LIVIVO - Search results -

Search results

Result 1 - 10 of total 40

Search options

Article ; Online: Role of primary tumor volume and metastatic lymph node volume in response to curative effect of definitive radiotherapy for locally advanced head and neck cancer.

Mao, Weiling / Zhang, Tao / Li, Longhao / Peng, Siyun / Gong, Huiying / Li, Minmin

2024 Volume 29, Issue 1, Page(s) 98

Abstract: Background: Studies have shown mixed results concerning the role of primary tumor volume (TV) and metastatic lymph node (NV) volume in response to the curative effect of definitive radiotherapy for locally advanced head and neck squamous cell carcinoma ( ...

Abstract	Background: Studies have shown mixed results concerning the role of primary tumor volume (TV) and metastatic lymph node (NV) volume in response to the curative effect of definitive radiotherapy for locally advanced head and neck squamous cell carcinoma (LAHNSCC). Objective: We aimed to evaluate the impact of TV and NV on the efficacy of radical radiotherapy in LAHNSCC patients, with the goal of guiding individualized therapy. Patients and methods: Patients with LAHNSCC who received radical radiation therapy and were reexamined within 6 months post-therapy from January 2012 to December 2021 were selected. The volumes of the primary tumors and metastatic lymph nodes were calculated by software and then were divided into a large TV group vs small TV group and a large NV group vs small NV group according to the relationship with the median. Additionally, patients who received concurrent chemoradiotherapy (CCRT) or not were divided into the CCRT group and the radiotherapy (RT) group. Patients with lymph node metastasis were divided into node concurrent chemotherapy (N-CCRT) group and a node metastatic chemotherapy (N-RT) group according to whether they received concurrent chemotherapy or not. The volume shrinkage rate (VSR), objective response rate (ORR), local control rate (LCR) and overall survival (OS) were recorded and analyzed. Results: 96 patients were included in the primary tumor volume group, and 73 patients were included in the metastatic lymph node group. Receiver operating characteristic (ROC) curves were constructed for objective remission (OR) endpoints, and a volume threshold was defined for TV and NV patients. The threshold primary tumor volume was 32.45 cm Conclusion: Primary tumor volume is not a prognostic factor for the response to curative effect radiotherapy in LAHNSCC patients. Nevertheless, metastatic lymph nodes are a prognostic factor for the response to curative effect radiotherapy in LAHNSCC patients. Patients with smaller lymph nodes have better local control.
MeSH term(s)	Humans ; Tumor Burden ; Head and Neck Neoplasms/radiotherapy ; Head and Neck Neoplasms/pathology ; Squamous Cell Carcinoma of Head and Neck/radiotherapy ; Squamous Cell Carcinoma of Head and Neck/pathology ; Lymph Nodes/pathology ; Chemoradiotherapy ; Retrospective Studies
Language	English
Publishing date	2024-02-04
Publishing country	England
Document type	Journal Article
ZDB-ID	1329381-3
ISSN	2047-783X ; 0949-2321
ISSN (online)	2047-783X
ISSN	0949-2321
DOI	10.1186/s40001-024-01691-0
Database	MEDical Literature Analysis and Retrieval System OnLINE

In stock of ZB MED Cologne/Königswinter

Zs.A 4636: Show issues

Location:
Je nach Verfügbarkeit (siehe Angabe bei Bestand)
bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
Jg. 1995 - 2021: Lesesall (2.OG)
ab Jg. 2022: Lesesaal (EG)

Order via subito

This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

Details ▾
- See ZB MED holdings
- Order with fees

Article ; Online: Correction: DJ-1 promotes epithelial-to-mesenchymal transition via enhancing FGF9 expression in colorectal cancer.

