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  1. Article ; Online: Comparative analysis of surgical modalities for the gynecomastia treatment: efficiency and aesthetic outcomes.

    Chen, Debo / Chen, Jialin / Huang, Yiqin / Hong, Chengye / Li, Liangqiang / Cai, Bimei / Hong, Zhipeng

    Andrology

    2024  

    Abstract: This retrospective study rigorously compares the clinical efficacy of three surgical methodologies for treating gynecomastia while providing guidance for future surgical modality selection. We analyzed records of 77 gynecomastia patients treated between ... ...

    Abstract This retrospective study rigorously compares the clinical efficacy of three surgical methodologies for treating gynecomastia while providing guidance for future surgical modality selection. We analyzed records of 77 gynecomastia patients treated between January 2015 and October 2022. Patients were categorized into three groups: Group A (subcutaneous gland resection via areola incision), Group B (liposuction combined with single-hole endoscopic gland resection), and Group C (liposuction combined with three-hole endoscopic gland resection). Parameters assessed included patient demographics, intraoperative bleeding, surgical duration, hospitalization duration, costs, postoperative drainage, complications, and patient satisfaction. Group A had significantly shorter operation time and lower cost than Groups B and C (P < 0.05). There were no significant differences in postoperative drainage (P > 0.05). Group A had a higher incidence of subcutaneous fluid complications. All groups achieved 100% overall postoperative efficiency. Group B demonstrated superior outcomes for scarring and patient satisfaction. All three surgical modalities effectively treat gynecomastia. Circumareolar incision subcutaneous gland resection is optimal for mild to moderate cases due to reduced operation time and cost. Liposuction with single-hole endoscopic gland resection and three-hole endoscopic gland resection offers fewer complications and discreet incisions. Notably, the liposuction and single-hole endoscopic approach yielded superior postoperative patient satisfaction, aligning with minimally invasive principles and warranting broad clinical application.
    Language English
    Publishing date 2024-01-16
    Publishing country England
    Document type Journal Article
    ZDB-ID 2696108-8
    ISSN 2047-2927 ; 2047-2919
    ISSN (online) 2047-2927
    ISSN 2047-2919
    DOI 10.1111/andr.13591
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article: A ceRNA network-mediated over-expression of cuproptosis-related gene SLC31A1 correlates with poor prognosis and positive immune infiltration in breast cancer.

    Lian, Weibin / Yang, Peidong / Li, Liangqiang / Chen, Debo / Wang, Chuan

    Frontiers in medicine

    2023  Volume 10, Page(s) 1194046

    Abstract: Introduction: Solute carrier family 31 member 1(SLC31A1) has been reported as the copper importer, and was identified to be involved in the process of "cuproptosis". However, the mechanism of SLC31A1 in breast cancer remains unclear.: Methods: We ... ...

    Abstract Introduction: Solute carrier family 31 member 1(SLC31A1) has been reported as the copper importer, and was identified to be involved in the process of "cuproptosis". However, the mechanism of SLC31A1 in breast cancer remains unclear.
    Methods: We examined the expression of SLC31A1 mRNA in breast cancer tissues and cell lines using Real-time PCR. The data for this study were obtained from The Cancer Genome Atlas (TCGA) database and analyzed via R 3.6.3. TIMER, UALCAN, GEPIA2, STRING, Metascape, Kaplan-Meier Plotter, starBase and miRNet websites were used for a comprehensive analysis of SLC31A1.
    Results: Our study suggested that SLC31A1 mRNA was over-expressed in breast tumor tissue and breast cancer cell lines, and which was closely related to poor relapse-free survival (RFS) and distant metastasis-free survival (DMFS). In addition, we constructed a co-expression network of SLC31A1. Functional enrichment analysis indicated that they were mainly involved in copper ion transport. Interestingly, SLC31A1 expression was positively associated with all m6A-related genes, especially with YTHDF3 (
    Conclusion: Up-regulation of SLC31A1 expression and regulation of copper ion transport mediated by LINC00511-miR-29-3p axis is related to poor prognosis and positively correlated with tumor immune infiltration in breast cancer.
    Language English
    Publishing date 2023-05-18
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2775999-4
    ISSN 2296-858X
    ISSN 2296-858X
    DOI 10.3389/fmed.2023.1194046
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article: A systemic pan-cancer analysis of MPZL3 as a potential prognostic biomarker and its correlation with immune infiltration and drug sensitivity in breast cancer.

