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Article ; Online: Clinical Effect of Intrauterine 3-Dimensional Ultrasound on the Function of the Intrauterine Cavity of Puerpera With Intrauterine Adhesions and Safety of Pregnancy.

Li, Qin

2022 Volume 38, Issue 4, Page(s) 267–271

Abstract: Abstract: This study aimed to analyze the diagnostic value of intrauterine 3-dimensional ultrasound and the functional characteristics of the intrauterine cavity for puerpera with intrauterine adhesions, and to explore the safety of pregnancy after ... ...

Abstract	Abstract: This study aimed to analyze the diagnostic value of intrauterine 3-dimensional ultrasound and the functional characteristics of the intrauterine cavity for puerpera with intrauterine adhesions, and to explore the safety of pregnancy after treatment. A total of 102 puerperas with intrauterine adhesions were randomly selected, and intrauterine 3-dimensional ultrasound and 2-dimensional ultrasound were performed, respectively. Patients were followed up for 3 years to observe the pregnancy outcome and safety. The overall accuracy of diagnosing intrauterine adhesions through intrauterine 3-dimensional ultrasound was significantly higher than that through 2-dimensional ultrasound, and the accuracy of detecting mild intrauterine adhesions was significantly higher than that through 2-dimensional ultrasound, with statistically significant difference ( P < 0.05). There was no significant difference in the accuracy between intrauterine 3-dimensional and 2-dimensional ultrasound in detecting moderate and severe intrauterine adhesions ( P > 0.05). The difference in missed diagnosis and misdiagnosis rates between the 2 methods was statistically significant ( P < 0.05). All patients received hysteroscopic surgery, and 78 cases (76.47%) were naturally fertilized during postoperative follow-up, including 24 cases of mature delivery, 45 cases of cesarean delivery, and 9 cases of spontaneous abortion. The intrauterine 3-dimensional ultrasound examination of the intrauterine cavity will provide intuitive and comprehensive diagnostic information for a parturient with intrauterine adhesion. Its detection accuracy is higher, and the clinical application is noninvasive and safe, which has certain guiding significance for treatment.
MeSH term(s)	Female ; Humans ; Pregnancy ; Uterine Diseases ; Tissue Adhesions/diagnostic imaging ; Tissue Adhesions/surgery ; Hysteroscopy/methods ; Uterus/diagnostic imaging ; Pregnancy Outcome
Language	English
Publishing date	2022-04-16
Publishing country	United States
Document type	Journal Article
ZDB-ID	645107-x
ISSN	1536-0253 ; 0894-8771
ISSN (online)	1536-0253
ISSN	0894-8771
DOI	10.1097/RUQ.0000000000000607
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Article ; Online: Analytical Study of Financial Accounting and Management Trends Based on the Internet Era.

Li, Qin

publication RETRACTED

Computational intelligence and neuroscience

2022 Volume 2022, Page(s) 5922614

Abstract: With the development of Internet technology and computer technology, the network has provided convenience to enterprises while putting forward new requirements for the development of the accounting industry. The combination of traditional financial ... ...

Abstract	With the development of Internet technology and computer technology, the network has provided convenience to enterprises while putting forward new requirements for the development of the accounting industry. The combination of traditional financial accounting methods and computerized information technology enables accurate and rapid transmission of financial data. At the same time, the application of network technology optimizes the financial accounting process of enterprises and greatly improves the efficiency of accounting work and accountants can devote more time and energy to the analysis of enterprise financial information. However, with the application of Internet technology, the change in financial accounting has also generated new problems. The article focuses on the topic of financial accounting; first, it briefly introduces the development history of financial accounting and the Internet; second, it discusses the changes in accounting work mode and its characteristics under the network environment and analyzes the advantages and problems of combining network technology and financial accounting; and finally, it puts forward the countermeasures to solve the "Internet+" era financial accounting work for the current situation. Finally, the countermeasures to solve the financial accounting work in the era of "Internet+" are proposed to improve the professional ability of financial personnel.
MeSH term(s)	Industry ; Internet ; Technology
Language	English
Publishing date	2022-08-22
Publishing country	United States
Document type	Journal Article ; Retracted Publication
ZDB-ID	2388208-6
ISSN	1687-5273 ; 1687-5273
ISSN (online)	1687-5273
ISSN	1687-5273
DOI	10.1155/2022/5922614
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Article ; Online: NGF contributes to activities of acid-sensing ion channels in dorsal root ganglion neurons of male rats with experimental peripheral artery disease.

Li, Qin / Li, Jianhua

Physiological reports

2024 Volume 12, Issue 3, Page(s) e15933

Abstract: A feature of peripheral artery diseases (PAD) includes limb ischemia/reperfusion (I/R) and ischemia. Both I/R and ischemia amplify muscle afferent nerve-activated reflex sympathetic nervous and blood pressure responses (termed as exercise pressor reflex). ...

