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  1. Article: Lipidomics, transcription analysis, and hormone profiling unveil the role of

    Zhang, Gaoyang / Wei, Jingjing / Li, Linyan / Cui, Dandan

    Horticulture research

    2024  Volume 11, Issue 3, Page(s) uhae032

    Abstract: Jasmonates, such as jasmonic acid (JA) and methyl jasmonate (MeJA), are crucial aspect of black tea quality. However, lipids species, hormones, and genes regulated mechanism in the jasmonate biosynthesis during black tea processing are lacking. In this ... ...

    Abstract Jasmonates, such as jasmonic acid (JA) and methyl jasmonate (MeJA), are crucial aspect of black tea quality. However, lipids species, hormones, and genes regulated mechanism in the jasmonate biosynthesis during black tea processing are lacking. In this study, we employed lipidomics, hormone metabolism analysis, and transcriptome profiling of genes associated with the MeJA biosynthesis pathway to investigate these factors. The contents of lipids GLs, PLs, and TAG are decreased, accompanied by the main lipids species reduced during black tea processing. Galactolipids, primarily 34:3/36:6/36:3 DGDG and 36:6/36:5/36:4 MGDG, are transformed into massive MeJA and JA in black tea processing, accompanied by the decreased SA, MeSA, IAA, and BA and increased zeatin. Additionally, the transcriptional activity of the primary genes in MeJA biosynthesis pathway exhibited downregulated trends except for
    Language English
    Publishing date 2024-01-30
    Publishing country England
    Document type Journal Article
    ISSN 2662-6810
    ISSN 2662-6810
    DOI 10.1093/hr/uhae032
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  2. Article: AlphaMobileSensing: A virtual testbed for mobile environmental monitoring.

    Zhou, Qi / Zhong, Haoran / Li, Linyan / Wang, Zhe

    Building simulation

    2023  , Page(s) 1–14

    Abstract: Environmental monitoring plays a critical role in creating and maintaining a comfortable, productive, and healthy environment. Built upon the advancements of robotics and data processing, mobile sensing demonstrates its potential to address problems ... ...

    Abstract Environmental monitoring plays a critical role in creating and maintaining a comfortable, productive, and healthy environment. Built upon the advancements of robotics and data processing, mobile sensing demonstrates its potential to address problems regarding cost, deployment, and resolution that stationary monitoring encounters, which therefore has attracted increasing research attentions recently. To facilitate mobile sensing, two key algorithms are needed: the field reconstruction algorithm and the route planning algorithm. The field reconstruction algorithm is to reconstruct the entire environment field from spatially- and temporally-discrete measurements collected by the mobile sensors. The route planning algorithm is to instruct the mobile sensors where the mobile sensor needs to move to for the next measurements. The performance of mobile sensors highly depends on these two algorithms. However, developing and testing those algorithms in the real world is expensive, challenging, and time-consuming. To address these issues, we proposed and implemented an open-source virtual testbed, AlphaMobileSensing, that can be used to develop, test, and benchmark mobile sensing algorithms. AlphaMobileSensing aims to help users more easily develop and test the field reconstruction and route planning algorithms for mobile sensing solutions, without worrying about hardware fault, test accidents (such as collision during the test), etc. The separation of concerns can significantly reduce the cost of developing software solutions for mobile sensing. For versatility and flexibility, AlphaMobileSensing was wrapped up using the standardized interface of OpenAI Gym, and it also provides an interface for loading physical fields that were generated by numerical simulations as virtual test sites to perform mobile sensing and retrieving monitoring data. We demonstrated applications of the virtual testbed by implementing and testing algorithms for physical field reconstruction in both static and dynamic indoor thermal environments. AlphaMobileSensing provides a novel and flexible platform to develop, test, and benchmark mobile sensing algorithms more easily, conveniently, and efficiently. AlphaMobileSensing is open sourced at https://github.com/kishuqizhou/AlphaMobileSensing.
    Electronic supplementary material esm: the Appendix is available in the online version of this article at 10.1007/s12273-023-1001-9.
    Language English
    Publishing date 2023-02-28
    Publishing country China
    Document type Journal Article
    ZDB-ID 2422327-X
    ISSN 1996-8744 ; 1996-3599
    ISSN (online) 1996-8744
    ISSN 1996-3599
    DOI 10.1007/s12273-023-1001-9
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  3. Article ; Online: Functional evaluation of

    Xu, Haoxiang / Gong, Joshua / Lu, Peng / Azevedo, Paula / Li, Linyan / Yu, Hai / Yang, Chengbo

    Translational animal science

    2024  Volume 8, Page(s) txae050

    Abstract: During the bacterial selection, isolate PF9 demonstrated tolerance to low pH and high bile salt and an ability to extend the lifespan ... ...

