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Article ; Online: Dendrobium fimbriatum

Wang, Yu-Jing / Li, Qiang-Ming / Zha, Xue-Qiang / Luo, Jian-Ping

2022 Volume 13, Issue 1, Page(s) 143–160

Abstract: The ameliorative effect ... ...

Abstract	The ameliorative effect of
MeSH term(s)	Animals ; Antioxidants/chemistry ; Antioxidants/pharmacology ; Colitis, Ulcerative/chemically induced ; Colitis, Ulcerative/metabolism ; Dendrobium/chemistry ; Dextran Sulfate/adverse effects ; Disease Models, Animal ; Gastrointestinal Microbiome/drug effects ; Inflammation/metabolism ; Male ; Mice ; Mice, Inbred C57BL ; Oxidative Stress/drug effects ; Polysaccharides/chemistry ; Polysaccharides/pharmacology ; Signal Transduction/drug effects
Chemical Substances	Antioxidants ; Polysaccharides ; Dextran Sulfate (9042-14-2)
Language	English
Publishing date	2022-01-04
Publishing country	England
Document type	Journal Article
ZDB-ID	2612033-1
ISSN	2042-650X ; 2042-6496
ISSN (online)	2042-650X
ISSN	2042-6496
DOI	10.1039/d1fo03003e
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Article ; Online: Intervention and potential mechanism of non-starch polysaccharides from natural resources on ulcerative colitis: A review.

Wang, Yu-Jing / Li, Qiang-Ming / Zha, Xue-Qiang / Luo, Jian-Ping

International journal of biological macromolecules

2022 Volume 210, Page(s) 545–564

Abstract: Ulcerative colitis (UC) is a chronic inflammatory bowel disease of unknown etiology that affects the colon and rectum. It has evolved into a global burden due to the high incidence in developed countries and the highly-increased incidence in developing ... ...

Abstract	Ulcerative colitis (UC) is a chronic inflammatory bowel disease of unknown etiology that affects the colon and rectum. It has evolved into a global burden due to the high incidence in developed countries and the highly-increased incidence in developing countries. Non-starch polysaccharides (NSPs) from natural resources, as a type of functional carbohydrates, have a significant therapeutic effect on UC because of their good anti-inflammatory and immunomodulatory activities. Based on the etiology and pathogenesis of UC, this review summarizes the intervention effects and mechanisms of NSPs in the prevention and treatment of UC. The results showed that NSPs can improve UC by protecting the intestinal mucosal barrier, regulating the immune response of the intestinal mucosa, and remodeling the intestinal flora and metabolites. These contents provide theoretical basis for the application of polysaccharides in the prevention and treatment of UC.
MeSH term(s)	Animals ; Colitis, Ulcerative/drug therapy ; Colitis, Ulcerative/pathology ; Colon/pathology ; Disease Models, Animal ; Gastrointestinal Microbiome ; Intestinal Mucosa/metabolism ; Natural Resources ; Polysaccharides/metabolism ; Polysaccharides/pharmacology ; Polysaccharides/therapeutic use
Chemical Substances	Polysaccharides
Language	English
Publishing date	2022-05-02
Publishing country	Netherlands
Document type	Journal Article ; Review
ZDB-ID	282732-3
ISSN	1879-0003 ; 0141-8130
ISSN (online)	1879-0003
ISSN	0141-8130
DOI	10.1016/j.ijbiomac.2022.04.208
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Article ; Online: Rapid Discovery of Aβ

Li, Qiang-Ming / Han, Hui-Hui / Zang, Dan-Dan / Zha, Xue-Qiang / Zhou, An / Zhang, Feng-Yun / Luo, Jian-Ping

Journal of agricultural and food chemistry

2024 Volume 72, Issue 8, Page(s) 4127–4141

Abstract: An amyloid-β (Aβ) fibril is a vital pathogenic factor of Alzheimer's disease (AD). Aβ fibril disintegrators possess great potential to be developed into novel anti-AD agents. Here, a ligand fishing method was employed to rapidly discover ... ...

