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  1. AU="Li, Qijun"
  2. AU="Schofield, Paul"
  3. AU="Maenhout, Thomas"
  4. AU="Hall, John C"
  5. AU="Ho, Chun-Ming"
  6. AU="Dymond, Ian W"
  7. AU="Álvarez, María Noel"
  8. AU="J. Muñoz i Vidal"
  9. AU="Zeng, Guangming"
  10. AU="Luigi Mazzeo, Pier"
  11. AU="Danilova, Olga V"
  12. AU="Jian, Shang"
  13. AU="Jae-Gyu Jeon"
  14. AU="Andrade, Letícia G."
  15. AU="Hosseinzadeh, Sara Ali"
  16. AU="Lee, Kristen"
  17. AU="Gentile, Giulia"
  18. AU="Shoben, Abigail B."
  19. AU="Rowe, Elizabeth"
  20. AU="Pandemic Response COVID-19 Research Collaboration Platform for HCQ/CQ Pooled Analyses"
  21. AU="Rahali, Anwar"
  22. AU="Zhang, Zhuang-Wei"
  23. AU="Townsend, Elizabeth C"
  24. AU="Lange, Mona V"
  25. AU="Bruner, Brenda G"
  26. AU="Michael Craigen"
  27. AU="Lambard, G."
  28. AU="Dempsey, Connor P"
  29. AU=Li Youxian
  30. AU="Bhosale, Chanakya R"

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  1. Artikel ; Online: Identifying Mixed Dementia With Lewy Bodies and Alzheimer Disease Using Multitracer PET Imaging: A Case Study.

    Li, Qijun / Wang, Junshan / Cui, Ruixue / Yuan, Jing

    Clinical nuclear medicine

    2024  Band 49, Heft 4, Seite(n) 364–365

    Abstract: Abstract: We reported imaging findings with complex signs that were corresponded with both dementia with Lewy bodies (DLB) and Alzheimer disease (AD) in the case of a 78-year-old woman. Initially suspected as DLB due to cognitive and movement issues, ... ...

    Abstract Abstract: We reported imaging findings with complex signs that were corresponded with both dementia with Lewy bodies (DLB) and Alzheimer disease (AD) in the case of a 78-year-old woman. Initially suspected as DLB due to cognitive and movement issues, diagnostic support included the cingulate island sign on 18 F-FDG PET, positive 131 I-MIBG cardiac scintigraphy, and DAT PET. However, MRI indicated hippocampal atrophy, and 18 F-FDG PET showed hypometabolism in the medial temporal lobe, suggesting the possibility of concomitant AD. Subsequent detection of β-amyloid pathology and tau accumulation in the brain further supported the concurrent presence of AD pathology.
    Mesh-Begriff(e) Female ; Humans ; Aged ; Mixed Dementias ; Alzheimer Disease/diagnostic imaging ; Fluorodeoxyglucose F18 ; Lewy Body Disease/diagnostic imaging ; Amyloid beta-Peptides
    Chemische Substanzen Fluorodeoxyglucose F18 (0Z5B2CJX4D) ; Amyloid beta-Peptides
    Sprache Englisch
    Erscheinungsdatum 2024-02-05
    Erscheinungsland United States
    Dokumenttyp Case Reports ; Journal Article
    ZDB-ID 197628-x
    ISSN 1536-0229 ; 0363-9762
    ISSN (online) 1536-0229
    ISSN 0363-9762
    DOI 10.1097/RLU.0000000000005081
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  2. Artikel ; Online: A Potential Role of CD82/KAI1 during Uterine Decidualization in Mice.

    Li, Qijun / Song, Mengyao / Cao, Ke / Zhang, Qian

    Current issues in molecular biology

    2024  Band 46, Heft 3, Seite(n) 1799–1809

    Abstract: The tumor metastasis suppressor gene CD82/KAI1 has been demonstrated to impact human trophoblast invasion and migration. Communication between trophoblasts and decidual stromal cells plays a crucial role in controlling the normal invasiveness of ... ...

