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  1. Article: New Strategy for Preparation of Yttria Powders with Atypical Morphologies and Their Sintering Behavior.

    Qu, Sheng / Li, Jinlian / Liu, Zhaoyang

    Materials (Basel, Switzerland)

    2023  Volume 16, Issue 7

    Abstract: A modified precipitation method was used to prepare yttria powers for the fabrication of yttria ceramics in this study. The precipitation behavior, phase evolution, and shape of the yttria precursor were all examined in the presence or absence of an ... ...

    Abstract A modified precipitation method was used to prepare yttria powers for the fabrication of yttria ceramics in this study. The precipitation behavior, phase evolution, and shape of the yttria precursor were all examined in the presence or absence of an electric field. The findings demonstrate that the phases of the yttria precursor were Y
    Language English
    Publishing date 2023-04-03
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2487261-1
    ISSN 1996-1944
    ISSN 1996-1944
    DOI 10.3390/ma16072854
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Design of gum Arabic/gelatin composite microcapsules and their cosmetic applications in encapsulating tea tree essential oil.

    Yang, Wei / Gong, Yuxi / Wang, Yansong / Wu, Chao / Zhang, Xiangyu / Li, Jinlian / Wu, Dongmei

    RSC advances

    2024  Volume 14, Issue 7, Page(s) 4880–4889

    Abstract: Microencapsulation has been widely used to protect essential oils, facilitating their application in cosmetics. In this study, gelatin, gum arabic ... ...

    Abstract Microencapsulation has been widely used to protect essential oils, facilitating their application in cosmetics. In this study, gelatin, gum arabic and
    Language English
    Publishing date 2024-02-06
    Publishing country England
    Document type Journal Article
    ISSN 2046-2069
    ISSN (online) 2046-2069
    DOI 10.1039/d3ra08526k
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Evaluation on purine metabolism in human skin fibroblast cells exposed to oxygenated polycyclic aromatic hydrocarbons.

    Liu, Junqi / Wang, Saijin / Wang, Meng / Li, Zan / Zhou, Shi / Li, Jinlian / Wu, Dongmei

    Toxicology and industrial health

    2024  Volume 40, Issue 4, Page(s) 176–184

    Abstract: A rapid and sensitive assessment of the toxicity of oxygenated polycyclic aromatic hydrocarbons (OPAHs), widely distributed persistent organic pollutants in the environment, is crucial for human health. In this study, using high-performance liquid ... ...

    Abstract A rapid and sensitive assessment of the toxicity of oxygenated polycyclic aromatic hydrocarbons (OPAHs), widely distributed persistent organic pollutants in the environment, is crucial for human health. In this study, using high-performance liquid chromatography, the separation and detection of four purines, xanthine (X), guanine (G), adenine (A), and hypoxanthine (HX) in cells were performed. The aim was to evaluate the cytotoxicity of three OPAHs, namely 1,4-benzoquinone (1,4-BQ), 1,2-naphthoquinone (1,2-NQ) and 9,10-phenanthrenequinone (9,10-PQ), with higher environmental concentrations, from the perspective of purine nucleotide metabolism in human skin fibroblast cells (HFF-1). The results revealed that the levels of G and A were low in HFF-1 cells, while the levels of HX and X showed a dose-response relationship with persistent organic pollutants concentration. With increased concentration of the three persistent organic pollutants, the purine metabolism in HFF-1 cells weakened, and the impact of the three persistent organic pollutants on purine metabolism in cells was in the order of 9,10-PQ > 1,4-BQ > 1,2-NQ. This study provided valuable insights into the toxic mechanisms of 1,4-BQ, 1,2-NQ and 9,10-PQ, contributing to the formulation of relevant protective measures and the safeguarding of human health.
    MeSH term(s) Humans ; Polycyclic Aromatic Hydrocarbons/toxicity ; Polycyclic Aromatic Hydrocarbons/analysis ; Persistent Organic Pollutants ; Chromatography, High Pressure Liquid/methods ; Purines/analysis ; Fibroblasts/chemistry
    Chemical Substances Polycyclic Aromatic Hydrocarbons ; Persistent Organic Pollutants ; Purines
    Language English
    Publishing date 2024-02-13
    Publishing country England
    Document type Journal Article
    ZDB-ID 56831-4
    ISSN 1477-0393 ; 0748-2337
    ISSN (online) 1477-0393
    ISSN 0748-2337
    DOI 10.1177/07482337241232716
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    Zs.A 2268: Show issues Location:
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  4. Article ; Online: Design of oleic acid/alkyl glycoside composite vesicles as cosmetics carrier: stability, skin permeability and antioxidant activity.

