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Article ; Online: Resol/triblock copolymer composite-guided smart fabrication of carbonized mesopores for efficiently decoding exosomal glycans.

Chen, Yijie / Wu, Yonglei / Li, Jiaomei / Deng, Chunhui / Sun, Nianrong

2023 Volume 190, Issue 8, Page(s) 319

Abstract: Soft-template carbonized mesopores were developed for the purpose of enriching urinary exosomal glycans through organic-organic self-assembly using block copolymers and resol precursors. With a high surface area of 229 ... ...

Abstract	Soft-template carbonized mesopores were developed for the purpose of enriching urinary exosomal glycans through organic-organic self-assembly using block copolymers and resol precursors. With a high surface area of 229 m
MeSH term(s)	Humans ; Polysaccharides ; Carbon ; Healthy Volunteers ; Mutation ; Polymers ; Carcinoma
Chemical Substances	Polysaccharides ; Carbon (7440-44-0) ; Polymers
Language	English
Publishing date	2023-07-25
Publishing country	Austria
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	89-9
ISSN	1436-5073 ; 0026-3672
ISSN (online)	1436-5073
ISSN	0026-3672
DOI	10.1007/s00604-023-05885-x
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Article ; Online: Preventive effect of low-carbohydrate high-fat dietary pattern on liver disease caused by alcohol consumption

Qiu, Jiannan / Dong, Fan / Zhuge, Hui / Han, Qiang / Li, Jiaomei / Guo, Rui / Dou, Xiaobing / Li, Jiayu / Li, Songtao

Food & function

2024 Volume 15, Issue 2, Page(s) 732–746

Abstract: A low-carbohydrate high-fat (LCHF) dietary pattern has been reported to improve chronic metabolic diseases. However, whether and how the LCHF diet affects the pathological progression in patients with alcohol-related liver diseases (ALD) is largely ... ...

Abstract	A low-carbohydrate high-fat (LCHF) dietary pattern has been reported to improve chronic metabolic diseases. However, whether and how the LCHF diet affects the pathological progression in patients with alcohol-related liver diseases (ALD) is largely unknown. This study was conducted to evaluate the effect of the LCHF diet on ALD and clarify its potential mechanism(s). The ALD model was established by feeding C57BL/6N mice with a Lieber-DeCarli liquid alcohol diet with a modified carbohydrate/fat ratio under an isoenergetic pattern. After an eight-week intervention, we observed that the LCHF diet significantly reduced alcohol-induced hepatic steatosis and liver injury, along with improved lipid metabolic-related gene disorders and redox imbalance. The alcohol-stimulated increase in pro-inflammatory cytokine cytokines expression, including
MeSH term(s)	Humans ; Mice ; Animals ; Liver Diseases, Alcoholic/metabolism ; Dietary Patterns ; Mice, Inbred C57BL ; Liver/metabolism ; Ethanol/metabolism ; Alcohol Drinking ; Cytokines/metabolism ; Carbohydrates/pharmacology ; Lipids/pharmacology
Chemical Substances	Ethanol (3K9958V90M) ; Cytokines ; Carbohydrates ; Lipids
Language	English
Publishing date	2024-01-22
Publishing country	England
Document type	Journal Article
ZDB-ID	2612033-1
ISSN	2042-650X ; 2042-6496
ISSN (online)	2042-650X
ISSN	2042-6496
DOI	10.1039/d3fo04335e
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Article ; Online: Torreya grandis Kernel Oil Alleviates Loperamide-Induced Slow Transit Constipation via Up-Regulating the Colonic Expressions of Occludin/Claudin-1/ZO-1 and 5-HT3R/5-HT4R in BALB/c Mice.

Wang, Xuezhu / Guo, Rui / Yu, Zhuoli / Zikela, Lalai / Li, Jiaomei / Li, Songtao / Han, Qiang

Molecular nutrition & food research

2023 Volume 68, Issue 4, Page(s) e2300615

Abstract: Scope: Torreya grandis kernel has traditionally been used to remove intestinal parasites and increases intestinal motility. However, the effect of Torreya grandis kernel oil (TKO) on constipation has not yet been investigated. Therefore, mouse model is ... ...