    Abstract The tumor metastasis suppressor gene CD82/KAI1 has been demonstrated to impact human trophoblast invasion and migration. Communication between trophoblasts and decidual stromal cells plays a crucial role in controlling the normal invasiveness of trophoblasts. However, whether CD82/KAI1 is involved in decidualization and what role it plays remain unclear. CD82/KAI1 demonstrates specific spatiotemporal expression patterns in stromal cells undergoing decidualization during pregnancy. This is observed in both naturally pregnant females post-implantation and pseudopregnant mice undergoing induced decidualization, as detected through in situ hybridization and immunofluorescence. CD82/KAI1 expression showed a significant time-dependent increase in cultured stromal cells after 24 and 48 h of progesterone (P
    Sprache Englisch
    Erscheinungsdatum 2024-02-27
    Erscheinungsland Switzerland
    Dokumenttyp Journal Article
    ZDB-ID 2000024-8
    ISSN 1467-3045 ; 1467-3037
    ISSN (online) 1467-3045
    ISSN 1467-3037
    DOI 10.3390/cimb46030118
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  3. Artikel ; Online: Transformation of Regional Spatial Coordinative Development of the Guangdong- Hong Kong-Macao Greater Bay Area in the Lens of Media Interaction Process

    Cheng Cheng-i / Zeng Bincheng / Li Qijun

    Redai dili, Vol 42, Iss 3, Pp 409-

    2022  Band 421

    Abstract: The Guangdong-Hong Kong-Macao Greater Bay Area (GBA) is built across three different governance contexts; these three cities have different socio-political structures, legal systems, and cultural identities. From the perspective of media geography, this ... ...

    Abstract The Guangdong-Hong Kong-Macao Greater Bay Area (GBA) is built across three different governance contexts; these three cities have different socio-political structures, legal systems, and cultural identities. From the perspective of media geography, this article proposes a framework with four dimensions and three categories, to explore how cross-border media communication affects the formation and accumulation of social capital, and thus influences regional coordination under the political structure of "one country, two systems" in the region. To fully understand the different characteristics of each development stage, the research further divides the synergic development process into five phases: economic bonding, policy-economic bonding, policy-economic bridging, policy-social linking, and policy-economic-social bridging. The study found that even though media interactions between Guangdong, Hong Kong, and Macao have intensified in frequency, social capital at the "socio-cultural" level is relatively weak. Owing to the lack of a widely accepted regional media platform that fits into the communication habits of people in all GBA cities, it is difficult to build an effective monitoring mechanism and feedback system that enables a detection and response to people's opinions on the ground. Consequently, disagreements and conflicts have led to high social costs for some cross-border infrastructure projects. By exploring the mechanisms of media interaction and social capital formation within the regional coordination process, this paper concludes with three strategies to achieve effective multilevel connection and coordination between GBA cities, especially in social and cultural aspects. 1) Governments in each city should work together to build up a regional platform and broaden media channels for the circulation of shared information, which fits various local situations and media usage habits. 2) There is a need for the GBA to establish an effective public opinion monitoring and feedback system on a regional scale, ...
    Schlagwörter guangdong-hong kong-macao greater bay area ; media ; regional coordination ; social capital ; Geography (General) ; G1-922
    Thema/Rubrik (Code) 910
    Sprache Chinesisch
    Erscheinungsdatum 2022-03-01T00:00:00Z
    Verlag Editorial Committee of Tropical Geography
    Dokumenttyp Artikel ; Online
    Datenquelle BASE - Bielefeld Academic Search Engine (Lebenswissenschaftliche Auswahl)

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  4. Artikel: A novel

    Li, Hang / Li, Qijun / Weng, Qin / Cui, Ruixue / Yen, Tzu-Chen / Li, Yanfeng

    Frontiers in neurology

    2024  Band 15, Seite(n) 1372507

    Abstract: Background: MAPT: Objective: To report a novel : Methods: A comprehensive clinical, genetic, and molecular neuroimaging investigation was conducted on a 61 years-old female proband diagnosed with PSP. We also collected the clinical presentation ... ...

