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  1. Article ; Online: Occurrence, consumption level, fate and ecotoxicology risk of beta-agonist pharmaceuticals in a wastewater treatment plant in Eastern China

    Zhang, Hui / Li, Kefang / Zhao, Xiangwei / Zou, Huiyun / Zhao, Ling / Li, Xuewen

    Environ Monit Assess. 2023 Apr., v. 195, no. 4 p.481-481

    2023  

    Abstract: Beta-agonist pharmaceuticals are widely used in humans and livestock for disease treatment, legal or illegal growth promotion in food animals, bodybuilding, weight loss, and sports doping. The occurrence of beta-agonists in wastewater treatment plants ... ...

    Abstract Beta-agonist pharmaceuticals are widely used in humans and livestock for disease treatment, legal or illegal growth promotion in food animals, bodybuilding, weight loss, and sports doping. The occurrence of beta-agonists in wastewater treatment plants and their subsequent environmental impacts require greater attention. This study determined the levels of 12 beta-agonists in a wastewater treatment plant and evaluated their ecotoxicological risks as well as consumption levels and risks to human health. Among the 12 selected beta-agonists, all were detected in wastewater and 11 in sludge. In most cases, the concentrations of beta-agonists were higher in spring than in summer. Their total average daily mass loads per capita in the influent and effluent were 1.35 μg/d/p and 2.11 μg/d/p, respectively. The overall removal efficiencies of individual beta-agonists ranged from -295.3 to 71.2%. Ecotoxicological risk assessment revealed a low risk to daphnid and green algae from the levels of fenoterol and the mixture of 12 selected beta-agonists in the effluent. The daily consumption levels of individual beta-agonists per capita were 0.028–1.200 μg/d/p. Regular monitoring of beta-agonists in municipal sewage systems and their risk assessment based on toxicological data are urgently required in the future.
    Keywords beta-adrenergic agonists ; ecotoxicology ; growth promotion ; human health ; livestock ; risk ; risk assessment ; sewage ; sludge ; spring ; strength training ; summer ; therapeutics ; wastewater ; wastewater treatment ; weight loss ; China
    Language English
    Dates of publication 2023-04
    Size p. 481.
    Publishing place Springer International Publishing
    Document type Article ; Online
    ZDB-ID 782621-7
    ISSN 1573-2959 ; 0167-6369
    ISSN (online) 1573-2959
    ISSN 0167-6369
    DOI 10.1007/s10661-023-11099-8
    Database NAL-Catalogue (AGRICOLA)

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  2. Article ; Online: Occurrence, consumption level, fate and ecotoxicology risk of beta-agonist pharmaceuticals in a wastewater treatment plant in Eastern China.

    Zhang, Hui / Li, Kefang / Zhao, Xiangwei / Zou, Huiyun / Zhao, Ling / Li, Xuewen

    Environmental monitoring and assessment

    2023  Volume 195, Issue 4, Page(s) 481

    Abstract: Beta-agonist pharmaceuticals are widely used in humans and livestock for disease treatment, legal or illegal growth promotion in food animals, bodybuilding, weight loss, and sports doping. The occurrence of beta-agonists in wastewater treatment plants ... ...

    Abstract Beta-agonist pharmaceuticals are widely used in humans and livestock for disease treatment, legal or illegal growth promotion in food animals, bodybuilding, weight loss, and sports doping. The occurrence of beta-agonists in wastewater treatment plants and their subsequent environmental impacts require greater attention. This study determined the levels of 12 beta-agonists in a wastewater treatment plant and evaluated their ecotoxicological risks as well as consumption levels and risks to human health. Among the 12 selected beta-agonists, all were detected in wastewater and 11 in sludge. In most cases, the concentrations of beta-agonists were higher in spring than in summer. Their total average daily mass loads per capita in the influent and effluent were 1.35 μg/d/p and 2.11 μg/d/p, respectively. The overall removal efficiencies of individual beta-agonists ranged from -295.3 to 71.2%. Ecotoxicological risk assessment revealed a low risk to daphnid and green algae from the levels of fenoterol and the mixture of 12 selected beta-agonists in the effluent. The daily consumption levels of individual beta-agonists per capita were 0.028-1.200 μg/d/p. Regular monitoring of beta-agonists in municipal sewage systems and their risk assessment based on toxicological data are urgently required in the future.
    MeSH term(s) Animals ; Humans ; Waste Disposal, Fluid ; Ecotoxicology ; Water Pollutants, Chemical/analysis ; Environmental Monitoring ; Sewage ; China ; Water Purification ; Pharmaceutical Preparations
    Chemical Substances Water Pollutants, Chemical ; Sewage ; Pharmaceutical Preparations
    Language English
    Publishing date 2023-03-17
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 782621-7
    ISSN 1573-2959 ; 0167-6369
    ISSN (online) 1573-2959
    ISSN 0167-6369
    DOI 10.1007/s10661-023-11099-8
    Database MEDical Literature Analysis and Retrieval System OnLINE

