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  1. Article ; Online: Tracing embryonic hematopoiesis guides induction of pluripotent stem cells to hematopoietic progenitors.

    Mao, Xinjian / Li, Linheng

    Developmental cell

    2024  Volume 59, Issue 9, Page(s) 1093–1095

    Abstract: In this issue of Developmental Cell, Fowler et al. applied genetic lineage-tracing mouse models to support the notion that artery endothelial cells are the predominant source of hematopoietic stem cells. They leveraged this and developed a method capable ...

    Abstract In this issue of Developmental Cell, Fowler et al. applied genetic lineage-tracing mouse models to support the notion that artery endothelial cells are the predominant source of hematopoietic stem cells. They leveraged this and developed a method capable of efficiently differentiating human pluripotent stem cells into HLF
    MeSH term(s) Hematopoietic Stem Cells/cytology ; Hematopoietic Stem Cells/metabolism ; Hematopoiesis ; Animals ; Humans ; Pluripotent Stem Cells/cytology ; Pluripotent Stem Cells/metabolism ; Cell Differentiation ; Mice ; Cell Lineage ; Endothelial Cells/cytology ; Endothelial Cells/metabolism
    Language English
    Publishing date 2024-05-03
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2054967-2
    ISSN 1878-1551 ; 1534-5807
    ISSN (online) 1878-1551
    ISSN 1534-5807
    DOI 10.1016/j.devcel.2024.04.001
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    Zs.A 5742: Show issues Location:
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  2. Article ; Online: Understanding and Overcoming Immunosuppression Shaped by Cancer Stem Cells.

    Li, Linheng / Jensen, Roy A

    Cancer research

    2023  Volume 83, Issue 13, Page(s) 2096–2104

    Abstract: Use of immunotherapy in recent years has revolutionized cancer treatment for certain types of cancers. However, the broad utility of immunotherapy is limited because there are still many types of cancer that do not respond effectively. Failure of a ... ...

    Abstract Use of immunotherapy in recent years has revolutionized cancer treatment for certain types of cancers. However, the broad utility of immunotherapy is limited because there are still many types of cancer that do not respond effectively. Failure of a cancer to respond is due, at least in part, to its phenotypic plasticity, a feature that is established by cancer stem cells (CSC) and their associated microenvironments. This article discusses the current understanding of CSC-mediated immune evasion and provides a prospective view on how researchers can better understand and overcome the intrinsic immune privilege of CSCs and the extrinsic immune-suppressive microenvironment shaped by them.
    MeSH term(s) Humans ; Prospective Studies ; Neoplasms/therapy ; Immunosuppression Therapy ; Immunotherapy ; Neoplastic Stem Cells ; Tumor Microenvironment
    Language English
    Publishing date 2023-07-04
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
    ZDB-ID 1432-1
    ISSN 1538-7445 ; 0008-5472
    ISSN (online) 1538-7445
    ISSN 0008-5472
    DOI 10.1158/0008-5472.CAN-23-0230
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  3. Article ; Online: YTHDF3 as a new player in hematopoietic stem cell regulation.

    Mao, Xinjian / Li, Linheng

    Haematologica

    2022  Volume 107, Issue 10, Page(s) 2290–2291

    MeSH term(s) Hematopoietic Stem Cells ; Humans ; RNA-Binding Proteins/genetics
    Chemical Substances RNA-Binding Proteins
    Language English
    Publishing date 2022-10-01
    Publishing country Italy
    Document type Journal Article ; Comment
    ZDB-ID 2333-4
    ISSN 1592-8721 ; 0017-6567 ; 0390-6078
    ISSN (online) 1592-8721
    ISSN 0017-6567 ; 0390-6078
    DOI 10.3324/haematol.2021.280467
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  4. Article ; Online: p57Kip2 indirectly regulates AGM HSCs.

    Mao, Xinjian / Li, Linheng

    Blood

    2022  Volume 140, Issue 5, Page(s) 411–412

    MeSH term(s) Embryonic Stem Cells ; Mesonephros/embryology
    Language English
    Publishing date 2022-07-29
    Publishing country United States
    Document type Editorial ; Comment
    ZDB-ID 80069-7
    ISSN 1528-0020 ; 0006-4971
    ISSN (online) 1528-0020
    ISSN 0006-4971
    DOI 10.1182/blood.2022017139
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  5. Article ; Online: Integrated driving risk surrogate model and car-following behavior for freeway risk assessment.