    Abstract Background: MAPT
    Objective: To report a novel
    Methods: A comprehensive clinical, genetic, and molecular neuroimaging investigation was conducted on a 61 years-old female proband diagnosed with PSP. We also collected the clinical presentation data and history of the patient's pedigree, and performed further genetic analysis of 4 relatives, from two generations, with and without symptoms.
    Results: The proband exhibited typical clinical manifestation of PSP. A cranial MRI revealed midbrain atrophy, and an FDG-PET scan suggested hypo-metabolic changes in caudate nucleus, left prefrontal lobe, both temporal poles, and midbrain.
    Conclusion: The PSP pedigree caused by the novel
    Sprache Englisch
    Erscheinungsdatum 2024-04-19
    Erscheinungsland Switzerland
    Dokumenttyp Journal Article
    ZDB-ID 2564214-5
    ISSN 1664-2295
    ISSN 1664-2295
    DOI 10.3389/fneur.2024.1372507
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  5. Artikel: Determination of intracellular lipid and main fatty acids of Nannochloropsis oceanica by ATR-FTIR spectroscopy

    Zhang, Dongmei / Li, Qijun / Yan, Chenghu / Cong, Wei

    Journal of applied phycology. 2022 Feb., v. 34, no. 1

    2022  

    Abstract: Fatty acid profile was one of the important characteristic parameters of edible oil. With the intensification of interest in microalgae as a potential source of edible oil, rapid methods are needed to determine the fatty acid composition of microalgae. ... ...

    Abstract Fatty acid profile was one of the important characteristic parameters of edible oil. With the intensification of interest in microalgae as a potential source of edible oil, rapid methods are needed to determine the fatty acid composition of microalgae. Attenuated total reflection-Fourier transform infrared spectroscopy (ATR-FTIR) was applied to determine the lipid and fatty acid contents of Nannochloropsis oceanica, a species rich in eicosapentaenoic acid. Samples with different intracellular components were obtained by setting different culture conditions (light intensity and nitrogen concentration). In the spectra of FTIR, some characteristic bands for lipids (3025–2800 cm⁻¹, 1770–1710 cm⁻¹, 1480–1350 cm⁻¹) were identified. Partial least square regression (PLSR) models were developed to predict total biomass, lipid contents, and main fatty acid contents (palmitic acid C16:0, palmitoleic acid C16:1, eicosatetraenoic acid C20:4, eicosapentaenoic acid C20:5). Generally, the prediction ability of the model established with full spectra was slightly better than that of the model established with specific bands. In the optimized model, excellent coefficients of determination (R² ≥ 0.90), both for calibration and prediction, were found for all variables, except for fatty acid C20:4, which was slightly worse (R² = 0.8797). The pretreatment methods of samples were further studied. It was found that the acid-heating method (0.1 M HCl, 100 °C, 0.5 h) effectively reduced the interference of the carbohydrate in samples, thus improving the measurement of the characteristic fatty acids C20:4 and C20:5 of N. oceanica. This study showed the feasibility of FTIR as a rapid screening method for evaluating biomass and lipid content, especially some special fatty acid profile of microalgae.
    Schlagwörter Nannochloropsis ; algology ; biomass ; carbohydrates ; cooking fats and oils ; eicosapentaenoic acid ; fatty acid composition ; least squares ; light intensity ; lipid content ; microalgae ; models ; nitrogen content ; palmitic acid ; palmitoleic acid ; prediction
    Sprache Englisch
    Erscheinungsverlauf 2022-02
    Umfang p. 343-352.
    Erscheinungsort Springer Netherlands
    Dokumenttyp Artikel
    ZDB-ID 1002324-0
    ISSN 1573-5176 ; 0921-8971
    ISSN (online) 1573-5176
    ISSN 0921-8971
    DOI 10.1007/s10811-021-02607-9
    Datenquelle NAL Katalog (AGRICOLA)

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  6. Artikel: Deacidification of Microalgal Oil with Alkaline Microcrystalline Cellulose

    Li, Qijun / Zhou, Zhenzhen / Zhang, Dongmei / Cong, Wei

    Applied biochemistry and biotechnology. 2021 Apr., v. 193, no. 4

    2021  

    Abstract: Microalgal oil is considered a promising candidate for edible oils. However, investigation of the refining processes of microalgal oil has been limited, especially deacidification. In this work, microcrystalline cellulose (MCC) was pretreated using ... ...

