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  1. Article ; Online: Donafenib treatment for hepatocellular carcinoma: A case report.

    Li, Qiaoqi / Zhu, Hong

    Medicine

    2021  Volume 100, Issue 25, Page(s) e26373

    Abstract: Rationale: Hepatocellular carcinoma (HCC) is the most common liver cancer. The efficacy of the present treatment is disappointing, and the prognosis is poor. Donafenib, a novel multikinase inhibitor, is a new deuterated derivative of sorafenib. It can ... ...

    Abstract Rationale: Hepatocellular carcinoma (HCC) is the most common liver cancer. The efficacy of the present treatment is disappointing, and the prognosis is poor. Donafenib, a novel multikinase inhibitor, is a new deuterated derivative of sorafenib. It can improve overall survival in patients with advanced HCC, with a favorable safety and tolerability profile over sorafenib.
    Patient concerns: Here, we report the case of a 51-year-old male patient who presented with experienced epigastric discomfort for the prior several days. He had a history of untreated chronic hepatitis B virus infection for >29 years and no other underlying diseases. Based on further investigations, he was diagnosed with advanced HCC and refused surgery.
    Diagnosis: Based on the patient's performance status, tumor status assessed by computed tomography, liver function, and percutaneous liver biopsy, he was diagnosed with advanced HCC Barcelona Clinic Liver Cancer Stage C.
    Interventions: The patient was administered a 200-mg oral dose of donafenib twice-daily.
    Outcomes: The patient was followed-up from the time of diagnosis. He received donafenib for 31 months, and the progression-free survival time was 31 months (from May 2017 to December 2019); the overall survival time was not reached. The patient reported little abdominal distension with no other obvious discomfort while taking the medication.
    Lesson: Donafenib showed good efficacy for the treatment of advanced HCC, with mild side effects. Deuterium-containing drugs seem to be a promising avenue for medical innovation.
    MeSH term(s) Biopsy ; Carcinoma, Hepatocellular/diagnosis ; Carcinoma, Hepatocellular/pathology ; Carcinoma, Hepatocellular/therapy ; Carcinoma, Hepatocellular/virology ; Disease Progression ; Drug Therapy, Combination/methods ; Guanine/analogs & derivatives ; Guanine/therapeutic use ; Hepatectomy ; Hepatitis B, Chronic/pathology ; Hepatitis B, Chronic/therapy ; Hepatitis B, Chronic/virology ; Humans ; Liver/diagnostic imaging ; Liver/pathology ; Liver/surgery ; Liver Neoplasms/diagnosis ; Liver Neoplasms/pathology ; Liver Neoplasms/therapy ; Liver Neoplasms/virology ; Male ; Middle Aged ; Neoadjuvant Therapy/methods ; Pyridines/therapeutic use ; Tomography, X-Ray Computed ; Treatment Outcome
    Chemical Substances Pyridines ; donafenib (41XGO0VS1U) ; entecavir (5968Y6H45M) ; Guanine (5Z93L87A1R)
    Language English
    Publishing date 2021-06-23
    Publishing country United States
    Document type Case Reports ; Journal Article
    ZDB-ID 80184-7
    ISSN 1536-5964 ; 0025-7974
    ISSN (online) 1536-5964
    ISSN 0025-7974
    DOI 10.1097/MD.0000000000026373
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Ua VI Zs.171: Show issues Location:
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  2. Article ; Online: T cells in pancreatic cancer stroma: Tryptophan metabolism plays an important role in immunoregulation.

    Yang, Ting / Li, Qiao-Qi / Liu, Yong-Mei / Yang, Biao

    World journal of gastroenterology

    2023  Volume 29, Issue 17, Page(s) 2701–2703

    Abstract: Several studies have shown that the immune system is highly regulated by tryptophan metabolism, which serves as an immunomodulatory factor. The indoleamine 2,3-dioxygenase 1 (IDO1), as an intracellular enzyme that participates in metabolism of the ... ...