    Huang, Renhong / Li, Liangqiang / Wang, Zheng / Shen, Kunwei

    Frontiers in oncology

    2022  Volume 12, Page(s) 901728

    Abstract: Background: This study aimed to analyze the role of myelin protein zero-like 3 (MPZL3), a single membrane glycoprotein, in prognosis, tumor immune infiltration, and drug susceptibility in human cancers.: Methods: Data regarding MPZL3 were extracted ... ...

    Abstract Background: This study aimed to analyze the role of myelin protein zero-like 3 (MPZL3), a single membrane glycoprotein, in prognosis, tumor immune infiltration, and drug susceptibility in human cancers.
    Methods: Data regarding MPZL3 were extracted from the TCGA, GTEx, CellMiner, CCLE, TIMER, GSEA, and USCS Xena databases. The expression difference, survival outcomes, DNA methylation, tumor mutation burden (TMB), microsatellite instability (MSI), mismatch repair (MMR), tumor microenvironment (TME), immune cell infiltration, and drug sensitivity of MPZL3 were analyzed by R language software. Cell proliferation and drug sensitivity tests were applied to analyze the biological role of MPZL3 and drug sensitivities in breast cancer.
    Results: MPZL3 was highly expressed in most cancer types and correlated with unfavorable survival outcomes in several cancers. TMB, MSI, MMR, DNA methylation, and RNA modification played a significant role in mediating MPZL3 dysregulation in cancers, and MPZL3 was closely linked to CD8+ T cells and CD4+ T immune infiltration. The MPML3 mRNA level was associated with protein secretion, the Notch signaling pathway, and heme metabolism. In addition, drug sensitivity analysis and validation also indicated that MPZL3 expression influenced the sensitivity of therapeutics targeting EGFR, ABL, FGFR, etc. Additionally, MPZL3 overexpression contributed to proliferation and drug sensitivity in different subtypes of breast cancer.
    Conclusions: This study provides a comprehensive analysis and understanding of the oncogenic roles of the pan-cancer gene MPZL3 across different tumors, including breast cancer. MPZL3 could be a potential prognostic biomarker and therapeutic target for breast cancer.
    Language English
    Publishing date 2022-07-29
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2649216-7
    ISSN 2234-943X
    ISSN 2234-943X
    DOI 10.3389/fonc.2022.901728
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article: A novel disulfidptosis-associated expression pattern in breast cancer based on machine learning.

    Wang, Zhitang / Du, Xianqiang / Lian, Weibin / Chen, Jialin / Hong, Chengye / Li, Liangqiang / Chen, Debo

    Frontiers in genetics

    2023  Volume 14, Page(s) 1193944

    Abstract: Background: ...

    Abstract Background:
    Language English
    Publishing date 2023-06-29
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2606823-0
    ISSN 1664-8021
    ISSN 1664-8021
    DOI 10.3389/fgene.2023.1193944
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Violent Video Games and Aggression Among Young Adults: The Moderating Effects of Adverse Environmental Factors.

    Addo, Prince Clement / Fang, Jiaming / Kulbo, Nora Bakabbey / Gumah, Bernard / Dagadu, Joshua Caleb / Li, Liangqiang

    Cyberpsychology, behavior and social networking

    2021  Volume 24, Issue 1, Page(s) 17–23

    Abstract: Research is divided on the effects of violent video games (VVGs). Some scholars claimed that VVG promotes aggression, reduces empathy, increases self-injury, and externalization, whereas others claim that a minimal or, in some cases, no traits as ... ...