Li, Longhao / Zhang, Chundong / Li, Yi / Zhang, Ying / Lei, Yunlong

Biology open

2023 Volume 12, Issue 1

Language	English
Publishing date	2023-01-12
Publishing country	England
Document type	Published Erratum
ZDB-ID	2632264-X
ISSN	2046-6390 ; 2046-6390
ISSN (online)	2046-6390
ISSN	2046-6390
DOI	10.1242/bio.059782
Database	MEDical Literature Analysis and Retrieval System OnLINE

Order via subito

Article ; Online: Research on short-term photovoltaic power prediction based on multi-scale similar days and ESN-KELM dual core prediction model

Li, Naiqing / Li, Longhao / Zhang, Fan / Jiao, Ticao / Wang, Shuang / Liu, Xuefeng / Wu, Xinghua

Energy. 2023 Apr. 20, p.127557-

2023 , Page(s) 127557–

Abstract: Photovoltaic (PV) power generation has emerged as an essential means of developing and utilizing new energy. Accurate PV power prediction is critical for building a new power system generation and guaranteeing system stability when a high proportion of ... ...

Abstract	Photovoltaic (PV) power generation has emerged as an essential means of developing and utilizing new energy. Accurate PV power prediction is critical for building a new power system generation and guaranteeing system stability when a high proportion of renewable energy is connected. Therefore, this research proposes a hybrid prediction method based on multi-scale similar days and ESN-KELM dual-kernel prediction to increase the prediction accuracy of PV power generation. First, the multi-scale similar days algorithm is used to determine similar days of the forecast day as the model training data. This operation can reduce the impact of the randomness of PV power output on the model performance. Second, the hidden features of PV power are mined using a fast iterative filter decomposition method. Based on the complexity of the components, the corresponding ESN-KELM dual-kernel prediction models are established. An improved Archimedes optimization approach is used to optimize the ESN-KELM model's parameters. Next, the predicted power is obtained by aggregating the predicted results of each component. Ultimately, the method is validated using historical operational data from PV power plants. The results indicate that the proposed model can achieve well prediction results for various seasons and weather conditions.
Keywords	algorithms ; energy ; model validation ; models ; power generation ; prediction ; solar energy ; weather ; Photovoltaic power prediction ; Fast iterative filter decomposition ; Multiscale similar days ; Improved archimedes algorithm ; Kernel extreme learning machine ; Echo state network
Language	English
Dates of publication	2023-0420
Publishing place	Elsevier Ltd
Document type	Article ; Online
Note	Pre-press version
ZDB-ID	2019804-8
ISSN	0360-5442 ; 0360-5442
ISSN (online)	0360-5442
ISSN	0360-5442
DOI	10.1016/j.energy.2023.127557
Database	NAL-Catalogue (AGRICOLA)

Order via subito

Article ; Online: Precious Gene: The Application of RET-Altered Inhibitors.

Gou, Qitao / Gan, Xiaochuan / Li, Longhao / Gou, Qiheng / Zhang, Tao

Molecules (Basel, Switzerland)

2022 Volume 27, Issue 24

Abstract: The well-known proto-oncogene rearrangement during transfection (RET), also known as ret proto-oncogene Homo sapiens (human), is a rare gene that is involved in the physiological development of some organ systems and can activate various cancers, such as ...

Abstract	The well-known proto-oncogene rearrangement during transfection (RET), also known as ret proto-oncogene Homo sapiens (human), is a rare gene that is involved in the physiological development of some organ systems and can activate various cancers, such as non-small cell lung cancer, thyroid cancer, and papillary thyroid cancer. In the past few years, cancers with RET alterations have been treated with multikinase inhibitors (MKIs). However, because of off-target effects, these MKIs have developed drug resistance and some unacceptable adverse effects. Therefore, these MKIs are limited in their clinical application. Thus, the novel highly potent and RET-specific inhibitors selpercatinib and pralsetinib have been accelerated for approval by the Food and Drug Administration (FDA), and clinical trials of TPX-0046 and zetletinib are underway. It is well tolerated and a potential therapeutic for RET-altered cancers. Thus, we will focus on current state-of-the-art therapeutics with these novel RET inhibitors and show their efficacy and safety in therapy.
Language	English
Publishing date	2022-12-13
Publishing country	Switzerland
Document type	Journal Article ; Review
ZDB-ID	1413402-0
ISSN	1420-3049 ; 1431-5165 ; 1420-3049
ISSN (online)	1420-3049
ISSN	1431-5165 ; 1420-3049
DOI	10.3390/molecules27248839
Database	MEDical Literature Analysis and Retrieval System OnLINE

