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  1. Book ; Conference proceedings: Neuroscience and biobehavioral research: a chinese perspective

    Li, Liang

    [th First International Symposium on Neurobehavioral Science ; China, July 2009] ; special section

    (Neuroscience & biobehavioral reviews ; 33,8)

    2009  

    Event/congress International Symposium on Neurobehavioral Science (2009)
    Author's details ed. by Liang Li
    Series title Neuroscience & biobehavioral reviews ; 33,8
    Collection
    Language English
    Size S. 1155 - 1242 : Ill., graph. Darst.
    Publisher Elsevier
    Publishing place Amsterdam u.a.
    Publishing country Netherlands
    Document type Book ; Conference proceedings
    HBZ-ID HT016082676
    Database Catalogue ZB MED Medicine, Health

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  2. Article ; Online: Studies of Labware Contamination during Lipid Extraction in Mass Spectrometry-Based Lipidome Analysis.

    Canez, Carlos R / Li, Liang

    Analytical chemistry

    2024  Volume 96, Issue 8, Page(s) 3544–3552

    Abstract: In lipidomic analysis, plasticware is increasingly being used for lipid extraction and other sample processing procedures over glassware. However, a systematic investigation of the consequences of plasticware use on mass spectrometry (MS)-based lipidome ... ...

    Abstract In lipidomic analysis, plasticware is increasingly being used for lipid extraction and other sample processing procedures over glassware. However, a systematic investigation of the consequences of plasticware use on mass spectrometry (MS)-based lipidome analysis is lacking. In this work, we present an analytical approach for detecting and comparing solvent and labware contaminants encountered in lipidomic workflows. It is shown that the contaminant profiles varied widely between microcentrifuge tubes from different manufacturers. The most suitable polypropylene tubes tested introduced 847 labware-originating contaminant
    MeSH term(s) Humans ; Tandem Mass Spectrometry/methods ; Lipidomics ; Polypropylenes ; Solvents/chemistry ; Fatty Acids
    Chemical Substances Polypropylenes ; Solvents ; Fatty Acids
    Language English
    Publishing date 2024-02-15
    Publishing country United States
    Document type Journal Article
    ZDB-ID 1508-8
    ISSN 1520-6882 ; 0003-2700
    ISSN (online) 1520-6882
    ISSN 0003-2700
    DOI 10.1021/acs.analchem.3c05431
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: An Anisotropic Damage-Plasticity Constitutive Model of Continuous Fiber-Reinforced Polymers.

    Chen, Siyuan / Li, Liang

    Polymers

    2024  Volume 16, Issue 3

    Abstract: Accurate structural analyses of continuous fiber-reinforced polymers (FRPs) are imperative for diverse engineering applications, demanding efficient material constitutive models. Nonetheless, the constitutive modeling of FRPs is complicated by the ... ...

    Abstract Accurate structural analyses of continuous fiber-reinforced polymers (FRPs) are imperative for diverse engineering applications, demanding efficient material constitutive models. Nonetheless, the constitutive modeling of FRPs is complicated by the nonlinear behavior resulting from internal damages and the inherent plasticity. Consequently, this study presents an innovative anisotropic constitutive model for FRPs, designed to adeptly capture both the damage evolution and plasticity. All requisite parameters can be easily obtained through fundamental mechanical tests, rendering the model practical and user-friendly. The model utilizes the three-dimensional Puck criteria to determine damages, initiating the evolution process through a combination of continuum damage mechanics and linear stiffness attenuation methods. This evolution is coupled with a one-parameter plastic model. Subsequently, the numerical implementation method, integrated into ANSYS, is detailed. This emphasizes the Cauchy stress and consistent tangent stiffness solution strategy. Finally, the effectiveness of the developed model is demonstrated through comprehensive verification, encompassing existing biaxial tension and open-hole-tension tests conducted on carbon and glass FRP laminates. The simulation results exhibit a remarkable correspondence with the experimental data, validating the reliability and accuracy of the proposed model.
    Language English
    Publishing date 2024-01-25
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2527146-5
    ISSN 2073-4360 ; 2073-4360
    ISSN (online) 2073-4360
    ISSN 2073-4360
    DOI 10.3390/polym16030334
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: A comparative study of various drought indices at different timescales and over different record lengths in the arid area of northwest China.