Abstract	An amyloid-β (Aβ) fibril is a vital pathogenic factor of Alzheimer's disease (AD). Aβ fibril disintegrators possess great potential to be developed into novel anti-AD agents. Here, a ligand fishing method was employed to rapidly discover Aβ
MeSH term(s)	Alzheimer Disease/drug therapy ; Neuroprotective Agents/pharmacology ; Reishi ; Ligands ; Amyloid beta-Peptides ; Amyloid ; Ergosterol ; Peptide Fragments/therapeutic use ; Triterpenes
Chemical Substances	3,7-dioxolanosta-8,24-dien-26-oic acid ; Neuroprotective Agents ; Ligands ; Amyloid beta-Peptides ; Amyloid ; Ergosterol (Z30RAY509F) ; Peptide Fragments ; Triterpenes
Language	English
Publishing date	2024-02-16
Publishing country	United States
Document type	Journal Article
ZDB-ID	241619-0
ISSN	1520-5118 ; 0021-8561
ISSN (online)	1520-5118
ISSN	0021-8561
DOI	10.1021/acs.jafc.3c08664
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Article ; Online: Codonopsis lanceolata polysaccharide ameliorates high-fat diet induced-postpartum hypogalactia via stimulating prolactin receptor-mediated Jak2/Stat5 signaling.

Chen, Shun / Long, Miao / Li, Xue-Ying / Li, Qiang-Ming / Pan, Li-Hua / Luo, Jian-Ping / Zha, Xue-Qiang

International journal of biological macromolecules

2024 Volume 259, Issue Pt 1, Page(s) 129114

Abstract: This study aims to investigate the ameliorative effect of Codonopsis lanceolata polysaccharide (PCL) on mice with hypogalatia induced by a high-fat diet (HFD) and the potential underlying mechanism. We found that oral administration of PCL demonstrated ... ...

Abstract	This study aims to investigate the ameliorative effect of Codonopsis lanceolata polysaccharide (PCL) on mice with hypogalatia induced by a high-fat diet (HFD) and the potential underlying mechanism. We found that oral administration of PCL demonstrated significant benefits in countering the negative effects of HFD, including weight gain, hepatic steatosis, mesenteric adipocyte hypertrophy, and abnormal glucose/lipid metabolism. In addition, PCL improved mammary gland development and enhanced lactogenesis performance. Histologically, PCL ameliorated the retardation of ductal growth, reduced mammary fat pad thickness, improved the incomplete linear encapsulation of luminal epithelium and myoepithelium, and increased the proliferation of mammary epithelial cells. Flow cytometry analysis showed that PCL mitigated the detrimental effects of HFD on mammary gland development by promoting the proliferation and differentiation of mammary epithelial cells. Mechanistic studies revealed that PCL upregulated the levels of prolactin (PRL) and its receptor (PRLR) in the mammary gland, activated JAK2/STAT5 signaling pathway, and increased the expression of p63, ERBB4, and NRG1. Overall, PCL can ameliorate HFD-induced hypogalactia by activating PRLR-mediated JAK2/STAT5 signaling. Our findings offer a methodological and theoretical foundation for investigating the functional constituents of traditional Chinese medicine in the treatment of hypogalactia.
MeSH term(s)	Humans ; Female ; Mice ; Animals ; Prolactin/metabolism ; Prolactin/pharmacology ; Receptors, Prolactin/metabolism ; Codonopsis/metabolism ; STAT5 Transcription Factor/metabolism ; Diet, High-Fat/adverse effects ; Signal Transduction ; Postpartum Period ; Polysaccharides/pharmacology ; Lactation Disorders
Chemical Substances	Prolactin (9002-62-4) ; Receptors, Prolactin ; STAT5 Transcription Factor ; Polysaccharides
Language	English
Publishing date	2024-01-03
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	282732-3
ISSN	1879-0003 ; 0141-8130
ISSN (online)	1879-0003
ISSN	0141-8130
DOI	10.1016/j.ijbiomac.2023.129114
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Article ; Online: Dendrobium fimbriatum polysaccharide ameliorates DSS-induced intestinal mucosal injury by IL-22-regulated intestinal stem cell regeneration.