    Full text online

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    In stock of ZB MED Bonn / Germany

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  3. Article: JNK and NF-κB signaling pathways are involved in cytokine changes in patients with congenital heart disease prior to and after transcatheter closure.

    Fan, Shunyang / Li, Kefang / Zhang, Deyin / Liu, Fuyun

    Experimental and therapeutic medicine

    2017  Volume 15, Issue 2, Page(s) 1525–1531

    Abstract: Congenital heart disease (CHD) is a problem in the structure of the heart that is present at birth. Due to advances in interventional cardiology, CHD may currently be without surgery. The present study aimed to explore the molecular mechanism underlying ... ...

    Abstract Congenital heart disease (CHD) is a problem in the structure of the heart that is present at birth. Due to advances in interventional cardiology, CHD may currently be without surgery. The present study aimed to explore the molecular mechanism underlying CHD. A total of 200 cases of CHD treated by transcatheter closure as well as 200 controls were retrospectively assessed. Serum cytokines prior to and after treatment were assessed by reverse-transcription quantitative polymerase chain reaction analysis. Furthermore, the levels of proteins associated with c-Jun N-terminal kinase (JNK) and nuclear factor (NF)-κB were assessed by western blot analysis and immunohistochemistry. Furthermore, an animal model of CHD in young pigs was successfully constructed and treated with inhibitors of JNK and/or NF-κB to investigate the roles of these pathways in CHD. The results revealed that tumor necrosis factor-α, interleukin (IL)-6 and IL-8 were significantly elevated in the experimental group following transcatheter closure treatment, compared with those in the healthy control group, and the serum levels of the anti-inflammatory cytokine IL-10 were significantly reduced. Phosphorylated c-Jun and p65 levels in the experimental group were notably higher in the experimental group compared with the control group, but were restored to normal levels following transcatheter closure treatment. Similar results were also obtained in the pig model. The results of the present study suggested that the CHD-associated changes in cytokines, as well as their recovery following transcatheter closure treatment were associated with the JNK and NF-κB signaling pathways. The present study may provide further understanding of the underlying molecular mechanisms in CHD and propose a potential novel target for the treatment of CHD.
    Language English
    Publishing date 2017-12-05
    Publishing country Greece
    Document type Journal Article
    ZDB-ID 2683844-8
    ISSN 1792-1015 ; 1792-0981
    ISSN (online) 1792-1015
    ISSN 1792-0981
    DOI 10.3892/etm.2017.5595
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Retrospective cohort study comparing the epidemiological and clinical characteristics between imported and local COVID-19 inpatients in Nanyang, China.

    Sun, Chan / Liu, Peipei / Cui, Yanhong / Li, Kefang / Qu, Weiwei / Jin, Bo / Peng, Fei / Zhao, Jiang / Zhang, Xiaoyu

    Journal of investigative medicine : the official publication of the American Federation for Clinical Research

    2020  Volume 69, Issue 3, Page(s) 704–709

    Abstract: China has experienced an outbreak of COVID-19 since December 2019. This study investigated the differences between the imported and local cases of COVID-19 in Nanyang, China. In this study, a total of 129 COVID-19 confirmed cases with a clear ... ...