    Abstract During the bacterial selection, isolate PF9 demonstrated tolerance to low pH and high bile salt and an ability to extend the lifespan of
    Language English
    Publishing date 2024-04-03
    Publishing country England
    Document type Journal Article
    ISSN 2573-2102
    ISSN (online) 2573-2102
    DOI 10.1093/tas/txae050
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  4. Article ; Online: Chronic household air pollution and exposure patterns among Himalayan nomads.

    Powers, Catlin I / Li, Linyan / Ezzati, Majid / Butler, James P / Zigler, Corwin M / Spengler, John D

    Journal of exposure science & environmental epidemiology

    2024  

    Abstract: Background: Household air pollution (HAP) is a major risk factor of non-communicable diseases, causing millions of premature deaths each year in developing nations. Populations living at high altitudes are particularly vulnerable to HAP and associated ... ...

    Abstract Background: Household air pollution (HAP) is a major risk factor of non-communicable diseases, causing millions of premature deaths each year in developing nations. Populations living at high altitudes are particularly vulnerable to HAP and associated health outcomes.
    Objectives: This study aims to explore the relationships between activity patterns, HAP, and an HAP biomarker among 100 Himalayan nomadic households during both cooking and heating-only periods.
    Methods: Household CO was monitored in 100 rural homes in Qinghai, China, at 3500 m on the Himalayan Plateau among Himalayan nomads. Carboxyhemoglobin (COHb) was used as a biomarker to assess exposure among 100 male and 100 female heads of household. Linear mixed-effects models were used to explore the relationship between COHb and activity patterns.
    Results: Cooking periods were associated with 7 times higher household CO concentrations compared with heating periods (94 ± 56 ppm and 13 ± 11 ppm, respectively). Over the three-day biomarker-monitoring period in each house, 99% of subjects had at least one COHb measurement exceeding the WHO safety level of 2%. Cooking was associated with a 32% increase in COHb (p < 0.001).
    Impact statement: This study on household air pollution (HAP) in high-altitude regions provides important insights into the exposure patterns of nomadic households in Qinghai, China. The study found that cooking is the primary factor influencing acute carbon monoxide (CO) exposure among women, while heating alone is sufficient to elevate CO exposure above WHO guidelines. The results suggest that cooking-only interventions have the potential to reduce HAP exposure among women, but solutions for both cooking and heating may be required to reduce COHb to below WHO guidelines. This study's findings may inform future interventions for fuel and stove selection to reduce HAP and exposure among other populations.
    Language English
    Publishing date 2024-03-05
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2218551-3
    ISSN 1559-064X ; 1559-0631
    ISSN (online) 1559-064X
    ISSN 1559-0631
    DOI 10.1038/s41370-024-00656-z
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  5. Article ; Online: Ophiogomphus tibeticus sp. nov. from Sichuan, China (Anisoptera: Gomphidae).

    Yu, Xin / Li, Linyan / Gu, Haijun

    Zootaxa

    2022  Volume 5213, Issue 5, Page(s) 569–577

    Abstract: A new gomphid species, Ophiogomphus tibeticus sp. nov., from Zoige alpine Wetland, Sichuan is described and illustrated. Assignment to the genus Ophiogomphus Selys, 1854 is based on both morphological and molecular analyses. This new species differs from ...

    Abstract A new gomphid species, Ophiogomphus tibeticus sp. nov., from Zoige alpine Wetland, Sichuan is described and illustrated. Assignment to the genus Ophiogomphus Selys, 1854 is based on both morphological and molecular analyses. This new species differs from other known Ophiogomphus mainly in the shape of the caudal appendages.
    MeSH term(s) Animals ; Odonata ; Dipterocarpaceae ; China
    Language English
    Publishing date 2022-11-29
    Publishing country New Zealand
    Document type Journal Article
    ISSN 1175-5334
    ISSN (online) 1175-5334
    DOI 10.11646/zootaxa.5213.5.5
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  6. Article ; Online: Current Advances and Prospects in Carbon Nanomaterials-based Drug Deliver Systems for Cancer Therapy.

    Lai, Chunmei / Li, Linyan / Luo, Bangyue / Shen, Jiangwen / Shao, Jingwei

    Current medicinal chemistry

    2022  Volume 30, Issue 24, Page(s) 2710–2733

    Abstract: The in-depth intersection between nanoscience and oncology comes from the fact that nanomaterials are in a similar dimension to basic biomolecules. Drug delivery systems (DDSs), which are either targeted to a particular site or intended for the ... ...