Wang, Yu-Jing / Wang, Hong-Yan / Li, Qiang-Ming / Zha, Xue-Qiang / Luo, Jian-Ping

International journal of biological macromolecules

2023 Volume 230, Page(s) 123199

Abstract: Ulcerative colitis (UC) is a chronic inflammatory bowel disease with unknown etiology and difficult treatment. In this study, the intervention effect of Dendrobium fimbriatum Hook polysaccharide (cDFPW1) on UC was verified by constructing a dextran ... ...

Abstract	Ulcerative colitis (UC) is a chronic inflammatory bowel disease with unknown etiology and difficult treatment. In this study, the intervention effect of Dendrobium fimbriatum Hook polysaccharide (cDFPW1) on UC was verified by constructing a dextran sulfate sodium (DSS)-induced colitis mouse model, and the protective effect of cDFPW1 on intestinal mucosal integrity in UC was explored by the co-culture system consisting of intestinal organoids and lamina propria lymphocytes (LPLs) combined with the experiment of microbial depletion mice. Results showed that cDFPW1 significantly alleviated UC symptoms in mice and promoted the proliferation of intestinal epithelial cells. Importantly, cDFPW1 could directly improve DSS-induced morphological damage of intestinal organoids and increase the number of epithelial cells, which was validated in mice. During repair, an increase in the number of Lgr5
MeSH term(s)	Animals ; Mice ; Colitis/chemically induced ; Colitis, Ulcerative/metabolism ; Dendrobium ; Dextran Sulfate/toxicity ; Disease Models, Animal ; Interleukins/metabolism ; Intestinal Mucosa/metabolism ; Mice, Inbred C57BL ; Stem Cells ; Interleukin-22
Chemical Substances	Dextran Sulfate (9042-14-2) ; Interleukins
Language	English
Publishing date	2023-01-10
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	282732-3
ISSN	1879-0003 ; 0141-8130
ISSN (online)	1879-0003
ISSN	0141-8130
DOI	10.1016/j.ijbiomac.2023.123199
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Article ; Online: Dendrobium huoshanense stem polysaccharide ameliorates alcohol-induced gastric ulcer in rats through Nrf2-mediated strengthening of gastric mucosal barrier

Ye, Hui-Yu / Shang, Zhen-Zi / Zhang, Feng-Yun / Zha, Xue-Qiang / Li, Qiang-Ming / Luo, Jian-Ping

International Journal of Biological Macromolecules. 2023 May, v. 236 p.124001-

2023

Abstract: This study aimed to explore whether Dendrobium huoshanense stem polysaccharide (cDHPS) ameliorates alcohol-induced gastric ulcer (GU) through the strengthening effect of the gastric mucosal barrier in rats and its potential mechanism. In normal rats, the ...

Abstract	This study aimed to explore whether Dendrobium huoshanense stem polysaccharide (cDHPS) ameliorates alcohol-induced gastric ulcer (GU) through the strengthening effect of the gastric mucosal barrier in rats and its potential mechanism. In normal rats, the pretreatment of cDHPS effectively strengthened gastric mucosal barrier by increasing mucus secretion and tight junction protein expression. In GU rats, cDHPS supplementation effectively alleviated alcohol-induced gastric mucosal injury and nuclear factor κB (NF-κB)-driven inflammation by strengthening gastric mucosal barrier. Moreover, cDHPS significantly activated nuclear factor E2-related factor 2 (Nrf2) signaling and promoted antioxidant enzymes activities in both normal and GU rats. These results suggested that the pretreatment of cDHPS could strengthen gastric mucosal barrier to inhibit oxidative stress and NF-κB-driven inflammation induced gastric mucosal injury, which was likely related to the activation of Nrf2 signaling.
Keywords	Dendrobium catenatum ; antioxidants ; inflammation ; mucus ; oxidative stress ; polysaccharides ; protein synthesis ; secretion ; stomach ulcers ; tight junctions ; Dendrobium huoshanense polysaccharide ; Gastric mucosal barrier ; Nrf2
Language	English
Dates of publication	2023-05
Publishing place	Elsevier B.V.
Document type	Article ; Online
ZDB-ID	282732-3
ISSN	1879-0003 ; 0141-8130
ISSN (online)	1879-0003
ISSN	0141-8130
DOI	10.1016/j.ijbiomac.2023.124001
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Article ; Online: Dendrobium fimbriatum polysaccharide ameliorates DSS-induced intestinal mucosal injury by IL-22-regulated intestinal stem cell regeneration