    Li, Liang / Cai, Huanjie

    Environmental science and pollution research international

    2024  Volume 31, Issue 17, Page(s) 25096–25113

    Abstract: Although many drought indices have been developed to monitor drought conditions, their applicability differs across climatic regions, which results in different characteristics of drought index assessments at different timescales and over different ... ...

    Abstract Although many drought indices have been developed to monitor drought conditions, their applicability differs across climatic regions, which results in different characteristics of drought index assessments at different timescales and over different record lengths. Therefore, the applicability of precipitation-based and precipitation-evapotranspiration/temperature-based drought indices was examined in this study using the Generalized Extreme Value Index (GEVI), Homogeneity Index (HI) of precipitation and temperature, K index (K), precipitation anomaly percentage (Pa), Standardized Precipitation Evapotranspiration Index (SPEI), Standardized Precipitation Index (SPI), and China-Z Index (CZI) over different record lengths and at a timescale range of 1-24 months. In addition, the results that were obtained using these indices were compared with the Self-Calibrating Palmer Drought Severity Index (scPDSI). The stability, accuracy, and consistency of the different drought indices were evaluated using precipitation and evapotranspiration/temperature data (1-24 months) collected from different climatic regions in the arid area of northwest China in the 1961-2017 period. The results indicated that the Pa, CZI, K, and SPEI were more stable; the SPI, SPEI, and HI were more accurate; and the GEVI, SPI, HI, and SPEI were more consistent with the scPDSI. In addition, the results indicated that it is more appropriate to select a long record length (> 35 years) to monitor drought when sufficient data are available. However, defining constant drought classes may not be appropriate for all drought timescales. In fact, precipitation and evapotranspiration data from different timescales had different optimal distribution functions. The drought indices also demonstrated that they were applicable to a temperate arid area in the study region. In addition, the HI and SPEI better captured the precipitation and evapotranspiration/temperature characteristics, while the CZI, K, and Pa overestimated or underestimated the frequency of different drought classes at different timescales to some extent in the study region. The results of this study suggest that greater priority should be given to the precipitation-evapotranspiration-based indices. In addition, it is suggested to change the drought index class thresholds in future related studies on drought event recognition at different timescales to ensure more accurate drought monitoring.
    MeSH term(s) Droughts ; Temperature ; China
    Language English
    Publishing date 2024-03-11
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 1178791-0
    ISSN 1614-7499 ; 0944-1344
    ISSN (online) 1614-7499
    ISSN 0944-1344
    DOI 10.1007/s11356-024-32803-2
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Modification mechanism of soybean protein isolate-soluble soy polysaccharide complex by EGCG through covalent and non-covalent interaction: Structural, interfacial, and functional properties.

    Ke, Chuxin / Li, Liang

    Food chemistry

    2024  Volume 448, Page(s) 139033

    Abstract: Soybean protein isolate was modified with polysaccharides and polyphenols to prepare a natural emulsifier with antioxidant capacity. Physicochemical, structural, interfacial, and functional properties of SPI-SSPS complex were investigated after covalent ... ...

    Abstract Soybean protein isolate was modified with polysaccharides and polyphenols to prepare a natural emulsifier with antioxidant capacity. Physicochemical, structural, interfacial, and functional properties of SPI-SSPS complex were investigated after covalent and non-covalent interacted with EGCG. SPI-SSPS-EGCG ternary complex with low EGCG concentrations (0.0625 and 0.125 mg/mL) showed a significant increase in absolute potential value and a decrease in turbidity. EGCG destroyed the original rigid structure of SPI-SSPS complex, and the covalent complexes had an ordered structure, while the non-covalent interaction resulted in disordered. The ternary complex with high EGCG concentrations (0.25 and 0.5 mg/mL) exhibited stronger EGCG binding capacity and lower surface hydrophobicity, which in turn affected its interfacial properties. The EAI and ESI of SPI-SSPS-EGCG covalent complex increased significantly, while the non-covalent complex had a significant change in EAI but no significant change in ESI with increasing EGCG concentration. The ternary complex showed significantly enhanced antioxidant capacity. The SPI-SSPS-EGCG ternary complex, with excellent antioxidant capacity and emulsifying property, making it suitable for emulsion delivery systems.
    MeSH term(s) Soybean Proteins/chemistry ; Catechin/chemistry ; Catechin/analogs & derivatives ; Polysaccharides/chemistry ; Antioxidants/chemistry ; Hydrophobic and Hydrophilic Interactions ; Glycine max/chemistry ; Emulsions/chemistry ; Emulsifying Agents/chemistry ; Solubility
    Chemical Substances Soybean Proteins ; Catechin (8R1V1STN48) ; Polysaccharides ; epigallocatechin gallate (BQM438CTEL) ; Antioxidants ; Emulsions ; Emulsifying Agents
    Language English
    Publishing date 2024-03-23
    Publishing country England
    Document type Journal Article
    ZDB-ID 243123-3
    ISSN 1873-7072 ; 0308-8146
    ISSN (online) 1873-7072
    ISSN 0308-8146
    DOI 10.1016/j.foodchem.2024.139033
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article: Full-coupled analysis of offshore floating wind turbine supported by very large floating structure with consideration of hydroelasticity

