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Article: Remnant Cholesterol, a Valuable Biomarker for Assessing Arteriosclerosis and Cardiovascular Risk: A Systematic Review.

Chen, Xiang / Li, Li-Hua

2023 Volume 15, Issue 8, Page(s) e44202

Abstract: Arteriosclerosis, as the foundation for the development of cardiovascular diseases, is influenced by disturbances in lipid metabolism. Extensive research has consistently shown a correlation between conventional lipid parameters, arteriosclerosis, and ... ...

Abstract	Arteriosclerosis, as the foundation for the development of cardiovascular diseases, is influenced by disturbances in lipid metabolism. Extensive research has consistently shown a correlation between conventional lipid parameters, arteriosclerosis, and cardiovascular diseases. Guidelines highlight the importance of targeting low-density lipoprotein cholesterol (LDL-C) for primary and secondary prevention of cardiovascular diseases, with reducing LDL-C remaining the primary lipid-lowering strategy. However, even when LDL-C is lowered to optimal levels, there is a residual risk of cardiovascular disease. Recent findings have brought attention to remnant cholesterol (RC) as a significant factor contributing to this residual risk. The close association between RC, arteriosclerosis, and cardiovascular diseases presents exciting opportunities for lifestyle interventions and medical treatments to control and lower RC levels, offering new targets for preventing and managing related cardiovascular conditions. Our systematic review sheds light on the importance of considering RC as a valuable biomarker in assessing arteriosclerosis and its potential impact on cardiovascular health. By understanding the link between remnant cholesterol and arteriosclerosis, researchers and healthcare professionals can develop targeted interventions to mitigate cardiovascular risks, thus improving public health outcomes and reducing the economic burden associated with cardiovascular diseases.
Language	English
Publishing date	2023-08-27
Publishing country	United States
Document type	Journal Article ; Review
ZDB-ID	2747273-5
ISSN	2168-8184
ISSN	2168-8184
DOI	10.7759/cureus.44202
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Clinical Efficacy of Early Administration of Human Immunoglobulin on Children with Severe Hand-foot-mouth Disease.

Wu, Hongbo / Li, Lihua

Journal of the College of Physicians and Surgeons--Pakistan : JCPSP

2023 Volume 33, Issue 2, Page(s) 234–236

Abstract: The objective of this study was to investigate the clinical effect of early administration of human immunoglobulin in children with severe hand, foot and mouth disease (HFMD) and its influence on serum c-reactive protein (CRP), creatine kinase (CK), and ... ...

Abstract	The objective of this study was to investigate the clinical effect of early administration of human immunoglobulin in children with severe hand, foot and mouth disease (HFMD) and its influence on serum c-reactive protein (CRP), creatine kinase (CK), and creatine kinase isoenzyme (CK-MB). One hundred and forty children with severe HFMD were randomly divided into Group A (n=70) and Group B (n=70) according to the random number table method. Group A was treated with routine treatment. Group B was treated with routine treatment, and an early intravenous injection of human immunoglobulin. Serum CRP, CK, and CK-MB in Group B were lower than those in Group A after treatment (all p <0.001). The total clinical effective rate of Group B was 92.9%, which was higher than that of Group A (80.0%, p=0.026). Early administration of human immunoglobulin may reduce the levels of serum markers CRP, CK, and CK-MB in children with severe HFMD. Key Words: Human immunoglobulin, Children, HFMD (Hand, foot and mouth disease).
MeSH term(s)	Humans ; Child ; Hand, Foot and Mouth Disease/drug therapy ; Treatment Outcome ; Biomarkers ; C-Reactive Protein ; Immunoglobulins ; Creatine Kinase ; Creatine Kinase, MB Form
Chemical Substances	Biomarkers ; C-Reactive Protein (9007-41-4) ; Immunoglobulins ; Creatine Kinase (EC 2.7.3.2) ; Creatine Kinase, MB Form (EC 2.7.3.2)
Language	English
Publishing date	2023-02-17
Publishing country	Pakistan
Document type	Randomized Controlled Trial ; Journal Article
ZDB-ID	2276646-7
ISSN	1681-7168 ; 1022-386X
ISSN (online)	1681-7168
ISSN	1022-386X
DOI	10.29271/jcpsp.2023.02.234
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Zs.A 6532: Show issues

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Article ; Online: Exploring the relationship between regional tourism development and land use efficiency: A case study of Guangxi Zhuang Autonomous Region, China.