    Abstract Microalgal oil is considered a promising candidate for edible oils. However, investigation of the refining processes of microalgal oil has been limited, especially deacidification. In this work, microcrystalline cellulose (MCC) was pretreated using different methods and utilized for the first time in the deacidification of microalgal oil. Detection results from FTIR and XRD indicated alkali pretreatment had a significant effect on the structure of MCC. Some inter- and intramolecular hydrogen bonds in AMCC (alkali-pretreated MCC) were destroyed, and crystallinity index of cellulose decreased, which increased its adsorption capacity and the reaction of OH groups with free fatty acids. Some NaOH was adsorbed into AMCC through cellulose swelling, which also contributed to deacidification. The interaction with oil was also improved with many cracks and voids on the surface of AMCC. AMCC could reduce the acid value to about 2 mg KOH/g. Comparatively, original MCC and MCC pretreated with microwave or ultrasound did not exhibit the ability to deacidify. Furthermore, the conditions of alkali treatment were optimized. Treatment with 20% NaOH for 20 min was optimal. Compared with other adsorbents, such as sodium silicate and chitosan treated with alkali and resin, only AMCC could effectively reduce acid value while maintaining high lipid recovery. Therefore, AMCC was considered a better adsorbent for the deacidification of microalgal oil.
    Schlagwörter acid value ; adsorbents ; adsorption ; alkali treatment ; biotechnology ; cellulose ; chitosan ; crystal structure ; deacidification ; hydrogen ; lipids ; microalgae ; sodium silicate ; ultrasonics
    Sprache Englisch
    Erscheinungsverlauf 2021-04
    Umfang p. 952-964.
    Erscheinungsort Springer US
    Dokumenttyp Artikel
    Anmerkung NAL-AP-2-clean
    ZDB-ID 392344-7
    ISSN 0273-2289
    ISSN 0273-2289
    DOI 10.1007/s12010-020-03457-w
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  7. Artikel ; Online: Erlotinib as a salvage treatment after gefitinib failure for advanced non-small-cell lung cancer patients with brain metastasis: A successful case report and review.

    Dong, Yong / Li, Qijun / Miao, Qian / Li, Da

    Medicine

    2021  Band 100, Heft 25, Seite(n) e26450

    Abstract: Rationale: The guidelines recommended gefitinib as a first-line targeted treatment for stage IV non-small-cell lung cancer (NSCLC) patients with EGFR mutations. However, resistance to gefitinib ensues invariably and there is little evidence as for the ... ...