Abstract	Scope: Torreya grandis kernel has traditionally been used to remove intestinal parasites and increases intestinal motility. However, the effect of Torreya grandis kernel oil (TKO) on constipation has not yet been investigated. Therefore, mouse model is used to investigate the effect of TKO on slow transit constipation (STC) and its possible mechanism. Methods and results: The effects of TKO on intestinal motility of STC mice are evaluated by fecal weight, fecal water content, colon length, defecation test, and intestinal propulsion test. The mechanism of TKO alleviating STC is explored by detecting biochemical analysis, histological analysis, western blot, qRT-PCR, immunohistochemistry, and gut microbiota analysis. The results reveal that TKO effectively promotes defecation and intestinal motility, increases the level of endothelin-1, and restores the histopathological morphology of the colon under LOP pretreatment. The expression levels of occludin, claudin-1, and zonula occludens-1 (ZO-1) mRNA and protein are up-regulated in mice receiving TKO treatment. The colonic 5-hydroxytryptamine 3R/4R (5-HT3R/5-HT4R) expressions are also increased by TKO supplementation. Additionally, TKO rescues LOP-caused disorders of the gut microbiota. Conclusion: Consumption of TKO is beneficial to STC recovery, and it can alleviate LOP-induced STC by up-regulating the colonic expressions of Occludin/Claudin-1/ZO-1 and 5-HT3R/5-HT4R.
MeSH term(s)	Mice ; Animals ; Loperamide/adverse effects ; Loperamide/metabolism ; Claudin-1/genetics ; Claudin-1/metabolism ; Occludin/genetics ; Occludin/metabolism ; Tight Junctions ; Mice, Inbred BALB C ; Constipation/chemically induced ; Constipation/drug therapy ; Constipation/metabolism
Chemical Substances	Loperamide (6X9OC3H4II) ; Claudin-1 ; Occludin
Language	English
Publishing date	2023-12-28
Publishing country	Germany
Document type	Journal Article
ZDB-ID	2160372-8
ISSN	1613-4133 ; 1613-4125
ISSN (online)	1613-4133
ISSN	1613-4125
DOI	10.1002/mnfr.202300615
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Article ; Online: Absolute quantitative lipidomics reveals lipids profiling in liver of mice with early-stage alcoholic liver disease

Zhao, Fei / Chen, Jun / Guo, Rui / Zhu, Jinyan / Gu, Weijia / Li, Songtao / Li, Jiaomei

Nutr Metab (Lond). 2022 Dec., v. 19, no. 1 p.42-42

2022

Abstract: BACKGROUND: Alcoholic liver disease (ALD) is one of the most prevalent chronic liver disease worldwide. Alcohol-induced alterations in hepatic lipids play an important role in ALD develpoment and progression. The present study aimed to thoroughly ... ...