    Abstract The in-depth intersection between nanoscience and oncology comes from the fact that nanomaterials are in a similar dimension to basic biomolecules. Drug delivery systems (DDSs), which are either targeted to a particular site or intended for the controlled release in a particular position, have been studied extensively at the nanoscale and are, by far, the most advanced technology in the area of nanoparticle applications. This, consequently lead to the improvement and development of convenient administration routes, lower toxicity, fewer side effects, and extended drug life cycle. Carbon nanomaterials (CNMs) with favorable size and unique fluorescence properties, which was considered an ideal candidate to transport or deliver therapeutic drugs to specific targets in a controlled manner. The development of DDSs based on them constitutes an interesting topic in highly effective and universal therapies to achieve better therapeutic outcomes and reduce the side effects of malignancies. In this review, the cutting-edge progress of CNMs in DDSs was comprehensively summarized. Additionally, the emphasis was placed on the applications of CNMs including fullerene, graphene, carbon nanotubes (CNTs), carbon dots (CDs), and nano-diamonds (NDs) in drug delivering. Further, we gave some insights into the future direction and foreseeable challenges of DDSs based on CNMs used in cancer therapy, which we hope these inspirations in DDSs associated with anti-cancer therapy will provide perspectives in designing new drugs for further tumor treatment.
    MeSH term(s) Humans ; Nanotubes, Carbon ; Pharmaceutical Preparations ; Nanostructures/therapeutic use ; Drug Delivery Systems/methods ; Fullerenes ; Neoplasms/drug therapy
    Chemical Substances Nanotubes, Carbon ; Pharmaceutical Preparations ; Fullerenes
    Language English
    Publishing date 2022-08-26
    Publishing country United Arab Emirates
    Document type Review ; Journal Article
    ZDB-ID 1319315-6
    ISSN 1875-533X ; 0929-8673
    ISSN (online) 1875-533X
    ISSN 0929-8673
    DOI 10.2174/0929867329666220821195353
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 4432: Show issues Location:
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    Jg. 1995 - 2021: Lesesall (2.OG)
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  7. Article ; Online: Comparison of inpatient spending and readmission rates for patients treated by male versus female physicians in China: An observational study.

    Shen, Menghan / Li, Linyan / Wu, Yushan / Yang, Yuanfan

    Journal of health services research & policy

    2021  Volume 27, Issue 2, Page(s) 114–121

    Abstract: Objective: To determine whether there are significant differences in costs of treatment and readmission rates for hospital consultations undertaken by female versus male physicians in China.: Methods: Using data from the Urban Employee Basic Medical ... ...

    Abstract Objective: To determine whether there are significant differences in costs of treatment and readmission rates for hospital consultations undertaken by female versus male physicians in China.
    Methods: Using data from the Urban Employee Basic Medical Insurance program from January 2018 through October 2019, we investigated spending patterns and clinical outcomes for patients at tertiary hospitals in one of the largest cities in China by the gender of the attending physician. Our sample included 79,085 hospitalizations treated by 3993 physicians in internal medicine departments. We examined the association between physician gender and visit cost using a multivariable linear model. We examined the association between physician gender and 30-days readmission rates using a multivariable probability model. We adjusted for a rich set of patient characteristics, primary diagnosis fixed effects, and hospital fixed effects. In addition, we used patient fixed effects in a robustness analysis.
    Results: Adjusting for primary diagnosis fixed effects, spending per visit was 4.1% higher for patients treated by male physicians than for those treated by female physicians, a statistically significant difference (95% CI [1.5%, 6.7%]). This pattern persisted after further adjusting for hospital fixed effects (3.2% [1.2%, 5.2%]), patient characteristics (3.2% [1.2%, 5.1%]), and patient fixed effects (4.2% [1.8%, 6.7%]). The difference is mainly driven by higher spending on drugs (8.7% [3.9%, 13.6%]) and out-of-pocket costs (3.9% [1.7%, 6.0%]). No statistically significant differences were observed in the readmission rates of patients treated by male and female physicians in any of our three model specifications.
    Conclusions: Spending per visit was significantly higher among patients treated by male physicians than among those treated by female physicians, with the difference mainly driven by spending on drugs and out-of-pocket costs. No significant difference was observed in the hospital readmission rates of patients treated by male and female physicians. These findings have important implications for gender equality in medicine and health care quality and efficiency in developing countries.
    MeSH term(s) China ; Female ; Health Expenditures ; Hospitalization ; Humans ; Inpatients ; Male ; Patient Readmission ; Physicians
    Language English
    Publishing date 2021-12-31
    Publishing country England
    Document type Journal Article ; Observational Study ; Research Support, Non-U.S. Gov't
    ZDB-ID 1330668-6
    ISSN 1758-1060 ; 1355-8196
    ISSN (online) 1758-1060
    ISSN 1355-8196
    DOI 10.1177/13558196211058974
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    Zs.A 4529: Show issues Location:
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  8. Article ; Online: Clinical effects of remimazolam alone or in combination with dexmedetomidine in patients receiving bronchoscopy and influences on postoperative cognitive function: a randomized-controlled trial.