    Li, Siqi / Wang, Di / Zhang, Meng / Yang, Ying / Zhang, Xiangyu / Li, Jinlian / Wu, Dongmei

    Journal of biomaterials science. Polymer edition

    2024  Volume 35, Issue 5, Page(s) 579–604

    Abstract: Biocompatible fatty acids are natural biological materials which exhibit widespread biomedical applications. Nevertheless, their application in vesicle forms is hampered by strong pH sensitivity and poor stability to changes in ionic strength, ... ...

    Abstract Biocompatible fatty acids are natural biological materials which exhibit widespread biomedical applications. Nevertheless, their application in vesicle forms is hampered by strong pH sensitivity and poor stability to changes in ionic strength, temperature, and storage. In the investigation, the incorporation of alkyl glycoside (APG), a surfactant with non-ionic properties, into the oleic acid (OA) vesicles was undertaken as a means to address this issue. The newly formed OA/APG composite vesicles form in a pH range of between 5.4 and 7.4, which is close to the pH range of the physiological environment. The stability studies results showed that the OA/APG composite vesicles have excellent stability in terms of ionic strengths, temperature and storage. The formation of NAR-loaded OA/APG composite vesicles was demonstrated through FT-IR, DSC and XRD.
    MeSH term(s) Antioxidants/chemistry ; Oleic Acid/chemistry ; Glycosides/metabolism ; Glycosides/pharmacology ; Spectroscopy, Fourier Transform Infrared ; Skin ; Permeability
    Chemical Substances Antioxidants ; Oleic Acid (2UMI9U37CP) ; Glycosides
    Language English
    Publishing date 2024-01-13
    Publishing country England
    Document type Journal Article
    ZDB-ID 1014190-x
    ISSN 1568-5624 ; 1568-5616 ; 0920-5063
    ISSN (online) 1568-5624 ; 1568-5616
    ISSN 0920-5063
    DOI 10.1080/09205063.2024.2302632
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  5. Article ; Online: Chinese characters carry special anatomical connotations.

    Xia, Xin / Li, Lei / Jin, Jianliang / Zhang, Yongjie / Li, Jinlian / Zuo, Yizhi

    Anatomical science international

    2024  

    Abstract: In the domain of anatomy, some Chinese characters in anatomical terms possess distinctive morphological significance. Chinese characters evolved from pictographic characters, with some of these pictographs being created by ancient people based on their ... ...

    Abstract In the domain of anatomy, some Chinese characters in anatomical terms possess distinctive morphological significance. Chinese characters evolved from pictographic characters, with some of these pictographs being created by ancient people based on their own body structure. This implies that the comprehension and depiction of the human body structure have been integral since the inception of Chinese characters, and this knowledge has been passed down and developed through the continued inheritance of Chinese characters. Even today, certain characters retain the appearance to reflect the shape of the human body structure. By examining the characters related to vertebrae, cranial fontanel and heart, we can find the unique and enduring link between Chinese characters and the fields of anatomy as well as Chinese traditional medicine.
    Language English
    Publishing date 2024-05-02
    Publishing country Japan
    Document type Journal Article
    ZDB-ID 2079994-9
    ISSN 1447-073X ; 1447-6959 ; 0022-7722
    ISSN (online) 1447-073X
    ISSN 1447-6959 ; 0022-7722
    DOI 10.1007/s12565-024-00771-9
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    Zs.A 219: Show issues Location:
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  6. Article ; Online: Photoredox/Bismuth Relay Catalysis Enabling Reductive Alkylation of Nitroarenes with Aldehydes.