    Abstract Several studies have shown that the immune system is highly regulated by tryptophan metabolism, which serves as an immunomodulatory factor. The indoleamine 2,3-dioxygenase 1 (IDO1), as an intracellular enzyme that participates in metabolism of the essential amino acid tryptophan in the kynurenine pathway, is an independent prognostic marker for pancreatic cancer (PC). First, overexpression of IDO1 inhibits the maturation of dendritic cells and T-cell proliferation in the liver and spleen. Second, the high expression of kynurenine induces and activates the aryl hydrocarbon receptor, resulting in upregulated programmed cell death protein 1 expression. Third, the induction of IDO1 can lead to loss of the T helper 17 cell/regulatory T cell balance, mediated by the proximal tryptophan catabolite from IDO metabolism. In our study, we found that overexpression of IDO1 upregulated CD8+ T cells and reduced natural killer T cells in pancreatic carcinoma in mice. Hence, it may be essential to pay more attention to tryptophan metabolism in patients, especially those who are tolerant to immunotherapy for PC.
    MeSH term(s) Animals ; Mice ; Tryptophan/metabolism ; Kynurenine ; Pancreatic Neoplasms ; Th17 Cells/metabolism ; Indoleamine-Pyrrole 2,3,-Dioxygenase/metabolism ; Pancreatic Neoplasms
    Chemical Substances Tryptophan (8DUH1N11BX) ; Kynurenine (343-65-7) ; Indoleamine-Pyrrole 2,3,-Dioxygenase
    Language English
    Publishing date 2023-05-12
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2185929-2
    ISSN 2219-2840 ; 1007-9327
    ISSN (online) 2219-2840
    ISSN 1007-9327
    DOI 10.3748/wjg.v29.i17.2701
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 6039: Show issues Location:
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  3. Article ; Online: The complete chloroplast genome of

    Luo, Lin / Lin, Hui / Luo, Hai-Lin / Li, Qiao-Qi / Lin, Dong-Mei / Lu, Guo-Dong

    Mitochondrial DNA. Part B, Resources

    2021  Volume 6, Issue 11, Page(s) 3207–3208

    Abstract: Tripsacum ... ...

    Abstract Tripsacum laxum
    Language English
    Publishing date 2021-10-15
    Publishing country England
    Document type Journal Article
    ISSN 2380-2359
    ISSN (online) 2380-2359
    DOI 10.1080/23802359.2021.1899872
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: A dual deep neural network for auto-delineation in cervical cancer radiotherapy with clinical validation.

    Nie, Shihong / Wei, Yuanfeng / Zhao, Fen / Dong, Ya / Chen, Yan / Li, Qiaoqi / Du, Wei / Li, Xin / Yang, Xi / Li, Zhiping

    Radiation oncology (London, England)

    2022  Volume 17, Issue 1, Page(s) 182

    Abstract: Background: Artificial intelligence (AI) algorithms are capable of automatically detecting contouring boundaries in medical images. However, the algorithms impact on clinical practice of cervical cancer are unclear. We aimed to develop an AI-assisted ... ...

    Abstract Background: Artificial intelligence (AI) algorithms are capable of automatically detecting contouring boundaries in medical images. However, the algorithms impact on clinical practice of cervical cancer are unclear. We aimed to develop an AI-assisted system for automatic contouring of the clinical target volume (CTV) and organs-at-risk (OARs) in cervical cancer radiotherapy and conduct clinical-based observations.
    Methods: We first retrospectively collected data of 203 patients with cervical cancer from West China Hospital. The proposed method named as SegNet was developed and trained with different data groups. Quantitative metrics and clinical-based grading were used to evaluate differences between several groups of automatic contours. Then, 20 additional cases were conducted to compare the workload and quality of AI-assisted contours with manual delineation from scratch.
    Results: For automatic CTVs, the dice similarity coefficient (DSC) values of the SegNet trained with incorporating multi-group data achieved 0.85 ± 0.02, which was statistically better than the DSC values of SegNet independently trained with the SegNet
    Conclusion: The proposed SegNet can improve the performance at automatic delineation for cervical cancer radiotherapy by incorporating multi-group data. It is clinically applicable that the AI-assisted system can shorten manual delineation time at no expense of quality.
    MeSH term(s) Female ; Humans ; Radiotherapy Planning, Computer-Assisted/methods ; Uterine Cervical Neoplasms/radiotherapy ; Retrospective Studies ; Artificial Intelligence ; Neural Networks, Computer ; Organs at Risk
    Language English
    Publishing date 2022-11-15
    Publishing country England
    Document type Journal Article
    ZDB-ID 2224965-5
    ISSN 1748-717X ; 1748-717X
    ISSN (online) 1748-717X
    ISSN 1748-717X
    DOI 10.1186/s13014-022-02157-5
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: d

    Wang, Rong / Li, Qiaoqi / Li, Weihua / Jiang, Pengfei / Cong, Rihong / Yang, Tao

    Chemical communications (Cambridge, England)

    2020  Volume 57, Issue 4, Page(s) 536–539

    Abstract: ... Rutile ... ...