    Abstract Rationale: The guidelines recommended gefitinib as a first-line targeted treatment for stage IV non-small-cell lung cancer (NSCLC) patients with EGFR mutations. However, resistance to gefitinib ensues invariably and there is little evidence as for the effectiveness of subsequent salvage treatment for patients without T790m mutation. The case is to evaluate the efficacy of erlotinib, another EGFR-TKI, after failed first-line use of gefitinib.
    Patient concerns: We described a 55-year-old man with good performance status (PS).
    Diagnoses: He was histopathologically diagnosed stage IV lung adenocarcinoma with EGFR mutations in November 2018.
    Interventions: He was administrated with gefitinib daily (250 mg) for activating epidermal growth factor receptor (EGFR) mutations (exon 19 deletions,19del), and combined with platinum-based dual-drug chemotherapy. During the target treatments, the optimal efficacy evaluation was partial remission (PR) with a 12-month progression-free survival (PFS) time. Later, the intracranial progression of the patient rendered the treatment change to erlotinib.
    Outcomes: It is surprising that the tumor lesion in brain as well as lung relieved obviously. His progression-free survival (PFS)was nearly 11 months, and the overall survival (OS)was>36 months up to now. The adverse events were tolerable.
    Lessions: This case manifests that re-biopsy of advanced or recurrent NSCLC is beneficial to make a better therapeutic regimen, and erlotinib can be used as a salvage treatment after gefitinib failure.
    Mesh-Begriff(e) Biopsy ; Brain/diagnostic imaging ; Brain/pathology ; Brain Neoplasms/genetics ; Brain Neoplasms/mortality ; Brain Neoplasms/secondary ; Brain Neoplasms/therapy ; Carcinoma, Non-Small-Cell Lung/genetics ; Carcinoma, Non-Small-Cell Lung/mortality ; Carcinoma, Non-Small-Cell Lung/secondary ; Carcinoma, Non-Small-Cell Lung/therapy ; Chemoradiotherapy/methods ; Drug Resistance, Neoplasm ; Drug Substitution ; ErbB Receptors/antagonists & inhibitors ; ErbB Receptors/genetics ; Erlotinib Hydrochloride/pharmacology ; Erlotinib Hydrochloride/therapeutic use ; Gefitinib/pharmacology ; Gefitinib/therapeutic use ; Humans ; Lung Neoplasms/genetics ; Lung Neoplasms/mortality ; Lung Neoplasms/pathology ; Lung Neoplasms/therapy ; Magnetic Resonance Imaging ; Male ; Middle Aged ; Mutation ; Neoplasm Recurrence, Local/diagnosis ; Neoplasm Recurrence, Local/pathology ; Neoplasm Recurrence, Local/therapy ; Progression-Free Survival ; Radiotherapy, Intensity-Modulated ; Response Evaluation Criteria in Solid Tumors ; Salvage Therapy/methods
    Chemische Substanzen Erlotinib Hydrochloride (DA87705X9K) ; EGFR protein, human (EC 2.7.10.1) ; ErbB Receptors (EC 2.7.10.1) ; Gefitinib (S65743JHBS)
    Sprache Englisch
    Erscheinungsdatum 2021-06-23
    Erscheinungsland United States
    Dokumenttyp Case Reports ; Journal Article ; Review
    ZDB-ID 80184-7
    ISSN 1536-5964 ; 0025-7974
    ISSN (online) 1536-5964
    ISSN 0025-7974
    DOI 10.1097/MD.0000000000026450
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  8. Artikel ; Online: Whole-Process Treatment of Combined Small Cell Lung Cancer Initially Diagnosed as "Lung Squamous Cell Carcinoma": A Case Report and Review of the Literature.

    Dong, Yong / Li, Qijun / Li, Da / Fang, Yong / Wang, Chongwei

    Frontiers in immunology

    2022  Band 13, Seite(n) 831698

    Abstract: The rarity and complexity of histology lead to the low diagnosis rate and high misdiagnosis rate of combined small cell lung cancer (C-SCLC). Nowadays, C-SCLC has no commonly recommended therapeutic regimen, mainly conforming to SCLC treatment. Here, we ... ...

    Abstract The rarity and complexity of histology lead to the low diagnosis rate and high misdiagnosis rate of combined small cell lung cancer (C-SCLC). Nowadays, C-SCLC has no commonly recommended therapeutic regimen, mainly conforming to SCLC treatment. Here, we report a patient initially diagnosed as IIIA "lung squamous cell carcinoma" by a small specimen. Radical resection was achieved after neoadjuvant immunochemotherapy, and the final surgical pathology was C-SCLC containing three different histological components. Moreover, in the literature review, we explored the therapeutic effect of neoadjuvant immunotherapy in C-SCLC, expounded the therapeutic conflicts among heterogeneous components, and analyzed the pathology complexity at the tissue, cell, and molecule levels in-depth, including possible genetic characteristics, origin, and evolution by next-generation sequencing (NGS).
    Mesh-Begriff(e) Carcinoma, Non-Small-Cell Lung/drug therapy ; Carcinoma, Small Cell ; Carcinoma, Squamous Cell/diagnosis ; Carcinoma, Squamous Cell/therapy ; Humans ; Lung/pathology ; Lung Neoplasms/drug therapy ; Lung Neoplasms/therapy ; Small Cell Lung Carcinoma/drug therapy ; Small Cell Lung Carcinoma/therapy
    Sprache Englisch
    Erscheinungsdatum 2022-03-02
    Erscheinungsland Switzerland
    Dokumenttyp Case Reports ; Review
    ZDB-ID 2606827-8
    ISSN 1664-3224 ; 1664-3224
    ISSN (online) 1664-3224
    ISSN 1664-3224
    DOI 10.3389/fimmu.2022.831698
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  9. Artikel ; Online: A multilevel recovery diagnosis model for rolling bearing faults from imbalanced and partially missing monitoring data.