Meng, Qiuli / Pi, Hongwen / Xu, Tao / Li, Lihua

PloS one

2024 Volume 19, Issue 1, Page(s) e0297196

Abstract: The utilization efficiency of land resources is an essential embodiment of economic development, social development, and ecological development and is a critical core to measure how to maximize the efficiency of land resources under limited conditions. ... ...

Abstract	The utilization efficiency of land resources is an essential embodiment of economic development, social development, and ecological development and is a critical core to measure how to maximize the efficiency of land resources under limited conditions. The land is an important content and essential carrier of the research of tourism development level. This paper selects Panel Data from 2010 to 2019 to research the Guangxi regional tourism development. The entropy weight method and stochastic frontier production function (SFA) model were used to evaluate the development level of urban-rural tourism and the utilization efficiency of land resources in Guangxi. This paper uses the Panel Vector Autoregression (PVAR) model to analyze the internal relationship between urban-rural tourism development. The results show that: (1) Guangxi has a good level of tourism development and a high land use efficiency. (2) There is a reciprocal causation relationship between the regional tourism development level and land use efficiency in Guangxi, with significant levels of 0.005 and 0.034 respectively, indicating high credibility. This indicates that there is a mutual promotion and interaction between the two, which rely on and drive each other, promoting the joint sustainability of tourism development and land use efficiency. (3) . The tourism development level is greatly influenced by itself, with impact values all above 0.99. At the same time, land use also has a significant self-impact, with impact values all above 0.87. Their internal optimization system is solid and endogenous impetus is robust, which can drive their development. Establishing an effective strategy for developing and protecting land use is beneficial to promote the long-term effectiveness of sustainable tourism development, enhancing high-quality development of the tourism economy and improving people's living standards and quality.
MeSH term(s)	Humans ; China ; Tourism ; Economic Development ; Entropy ; Social Change ; Cities ; Efficiency
Language	English
Publishing date	2024-01-25
Publishing country	United States
Document type	Journal Article
ZDB-ID	2267670-3
ISSN	1932-6203 ; 1932-6203
ISSN (online)	1932-6203
ISSN	1932-6203
DOI	10.1371/journal.pone.0297196
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Article ; Online: Deconvolution-Based Pharmacokinetic Analysis to Improve the Prediction of Pathological Information of Breast Cancer.

Zhang, Liangliang / Fan, Ming / Li, Lihua

Journal of imaging informatics in medicine

2024 Volume 37, Issue 1, Page(s) 13–24

Abstract: Pharmacokinetic (PK) parameters, revealing changes in the tumor microenvironment, are related to the pathological information of breast cancer. Tracer kinetic models (e.g., Tofts-Kety model) with a nonlinear least square solver are commonly used to ... ...

Abstract	Pharmacokinetic (PK) parameters, revealing changes in the tumor microenvironment, are related to the pathological information of breast cancer. Tracer kinetic models (e.g., Tofts-Kety model) with a nonlinear least square solver are commonly used to estimate PK parameters. However, the method is sensitive to noise in images. To relieve the effects of noise, a deconvolution (DEC) method, which was validated on synthetic concentration-time series, was proposed to accurately calculate PK parameters from breast dynamic contrast-enhanced magnetic resonance imaging. A time-to-peak-based tumor partitioning method was used to divide the whole tumor into three tumor subregions with different kinetic patterns. Radiomic features were calculated from the tumor subregion and whole tumor-based PK parameter maps. The optimal features determined by the fivefold cross-validation method were used to build random forest classifiers to predict molecular subtypes, Ki-67, and tumor grade. The diagnostic performance evaluated by the area under the receiver operating characteristic curve (AUC) was compared between the subregion and whole tumor-based PK parameters. The results showed that the DEC method obtained more accurate PK parameters than the Tofts method. Moreover, the results showed that the subregion-based K
Language	English
Publishing date	2024-01-10
Publishing country	Switzerland
Document type	Journal Article
ISSN	2948-2933
ISSN (online)	2948-2933
DOI	10.1007/s10278-023-00915-9
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Article ; Online: Predicting individual autistic symptoms for patients with autism spectrum disorder using interregional morphological connectivity.