    Li, Jinlian / Chen, Xing / Xie, Shenxia / Wang, Huabing / Mo, Jiayu / Huang, Huawen

    Chemistry (Weinheim an der Bergstrasse, Germany)

    2024  , Page(s) e202401456

    Abstract: The effective transition metal-free photoredox/bismuth dual catalytic reductive dialkylation of nitroarenes with benzaldehydes has been reported. The nitroarene redution through visible light-driven photoredox catalysis was integrated with subsequent ... ...

    Abstract The effective transition metal-free photoredox/bismuth dual catalytic reductive dialkylation of nitroarenes with benzaldehydes has been reported. The nitroarene redution through visible light-driven photoredox catalysis was integrated with subsequent reductive dialkylation of anilines under bismuth catalysis to enable the cascade reductive alkylation of nitroarenes with carbonyls. Salient features of this relay catalysis system include mild reaction conditions, no requirement for transition metal catalysts, easy handling, step-economy, and high selectivity.
    Language English
    Publishing date 2024-05-13
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 1478547-X
    ISSN 1521-3765 ; 0947-6539
    ISSN (online) 1521-3765
    ISSN 0947-6539
    DOI 10.1002/chem.202401456
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  7. Article ; Online: The Impact of Regulatory Reforms in China on Drug Lag: The Role of Clinical Development Strategies.

    Han, Yue / Jiang, Rong / Li, Jinlian / Wang, Yifei / Shao, Rong / Xie, Jinping

    Clinical pharmacology and therapeutics

    2024  Volume 115, Issue 6, Page(s) 1400–1407

    Abstract: In recent years, there has been significant focus on China's new drug lag, but relevant research is limited. This study explores the reasons for drug lag by assessing the impact of reforms in China's drug review system, particularly focusing on the ... ...

    Abstract In recent years, there has been significant focus on China's new drug lag, but relevant research is limited. This study explores the reasons for drug lag by assessing the impact of reforms in China's drug review system, particularly focusing on the influence of clinical development strategies. This study selected drugs first launched in the United States between 2017 and 2022, examining absolute and relative lag between China and the first-launch country (including submission and review lag). These delays with drugs approved in the European Union and Japan during the same period were compared with uncover the roots of delays in China, further identifying potential factors that could reduce these delays. The results indicate that the National Medical Products Administration (NMPA) has a longer relative lag compared with the European Medicines Agency (EMA) and the Pharmaceuticals and Medical Devices Agency (PMDA). The submission lag time of the NMPA significantly surpasses that of the EMA and PMDA, whereas the review lag time of the NMPA exceeds that of the PMDA but falls short of the EMA. Focusing on clinical trial strategies, bridging trials and multiregional clinical trials (MRCTs) are typically required by the NMPA in East Asia, resulting in longer clinical delay time. Whereas the EMA and PMDA primarily require international MRCTs in Europe and America, with a clinical delay of < 5 months. It is evident that there is a significant gap in clinical trial durations between China and other countries. Further optimization of clinical trial management is necessary to address the lag for new drugs in China.
    MeSH term(s) China ; Humans ; Drug Approval/legislation & jurisprudence ; Drug Development/legislation & jurisprudence ; United States ; European Union ; Clinical Trials as Topic/legislation & jurisprudence ; Time Factors ; Japan
    Language English
    Publishing date 2024-03-01
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 123793-7
    ISSN 1532-6535 ; 0009-9236
    ISSN (online) 1532-6535
    ISSN 0009-9236
    DOI 10.1002/cpt.3227
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  8. Article ; Online: An Attempt of a New Strategy in PRV Prevention: Co-Injection with Inactivated

    Cui, Yuan / Huang, Libo / Li, Jinlian / Wang, Gang / Shi, Youfei

    Viruses

    2023  Volume 15, Issue 8

    Abstract: Pseudorabies virus (PRV) is one of the causative agents of common infectious diseases in swine herds. ...