    Li, Liang

    Renewable energy. 2022 Apr., v. 189

    2022  

    Abstract: A multi-bodies hydroelastic model is developed and coupled to the full aero-hydro-servo-elastic analysis of a VLFS (very large floating structure) floating wind turbine. The proposed hydroelastic model discretizes the VLFS into a set of interconnected ... ...

    Abstract A multi-bodies hydroelastic model is developed and coupled to the full aero-hydro-servo-elastic analysis of a VLFS (very large floating structure) floating wind turbine. The proposed hydroelastic model discretizes the VLFS into a set of interconnected submodules. The hydrodynamic load acting on the entire VFLS is lumped to the mass center of submodules whilst the structural flexibility is represented by the finite element model used to connect submodules. The multi-bodies character makes the developed hydroelastic model robust to the floating structure and convenient to be embedded into coupled dynamic modelling of offshore floating wind turbines. The established model is validated against model test first and subsequently coupled to the numerical model of a moored VFLS floating wind turbine. The wind turbine power production, VFLS flexible deformation and structural loads are investigated. The analysis results reveal the significance of hydroelasticity on wind turbine power production and structural dynamics.
    Keywords deformation ; finite element analysis ; hydrodynamics ; mathematical models ; power generation ; wind ; wind turbines
    Language English
    Dates of publication 2022-04
    Size p. 790-799.
    Publishing place Elsevier Ltd
    Document type Article
    ZDB-ID 2001449-1
    ISSN 1879-0682 ; 0960-1481
    ISSN (online) 1879-0682
    ISSN 0960-1481
    DOI 10.1016/j.renene.2022.03.063
    Database NAL-Catalogue (AGRICOLA)

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  7. Article ; Online: Association between the interferon-γ +874T/A polymorphism and susceptibility to hepatitis B virus infection: a meta-analysis.

    Li, Liang

    The Journal of international medical research

    2020  Volume 48, Issue 8, Page(s) 300060520945511

    Abstract: Objective: This study investigated the correlation between the interferon (IFN)-γ +874T/A polymorphism and hepatitis B virus (HBV) susceptibility using meta-analysis.: Methods: PubMed, EMBASE, Web of Science, CNKI, and China Wanfang databases were ... ...

    Abstract Objective: This study investigated the correlation between the interferon (IFN)-γ +874T/A polymorphism and hepatitis B virus (HBV) susceptibility using meta-analysis.
    Methods: PubMed, EMBASE, Web of Science, CNKI, and China Wanfang databases were searched for case-control studies investigating the IFN-γ +874T/A polymorphism and HBV susceptibility from the time of database establishment to April 2020. Stata 15.0 software was used, and the subgroups of ethnicity and Hardy-Weinberg equilibrium were analyzed.
    Results: Thirteen articles were included in this study. Significant differences were seen in the allelic model, dominant model, homozygous model, and heterozygous model, but heterogeneity was high. Analysis of the East Asian population revealed combined odds ratios of the allelic model (T vs. A), dominant model (TT + TA vs. AA), homozygous model (TT vs. AA), and heterozygous model (TA vs. AA) of 0.61, 0.56, 0.50, and 0.59, respectively. The difference was significant and the heterogeneity low. The recessive model showed no significance in the overall comparison, or in East Asian and Caucasian populations.
    Conclusions: The IFN-γ +874T/A polymorphism is associated with the risk of HBV, especially in the East Asian population. Individuals with the T allele and TT and TA genotypes have a reduced risk of HBV infection.
    MeSH term(s) China ; Genetic Predisposition to Disease ; Hepatitis B/genetics ; Hepatitis B virus/genetics ; Humans ; Interferon-gamma/genetics ; Polymorphism, Single Nucleotide/genetics
    Chemical Substances Interferon-gamma (82115-62-6)
    Language English
    Publishing date 2020-08-13
    Publishing country England
    Document type Journal Article ; Meta-Analysis
    ZDB-ID 184023-x
    ISSN 1473-2300 ; 0300-0605 ; 0142-2596
    ISSN (online) 1473-2300
    ISSN 0300-0605 ; 0142-2596
    DOI 10.1177/0300060520945511
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: Confounding adjustment in the analysis of augmented randomized controlled trial with hybrid control arm.