In stock of ZB MED Cologne/Königswinter

Zs.MO 81: Show issues

Order via subito

Details ▾
- See ZB MED holdings
- Order with fees

Article: The Prognostic Value of Preoperative Systemic Inflammatory Response Index (SIRI) in Patients With High-Grade Glioma and the Establishment of a Nomogram.

He, Qian / Li, Longhao / Ren, Qinglan

Frontiers in oncology

2021 Volume 11, Page(s) 671811

Abstract: Background: The predictive value of systemic inflammatory response index (SIRI) was confirmed in some malignant tumors. However, few studies investigated the prognostic value of SIRI in high-grade gliomas. This study aimed to evaluate the prognostic ... ...

Abstract	Background: The predictive value of systemic inflammatory response index (SIRI) was confirmed in some malignant tumors. However, few studies investigated the prognostic value of SIRI in high-grade gliomas. This study aimed to evaluate the prognostic relationship of preoperative SIRI in high-grade gliomas and established a nomogram accordingly. Methods: Data of operable high-grade glioma patients were analyzed. Kaplan-Meier, log-rank test, cox regression and propensity score matching (PSM) analysis were used to analyze survival. ROC curve and area under the curve (AUC) were used to compare the ability of preoperative SIRI, neutrophil-lymphocyte ratio (NLR), platelet-lymphocyte ratio (PLR) and monocyte-lymphocyte ratio (MLR) to predict prognosis. A nomogram based on the results was established. The consistency index (C-index) was calculated and a calibration curve was drawn.The prediction effect of the nomogram and WHO grade was compared by AUC. Results: A total of 105 patients were included. Kaplan-Meier survival analysis showed that the overall survival (OS) of grade III gliomas patients with lower preoperative SIRI (SIRI<1.26) was significantly prolonged (p=0.037), and grade IV gliomas patients with lower preoperative SIRI had a tendency to obtain longer OS (p = 0.107). Cox regression showed preoperative SIRI was an independent prognostic factor for grade IV and grade III glioma, however, in IDH mutant-type IV gliomas, patients with lower SIRI only showed a tendency to obtain better OS. Similar results were obtained in PSM. The prognostic value of SIRI were better than PLR and MLR by ROC analysis. And in grade IV gliomas, the predictive value of SIRI was better than NLR. The nomogram established based on preoperative SIRI, age, extent of resection, number of gliomas, MGMT methylation status and histological types (only in grade III gliomas) could predict the prognosis more accurately. Conclusion: SIRI was valuable for prognosis prediction in high-grade glioma. The nomogram covering SIRI could more accurately predict the survival rate in operable high-grade glioma patients.
Language	English
Publishing date	2021-05-14
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2649216-7
ISSN	2234-943X
ISSN	2234-943X
DOI	10.3389/fonc.2021.671811
Database	MEDical Literature Analysis and Retrieval System OnLINE

Order via subito

Article ; Online: Pact-Net: Parallel CNNs and Transformers for medical image segmentation.

Chen, Weilin / Zhang, Rui / Zhang, Yunfeng / Bao, Fangxun / Lv, Haixia / Li, Longhao / Zhang, Caiming

Computer methods and programs in biomedicine

2023 Volume 242, Page(s) 107782

Abstract: Background and objective: The image segmentation of diseases can help clinical diagnosis and treatment in medical image analysis. Because medical images usually have low contrast and large changes in the size and shape of some structures, this will lead ...