Abstract	BACKGROUND: Alcoholic liver disease (ALD) is one of the most prevalent chronic liver disease worldwide. Alcohol-induced alterations in hepatic lipids play an important role in ALD develpoment and progression. The present study aimed to thoroughly describe the changes of lipid profiling in liver of mice with early-stage alcoholic liver disease. METHODS: C57BL/6J male mice aged 7-week were randomized into alcohol-fed (AF) group and pair-fed control group (PF) (n = 10 per group). The early stage of ALD was induced with Lieber-DeCarli liquid diet. The lipids profiling was analyzed by absolute quantitative lipidomics with UHPLC-QTRAP-MS/MS. RESULTS: Alcohol intake significantly increased the levels of alanine aminotransferase (ALT) in plasma, and tumor necrosis factor-α (TNF-α), interleukin-6 (IL-6) and triacylglycerols (TAG) levels in liver. Lipidomis analyses showed that 41 TAGs were up-regulated and 8 TAGs were down-regulated in response to alcohol intake. The 8 decreased TAGs were with more double bond, longer carbon chain length and mostly contained docosahexaenoic acid (C22:6n-3) and eicosapentaenoic acid (C20:5n-3), compared with the up-regulated TAGs. Furthermore, the down-regulated TAG(56:9)_FA20:5 was inversely associated with ALT and IL-6 levels. In addition, several altered lysophosphatidylcholines (LPC), lysophosphatidylethanolamines (LPE) and hexosylceramides (HCER) were all significantly decreased in response to alcohol consumption, especially HCer(18:1/22:0), with the top reduction among all the down-regulated lipids. CONCLUSIONS: These findings suggest that not only the up-regulated lipids, alcohol-induced reduction in some specific lipids might also contribute to the ALD development, especially TAG(56:9)_FA20:5 and HCer(18:1/22:0). Their physiological functions and effects on ALD development warrants further investigation.
Keywords	alanine transaminase ; alcohol drinking ; carbon ; docosahexaenoic acid ; eicosapentaenoic acid ; interleukin-6 ; lipidomics ; liquid diet ; liver ; liver diseases ; lysophosphatidylcholine ; males ; necrosis ; neoplasms ; triacylglycerols
Language	English
Dates of publication	2022-12
Size	p. 42.
Publishing place	BioMed Central
Document type	Article ; Online
ZDB-ID	2160376-5
ISSN	1743-7075
ISSN	1743-7075
DOI	10.1186/s12986-022-00679-z
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Article: Absolute quantitative lipidomics reveals lipids profiling in liver of mice with early-stage alcoholic liver disease.

Zhao, Fei / Chen, Jun / Guo, Rui / Zhu, Jinyan / Gu, Weijia / Li, Songtao / Li, Jiaomei

Nutrition & metabolism

2022 Volume 19, Issue 1, Page(s) 42

Abstract: Background: Alcoholic liver disease (ALD) is one of the most prevalent chronic liver disease worldwide. Alcohol-induced alterations in hepatic lipids play an important role in ALD develpoment and progression. The present study aimed to thoroughly ... ...

Abstract	Background: Alcoholic liver disease (ALD) is one of the most prevalent chronic liver disease worldwide. Alcohol-induced alterations in hepatic lipids play an important role in ALD develpoment and progression. The present study aimed to thoroughly describe the changes of lipid profiling in liver of mice with early-stage alcoholic liver disease. Methods: C57BL/6J male mice aged 7-week were randomized into alcohol-fed (AF) group and pair-fed control group (PF) (n = 10 per group). The early stage of ALD was induced with Lieber-DeCarli liquid diet. The lipids profiling was analyzed by absolute quantitative lipidomics with UHPLC-QTRAP-MS/MS. Results: Alcohol intake significantly increased the levels of alanine aminotransferase (ALT) in plasma, and tumor necrosis factor-α (TNF-α), interleukin-6 (IL-6) and triacylglycerols (TAG) levels in liver. Lipidomis analyses showed that 41 TAGs were up-regulated and 8 TAGs were down-regulated in response to alcohol intake. The 8 decreased TAGs were with more double bond, longer carbon chain length and mostly contained docosahexaenoic acid (C22:6n-3) and eicosapentaenoic acid (C20:5n-3), compared with the up-regulated TAGs. Furthermore, the down-regulated TAG(56:9)_FA20:5 was inversely associated with ALT and IL-6 levels. In addition, several altered lysophosphatidylcholines (LPC), lysophosphatidylethanolamines (LPE) and hexosylceramides (HCER) were all significantly decreased in response to alcohol consumption, especially HCer(18:1/22:0), with the top reduction among all the down-regulated lipids. Conclusions: These findings suggest that not only the up-regulated lipids, alcohol-induced reduction in some specific lipids might also contribute to the ALD development, especially TAG(56:9)_FA20:5 and HCer(18:1/22:0). Their physiological functions and effects on ALD development warrants further investigation.
Language	English
Publishing date	2022-07-05
Publishing country	England
Document type	Journal Article
ZDB-ID	2160376-5
ISSN	1743-7075
ISSN	1743-7075
DOI	10.1186/s12986-022-00679-z
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Article ; Online: Monounsaturated fatty acid-enriched olive oil exacerbates chronic alcohol-induced hepatic steatosis and liver injury in C57BL/6J mice.

