Article ; Online: Sarcoma of the uterine cervix: experience of a single center.
World journal of surgical oncology
2024 Volume 22, Issue 1, Page(s) 104
Abstract: Objectives: To investigate the clinicopathological characteristics and prognosis of patients with primary sarcoma of the uterine cervix.: Methods: We identified all patients with primary cervical sarcomas treated at our institution from 2002 to 2020 ... ...
Abstract | Objectives: To investigate the clinicopathological characteristics and prognosis of patients with primary sarcoma of the uterine cervix. Methods: We identified all patients with primary cervical sarcomas treated at our institution from 2002 to 2020 and analyzed the clinicopathological characteristics and prognosis. Results: 34 patients were identified, 7 (20.6%) patients had leiomyosarcoma, 6 (17.6%) had carcinosarcoma, 5 (14.7%) had Ewing sarcoma, 4 (11.8%) had rhabdomyosarcoma, 4 (11.8%) had undifferentiated sarcoma, 2 (5.9%) had adenosarcoma, 2 (5.9%) had endometrial stromal sarcoma, 1 (2.9%) had dermatofibrosarcoma protuberans, 1 (2.9%) had alveolar soft tissue sarcoma and 2 (5.9%) had sarcoma not otherwise specified. The median age of the whole patients was 43.5 years (range, 13-63). The median age of patients with Ewing sarcoma or rhabdomyosarcoma was 22 years (range, 13-39) and 17 years (range, 13-36 years), respectively. The distribution by stage was: stage I in 21 (61.8%) patients, stage II in 4 (11.8%), stage III in 6 (17.6%) and stage IV in 3 (8.8%). Overall, 30 patients (88.2%) received surgical treatment. The median follow-up was 33.3 months (range 3.6-187.3 months). 11 patients died within 2 years after diagnosis, most of them were patients with carcinosarcoma or undifferentiated sarcoma (45.5%, 5/11). In the entire cohort, 2- and 5-year OS were 67.2% and 56.9%, respectively. 5-year OS was 25.0% for undifferentiated sarcoma, 50.0% for rhabdomyosarcoma, 50.0% for carcinosarcoma, 53.3% for Ewing sarcoma, 57.1% for leiomyosarcoma. Conclusion: Cervical sarcomas are rare neoplasms with multiple histological subtypes and follow an aggressive course. Prognosis may be associated with tumor histology and stage. |
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MeSH term(s) | Female ; Humans ; Adolescent ; Young Adult ; Adult ; Middle Aged ; Leiomyosarcoma/pathology ; Sarcoma, Ewing/surgery ; Uterine Cervical Neoplasms/surgery ; Uterine Neoplasms/diagnosis ; Sarcoma/surgery ; Sarcoma/diagnosis ; Carcinosarcoma/pathology ; Rhabdomyosarcoma/surgery ; Prognosis |
Language | English |
Publishing date | 2024-04-18 |
Publishing country | England |
Document type | Journal Article |
ZDB-ID | 2118383-1 |
ISSN | 1477-7819 ; 1477-7819 |
ISSN (online) | 1477-7819 |
ISSN | 1477-7819 |
DOI | 10.1186/s12957-024-03376-8 |
Database | MEDical Literature Analysis and Retrieval System OnLINE |
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