    Abstract Rutile GeO
    Language English
    Publishing date 2020-12-18
    Publishing country England
    Document type Journal Article
    ZDB-ID 1472881-3
    ISSN 1364-548X ; 1359-7345 ; 0009-241X
    ISSN (online) 1364-548X
    ISSN 1359-7345 ; 0009-241X
    DOI 10.1039/d0cc06883g
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article: Gastric cancer patients have elevated plasmacytoid and CD1c

    Liu, Weihuang / Zhao, Jie / Li, Qiaoqi / Wang, Qiaona / Zhou, Ying / Tong, Zan

    Oncology letters

    2018  Volume 15, Issue 4, Page(s) 5087–5092

    Abstract: Dendritic cells (DCs) are important in tumor immunology. Identifying DC subset markers in the peripheral blood, which are informative for gastric cancer stages, is not only useful for prognosis but may also provide mechanistic insights into processes ... ...

    Abstract Dendritic cells (DCs) are important in tumor immunology. Identifying DC subset markers in the peripheral blood, which are informative for gastric cancer stages, is not only useful for prognosis but may also provide mechanistic insights into processes facilitating therapy. The present study investigated plasmacytoid dendritic cells (pDCs) and myeloid CD1c
    Language English
    Publishing date 2018-02-07
    Publishing country Greece
    Document type Journal Article
    ZDB-ID 2573196-8
    ISSN 1792-1082 ; 1792-1074
    ISSN (online) 1792-1082
    ISSN 1792-1074
    DOI 10.3892/ol.2018.7990
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: A versatile polar-embedded polyphenyl phase for multimodal separation in liquid chromatography.

    Zhang, Yujie / Li, Qiaoqi / Dai, Benlin / Zhou, Shouyong / Zhang, Mingliang / Han, Haifeng / Qiu, Hongdeng

    Journal of chromatography. A

    2018  Volume 1553, Page(s) 81–89

    Abstract: A new polar-embedded aromatic stationary phase has been prepared by covalently attaching p-biphenylacetamide silane to silica spheres. The retention behavior of this phase was compared with an alkylamide counterpart and octadecyl phases using different ... ...

    Abstract A new polar-embedded aromatic stationary phase has been prepared by covalently attaching p-biphenylacetamide silane to silica spheres. The retention behavior of this phase was compared with an alkylamide counterpart and octadecyl phases using different classes of analytes, including geometric isomers and congeners from Standard Reference Materials 869b, 870 and 1647e, positional isomers of electron-deficient benzenes, as well as alkylbenzenes and alkylbiphenyls. The relationship between shape selectivity and surface chemistry of stationary phase was comparatively studied. Influences of the embedded group and ligand length and/or size on the chromatographic selectivity towards various congeners were established. The new polar-embedded aromatic phase possessed unique benzenoid affinity, enhanced aromatic selectivity, distinct charge-transfer properties, as well as good water-wettablity, as a result it can be employed in normal phase, reversed-phase and per-aqueous modes.
    MeSH term(s) Benzene Derivatives/chemistry ; Biphenyl Compounds/chemistry ; Chromatography, Liquid/methods ; Isomerism ; Silicon Dioxide/chemistry
    Chemical Substances Benzene Derivatives ; Biphenyl Compounds ; Silicon Dioxide (7631-86-9)
    Language English
    Publishing date 2018-06-08
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 1171488-8
    ISSN 1873-3778 ; 0021-9673
    ISSN (online) 1873-3778
    ISSN 0021-9673
    DOI 10.1016/j.chroma.2018.04.025
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 813: Show issues Location:
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  8. Article ; Online: Tuning selectivity via electronic interaction: Preparation and systematic evaluation of serial polar-embedded aryl stationary phases bearing large polycyclic aromatic hydrocarbons.