Wang, Xun-Heng / Wu, Peng / Li, Lihua

Psychiatry research. Neuroimaging

2024 Volume 341, Page(s) 111822

Abstract: Intelligent predictive models for autistic symptoms based on neuroimaging datasets were beneficial for the precise intervention of patients with ASD. The goals of this study were twofold: investigating predictive models for autistic symptoms and ... ...

Abstract	Intelligent predictive models for autistic symptoms based on neuroimaging datasets were beneficial for the precise intervention of patients with ASD. The goals of this study were twofold: investigating predictive models for autistic symptoms and discovering the brain connectivity patterns for ASD-related behaviors. To achieve these goals, we obtained a cohort of patients with ASD from the ABIDE project. The autistic symptoms were measured using the Autism Diagnostic Observation Schedule (ADOS). The anatomical MRI datasets were preprocessed using the Freesurfer package, resulting in regional morphological features. For each individual, the interregional morphological network was constructed using a novel feature distance-based method. The predictive models for autistic symptoms were built using the support vector regression (SVR) algorithm with feature selection method. The predicted autistic symptoms (i.e., ADOS social score, ADOS behavior) were significantly correlated to the original measures. The most predictive features for ADOS social scores were located in the bilateral fusiform. The most predictive features for ADOS behavior scores were located in the temporal pole and the lingual gyrus. In summary, the autistic symptoms could be predicted using the interregional morphological connectivity and machine learning. The interregional morphological connectivity could be a potential biomarker for autistic symptoms.
Language	English
Publishing date	2024-04-19
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	445361-x
ISSN	1872-7506 ; 1872-7123 ; 0925-4927 ; 0165-1781
ISSN (online)	1872-7506 ; 1872-7123
ISSN	0925-4927 ; 0165-1781
DOI	10.1016/j.pscychresns.2024.111822
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Zs.A 1541: Show issues

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Jg. 1995 - 2021: Lesesall (1.OG)
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Article ; Online: Using Tree-Based Machine Learning for Health Studies: Literature Review and Case Series.

Hu, Liangyuan / Li, Lihua

International journal of environmental research and public health

2022 Volume 19, Issue 23

Abstract: Tree-based machine learning methods have gained traction in the statistical and data science fields. They have been shown to provide better solutions to various research questions than traditional analysis approaches. To encourage the uptake of tree- ... ...

Abstract	Tree-based machine learning methods have gained traction in the statistical and data science fields. They have been shown to provide better solutions to various research questions than traditional analysis approaches. To encourage the uptake of tree-based methods in health research, we review the methodological fundamentals of three key tree-based machine learning methods: random forests, extreme gradient boosting and Bayesian additive regression trees. We further conduct a series of case studies to illustrate how these methods can be properly used to solve important health research problems in four domains: variable selection, estimation of causal effects, propensity score weighting and missing data. We exposit that the central idea of using ensemble tree methods for these research questions is accurate prediction via flexible modeling. We applied ensemble trees methods to select important predictors for the presence of postoperative respiratory complication among early stage lung cancer patients with resectable tumors. We then demonstrated how to use these methods to estimate the causal effects of popular surgical approaches on postoperative respiratory complications among lung cancer patients. Using the same data, we further implemented the methods to accurately estimate the inverse probability weights for a propensity score analysis of the comparative effectiveness of the surgical approaches. Finally, we demonstrated how random forests can be used to impute missing data using the Study of Women's Health Across the Nation data set. To conclude, the tree-based methods are a flexible tool and should be properly used for health investigations.
Language	English
Publishing date	2022-12-01
Publishing country	Switzerland
Document type	Journal Article ; Review
ZDB-ID	2175195-X
ISSN	1660-4601 ; 1661-7827
ISSN (online)	1660-4601
ISSN	1661-7827
DOI	10.3390/ijerph192316080
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Article ; Online: Effect of miR-663 on atherosclerosis by regulating the proliferation of vascular smooth muscle cells in lipid plaques.