    Gao, Shenqiang / Wang, Tingting / Cao, Li / Li, Linyan / Yang, Shengqiang

    International journal of clinical pharmacy

    2022  Volume 45, Issue 1, Page(s) 137–145

    Abstract: Background: Remimazolam and dexmedetomidine are commonly used as sedatives. However, the effects and safety of remimazolam alone or in combination with dexmedetomidine have not been investigated.: Aim: We sought to investigate the clinical effects of ...

    Abstract Background: Remimazolam and dexmedetomidine are commonly used as sedatives. However, the effects and safety of remimazolam alone or in combination with dexmedetomidine have not been investigated.
    Aim: We sought to investigate the clinical effects of remimazolam alone or in combination with dexmedetomidine in bronchoscopy, and their influence on cognitive function.
    Method: Ninety eligible patients who underwent bronchoscopy under intravenous anesthesia were randomly divided into three groups: propofol control, remimazolam, and remimazolam plus dexmedetomidine. The primary outcome was the incidence of perioperative hypoxemia. Secondary outcomes included induction and maintenance doses of remimazolam, hemodynamic variables, scores for modified Observer's Assessment of Alertness/Sedation (MOAA/S), coughing, limb movement, incidence of adverse events, patient satisfaction, bronchoscopist satisfaction, incidence of post-operative cognitive dysfunction (POCD), time to loss of consciousness (LoC), and time to awake.
    Results: The incidence of hypoxemia, hypotension, and bronchoscopist satisfaction score were significantly decreased, and time to LoC and time to awake were markedly longer in the remimazolam and remimazolam plus dexmedetomidine groups than in the propofol control group (p < 0.05). The remimazolam group had significantly decreased induction and maintenance doses of remimazolam and a shorter time to LoC than the remimazolam plus dexmedetomidine group (p < 0.05). Scores for coughing, limb movement, MOAA/S, and post-operative patient satisfaction were comparable among the three groups. POCD was not induced in any of the groups.
    Conclusion: Remimazolam is safe and effective for painless bronchoscopy, with a low incidence of adverse reactions, and exhibits a good synergistic effect with dexmedetomidine.
    Trial registration: This trial protocol had been registered on Chinese Clinical Trial Registry (ChiCTR2000041435, date: 2020 12 26.
    MeSH term(s) Humans ; Propofol ; Dexmedetomidine/adverse effects ; Bronchoscopy/methods ; Hypnotics and Sedatives ; Cognition ; Hypoxia/chemically induced ; Hypoxia/drug therapy
    Chemical Substances remimazolam (7V4A8U16MB) ; Propofol (YI7VU623SF) ; Dexmedetomidine (67VB76HONO) ; Hypnotics and Sedatives
    Language English
    Publishing date 2022-11-08
    Publishing country Netherlands
    Document type Randomized Controlled Trial ; Journal Article
    ZDB-ID 2601204-2
    ISSN 2210-7711 ; 2210-7703 ; 0928-1231
    ISSN (online) 2210-7711
    ISSN 2210-7703 ; 0928-1231
    DOI 10.1007/s11096-022-01487-4
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  9. Article ; Online: Peripheral amyloid-β clearance mediates cognitive impairment in non-alcoholic fatty liver disease.

    Peng, Xiaobo / Zhang, Xing / Xu, Zihui / Li, Linyan / Mo, Xiaoxing / Peng, Zhao / Shan, Zhilei / Yan, Hong / Xu, Jian / Liu, Liegang

    EBioMedicine

    2024  Volume 102, Page(s) 105079

    Abstract: Background: Non-alcoholic fatty liver disease (NAFLD) is a prevalent risk factor for cognitive impairment. Cerebral amyloid-β (Aβ) accumulation, as an important pathology of cognitive impairment, can be caused by impaired Aβ clearance in the periphery. ... ...