    Zhang, Yujie / Li, Qiaoqi / Zhong, Hui / Zhou, Shouyong / Zhao, Yijiang / Zhang, Mingliang / Han, Haifeng / Qiu, Hongdeng

    Analytica chimica acta

    2018  Volume 1036, Page(s) 162–171

    Abstract: Aromatic stationary phases showing complementary selectivity to their alkyl counterparts are extremely useful for certain challenging separation tasks. Herein, a series of polar-embedded aryl stationary phases were synthesized from reactive derivatives ... ...

    Abstract Aromatic stationary phases showing complementary selectivity to their alkyl counterparts are extremely useful for certain challenging separation tasks. Herein, a series of polar-embedded aryl stationary phases were synthesized from reactive derivatives of large polycyclic aromatic hydrocarbons (PAHs), including anthracene (three-ring, catacondensed), pyrene (four-ring, pericondensed) and triphenylene (four-ring, fully-benzenoid). These PAHs were functionalized with hydroxymethyl group (PAH-CH
    Language English
    Publishing date 2018-09-04
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 1483436-4
    ISSN 1873-4324 ; 0003-2670
    ISSN (online) 1873-4324
    ISSN 0003-2670
    DOI 10.1016/j.aca.2018.09.002
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  9. Article ; Online: Systematic study of Cr3+ substitution into octahedra-based microporous aluminoborates.

    Li, Qiaoqi / Lin, Cong / Zhou, Zhengyang / Ju, Jing / Li, Guobao / Lin, Jianhua / Gao, Wenliang / Cong, Rihong / Yang, Tao

    Inorganic chemistry

    2014  Volume 53, Issue 11, Page(s) 5600–5608

    Abstract: Single crystals of pure aluminoborate PKU-1 (Al3B6O11(OH)5·nH2O) were obtained, and the structure was redetermined by X-ray diffraction. There are three independent Al atoms in the R3 structure model, and Al3 locates in a quite distorted octahedral ... ...

    Abstract Single crystals of pure aluminoborate PKU-1 (Al3B6O11(OH)5·nH2O) were obtained, and the structure was redetermined by X-ray diffraction. There are three independent Al atoms in the R3 structure model, and Al3 locates in a quite distorted octahedral environment, which was evidenced by (27)Al NMR results. This distortion of Al3O6 octahedra release the strong static stress of the main framework and leads to a symmetry lowering from the previously reported R3 to the presently reported R3. We applied a pretreatment to prepare Al(3+)/Cr(3+) aqueous solutions; as a consecquence, a very high Cr(3+)-to-Al(3+) substitution content (∼50 atom %) in PKU-1 can be achieved, which is far more than enough for catalytic purposes. Additionally, the preference for Cr(3+) substitution at the Al1 and Al2 sites was observed in the Rietveld refinements of the powder X-ray data of PKU-1:0.32Cr(3+). We also systematically investigated the thermal behaviors of PKU-1:xCr(3+) (0 ≤ x ≤ 0.50) by thermogravimetric-differential scanning calorimetry, in situ high-temperature XRD in vacuum, and postannealing experiments in furnace. The main framework of Cr(3+)-substituted PKU-1 could be partially retained at 1100 °C in vacuum. When 0.04 ≤ x ≤ 0.20, PKU-1:xCr(3+) transferred to the PKU-5:xCr(3+) (Al4B6O15:xCr(3+)) structure at ∼750 °C by a 5 h annealing in air. Further elevating the temperature led to a decomposition into the mullite phase, Al4B2O9:xCr(3+). For x > 0.20 in PKU-1:xCr(3+), the heat treatment led to a composite of Cr(3+)-substituted PKU-5 and Cr2O3, so the doping upper limit of Cr(3+) in PKU-5 structure is around 20 atom %.
    Language English
    Publishing date 2014-06-02
    Publishing country United States
    Document type Journal Article
    ZDB-ID 1484438-2
    ISSN 1520-510X ; 0020-1669
    ISSN (online) 1520-510X
    ISSN 0020-1669
    DOI 10.1021/ic500352g
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