    Abstract Research is divided on the effects of violent video games (VVGs). Some scholars claimed that VVG promotes aggression, reduces empathy, increases self-injury, and externalization, whereas others claim that a minimal or, in some cases, no traits as reported by the former is associated with playing VVGs. This study provides evidence to support claims that VVG is associated with aggressive behavior among young adults. However, the study focused more importantly on the moderating effects of adverse environmental factors on this relationship from a cross-cultural perspective. A total of 3,219 young adults between 18 and 35 years sampled from colleges and game centers in Ghana and China provided support for this study. We adopted a parallel moderated-mediation regression analysis and found that increased exposure to VVG is associated with reduced empathy concerns, aggression-related thoughts, and increased aggressive behavior. Although controlling for gender, setting, and location, the results pointed to the magnifying effects of the adverse environments in explaining the association between VVG and aggressive behavior. This study thus provides strong support for the frequently debated adverse effects of playing VVG among young adults with a particular reference to environmental factors and will hence aid in communicating a more representative viewpoint on the effects of VVG.
    MeSH term(s) Adolescent ; Adult ; Aggression/psychology ; China ; Cross-Cultural Comparison ; Empathy ; Environment ; Female ; Ghana ; Humans ; Male ; Regression Analysis ; Video Games/psychology ; Violence/ethnology ; Violence/psychology ; Young Adult
    Language English
    Publishing date 2021-01-12
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2545735-4
    ISSN 2152-2723 ; 2152-2715
    ISSN (online) 2152-2723
    ISSN 2152-2715
    DOI 10.1089/cyber.2020.0018
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Book ; Online: SparseByteNN

    Xu, Haitao / Liu, Songwei / Xu, Yuyang / Wang, Shuai / Li, Jiashi / Yan, Chenqian / Li, Liangqiang / Fu, Lean / Pan, Xin / Chen, Fangmin

    A Novel Mobile Inference Acceleration Framework Based on Fine-Grained Group Sparsity

    2023  

    Abstract: To address the challenge of increasing network size, researchers have developed sparse models through network pruning. However, maintaining model accuracy while achieving significant speedups on general computing devices remains an open problem. In this ... ...

    Abstract To address the challenge of increasing network size, researchers have developed sparse models through network pruning. However, maintaining model accuracy while achieving significant speedups on general computing devices remains an open problem. In this paper, we present a novel mobile inference acceleration framework SparseByteNN, which leverages fine-grained kernel sparsity to achieve real-time execution as well as high accuracy. Our framework consists of two parts: (a) A fine-grained kernel sparsity schema with a sparsity granularity between structured pruning and unstructured pruning. It designs multiple sparse patterns for different operators. Combined with our proposed whole network rearrangement strategy, the schema achieves a high compression rate and high precision at the same time. (b) Inference engine co-optimized with the sparse pattern. The conventional wisdom is that this reduction in theoretical FLOPs does not translate into real-world efficiency gains. We aim to correct this misconception by introducing a family of efficient sparse kernels for ARM and WebAssembly. Equipped with our efficient implementation of sparse primitives, we show that sparse versions of MobileNet-v1 outperform strong dense baselines on the efficiency-accuracy curve. Experimental results on Qualcomm 855 show that for 30% sparse MobileNet-v1, SparseByteNN achieves 1.27x speedup over the dense version and 1.29x speedup over the state-of-the-art sparse inference engine MNN with a slight accuracy drop of 0.224%. The source code of SparseByteNN will be available at https://github.com/lswzjuer/SparseByteNN
    Keywords Computer Science - Artificial Intelligence ; Computer Science - Computer Vision and Pattern Recognition
    Subject code 006 ; 005
    Publishing date 2023-10-30
    Publishing country us
    Document type Book ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  7. Article: Upregulated Long Non-Coding RNA LL22NC03-N64E9.1 Promotes the Proliferation and Migration of Human Breast Cancer Cells by Silencing Kruppel-Like Factor 2 Expression.

    Lian, Weibin / Jiang, Xiaohua / Li, Liangqiang / Wang, Qinglan / Hong, Chengye / Yang, Peidong / Chen, Debo

    Cancer management and research

    2020  Volume 12, Page(s) 10763–10770

    Abstract: Introduction: Recently, the significant regulatory effects of lncRNAs on the oncogenesis and growth of tumor have been demonstrated by an increasing number of research projects. A previous study showed that : Methods: qRT-PCR was used to assess the ... ...