Deng, Zhisheng / Li, Lihua

Vascular

2022 Volume 31, Issue 6, Page(s) 1240–1252

Abstract: Objectives: Atherosclerosis (AS) is the main cause of coronary heart disease, cerebral infarction, and peripheral vascular disease. microRNAs (miRNAs) are widely distributed in the human body and closely related to the pathological progress of AS. This ... ...

Abstract	Objectives: Atherosclerosis (AS) is the main cause of coronary heart disease, cerebral infarction, and peripheral vascular disease. microRNAs (miRNAs) are widely distributed in the human body and closely related to the pathological progress of AS. This study probed into the function of miR-663 in AS. Methods: The atherosclerotic plaques, cholesterol (CHOL), low-density lipoprotein (LDL), inflammatory factors, and miR-663 expression in ApoE Results: Atherosclerotic plaques appeared in ApoE Conclusion: miR-663 targeted HMGA2 to inhibit VSMC proliferation and AS development, which may offer insights into AS treatment.
MeSH term(s)	Humans ; Mice ; Animals ; Plaque, Atherosclerotic/complications ; Plaque, Atherosclerotic/metabolism ; Plaque, Atherosclerotic/pathology ; Muscle, Smooth, Vascular/metabolism ; Osteopontin/metabolism ; Osteopontin/pharmacology ; Matrix Metalloproteinase 2 ; Atherosclerosis/genetics ; Atherosclerosis/metabolism ; MicroRNAs/genetics ; Cell Proliferation ; Apolipoproteins E/genetics ; Apolipoproteins E/metabolism ; Apolipoproteins E/pharmacology ; Lipids ; Lipoproteins, LDL/pharmacology ; Myocytes, Smooth Muscle/metabolism
Chemical Substances	Osteopontin (106441-73-0) ; Matrix Metalloproteinase 2 (EC 3.4.24.24) ; MicroRNAs ; Apolipoproteins E ; Lipids ; Lipoproteins, LDL ; MIRN663 microRNA, human
Language	English
Publishing date	2022-05-23
Publishing country	England
Document type	Journal Article
ZDB-ID	2137151-9
ISSN	1708-539X ; 1708-5381
ISSN (online)	1708-539X
ISSN	1708-5381
DOI	10.1177/17085381221098826
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Zs.A 4277: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (2.OG) ab Jg. 2022: Lesesaal (EG)
Zs.MO 590: Show issues

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Article ; Online: The effect of morphology and crystal structure on the photocatalytic and photoelectrochemical performances of WO

Li, Lihua / Li, Jingjing / Kim, BoK-Hee / Huang, Jinliang

RSC advances

2024 Volume 14, Issue 3, Page(s) 2080–2087

Abstract: A template-based solvothermal method was successfully developed for the controlled synthesis of two-dimensional (2D) monoclinic ... ...

Abstract	A template-based solvothermal method was successfully developed for the controlled synthesis of two-dimensional (2D) monoclinic WO
Language	English
Publishing date	2024-01-09
Publishing country	England
Document type	Journal Article
ISSN	2046-2069
ISSN (online)	2046-2069
DOI	10.1039/d3ra07329g
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Article ; Online: Therapeutic Strategies for Angiogenesis Based on Endothelial Cell Epigenetics.