Abstract	Background and objective: The image segmentation of diseases can help clinical diagnosis and treatment in medical image analysis. Because medical images usually have low contrast and large changes in the size and shape of some structures, this will lead to over-segmentation and under-segmentation. These problems are particularly evident in the segmentation of skin damage. The blurring of the boundary in skin images and the specificity of patients will further increase the difficulty of skin lesion segmentation. Currently, most researchers use deep learning networks to solve these skin segmentation problems. However, traditional convolution methods often fail to obtain satisfactory segmentation performance due to their shortcomings in obtaining global features. Recently, Transformers with good global information extraction ability has achieved satisfactory results in computer vision, which brings new solutions to optimize the model of medical image segmentation further. Methods: To extract more features related to medical image segmentation and effectively use features to further optimize the skin image segmentation model, we designed a network that combines CNNs and Transformers to improve local and global features, called Parallel CNNs and Transformers for Medical Image Segmentation (Pact-Net). Specifically, due to the advantages of Transformers in extracting global information, we create a novel fusion module CSMF, which uses channel and spatial attention mechanism and multi-scale mechanism to effectively fuse the global information extracted by Transformers into the local features extracted by CNNs. Therefore, our Pact-Net dual-branch runs in parallel to effectively capture global and local information. Results: Our Pact-Net exceeds the models submitted on the three datasets ISIC 2016, ISIC 2017 and ISIC 2018, and the indicators required for the datasets reach 86.95%, 79.31% and 84.14%, respectively. We also conducted medical image segmentation experiments on cell and polyp datasets to evaluate the robustness, learning and generalization ability of the network. The ablation study of each part of Pact-Net proves the validity of each component, and the comparison with state-of-the-art methods on different indicators proves the predominance of the network. Conclusions: This paper uses the advantages of CNNs and Transformers in extracting local and global features, and further integrates features for skin lesion segmentation. Compared with the state-of-the-art methods, Pact-Net can achieve the most advanced segmentation ability on the skin lesion segmentation dataset, which can help doctors diagnose and treat diseases.
MeSH term(s)	Humans ; Electric Power Supplies ; Information Storage and Retrieval ; Physicians ; Polyps ; Skin/diagnostic imaging ; Image Processing, Computer-Assisted
Language	English
Publishing date	2023-09-01
Publishing country	Ireland
Document type	Journal Article
ZDB-ID	632564-6
ISSN	1872-7565 ; 0169-2607
ISSN (online)	1872-7565
ISSN	0169-2607
DOI	10.1016/j.cmpb.2023.107782
Database	MEDical Literature Analysis and Retrieval System OnLINE

In stock of ZB MED Cologne/Königswinter

Zs.B 521: Show issues

Location:
Je nach Verfügbarkeit (siehe Angabe bei Bestand)
bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
ab Jg. 2022: Lesesaal (EG)

Order via subito

Details ▾
- See ZB MED holdings
- Order with fees

Article: Lidocaine-Loaded Hyaluronic Acid Adhesive Microneedle Patch for Oral Mucosal Topical Anesthesia.

Zhu, Tingting / Yu, Xixi / Yi, Xin / Guo, Xiaoli / Li, Longhao / Hao, Yuanping / Wang, Wanchun

Pharmaceutics

2022 Volume 14, Issue 4

Abstract: The pain and fear caused by direct local injection of anesthetic or the poor experience with surface anesthetic cream increase the difficulty of clinical treatment for oral diseases. To address this problem, a hyaluronic acid microneedle patch (Li-HAMNs) ...