    Wu, Renfei / Li, Linheng / Shi, Haotian / Rui, Yikang / Ngoduy, Dong / Ran, Bin

    Accident; analysis and prevention

    2024  Volume 201, Page(s) 107571

    Abstract: Drivers' risk perception plays a crucial role in understanding vehicle interactions and car-following behavior under complex conditions and physical appearances. Therefore, it is imperative to evaluate the variability of risks involved. With advancements ...

    Abstract Drivers' risk perception plays a crucial role in understanding vehicle interactions and car-following behavior under complex conditions and physical appearances. Therefore, it is imperative to evaluate the variability of risks involved. With advancements in communication technology and computing power, real-time risk assessment has become feasible for enhancing traffic safety. In this study, a novel approach for evaluating driving interaction risk on freeways is presented. The approach involves the integration of an interaction risk perception model with car-following behavior. The proposed model, named the driving risk surrogate (DRS), is based on the potential field theory and incorporates a virtual energy attribute that considers vehicle size and velocity. Risk factors are quantified through sub-models, including an interactive vehicle risk surrogate, a restrictions risk surrogate, and a speed risk surrogate. The DRS model is applied to assess driving risk in a typical scenario on freeways, and car-following behavior. A sensitivity analysis is conducted on the effect of different parameters in the DRS on the stability of traffic dynamics in car-following behavior. This behavior is then calibrated using a naturalistic driving dataset, and then car-following predictions are made. It was found that the DRS-simulated car-following behavior has a more accurate trajectory prediction and velocity estimation than other car-following methods. The accuracy of the DRS risk assessments was verified by comparing its performance to that of traditional risk models, including TTC, DRAC, MTTC, and DRPFM, and the results show that the DRS model can more accurately estimate risk levels in free-flow and congested traffic states. Thus the proposed risk assessment model provides a better approach for describing vehicle interactions and behavior in the digital world for both researchers and practitioners.
    MeSH term(s) Humans ; Automobile Driving/psychology ; Risk Assessment/methods ; Accidents, Traffic/prevention & control ; Models, Theoretical ; Automobiles ; Risk Factors
    Language English
    Publishing date 2024-04-11
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 210223-7
    ISSN 1879-2057 ; 0001-4575
    ISSN (online) 1879-2057
    ISSN 0001-4575
    DOI 10.1016/j.aap.2024.107571
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    Zs.A 2461: Show issues Location:
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  6. Article: Overcoming resistance to immunotherapy by teaching old drugs new tricks.

    Perry, John M / Li, Linheng

    Molecular & cellular oncology

    2020  Volume 7, Issue 5, Page(s) 1801088

    Abstract: Cancer stem cells (CSCs) underlie resistance to therapy. Cancer develops only in the context of failing immunosurveillance, and stem cells occupy immune privileged microenvironments. Recent evidence demonstrates that CSCs borrow immune privilege from ... ...

    Abstract Cancer stem cells (CSCs) underlie resistance to therapy. Cancer develops only in the context of failing immunosurveillance, and stem cells occupy immune privileged microenvironments. Recent evidence demonstrates that CSCs borrow immune privilege from their normal counterparts. However, low doses of doxorubicin can target CSCs by restoring anticancer immunity.
    Language English
    Publishing date 2020-08-12
    Publishing country United States
    Document type Journal Article
    ISSN 2372-3556
    ISSN 2372-3556
    DOI 10.1080/23723556.2020.1801088
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  7. Article ; Online: Atlas of the human intestine.

    He, Xi C / Li, Linheng

    The Journal of experimental medicine

    2020  Volume 217, Issue 2

    Abstract: In this issue of JEM, Wang et al. (https://doi.org/10.1084/jem.20191130), using a single-cell RNA-seq approach, establish an atlas of human colon, rectum, and ileum epithelial cells. Their study reveals that different regions have specialized nutrient ... ...