    Abstract Background: Non-alcoholic fatty liver disease (NAFLD) is a prevalent risk factor for cognitive impairment. Cerebral amyloid-β (Aβ) accumulation, as an important pathology of cognitive impairment, can be caused by impaired Aβ clearance in the periphery. The liver is the primary organ for peripheral Aβ clearance, but the role of peripheral Aβ clearance in NAFLD-induced cognitive impairment remains unclear.
    Methods: We examined correlations between NAFLD severity, Aβ accumulation, and cognitive performance in female Sprague-Dawley rats. The impact of NAFLD on hepatic Aβ clearance and the involvement of low-density lipoprotein receptor-related protein 1 (LRP-1) were assessed in rat livers and cultured hepatocytes. Additionally, a case-control study, including 549 NAFLD cases and 549 controls (782 males, 316 females), investigated the interaction between NAFLD and LRP-1 rs1799986 polymorphism on plasma Aβ levels.
    Findings: The severity of hepatic steatosis and dysfunction closely correlated with plasma and cerebral Aβ accumulations and cognitive deficits in rats. The rats with NAFLD manifested diminished levels of LRP-1 and Aβ in liver tissue, with these reductions inversely proportional to plasma and cerebral Aβ concentrations and cognitive performance. In vitro, exposure of HepG2 cells to palmitic acid inhibited LRP-1 expression and Aβ uptake, which was subsequently reversed by a peroxisome proliferator-activated receptor α (PPARα) agonist. The case-control study revealed NAFLD to be associated with an increment of 8.24% and 10.51% in plasma Aβ40 and Aβ42 levels, respectively (both P < 0.0001). Moreover, the positive associations between NAFLD and plasma Aβ40 and Aβ42 levels were modified by the LRP-1 rs1799986 polymorphism (P for interaction = 0.0017 and 0.0015, respectively).
    Interpretation: LRP-1 mediates the adverse effect of NAFLD on peripheral Aβ clearance, thereby contributing to cerebral Aβ accumulation and cognitive impairment in NAFLD.
    Funding: Major International (Regional) Joint Research Project, National Key Research and Development Program of China, National Natural Science Foundation of China, and the Angel Nutrition Research Fund.
    MeSH term(s) Male ; Rats ; Female ; Animals ; Non-alcoholic Fatty Liver Disease/etiology ; Non-alcoholic Fatty Liver Disease/metabolism ; Case-Control Studies ; Rats, Sprague-Dawley ; Amyloid beta-Peptides/metabolism ; Liver/metabolism ; Cognitive Dysfunction/etiology ; Cognitive Dysfunction/metabolism ; Alzheimer Disease/metabolism
    Chemical Substances Amyloid beta-Peptides
    Language English
    Publishing date 2024-03-19
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 2851331-9
    ISSN 2352-3964
    ISSN (online) 2352-3964
    DOI 10.1016/j.ebiom.2024.105079
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    Zs.A 7090: Show issues Location:
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  10. Article ; Online: Differences in Cesarean section rates by fetal sex among Chinese women in the United States: Does Chinese culture play a role?

    Shen, Menghan / Li, Linyan

    Economics and human biology

    2019  Volume 36, Page(s) 100824

    Abstract: To investigate whether elements of Chinese culture, such as son preference, influence women's mode of child delivery, this paper analyzes how fetal sex affects C-section rates among Chinese mothers compared with Japanese mothers in the United States. It ... ...

    Abstract To investigate whether elements of Chinese culture, such as son preference, influence women's mode of child delivery, this paper analyzes how fetal sex affects C-section rates among Chinese mothers compared with Japanese mothers in the United States. It uses birth certificate data from 1990 to 2000, a period when women were routinely able to learn the sex of the fetus during pregnancy. Compared with Japanese mothers, Chinese mothers were 1 percentage point more likely to undergo C-section when giving birth to boys than when giving birth to girls. This result is robust to the addition of a rich set of controls and the restriction of the sample to infants without congenital diseases or anomalies at birth. The effects are concentrated in subgroups that are more likely to prefer sons-specifically, where both parents are Asian or where mothers are first-generation immigrants. The findings offer valuable insights for health professionals into culturally driven pregnancy behaviors among Chinese women, potentially enabling them to offer more culturally appropriate healthcare as they support women in making a healthy transition to motherhood.
    MeSH term(s) Adult ; Asian Americans ; Cesarean Section/statistics & numerical data ; China/ethnology ; Cultural Characteristics ; Emigrants and Immigrants/statistics & numerical data ; Female ; Humans ; Japan/ethnology ; Mothers/psychology ; Pregnancy ; Sex Ratio ; United States/epidemiology
    Language English
    Publishing date 2019-10-14
    Publishing country Netherlands
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2099749-8
    ISSN 1873-6130 ; 1570-677X
    ISSN (online) 1873-6130
    ISSN 1570-677X
    DOI 10.1016/j.ehb.2019.100824
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