    Abstract Pseudorabies virus (PRV) is one of the causative agents of common infectious diseases in swine herds.
    MeSH term(s) Animals ; Mice ; Swine ; Enterococcus faecium ; Herpesvirus 1, Suid ; Injections ; Agriculture ; Animal Diseases
    Language English
    Publishing date 2023-08-17
    Publishing country Switzerland
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2516098-9
    ISSN 1999-4915 ; 1999-4915
    ISSN (online) 1999-4915
    ISSN 1999-4915
    DOI 10.3390/v15081755
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  9. Article ; Online: A dual-functional module cellular electrochemical sensing platform for simultaneous detection guanine and xanthine

    Zhang, Shumeng / Cui, Jiwen / Zhou, Shi / Zhao, Yanli / Li, Jinlian / Wu, Dongmei

    Biosensors and Bioelectronics. 2023 Apr., v. 226 p.115104-

    2023  

    Abstract: The separation of the superimposed electrochemical signals of intracellular guanine (G) and xanthine (X) is difficult, which is great obstacle to the application of cell electrochemistry. In this paper, independent functional modules, G-functional module ...

    Abstract The separation of the superimposed electrochemical signals of intracellular guanine (G) and xanthine (X) is difficult, which is great obstacle to the application of cell electrochemistry. In this paper, independent functional modules, G-functional module (G-FM) and X-functional module (X-FM), were constructed by molecular imprinting technology for sensitive detection of G and X without mutual interference, then integrated in dual-functional module cellular electrochemical sensing platform (DMCEP) as signal sensing units. DMCEP transmitted signals of G and X in cells synchronously to two windows by two signal sensing channels, and achieved the separation of superimposed signals of G and X in cells. DMCEP exhibited satisfactory reproducibility with relative standard deviation (RSD) of 3.10 and 2.22 %, repeatability with RSD of 3.72 and 3.05 % for G and X detection, and detection limit 0.05 μΜ for G and 0.06 μΜ for X. Good linear relationships between cell concentrations and the signals of G and X on DMCEP were shown in range of 0.75–85 × 10⁶ and 3–85 × 10⁶ cells/mL, respectively. The growth of MCF-7 cells was tracked by DMCEP, and showed consistent trend with the cell counting method, while the change of cell viability from lag to logarithmic phase captured by DMCEP was earlier than that of cell counting method. This strategy provided the foundation for the establishment of the cell viability electrochemical detection method, and new insights into the simultaneous recording of other analyses with superimposed peak positions and the simultaneous tracking of multiple biomarkers.
    Keywords biosensors ; cell viability ; detection limit ; electrochemistry ; guanine ; standard deviation ; xanthine ; Molecular imprinting
    Language English
    Dates of publication 2023-04
    Publishing place Elsevier B.V.
    Document type Article ; Online
    ZDB-ID 1011023-9
    ISSN 1873-4235 ; 0956-5663
    ISSN (online) 1873-4235
    ISSN 0956-5663
    DOI 10.1016/j.bios.2023.115104
    Database NAL-Catalogue (AGRICOLA)

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    Zs.A 2275: Show issues Location:
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  10. Article ; Online: The toxicity response of the electrochemical signal of the cell to the drug metabolized by the S9 system.

    Zhang, Jiahuan / Fei, Chaoqun / Qi, Shulan / Fu, Jiaqi / Zhou, Shi / Wang, Zhong / Li, Jinlian / Zhao, Yanli / Wu, Dongmei

    The Analyst

    2024  Volume 149, Issue 6, Page(s) 1921–1928

    Abstract: The electrochemical detection method of cytotoxicity using intracellular purines as biomarkers has shown great potential ... ...

    Abstract The electrochemical detection method of cytotoxicity using intracellular purines as biomarkers has shown great potential for
    MeSH term(s) Benzo(a)pyrene/metabolism ; Benzo(a)pyrene/toxicity ; Fluorenes/toxicity ; Guanine ; Biochemical Phenomena ; Mutagens
    Chemical Substances fluoranthene (360UOL779Z) ; Benzo(a)pyrene (3417WMA06D) ; Fluorenes ; Guanine (5Z93L87A1R) ; Mutagens
    Language English
    Publishing date 2024-03-11
    Publishing country England
    Document type Journal Article
    ZDB-ID 210747-8
    ISSN 1364-5528 ; 0003-2654
    ISSN (online) 1364-5528
    ISSN 0003-2654
    DOI 10.1039/d4an00010b
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