    Li, Liang / Jemielita, Thomas

    Statistics in medicine

    2023  Volume 42, Issue 16, Page(s) 2855–2872

    Abstract: The augmented randomized controlled trial (RCT) with hybrid control arm includes a randomized treatment group (RT), a smaller randomized control group (RC), and a large synthetic control (SC) group from real-world data. This kind of trial is useful when ... ...

    Abstract The augmented randomized controlled trial (RCT) with hybrid control arm includes a randomized treatment group (RT), a smaller randomized control group (RC), and a large synthetic control (SC) group from real-world data. This kind of trial is useful when there is logistics and ethics hurdle to conduct a fully powered RCT with equal allocation, or when it is necessary to increase the power of the RCT by incorporating real-world data. A difficulty in the analysis of augmented RCT is that the SC and RC may be systematically different in the distribution of observed and unmeasured confounding factors, causing bias when the two control groups are analyzed together as hybrid controls. We propose to use propensity score (PS) analysis to balance the observed confounders between SC and RC. The possible bias caused by unmeasured confounders can be estimated and tested by analyzing propensity score adjusted outcomes from SC and RC. We also propose a partial bias correction (PBC) procedure to reduce bias from unmeasured confounding. Extensive simulation studies show that the proposed PS + PBC procedures can improve the efficiency and statistical power by effectively incorporating the SC into the RCT data analysis, while still control the estimation bias and Type I error inflation that might arise from unmeasured confounding. We illustrate the proposed statistical procedures with data from an augmented RCT in oncology.
    MeSH term(s) Humans ; Computer Simulation ; Bias ; Propensity Score
    Language English
    Publishing date 2023-04-25
    Publishing country England
    Document type Randomized Controlled Trial ; Journal Article
    ZDB-ID 843037-8
    ISSN 1097-0258 ; 0277-6715
    ISSN (online) 1097-0258
    ISSN 0277-6715
    DOI 10.1002/sim.9753
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: Asperulosidic Acid Restrains Hepatocellular Carcinoma Development and Enhances Chemosensitivity Through Inactivating the MEKK1/NF-κB Pathway.

    Li, Liang / Qiu, Huiwen

    Applied biochemistry and biotechnology

    2023  Volume 196, Issue 1, Page(s) 1–17

    Abstract: Asperulosidic acid (ASPA) is a plant-extracted iridoid terpenoid with tumor-suppressive and anti-inflammatory properties. At present, the antitumor function of ASPA and its related mechanisms in hepatocellular carcinoma (HCC) cells were explored. Human ... ...