    Abstract In this issue of JEM, Wang et al. (https://doi.org/10.1084/jem.20191130), using a single-cell RNA-seq approach, establish an atlas of human colon, rectum, and ileum epithelial cells. Their study reveals that different regions have specialized nutrient absorption preferences, microbe defenses, and endocrine function. They also identify new markers for a variety of cell types.
    MeSH term(s) Gene Expression Profiling ; Humans ; Intestines ; Nutrients ; Single-Cell Analysis ; Transcriptome
    Language English
    Publishing date 2020-03-03
    Publishing country United States
    Document type Journal Article ; Comment
    ZDB-ID 218343-2
    ISSN 1540-9538 ; 0022-1007
    ISSN (online) 1540-9538
    ISSN 0022-1007
    DOI 10.1084/jem.20191997
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  8. Article ; Online: Niche cells rewired to maintain HSCs ex vivo.

    Venkatraman, Aparna / Li, Linheng

    Nature cell biology

    2019  Volume 21, Issue 5, Page(s) 540–541

    MeSH term(s) Hematopoietic Stem Cells ; Mesenchymal Stem Cells ; Stem Cell Niche
    Language English
    Publishing date 2019-05-02
    Publishing country England
    Document type Journal Article ; Comment
    ZDB-ID 1474722-4
    ISSN 1476-4679 ; 1465-7392
    ISSN (online) 1476-4679
    ISSN 1465-7392
    DOI 10.1038/s41556-019-0322-5
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  9. Article ; Online: Stress-protecting harbors for hematopoietic stem cells.

    Yang, Zhe / Dong, Ruochen / Mao, Xinjian / He, Xi C / Li, Linheng

    Current opinion in cell biology

    2023  Volume 86, Page(s) 102284

    Abstract: Hematopoietic stem cells (HSCs) rely on specialized microenvironments known as niches to maintain their self-renewal and multilineage potential to generate diverse types of blood cells continuously. Over the last two decades, substantial advancements ... ...

    Abstract Hematopoietic stem cells (HSCs) rely on specialized microenvironments known as niches to maintain their self-renewal and multilineage potential to generate diverse types of blood cells continuously. Over the last two decades, substantial advancements have been made in unraveling the niche cell components and HSC localizations under homeostatic and stressed circumstances. Advances in imaging, combined with the discovery of phenotypic surface markers combinations and single cell sequencing, have greatly facilitated the systematic examination of HSC localizations. This review aims to present a summary of HSC localizations, highlighting potential distinctions between phenotypically and functionally defined HSCs, and explore the functionality of niches in ensuring the integrity and long-term maintenance of HSCs.
    MeSH term(s) Stem Cell Niche ; Hematopoietic Stem Cells/metabolism ; Homeostasis
    Language English
    Publishing date 2023-11-23
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 1026381-0
    ISSN 1879-0410 ; 0955-0674
    ISSN (online) 1879-0410
    ISSN 0955-0674
    DOI 10.1016/j.ceb.2023.102284
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  10. Article ; Online: An optimized chromatin immunoprecipitation protocol using Staph-seq for analyzing genome-wide protein-DNA interactions.

    Tao, Fang / Rhonda, Egidy / He, Xi / Perry, John M / Li, Linheng

    STAR protocols

    2022  Volume 3, Issue 4, Page(s) 101918

    Abstract: Genome-wide mapping of transcription factors (TFs) is critical to understand their functions. In chromatin immunoprecipitation (ChIP)-seq assay, it's challenging to study recruitment of low-abundant TFs transiently boud to the genome. Here, we present an ...

    Abstract Genome-wide mapping of transcription factors (TFs) is critical to understand their functions. In chromatin immunoprecipitation (ChIP)-seq assay, it's challenging to study recruitment of low-abundant TFs transiently boud to the genome. Here, we present an optimized protocol using ChIP Next-Gen Seq Sepharose (Staph-seq) to efficiently pull down chromatin complexes. The double size selection promotes sensitive capture of genome-wide protein-DNA associations while eliminating potential Staph A contamination, which is a common problem in protocols using Staph A cells. For complete details on the use and execution of this protocol, please refer to Tao et al. (2020).
    MeSH term(s) Sepharose ; DNA/genetics ; Transcription Factors/genetics ; Chromatin Immunoprecipitation/methods ; Chromatin/genetics
    Chemical Substances Sepharose (9012-36-6) ; DNA (9007-49-2) ; Transcription Factors ; Chromatin
    Language English
    Publishing date 2022-12-09
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ISSN 2666-1667
    ISSN (online) 2666-1667
    DOI 10.1016/j.xpro.2022.101918
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