    Yang, Jing / Xie, Guo / Yang, Yanxi / Li, Qijun / Yang, Cheng

    Mathematical biosciences and engineering : MBE

    2022  Band 20, Heft 3, Seite(n) 5223–5242

    Abstract: As an indispensable part of large Computer Numerical Control machine tool, rolling bearing faults diagnosis is particularly important. However, due to the imbalanced distribution and partially missing of collected monitoring data, such diagnostic issue ... ...

    Abstract As an indispensable part of large Computer Numerical Control machine tool, rolling bearing faults diagnosis is particularly important. However, due to the imbalanced distribution and partially missing of collected monitoring data, such diagnostic issue generally emerging in manufacturing industry is still hardly to be solved. Thus, a multilevel recovery diagnosis model for rolling bearing faults from imbalanced and partially missing monitoring data is formulated in this paper. Firstly, a regulable resampling plan is designed to handle the imbalanced distribution of data. Secondly, a multilevel recovery scheme is formed to deal with partially missing. Thirdly, an improved sparse autoencoder based multilevel recovery diagnosis model is built to identify the health status of rolling bearings. Finally, the diagnostic performance of the designed model is verified by artificial faults and practical faults tests, respectively.
    Sprache Englisch
    Erscheinungsdatum 2022-12-27
    Erscheinungsland United States
    Dokumenttyp Journal Article
    ZDB-ID 2265126-3
    ISSN 1551-0018 ; 1551-0018
    ISSN (online) 1551-0018
    ISSN 1551-0018
    DOI 10.3934/mbe.2023242
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  10. Artikel ; Online: Exosomes and their roles in the chemoresistance of pancreatic cancer.

    Pan, Yubin / Tang, Honglin / Li, Qijun / Chen, Guangpeng / Li, Da

    Cancer medicine

    2022  Band 11, Heft 24, Seite(n) 4979–4988

    Abstract: Pancreatic cancer (PC) remains one of the most lethal human malignancies worldwide. Due to the insidious onset and the rapid progression, most patients with PC are diagnosed at an advanced stage rendering them inoperable. Despite the development of ... ...

    Abstract Pancreatic cancer (PC) remains one of the most lethal human malignancies worldwide. Due to the insidious onset and the rapid progression, most patients with PC are diagnosed at an advanced stage rendering them inoperable. Despite the development of multiple promising chemotherapeutic agents as recommended first-line treatment for PC, the therapeutic efficacy is largely limited by unwanted drug resistance. Recent studies have identified exosomes as essential mediators of intercellular communications during the occurrence of drug resistance. Understanding the underlying molecular mechanisms and complex signaling pathways of exosome-mediated drug resistance will contribute to the improvement of the design of new oncologic therapy regimens. This review focuses on the intrinsic connections between the chemoresistance of PC cells and exosomes in the tumor microenvironment (TME).
    Mesh-Begriff(e) Humans ; Exosomes/metabolism ; Drug Resistance, Neoplasm ; Pancreatic Neoplasms/pathology ; Tumor Microenvironment ; Pancreatic Neoplasms
    Sprache Englisch
    Erscheinungsdatum 2022-05-19
    Erscheinungsland United States
    Dokumenttyp Journal Article ; Review ; Research Support, Non-U.S. Gov't
    ZDB-ID 2659751-2
    ISSN 2045-7634 ; 2045-7634
    ISSN (online) 2045-7634
    ISSN 2045-7634
    DOI 10.1002/cam4.4830
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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