    Abstract Asperulosidic acid (ASPA) is a plant-extracted iridoid terpenoid with tumor-suppressive and anti-inflammatory properties. At present, the antitumor function of ASPA and its related mechanisms in hepatocellular carcinoma (HCC) cells were explored. Human normal hepatocytes HL-7702 and HCC cells (Huh7 and HCCLM3) were treated with varying concentrations (0 to 200 μg/mL) of ASPA. Cell viability, proliferation, apoptosis, migration, and invasion were checked. The expression of proteins was detected by Western blot. Furthermore, the effect of ASPA (100 μg/mL) on the sensitivity of HCC cells to chemotherapeutic agents, including doxorubicin and cisplatin, was evaluated. A subcutaneous xenografted tumor model was set up in nude mice, and the antitumor effects of ASPA were evaluated. ASPA hindered HCC cells' proliferation, migration, and invasion, and amplified their apoptosis and sensitivity to chemotherapeutic agents. Additionally, ASPA inactivated the MEKK1/NF-κB pathway. Overexpression of MEKK1 increased HCC proliferation, migration, and invasion and facilitated chemoresistance. ASPA treatment alleviated the carcinogenic effect mediated by MEKK1 overexpression. MEKK1 knockdown slowed down HCC progression. However, ASPA could not exert additional antitumor effects in MEKK1 knockdown cells. In vivo results displayed that ASPA substantially curbed tumor growth and inactivated the MEKK1/NF-κB pathway in mice. All over, ASPA exerts antitumor effects in HCC by suppressing the MEKK1/NF-κB pathway.
    MeSH term(s) Humans ; Animals ; Mice ; Carcinoma, Hepatocellular/drug therapy ; Carcinoma, Hepatocellular/metabolism ; NF-kappa B/metabolism ; Liver Neoplasms/drug therapy ; Liver Neoplasms/metabolism ; Mice, Nude ; Cell Line, Tumor ; Cell Proliferation ; Apoptosis ; Gene Expression Regulation, Neoplastic ; Glycosides
    Chemical Substances NF-kappa B ; asperulosidic acid ; Glycosides
    Language English
    Publishing date 2023-04-25
    Publishing country United States
    Document type Journal Article
    ZDB-ID 392344-7
    ISSN 1559-0291 ; 0273-2289
    ISSN (online) 1559-0291
    ISSN 0273-2289
    DOI 10.1007/s12010-023-04500-2
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: Outcome analysis of ICSI assisted pregnancy using testicular sperm versus ejaculated sperm in man with severe oligozoospermia in the same ART cycle: A case report.

    Li, Liang / Zhao, Shi Bin

    Medicine

    2023  Volume 102, Issue 5, Page(s) e32833

    Abstract: Rationale: Intracytoplasmic sperm injection (ICSI) has become the most common method for couples with male factor infertility, and source of sperm for the procedure have evolved over time. but few have examined testicular sperm extraction vs. ejaculated ...

    Abstract Rationale: Intracytoplasmic sperm injection (ICSI) has become the most common method for couples with male factor infertility, and source of sperm for the procedure have evolved over time. but few have examined testicular sperm extraction vs. ejaculated sperm use for severe oligozoospermia in the same assisted reproductive technology (ART) cycle.
    Patient concerns: Here, we evaluated the clinical outcomes after ICSI with testicular sperm or ejaculated in man with severe oligozoospermia in the same ART cycle. A couple who had failed the first ART cycle with ejaculated sperm, using the freshly ejaculated sperm and testicular sperm for ICSI during the second ART cycle by lack of enough sperm to fertilize in an ICSI attempt.
    Diagnoses: The patient was diagnosed with severe oligozoospermia, and routine semen analysis revealed sperm concentration is less than 2 million/mL.
    Interventions: The patient using testicular sperm versus ejaculated sperm with ICSI assisted pregnancy in the same ART cycle.
    Outcomes: We found that superior cleavage rate, number of embryos transferred and blastocyst rate with the use of testicular rather than ejaculated sperm-ICSI in the couple. The results described here suggest that use of testicular sperm may improve biologic outcomes, especially for couples with male-partner oligozoospermia who previous ICSI failures.
    Lessons: Our case report supported the efficacy of testicular sperm preference over ejaculated sperm for ICSI in men with severe male factor infertility. It is a paradigm shift concerning the use of ejaculated sperm as the preferable source of sperm for ICSI, add to the small amount of literature on testicular sperm extraction vs. ejaculated sperm use for severe oligozoospermia in the same ART cycle.
    MeSH term(s) Pregnancy ; Female ; Male ; Humans ; Oligospermia/diagnosis ; Sperm Injections, Intracytoplasmic/methods ; Semen ; Sperm Retrieval ; Spermatozoa ; Infertility, Male ; Pregnancy Rate
    Language English
    Publishing date 2023-02-07
    Publishing country United States
    Document type Case Reports ; Journal Article
    ZDB-ID 80184-7
    ISSN 1536-5964 ; 0025-7974
    ISSN (online) 1536-5964
    ISSN 0025-7974
    DOI 10.1097/MD.0000000000032833
    Database MEDical Literature Analysis and Retrieval System OnLINE

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