Wang, Yu-Jing / Wang, Hong-Yan / Li, Qiang-Ming / Zha, Xue-Qiang / Luo, Jian-Ping

International Journal of Biological Macromolecules. 2023 Mar., v. 230 p.123199-

2023

Abstract	Ulcerative colitis (UC) is a chronic inflammatory bowel disease with unknown etiology and difficult treatment. In this study, the intervention effect of Dendrobium fimbriatum Hook polysaccharide (cDFPW1) on UC was verified by constructing a dextran sulfate sodium (DSS)-induced colitis mouse model, and the protective effect of cDFPW1 on intestinal mucosal integrity in UC was explored by the co-culture system consisting of intestinal organoids and lamina propria lymphocytes (LPLs) combined with the experiment of microbial depletion mice. Results showed that cDFPW1 significantly alleviated UC symptoms in mice and promoted the proliferation of intestinal epithelial cells. Importantly, cDFPW1 could directly improve DSS-induced morphological damage of intestinal organoids and increase the number of epithelial cells, which was validated in mice. During repair, an increase in the number of Lgr5⁺ cells in intestinal organoids and mouse intestines was promoted by cDFPW1. Meanwhile, cDFPW1 promoted intestinal stem cells (ISCs)-mediated intestinal epithelial regeneration by significantly upregulating IL-22 expression. We further confirmed that the secretion of IL-22 was mediated by LPLs. Together, these findings suggest that cDFPW1 promotes ISCs regeneration by LPLs-mediated up-regulation of IL-22 to protect the intestinal mucosal integrity, thereby playing an important role in improving UC.
Keywords	Dendrobium ; coculture ; dextran sulfate ; epithelium ; etiology ; intestines ; mice ; models ; organoids ; protective effect ; secretion ; stem cells ; ulcerative colitis ; Dendrobium fimbriatum polysaccharide ; Intestinal mucus ; Intestinal organoids ; IL-22
Language	English
Dates of publication	2023-03
Publishing place	Elsevier B.V.
Document type	Article ; Online
ZDB-ID	282732-3
ISSN	1879-0003 ; 0141-8130
ISSN (online)	1879-0003
ISSN	0141-8130
DOI	10.1016/j.ijbiomac.2023.123199
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Article: Dendrobium fimbriatum Hook polysaccharide ameliorates dextran-sodium-sulfate-induced colitis in mice via improving intestinal barrier function, modulating intestinal microbiota, and reducing oxidative stress and inflammatory responses

Wang, Yu-Jing / Li, Qiang-Ming / Zha, Xue-Qiang / Luo, Jian-Ping

Food & function. 2022 Jan. 4, v. 13, no. 1

2022

Abstract: The ameliorative effect of Dendrobium fimbriatum polysaccharide (cDFPW1) on ulcerative colitis (UC) was investigated using a dextran-sodium-sulfate-induced (DSS-induced) mouse model in the present study. The results showed that cDFPW1 effectively ... ...