Guo, Rui / Chen, Lin / Zhu, Jinyan / Li, Jiaomei / Ding, Qingchao / Chang, Kaixin / Han, Qiang / Li, Songtao

Food & function

2023 Volume 14, Issue 3, Page(s) 1573–1583

Abstract: Dietary oil composition determines the pathological processes of alcoholic fatty liver disease (AFLD). Oil rich in saturated fatty acids protects, whereas oil rich in polyunsaturated fatty acids aggravates the alcohol-induced liver injury. However, ... ...

Abstract	Dietary oil composition determines the pathological processes of alcoholic fatty liver disease (AFLD). Oil rich in saturated fatty acids protects, whereas oil rich in polyunsaturated fatty acids aggravates the alcohol-induced liver injury. However, limited studies have been conducted to address how monounsaturated fatty acids (MUFAs) enriched oil controls the pathological development of AFLD. Therefore, this study was designed to evaluate the effect of MUFA-enriched extra virgin olive oil (OO) on AFLD. Twenty C57BL/6J mice were randomly allocated into four groups and fed modified Lieber-DeCarli liquid diets containing isocaloric maltose dextrin a non-alcohol or alcohol with corn oil and OO for four weeks. Dietary OO significantly exacerbated alcohol-induced liver dysfunction, evidenced by histological examinations and disturbed biochemical parameters. Dietary OO with alcohol decreased hormone-sensitive lipase (HSL), phosphorylated 5'-AMP-activated protein kinase (p-AMPK), and carnitine palmitoyltransferase-Iα (CPT1α) expression, and increased sterol regulatory element-binding protein-1c (SREBP-1c), diacylglycerol acyltransferase-2 (DGAT2), and very low-density lipoprotein receptor (VLDLR) expression in the liver. It also promoted the expression of hepatic interleukin-6 (
MeSH term(s)	Mice ; Animals ; Olive Oil/pharmacology ; Fatty Liver, Alcoholic/etiology ; Fatty Liver, Alcoholic/metabolism ; Fatty Acids, Monounsaturated/metabolism ; Mice, Inbred C57BL ; Liver/metabolism ; Ethanol/metabolism ; Fatty Acids/metabolism ; Corn Oil/metabolism
Chemical Substances	Olive Oil ; Fatty Acids, Monounsaturated ; Ethanol (3K9958V90M) ; Fatty Acids ; Corn Oil (8001-30-7)
Language	English
Publishing date	2023-02-06
Publishing country	England
Document type	Journal Article
ZDB-ID	2612033-1
ISSN	2042-650X ; 2042-6496
ISSN (online)	2042-650X
ISSN	2042-6496
DOI	10.1039/d2fo03323b
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Article ; Online: Uptake, translocation and metabolism of acetamiprid and cyromazine by cowpea (Vigna unguiculata L.).

Zhang, Shanying / Zhang, Yu / Ren, Saihao / Lu, Hongwei / Li, Jiaomei / Liang, Xiaoyu / Wang, Lifeng / Li, Yuanbo / Wang, Meng / Zhang, Chenghui

Environmental pollution (Barking, Essex : 1987)

2023 Volume 331, Issue Pt 1, Page(s) 121839

Abstract: Acetamiprid (ACE) and cyromazine (CYR) are the two pesticides that are used relatively frequently and in large quantities in cowpea growing areas in Hainan. The uptake, translocation and metabolic patterns and subcellular distribution of these two ... ...