Abstract	The pain and fear caused by direct local injection of anesthetic or the poor experience with surface anesthetic cream increase the difficulty of clinical treatment for oral diseases. To address this problem, a hyaluronic acid microneedle patch (Li-HAMNs) that consists of fast-dissolving lidocaine hydrochloride (LDC)-loaded tips and a wet-adhesive backing layer made of polyvinyl alcohol (PVA)/carboxymethylcellulose sodium (CMC-Na) was fabricated to explore its potential use in dental topical anesthesia. Li-HAMNs could puncture the stratum corneum with an insertion depth of about 279 μm in the isolated porcine oral mucosal. The fast-dissolving tips could release LDC to improve the patients' convenience and compliance. Importantly, the backing layer, which has good adhesion ability and water-absorbing properties, could surmount the contraction and extension of oral masticatory muscles and the saliva scour. In the tail flick test, the topical anesthesia efficacy of the Li-HAMNs group was much better than clinical lidocaine cream (EMLA cream, LDC, 1.2 mg) in spite of a relatively lower LDC dose with Li-HAMNs (LDC, 0.5 mg). It is believed that the proposed adhesive microneedle patch could enhance transmucosal delivery of anesthetics and thus open a new chapter in the painless treatment of oral diseases.
Language	English
Publishing date	2022-03-22
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2527217-2
ISSN	1999-4923
ISSN	1999-4923
DOI	10.3390/pharmaceutics14040686
Database	MEDical Literature Analysis and Retrieval System OnLINE

Order via subito

Article ; Online: Advanced navigation technology enables endobronchial brachytherapy for peripheral lung cancer: An old technique plays a new role.

Li, Yishi / Jiang, Juan / Jiang, Qingfeng / Lu, Wenli / Cui, Haixia / Song, Yanbo / Li, Wencong / Zhang, Tao / Li, Longhao

Brachytherapy

2023 Volume 23, Issue 2, Page(s) 199–206

Abstract: Purpose: To investigate the feasibility of super-selectively endobronchial brachytherapy in the treatment of peripheral lung cancer guided by advanced navigation technology.: Methods and materials: Six patients with peripheral lung tumors ... ...

Abstract	Purpose: To investigate the feasibility of super-selectively endobronchial brachytherapy in the treatment of peripheral lung cancer guided by advanced navigation technology. Methods and materials: Six patients with peripheral lung tumors successfully underwent treatment with super-selectively endobronchial brachytherapy guided by advanced navigation technology following pathway planning and were subsequently followed up to assess survival and treatment-related toxicities. Results: The endobronchial applicators were successfully placed inside the tumors of all patients using advanced navigation techniques according to the pretreatment plan, and brachytherapy was delivered at curative doses after evaluation using radiotherapy planning software. None of the patients showed local progression of the treated lesions during the follow-up for a duration ranging from 11 months to 35 months, with a median follow-up time of 23 months. The patient with the longest follow-up, nearly 3 years, exhibited a stable condition. After undergoing endobronchial brachytherapy, patients predominantly experienced localized fibrosis as indicated. No significant alterations in cardiopulmonary function were detected during the follow-up, and no other adverse effects were found. Conclusions: The use of endobronchial brachytherapy for the curative treatment of peripheral lung cancers is feasible. Furthermore, the development of novel bronchial navigation techniques has the potential to broaden the application of endobronchial brachytherapy.
MeSH term(s)	Humans ; Lung Neoplasms/pathology ; Brachytherapy/methods ; Radiotherapy Dosage ; Bronchi/pathology
Language	English
Publishing date	2023-12-30
Publishing country	United States
Document type	Journal Article
ZDB-ID	2098608-7
ISSN	1873-1449 ; 1538-4721
ISSN (online)	1873-1449
ISSN	1538-4721
DOI	10.1016/j.brachy.2023.12.003
Database	MEDical Literature Analysis and Retrieval System OnLINE

In stock of ZB MED Cologne/Königswinter

Zs.A 6116: Show issues

Location:
Je nach Verfügbarkeit (siehe Angabe bei Bestand)
bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
ab Jg. 2022: Lesesaal (EG)

Order via subito

Details ▾
- See ZB MED holdings
- Order with fees

Article ; Online: Elucidating the impact of oxygen functional groups on the catalytic activity of M-N

Xie, Liang / Zhou, Wei / Huang, Yuming / Qu, Zhibin / Li, Longhao / Yang, Chaowei / Ding, Yani / Li, Junfeng / Meng, Xiaoxiao / Sun, Fei / Gao, Jihui / Zhao, Guangbo / Qin, Yukun

Materials horizons

2024 Volume 11, Issue 7, Page(s) 1719–1731

Abstract: Efforts to enhance the efficiency of electrocatalysts for the oxygen reduction reaction (ORR) in energy conversion and storage devices present formidable challenges. In this endeavor, M- ... ...