Abstract	The ameliorative effect of Dendrobium fimbriatum polysaccharide (cDFPW1) on ulcerative colitis (UC) was investigated using a dextran-sodium-sulfate-induced (DSS-induced) mouse model in the present study. The results showed that cDFPW1 effectively improved colitis in mice by ameliorating weight loss, disease activity index (DAI) and colonic pathological damage, and by protecting the intestinal barrier function integrity. Moreover, cDFPW1 modulated the composition and metabolism of intestinal microbiota through enhancing Romboutsia, Lactobacillus and Odoribacter, and reducing Parasutterella, Burkholderia-Caballeronia-Paraburkholderia and Acinetobacter in colitis mice. Notably, cDFPW1 significantly restored the homeostasis of Th17/regulatory T (Treg) cells and the expression of specific cytokines. Western blotting of colon tissues showed that cDFPW1 markedly up-regulated the expression of Nrf2 and inhibited the phosphorylation of NF-κB signaling. These results indicated that cDFPW1 possesses the potential of improving UC and its effect on palliating colitis may be connected with the regulation of Nrf2/NF-κB signaling.
Keywords	Acinetobacter ; Dendrobium ; Lactobacillus ; colon ; cytokines ; homeostasis ; intestinal microorganisms ; metabolism ; mice ; oxidative stress ; phosphorylation ; polysaccharides ; ulcerative colitis ; weight loss
Language	English
Dates of publication	2022-0104
Size	p. 143-160.
Publishing place	The Royal Society of Chemistry
Document type	Article
ZDB-ID	2612033-1
ISSN	2042-650X ; 2042-6496
ISSN (online)	2042-650X
ISSN	2042-6496
DOI	10.1039/d1fo03003e
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Article: Intervention and potential mechanism of non-starch polysaccharides from natural resources on ulcerative colitis: A review

Wang, Yu-Jing / Li, Qiang-Ming / Zha, Xue-Qiang / Luo, Jian-Ping

International journal of biological macromolecules. 2022 June 15, v. 210

2022

Abstract	Ulcerative colitis (UC) is a chronic inflammatory bowel disease of unknown etiology that affects the colon and rectum. It has evolved into a global burden due to the high incidence in developed countries and the highly-increased incidence in developing countries. Non-starch polysaccharides (NSPs) from natural resources, as a type of functional carbohydrates, have a significant therapeutic effect on UC because of their good anti-inflammatory and immunomodulatory activities. Based on the etiology and pathogenesis of UC, this review summarizes the intervention effects and mechanisms of NSPs in the prevention and treatment of UC. The results showed that NSPs can improve UC by protecting the intestinal mucosal barrier, regulating the immune response of the intestinal mucosa, and remodeling the intestinal flora and metabolites. These contents provide theoretical basis for the application of polysaccharides in the prevention and treatment of UC.
Keywords	colon ; etiology ; immune response ; intestinal microorganisms ; intestinal mucosa ; metabolites ; pathogenesis ; polysaccharides ; rectum ; therapeutics ; ulcerative colitis
Language	English
Dates of publication	2022-0615
Size	p. 545-564.
Publishing place	Elsevier B.V.
Document type	Article
ZDB-ID	282732-3
ISSN	1879-0003 ; 0141-8130
ISSN (online)	1879-0003
ISSN	0141-8130
DOI	10.1016/j.ijbiomac.2022.04.208
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Article ; Online: Inhibition of Ca

Li, Xue-Ying / Kuang, Dan-Dan / Guo, An-Jun / Deng, Yuan-Yuan / Pan, Li-Hua / Li, Qiang-Ming / Luo, Jian-Ping / Zha, Xue-Qiang

Food & function

2023 Volume 14, Issue 9, Page(s) 4036–4048

Abstract: ... The ... ...

Abstract	The Ca
MeSH term(s)	Animals ; Mice ; Foam Cells ; Laminaria/metabolism ; Calpain/metabolism ; Calpain/pharmacology ; Macrophages ; Atherosclerosis/drug therapy ; Atherosclerosis/metabolism ; Lipoproteins, LDL/metabolism ; Signal Transduction ; Polysaccharides/pharmacology ; Polysaccharides/metabolism ; Autophagy
Chemical Substances	Calpain (EC 3.4.22.-) ; Lipoproteins, LDL ; Polysaccharides
Language	English
Publishing date	2023-05-11
Publishing country	England
Document type	Journal Article
ZDB-ID	2612033-1
ISSN	2042-650X ; 2042-6496
ISSN (online)	2042-650X
ISSN	2042-6496
DOI	10.1039/d2fo04099a
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