    Abstract China has experienced an outbreak of COVID-19 since December 2019. This study investigated the differences between the imported and local cases of COVID-19 in Nanyang, China. In this study, a total of 129 COVID-19 confirmed cases with a clear epidemiological history admitted to hospitals in Nanyang from January 24 to February 26, 2020 were enrolled. Patients who had a travel history to or a residence history in Wuhan or in the surrounding areas in Hubei Province within 14 days before the illness onset were assigned to the imported group (n=70), and the others were assigned to the local group (n=59). The differences in epidemiological characteristics, clinical features, laboratory and imaging results, and prognosis were compared between the 2 groups. The early diagnosed cases were mainly imported cases, and the later diagnosed ones were mainly local cases. The most common first symptom was fever; moderate fever was commonly seen in imported cases whereas low fever was commonly seen in local cases. Lymphocyte counts in the imported group were lower than those in the local group. The imported group showed more advanced and severe abnormalities in the CT scan whereas the local group showed milder pulmonary abnormalities. The proportion of severe and critically severe patients in the imported group was higher than that in the local group. In conclusion, the imported cases have more severe or critically severe patients with a higher mortality rate than the local cases.
    MeSH term(s) Adult ; COVID-19/epidemiology ; COVID-19/mortality ; COVID-19/transmission ; COVID-19 Testing ; China/epidemiology ; Cohort Studies ; Female ; Hospitalization ; Humans ; Male ; Middle Aged ; Pandemics ; Prognosis ; Retrospective Studies ; SARS-CoV-2 ; Severity of Illness Index ; Travel
    Language English
    Publishing date 2020-12-23
    Publishing country England
    Document type Journal Article
    ZDB-ID 1217870-6
    ISSN 1708-8267 ; 0009-9279 ; 1081-5589
    ISSN (online) 1708-8267
    ISSN 0009-9279 ; 1081-5589
    DOI 10.1136/jim-2020-001643
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

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    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
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  5. Article: [NMDAR expression in the cochlear nucleus and hearing damage in neonatal rats with hyperbilirubinemia].

    Li, Ke-Fang / Du, Kai-Xian / Jiang, Yue-Xing / Dong, Xue-Lei / Zhang, Yan

    Zhongguo dang dai er ke za zhi = Chinese journal of contemporary pediatrics

    2010  Volume 12, Issue 3, Page(s) 201–204

    Abstract: Objective: To study the role of N-methyl-D-aspartate-receptor (NMDAR) expression in the development of hearing damage in neonatal rats with hyperbilirubinemia.: Methods: Sixty seven-day-old Sprague-Dawley rats were randomly injected with bilirubin of ...

    Abstract Objective: To study the role of N-methyl-D-aspartate-receptor (NMDAR) expression in the development of hearing damage in neonatal rats with hyperbilirubinemia.
    Methods: Sixty seven-day-old Sprague-Dawley rats were randomly injected with bilirubin of 100 microg/g (low-dose treatment group) or 200 microg/g (high-dose treatment group) or normal saline (control group). Auditory brainstem response (ABR) was examined. The concentrations of bilirubin in blood and brain were measured. NMDAR expression in the cochlear nucleus slices was examined by immunohistochemistry assay.
    Results: ABR reflecting threshold obviously increased, and I, II and III wave latency as well as I-II, II-III and I-III interval were more prolonged in the two bilirubin treatment groups when compared with the control group. The NMDAR expression in the cochlear nucleuse in the two bilirubin treatment groups was obviously lower than that in the control group. The NMDAR expression in the cochlear nucleuse was negatively correlated with the brain bilirubin content and the ABR reflecting threshold in the two bilirubin treatment groups.
    Conclusions: An increased NMDAR activity may play an important role in hearing damage following hyperbilirubinemia.
    MeSH term(s) Animals ; Animals, Newborn ; Bilirubin/analysis ; Cochlear Nucleus/chemistry ; Evoked Potentials, Auditory, Brain Stem ; Female ; Hearing Disorders/etiology ; Hyperbilirubinemia/complications ; Hyperbilirubinemia/metabolism ; Immunohistochemistry ; Male ; Rats ; Rats, Sprague-Dawley ; Receptors, N-Methyl-D-Aspartate/analysis
    Chemical Substances Receptors, N-Methyl-D-Aspartate ; Bilirubin (RFM9X3LJ49)
    Language Chinese
    Publishing date 2010-03
    Publishing country China
    Document type English Abstract ; Journal Article
    ISSN 1008-8830
    ISSN 1008-8830
    Database MEDical Literature Analysis and Retrieval System OnLINE

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