Abstract	Acetamiprid (ACE) and cyromazine (CYR) are the two pesticides that are used relatively frequently and in large quantities in cowpea growing areas in Hainan. The uptake, translocation and metabolic patterns and subcellular distribution of these two pesticides in cowpea are important factors affecting pesticide residues in cowpea and assessing the dietary safety of cowpea. In this study, we investigated the uptake, translocation, subcellular distribution, and metabolic pathway of ACE and CYR in cowpea under laboratory hydroponic conditions. The distribution trends of both ACE and CYR in cowpea plants were leaves > stems > roots. The distribution of both pesticides in subcellular tissues of cowpea was cell soluble fraction > cell wall > cell organelle, and both transport modes were passive. A multiplicity of metabolic reactions of both pesticides occurred in cowpea, including dealkylation, hydroxylation and methylation. The results of the dietary risk assessment indicate that ACE is safe for use in cowpeas, but CYR poses an acute dietary risk to infants and young children. This study provided a basis for insights into the transport and distribution of ACE and CYR in vegetables and contributes to the assessment of whether pesticide residues in vegetables could pose a potential threat to human health at high concentrations of pesticides in the environment.
MeSH term(s)	Child ; Humans ; Child, Preschool ; Vigna/chemistry ; Vigna/metabolism ; Pesticide Residues/metabolism ; Pesticides/metabolism
Chemical Substances	acetamiprid (5HL5N372P0) ; cyromazine (CA49Y29RA9) ; Pesticide Residues ; Pesticides
Language	English
Publishing date	2023-05-17
Publishing country	England
Document type	Journal Article
ZDB-ID	280652-6
ISSN	1873-6424 ; 0013-9327 ; 0269-7491
ISSN (online)	1873-6424
ISSN	0013-9327 ; 0269-7491
DOI	10.1016/j.envpol.2023.121839
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Article: Relationship between the n-3 index, serum metabolites and breast cancer risk

Li, Jiaomei / Zheng, Zhaohong / Liu, Min / Ren, Yiping / Ruan, Yue / Li, Duo

Food & function. 2021 Aug. 31, v. 12, no. 17

2021

Abstract: The present study aimed to investigate the relationship between the n-3 index, serum metabolites and breast cancer risk. A total of 104 newly diagnosed breast cancer patients and 70 healthy controls were recruited. The erythrocyte phospholipid fatty acid ...

Abstract	The present study aimed to investigate the relationship between the n-3 index, serum metabolites and breast cancer risk. A total of 104 newly diagnosed breast cancer patients and 70 healthy controls were recruited. The erythrocyte phospholipid fatty acid composition was determined by gas–liquid chromatography, and the n-3 index was calculated with the percentage of eicosapentaenoic acid plus docosahexaenoic acid in total fatty acids. Serum metabolomic profiles were analyzed by UHPLC-Q-Exactive Orbitrap/MS. The results showed that the erythrocyte phospholipid n-3 index was significantly lower in breast cancer patients than in healthy controls, and it was inversely associated with breast cancer risk (OR = 0.60; 95% CI: 0.36–0.84). Metabolomics analyses showed that serum 16α-hydroxy dehydroepiandrosterone (DHEA) 3-sulfate, lysophatidylethanolamines (LPE) 22:0/0:0 and hexanoylcarnitine were significantly higher, while thromboxane B₃, prostaglandin E₃ (PGE₃) and 18β-glycyrrhetinic acid were significantly lower in breast cancer patients than those in healthy controls. In addition, serum 16α-hydroxy DHEA 3-sulfate was inversely correlated with the n-3 index (r = −0.412, p = 0.036). In conclusion, our findings suggest that the lack of n-3 PUFAs might be a potential risk factor for breast cancer, and the serum metabolite 16α-hydroxy DHEA 3-sulfate may play an important role in linking n-3 PUFA deficiency and breast disease etiology.
Keywords	blood serum ; breast neoplasms ; breasts ; docosahexaenoic acid ; eicosapentaenoic acid ; erythrocytes ; etiology ; fatty acid composition ; gas chromatography ; metabolites ; metabolomics ; omega-3 fatty acids ; phospholipid fatty acids ; prasterone ; prostaglandins ; risk factors
Language	English
Dates of publication	2021-0831
Size	p. 7741-7748.
Publishing place	The Royal Society of Chemistry
Document type	Article
ZDB-ID	2612033-1
ISSN	2042-650X ; 2042-6496
ISSN (online)	2042-650X
ISSN	2042-6496
DOI	10.1039/d1fo01245b
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Article ; Online: Uptake, translocation and metabolism of acetamiprid and cyromazine by cowpea (Vigna unguiculata L.)