Abstract	Efforts to enhance the efficiency of electrocatalysts for the oxygen reduction reaction (ORR) in energy conversion and storage devices present formidable challenges. In this endeavor, M-N
Language	English
Publishing date	2024-04-02
Publishing country	England
Document type	Journal Article
ZDB-ID	2744250-0
ISSN	2051-6355 ; 2051-6347
ISSN (online)	2051-6355
ISSN	2051-6347
DOI	10.1039/d3mh02115g
Database	MEDical Literature Analysis and Retrieval System OnLINE

Order via subito

Article: DJ-1 promotes epithelial-to-mesenchymal transition via enhancing FGF9 expression in colorectal cancer.

Li, Longhao / Zhang, Chundong / Li, Yi / Zhang, Ying / Lei, Yunlong

Biology open

2020 Volume 9, Issue 5

Abstract: Tumor metastasis is the main contributor to high recurrence and mortality in colorectal cancer (CRC). In a previous study, we found that DJ-1 plays an important role in CRC metastasis, and is the main target in Ciclopirox olamine (CPX)-treated CRC. ... ...

Abstract	Tumor metastasis is the main contributor to high recurrence and mortality in colorectal cancer (CRC). In a previous study, we found that DJ-1 plays an important role in CRC metastasis, and is the main target in Ciclopirox olamine (CPX)-treated CRC. However, the mechanism underlying DJ-1-induced CRC metastasis remains elusive. In the present study, our results showed that DJ-1 could activate Wnt signaling resulting in enhanced invasive potential and epithelial-to-mesenchymal transition (EMT) in CRC cells. RNA-seq and bioinformatics analysis reveals that the DJ-1/Wnt signaling pathway may promote CRC cells' EMT by regulating fibroblast growth factor 9 (FGF9) expression. Molecular validation showed that expression of FGF9 was upregulated by the DJ-1/Wnt signaling pathway and decreasing FGF9-expression impeded DJ-1-induced CRC invasive ability and EMT, suggesting that FGF9 is involved in DJ-1-enhanced CRC metastasis. In addition, we show that FGF9 was overexpressed in CRC human specimens and was significantly associated with tumor differentiation. High FGF9 expression was correlated with worse overall survival, and a correlation exhibited between FGF9 and EMT markers (E-cadherin and Vimentin) in CRC samples. Together, our results determined that FGF9 was involved in DJ-1-induced invasion and EMT in CRC cells, and may represent a promising therapeutic candidate for CRC anti-metastatic strategies.
MeSH term(s)	Cell Line, Tumor ; Colorectal Neoplasms/genetics ; Colorectal Neoplasms/metabolism ; Colorectal Neoplasms/mortality ; Colorectal Neoplasms/pathology ; Epithelial-Mesenchymal Transition/genetics ; Fibroblast Growth Factor 9/genetics ; Fibroblast Growth Factor 9/metabolism ; Gene Expression Regulation, Neoplastic ; Humans ; Immunohistochemistry ; Prognosis ; Protein Deglycase DJ-1/genetics ; Protein Deglycase DJ-1/metabolism ; Wnt Signaling Pathway
Chemical Substances	FGF9 protein, human ; Fibroblast Growth Factor 9 ; PARK7 protein, human (EC 3.1.2.-) ; Protein Deglycase DJ-1 (EC 3.1.2.-)
Language	English
Publishing date	2020-05-19
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2632264-X
ISSN	2046-6390
ISSN	2046-6390
DOI	10.1242/bio.051680
Database	MEDical Literature Analysis and Retrieval System OnLINE

Order via subito

To top

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

More links

Kategorien

Order via subito

More links

Kategorien

Order via subito

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

More links

Kategorien

Order via subito

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

More links

Kategorien

Order via subito

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

More links

Kategorien

Order via subito

More links

Kategorien

Order via subito