered when a female had a tumor of lung with increasing β-HCG.
Language	English
Publishing date	2023-06-13
Publishing country	India
Document type	Journal Article
ZDB-ID	197621-7
ISSN	0974-5130 ; 0377-4929
ISSN (online)	0974-5130
ISSN	0377-4929
DOI	10.4103/ijpm.ijpm_516_22
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Book: Sisheng zhi yu

Li, Jianmin

Zhou Qin Han maixue zhi yuanliu

(Zhongyang yanjiuyuan lishiyuyanyanjiusuo zhuankan ; 101)

2000

Author's details	Li Jianmin
Series title	Zhongyang yanjiuyuan lishiyuyanyanjiusuo zhuankan ; 101 Zhong yang yan jiu yuan li shi yu yan yan jiu suo zhuan kan
Collection	Zhong yang yan jiu yuan li shi yu yan yan jiu suo zhuan kan
Language	Chinese
Size	IV, 435 S. : Ill.
Publisher	Zhongyanjiushiyusuo
Publishing place	Taibei
Publishing country	Taiwan
Document type	Book
HBZ-ID	TT002248783
ISBN	957-671-704-3 ; 957-671-703-5 ; 978-957-671-704-8 ; 978-957-671-703-1
Database	Catalogue ZB MED Medicine, Health

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Article: Association between SpO

Zhang, Shuo / Ji, Jiaqi / Gao, Siqi / Yang, Shu / Song, Zeyi / Li, Jianmin / Liu, Junjie

Frontiers in neurology

2024 Volume 15, Page(s) 1344000

Abstract: Objective: This study aimed to evaluate the SpO: Methods: In this investigation, we employed a comprehensive approach. Initially, we screened the MIMIC-IV database, identifying elderly T2DM patients with cerebral infarction, utilizing specific ICD-9 ... ...

Abstract	Objective: This study aimed to evaluate the SpO Methods: In this investigation, we employed a comprehensive approach. Initially, we screened the MIMIC-IV database, identifying elderly T2DM patients with cerebral infarction, utilizing specific ICD-9 and ICD-10 codes. We then harnessed the power of restricted cubic splines to craft a visual representation of the correlation between SpO Results: In this study, 448 elderly T2DM patients with cerebral infarction were included. Within 1-year post-discharge, 161 patients (35.94%) succumbed. Employing Restricted Cubic Spline analysis, a statistically significant Conclusions: Striking an optimal balance is paramount, as fixating solely on lower SpO
Language	English
Publishing date	2024-03-12
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2564214-5
ISSN	1664-2295
ISSN	1664-2295
DOI	10.3389/fneur.2024.1344000
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