Zhang, Shanying / Zhang, Yu / Ren, Saihao / Lu, Hongwei / Li, Jiaomei / Liang, Xiaoyu / Wang, Lifeng / Li, Yuanbo / Wang, Meng / Zhang, Chenghui

Environmental Pollution. 2023 Aug., v. 331 p.121839-

2023

Abstract	Acetamiprid (ACE) and cyromazine (CYR) are the two pesticides that are used relatively frequently and in large quantities in cowpea growing areas in Hainan. The uptake, translocation and metabolic patterns and subcellular distribution of these two pesticides in cowpea are important factors affecting pesticide residues in cowpea and assessing the dietary safety of cowpea. In this study, we investigated the uptake, translocation, subcellular distribution, and metabolic pathway of ACE and CYR in cowpea under laboratory hydroponic conditions. The distribution trends of both ACE and CYR in cowpea plants were leaves > stems > roots. The distribution of both pesticides in subcellular tissues of cowpea was cell soluble fraction > cell wall > cell organelle, and both transport modes were passive. A multiplicity of metabolic reactions of both pesticides occurred in cowpea, including dealkylation, hydroxylation and methylation. The results of the dietary risk assessment indicate that ACE is safe for use in cowpeas, but CYR poses an acute dietary risk to infants and young children. This study provided a basis for insights into the transport and distribution of ACE and CYR in vegetables and contributes to the assessment of whether pesticide residues in vegetables could pose a potential threat to human health at high concentrations of pesticides in the environment.
Keywords	Vigna unguiculata ; acetamiprid ; acute dietary exposure ; biochemical pathways ; cell walls ; cowpeas ; cyromazine ; dealkylation ; human health ; hydroponics ; hydroxylation ; methylation ; nutrition risk assessment ; pollution ; China ; Transport modes ; Distribution ; Root sorption ; Subcellular distribution ; Degradation
Language	English
Dates of publication	2023-08
Publishing place	Elsevier Ltd
Document type	Article ; Online
ZDB-ID	280652-6
ISSN	1873-6424 ; 0013-9327 ; 0269-7491
ISSN (online)	1873-6424
ISSN	0013-9327 ; 0269-7491
DOI	10.1016/j.envpol.2023.121839
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Article: Xie Zhuo Tiao Zhi formula ameliorates chronic alcohol-induced liver injury in mice.

Chang, Kaixin / Guo, Rui / Hu, Wenbo / Wang, Xuezhu / Cao, Feiwei / Qiu, Jiannan / Li, Jiaomei / Han, Qiang / Du, Zhongyan / Dou, Xiaobing / Li, Songtao

Frontiers in pharmacology

2024 Volume 15, Page(s) 1363131

Abstract: This study aimed to evaluate the protective role and potential mechanisms of Xie Zhuo Tiao Zhi decoction (XZTZ) on alcohol-associated liver disease (ALD). XZTZ significantly alleviated alcohol-induced liver dysfunction, based on histological examinations ...

Abstract	This study aimed to evaluate the protective role and potential mechanisms of Xie Zhuo Tiao Zhi decoction (XZTZ) on alcohol-associated liver disease (ALD). XZTZ significantly alleviated alcohol-induced liver dysfunction, based on histological examinations and biochemical parameters after 4-week administration. Mechanically, alcohol-stimulated hepatic oxidative stress was ameliorated by XZTZ, accompanied by the improvement of Nrf2/Keap1 expression and alcohol-activated phosphorylation of pro-inflammatory transcription factors, including JNK, P38, P65, and IκBα, were rescued by XZTZ. In conclusion, XZTZ demonstrates potential in alleviating alcohol-induced liver injury, oxidative stress, and inflammation possibly through modulation of Nrf2/Keap1 and MAPKs/NF-κB signaling pathways, suggesting its potential as a therapeutic option for patients with alcoholic liver disease.
Language	English
Publishing date	2024-04-12
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2587355-6
ISSN	1663-9812
ISSN	1663-9812
DOI	10.3389/fphar.2024.1363131
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