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  1. Article ; Online: Building a Poly(amino acid)/Chitosan-Based Self-Healing Hydrogel via Host-Guest Interaction for Cartilage Regeneration.

    Li, Pengqiang / Zong, Hongjie / Li, Guifei / Shi, Zhen / Yu, Xi / Zhang, Kunxi / Xia, Pengfei / Yan, Shifeng / Yin, Jingbo

    ACS biomaterials science & engineering

    2023  Volume 9, Issue 8, Page(s) 4855–4866

    Abstract: Cartilage injury is a very common joint disease, and cartilage repair is a great challenge in clinical treatment due to the specific structure of cartilage tissue and its ... ...

    Abstract Cartilage injury is a very common joint disease, and cartilage repair is a great challenge in clinical treatment due to the specific structure of cartilage tissue and its microenvironment
    MeSH term(s) Rats ; Animals ; Chitosan ; Hydrogels/pharmacology ; Hydrogels/chemistry ; Amino Acids/pharmacology ; Cartilage ; Regeneration
    Chemical Substances Chitosan (9012-76-4) ; Hydrogels ; Amino Acids
    Language English
    Publishing date 2023-06-30
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ISSN 2373-9878
    ISSN (online) 2373-9878
    DOI 10.1021/acsbiomaterials.2c01547
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Synergistically Enhanced Mucoadhesive and Penetrable Polypeptide Nanogel for Efficient Drug Delivery to Orthotopic Bladder Cancer.

    Guo, Hui / Li, Faping / Qiu, Heping / Xu, Weiguo / Li, Pengqiang / Hou, Yuchuan / Ding, Jianxun / Chen, Xuesi

    Research (Washington, D.C.)

    2020  Volume 2020, Page(s) 8970135

    Abstract: Intravesical chemotherapy has been recommended after the gold standard of transurethral resection of the bladder tumor to prevent bladder cancer (BC) from local recurrence in the clinic. However, due to rapid urine excretion and barrier protection of the ...

    Abstract Intravesical chemotherapy has been recommended after the gold standard of transurethral resection of the bladder tumor to prevent bladder cancer (BC) from local recurrence in the clinic. However, due to rapid urine excretion and barrier protection of the bladder wall, the clinical performances of chemotherapeutic drugs are severely compromised. In the present work, a smart positively charged disulfide-crosslinked nanogel of oligoarginine-poly(ethylene glycol)-poly(L-phenylalanine-
    Language English
    Publishing date 2020-08-03
    Publishing country United States
    Document type Journal Article
    ISSN 2639-5274
    ISSN (online) 2639-5274
    DOI 10.34133/2020/8970135
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Synthetic Glycopolypeptide Micelle for Targeted Drug Delivery to Hepatic Carcinoma.

    Li, Pengqiang / Han, Jiandong / Li, Di / Chen, Jinjin / Wang, Wei / Xu, Weiguo

    Polymers

    2018  Volume 10, Issue 6

    Abstract: The targeted delivery of chemotherapy drugs to tumor lesions is a major challenge for the treatment of tumors. Up until now, various polymeric nanoparticles have been explored to improve the targetability of these therapeutic drugs through passive or ... ...

    Abstract The targeted delivery of chemotherapy drugs to tumor lesions is a major challenge for the treatment of tumors. Up until now, various polymeric nanoparticles have been explored to improve the targetability of these therapeutic drugs through passive or active targeting processes. In the design and construction of polymer nanoparticles, glycopolypeptide has shown great potential owing to its excellent targeting ability and biocompatibility. In order to enhance the antitumor effect of doxorubicin (DOX), a glycopolypeptide-based micelle (GPM) modified by α-lactose (Lac) was synthesized for targeted treatment of hepatoma. The DOX-loaded GPM (i.e., GPM/DOX) could significantly target human hepatoma (HepG2) cells and further inhibit their proliferation
    Language English
    Publishing date 2018-06-04
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2527146-5
    ISSN 2073-4360 ; 2073-4360
    ISSN (online) 2073-4360
    ISSN 2073-4360
    DOI 10.3390/polym10060611
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Self-Targeted Polysaccharide Prodrug Suppresses Orthotopic Hepatoma.

    Li, Di / Xu, Weiguo / Li, Pengqiang / Ding, Jianxun / Cheng, Zhiliang / Chen, Li / Yan, Lesan / Chen, Xuesi

    Molecular pharmaceutics

    2016  Volume 13, Issue 12, Page(s) 4231–4235

    Abstract: Self-targetability is an emerging targeting strategy for polymer nanocarriers with facile preparation and high targeting efficiency. An acid-sensitive dextran-doxorubicin prodrug (Dex-g-DOX) has been synthesized and used as a self-targeted drug delivery ... ...

    Abstract Self-targetability is an emerging targeting strategy for polymer nanocarriers with facile preparation and high targeting efficiency. An acid-sensitive dextran-doxorubicin prodrug (Dex-g-DOX) has been synthesized and used as a self-targeted drug delivery system for the treatment of orthotopic hepatoma. The polysaccharide prodrug exhibits ultraselective accumulation in cancerous liver tissue, acid-sensitive DOX release within cells, and high antitumor efficacy in vitro and in vivo. Therefore, Dex-g-DOX demonstrates great potential for chemotherapy of orthotopic hepatoma.
    MeSH term(s) Animals ; Antibiotics, Antineoplastic/pharmacology ; Carcinoma, Hepatocellular/prevention & control ; Cell Survival/drug effects ; Dextrans/administration & dosage ; Dextrans/chemistry ; Doxorubicin/pharmacology ; Drug Delivery Systems ; Humans ; Hydrogen-Ion Concentration ; Liver Neoplasms/prevention & control ; Mice ; Mice, Inbred BALB C ; Prodrugs/pharmacology ; Tumor Cells, Cultured
    Chemical Substances Antibiotics, Antineoplastic ; Dextrans ; Prodrugs ; Doxorubicin (80168379AG)
    Language English
    Publishing date 2016-12-05
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2138405-8
    ISSN 1543-8392 ; 1543-8384
    ISSN (online) 1543-8392
    ISSN 1543-8384
    DOI 10.1021/acs.molpharmaceut.6b00747
    Database MEDical Literature Analysis and Retrieval System OnLINE

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