Cai, Yue / Li, Lihua / Shao, Chen / Chen, Yiliu / Wang, Zhongqun

Journal of cardiovascular translational research

2024

Abstract: With the in-depth investigation of various diseases, angiogenesis has gained increasing attention. Among the contributing factors to angiogenesis research, endothelial epigenetics has emerged as an influential player. Endothelial epigenetic therapy ... ...

Abstract	With the in-depth investigation of various diseases, angiogenesis has gained increasing attention. Among the contributing factors to angiogenesis research, endothelial epigenetics has emerged as an influential player. Endothelial epigenetic therapy exerts its regulatory effects on endothelial cells by controlling gene expression, RNA, and histone modification within these cells, which subsequently promotes or inhibits angiogenesis. As a result, this therapeutic approach offers potential strategies for disease treatment. The purpose of this review is to outline the pertinent mechanisms of endothelial cell epigenetics, encompassing glycolysis, lactation, amino acid metabolism, non-coding RNA, DNA methylation, histone modification, and their connections to specific diseases and clinical applications. We firmly believe that endothelial cell epigenetics has the potential to become an integral component of precision medicine therapy, unveiling novel therapeutic targets and providing new directions and opportunities for disease treatment.
Language	English
Publishing date	2024-01-31
Publishing country	United States
Document type	Journal Article ; Review
ZDB-ID	2422411-X
ISSN	1937-5395 ; 1937-5387
ISSN (online)	1937-5395
ISSN	1937-5387
DOI	10.1007/s12265-024-10485-y
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Article ; Online: Method comparison and overview of refractive measurements in children: implications for myopia management.

Müller, Jonas / Chen, Xiaoqin / Ohlendorf, Arne / Li, Lihua / Wahl, Siegfried

BMJ open ophthalmology

2024 Volume 9, Issue 1

Abstract: Objective: This study investigated the agreement between objective wavefront-based refraction and subjective refraction in myopic children. It also assessed the impact of cyclopentolate and refraction levels on the agreement.: Methods: A total of 84 ... ...

Abstract	Objective: This study investigated the agreement between objective wavefront-based refraction and subjective refraction in myopic children. It also assessed the impact of cyclopentolate and refraction levels on the agreement. Methods: A total of 84 eyes of myopic children aged 6-13 years were included in the analysis. Non-cycloplegic and cycloplegic objective wavefront-based refraction were determined and cycloplegic subjective refraction was performed for each participant. The data were converted into spherical equivalent, J Results: Linear functions were used to determine the dependency between the central myopic refractive error and the difference between the method of refraction (=bias). The influence of central myopia was not clinically relevant when analysing the agreement between wavefront results with and without cyclopentolate (comparison 1). The bias for wavefront-based minus subjective spherical equivalent refraction (comparison 2) was ≤-0.50 D (95% limits of agreement -0.010 D to -1.00 D) for myopia of -4.55 D and higher when cycloplegia was used (p<0.05). When no cyclopentolate was used for the wavefront-based refraction (comparison 3), the bias of -0.50 D (95% limits of agreement -0.020 D to -0.97 D) was already reached at a myopic error of -2.97 D. Both astigmatic components showed no clinically relevant bias. Conclusion: The spherical equivalent, measured without cycloplegic agents, led to more myopic measurements when wavefront-based refraction was used. The observed bias increased with the amount of myopic refractive error for comparisons 2 and 3, which needs to be considered when interpreting wavefront-refraction data. Trial registration number: NCT05288335.
MeSH term(s)	Child ; Humans ; Mydriatics ; Cyclopentolate ; Refractive Errors/diagnosis ; Myopia/diagnosis ; Pupil
Chemical Substances	Mydriatics ; Cyclopentolate (I76F4SHP7J)
Language	English
Publishing date	2024-03-01
Publishing country	England
Document type	Journal Article
ISSN	2397-3269
ISSN (online)	2397-3269
DOI	10.1136/bmjophth-2023-001322
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