    Abstract Introduction: Recently, the significant regulatory effects of lncRNAs on the oncogenesis and growth of tumor have been demonstrated by an increasing number of research projects. A previous study showed that
    Methods: qRT-PCR was used to assess the relative expression of
    Results: We identified that
    Conclusion: Relying on the
    Language English
    Publishing date 2020-10-29
    Publishing country New Zealand
    Document type Journal Article
    ZDB-ID 2508013-1
    ISSN 1179-1322
    ISSN 1179-1322
    DOI 10.2147/CMAR.S268725
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: MicroRNA‑126‑3p inhibits the proliferation, migration, invasion, and angiogenesis of triple‑negative breast cancer cells by targeting RGS3.

    Hong, Zhipeng / Hong, Chengye / Ma, Bo / Wang, Qinglan / Zhang, Xi / Li, Liangqiang / Wang, Chuan / Chen, Debo

    Oncology reports

    2019  Volume 42, Issue 4, Page(s) 1569–1579

    Abstract: Triple‑negative breast cancer (TNBC) is characterized by fast progression with high potential for metastasis, and poor prognosis. The dysregulation of microRNAs (miRNAs) occurring in the initiation or progression of cancers often leads to aberrant gene ... ...

    Abstract Triple‑negative breast cancer (TNBC) is characterized by fast progression with high potential for metastasis, and poor prognosis. The dysregulation of microRNAs (miRNAs) occurring in the initiation or progression of cancers often leads to aberrant gene expression. The aim of the present study was to explore the function of miR‑126 in TNBC cells. Expression levels of miR‑126‑3p were determined by quantitative real‑time PCR. Then, the effects of miR‑126‑3p on migration, proliferation, invasion, and angiogenesis were assessed through in vitro experiments including Cell Counting Kit‑8, colony formation, Transwell invasion and vasculogenic mimicry formation assays. One of the target genes for miR‑126‑3p predicted by TargetScan was confirmed by luciferase activity assay. Results indicated that miR‑126‑3p expression was reduced in TNBC cell lines. Functional assays revealed that miR‑126‑3p overexpression inhibited cell proliferation, migration, invasion, colony formation capacity and vasculogenesis by 1.2‑, 1.8‑, 2.3‑, 2.0‑ and 3.3‑fold, respectively, compared to the miRNA‑negative control group of MDA‑MB‑231 cells (P<0.001, respectively). In addition, the regulator of G‑protein signaling 3 (RGS3) was hypothesized and validated as a direct target of miR‑126‑3p in TNBC. The proliferation, migration, invasion, colony formation capacity and vasculogenesis of MDA‑MB‑231 cells were significantly increased by 1.4‑, 2.0‑, 1.8‑, 1.4‑ and 3.2‑fold, respectively, in cells transfected with pcDNA3.0‑RGS3 compared to pcDNA3.0‑negative control groups (P<0.001, respectively). The influence of miR‑126‑3p expression was reversed by RGS3 restoration. Collectively, the present study revealed that miR‑126‑3p plays a role as a tumor suppressor in regulating TNBC cell activities by targeting RGS3, indicating that the miR‑126‑3p/RGS3 axis may be a potential treatment target.
    MeSH term(s) Cell Line, Tumor ; Cell Movement/genetics ; Disease Progression ; Female ; Gene Expression Regulation, Neoplastic ; Genes, Tumor Suppressor ; Humans ; MicroRNAs/biosynthesis ; MicroRNAs/genetics ; Neoplasm Invasiveness ; Neovascularization, Pathologic/genetics ; Neovascularization, Pathologic/metabolism ; RGS Proteins/biosynthesis ; RGS Proteins/genetics ; RGS Proteins/metabolism ; Triple Negative Breast Neoplasms/blood supply ; Triple Negative Breast Neoplasms/genetics ; Triple Negative Breast Neoplasms/metabolism ; Triple Negative Breast Neoplasms/pathology
    Chemical Substances MIRN126 microRNA, human ; MicroRNAs ; RGS Proteins ; RGS3 protein, human
    Language English
    Publishing date 2019-07-26
    Publishing country Greece
    Document type Journal Article
    ZDB-ID 1222484-4
    ISSN 1791-2431 ; 1021-335X
    ISSN (online) 1791-2431
    ISSN 1021-335X
    DOI 10.3892/or.2019.7251
    Database MEDical Literature Analysis and Retrieval System OnLINE

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