Abstract	A feature of peripheral artery diseases (PAD) includes limb ischemia/reperfusion (I/R) and ischemia. Both I/R and ischemia amplify muscle afferent nerve-activated reflex sympathetic nervous and blood pressure responses (termed as exercise pressor reflex). Nevertheless, the underlying mechanisms responsible for the exaggerated autonomic responses in PAD are undetermined. Previous studies suggest that acid-sensing ion channels (ASICs) in muscle dorsal root ganglion (DRG) play a leading role in regulating the exercise pressor reflex in PAD. Thus, we determined if signaling pathways of nerve growth factor (NGF) contribute to the activities of ASICs in muscle DRG neurons of PAD. In particular, we examined ASIC1a and ASIC3 currents in isolectin B
MeSH term(s)	Animals ; Male ; Rats ; Acid Sensing Ion Channels/metabolism ; Femoral Artery/metabolism ; Ganglia, Spinal/metabolism ; Ischemia/metabolism ; Muscle, Skeletal/metabolism ; Nerve Growth Factor/metabolism ; NF-kappa B/metabolism ; Peripheral Arterial Disease ; Rats, Sprague-Dawley ; Sensory Receptor Cells/metabolism
Chemical Substances	Acid Sensing Ion Channels ; Nerve Growth Factor (9061-61-4) ; NF-kappa B
Language	English
Publishing date	2024-02-03
Publishing country	United States
Document type	Journal Article
ZDB-ID	2724325-4
ISSN	2051-817X ; 2051-817X
ISSN (online)	2051-817X
ISSN	2051-817X
DOI	10.14814/phy2.15933
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Article: Long-term complete response to anti-programmed-death-1 monotherapy in a patient with relapsed and refractory ovarian adenocarcinoma: A case report.

Zhou, Guang-Di / Li, Qin

World journal of clinical cases

2024 Volume 12, Issue 11, Page(s) 1967–1973

Abstract: Background: Ovarian cancer is the most common malignant tumor of the female reproductive system, and the survival rate of patients with relapsed and refractory ovarian cancer is very low.: Case summary: Here, we report a case of high-grade serous ... ...

Abstract	Background: Ovarian cancer is the most common malignant tumor of the female reproductive system, and the survival rate of patients with relapsed and refractory ovarian cancer is very low. Case summary: Here, we report a case of high-grade serous papillary adenocarcinoma of the ovary that was successfully treated with immunotherapy. Radical surgery and adjuvant chemotherapy for the 56-year-old patient were successful; however, her tumor relapsed. Subsequent second-line chemotherapy, targeted agents, and other treatments were ineffective, as the tumor continued to recur and metastasize. Anti-programmed cell death-1 (PD-1) monotherapy (tislelizumab) completely alleviated the tumor, and the multiple metastatic tumors disappeared. To date, the patient has used anti-PD-1 for 32 months, experiencing no disease progression and maintaining good health without additional treatment. Conclusion: This case suggests that anti-PD-1 immunotherapy may have long-term positive effects on outcomes in some refractory recurrent solid tumors. Further research is needed to identify patients most likely to respond to anti-PD-1 therapy.
Language	English
Publishing date	2024-04-10
Publishing country	United States
Document type	Case Reports
ISSN	2307-8960
ISSN	2307-8960
DOI	10.12998/wjcc.v12.i11.1967
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Article ; Online: Research on Discrete Dynamic Forecasting Model of Government Human Resources

Li Qin

E3S Web of Conferences, Vol 214, p

2020 Volume 02011

Abstract: For the evolution of complex system, especially the unbalanced complex system, dynamic is its universal attribute. In this paper, by introducing the discrete dynamic system model in complex system research, a method of establishing the discrete dynamic ... ...

Abstract	For the evolution of complex system, especially the unbalanced complex system, dynamic is its universal attribute. In this paper, by introducing the discrete dynamic system model in complex system research, a method of establishing the discrete dynamic system model of government human resources system is proposed from the vertical level. In this study, human resources were forecasted by the method of manpower/population ratio, linear regression and grey system, and the total number of health human resources in A city from 2018 to 2022 was forecasted by weighted average combination method. The results show that we should make great efforts to innovate the training mode of health personnel, improve the enthusiasm of staff, and reasonably control the expansion of hospitals.
Keywords	Environmental sciences ; GE1-350
Language	English
Publishing date	2020-01-01T00:00:00Z
Publisher	EDP Sciences
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article: The Role of Pyroptosis in the Pathogenesis of Kidney Diseases.

Zhou, Zhuanli / Li, Qin

Kidney diseases (Basel, Switzerland)

2023 Volume 9, Issue 6, Page(s) 443–458

Abstract: Background: Recently, in addition to apoptosis and necrosis, several other forms of cell death have been discovered, such as necroptosis, autophagy, pyroptosis, and ferroptosis. These cell death modalities play diverse roles in kidney diseases. ... ...

Abstract	Background: Recently, in addition to apoptosis and necrosis, several other forms of cell death have been discovered, such as necroptosis, autophagy, pyroptosis, and ferroptosis. These cell death modalities play diverse roles in kidney diseases. Pyroptosis is a newly described type of proinflammatory programmed necrosis. Further exploring pyroptosis is helpful to slow the progression of kidney diseases and reduce their complications. Summary: Pyroptosis is mainly mediated by the cleavage of gasdermin D (GSDMD) along with downstream inflammasome activation. Activated caspase-1 induces the release of cytokines by cleaving GSDMD. Inflammation is a major pathogenic mechanism for kidney diseases. Increasing evidence corroborated that pyroptosis was closely related to the progression of renal diseases, including acute kidney injury, renal fibrosis, diabetic nephropathy, and kidney cancer. In this paper, we reviewed the role and the therapeutic treatment of pyroptosis in renal diseases. Key messages: The better understanding of the progress and new intervention approaches of pyroptosis in kidney diseases may pave the way for new therapeutic opportunities in clinical practice.
Language	English
Publishing date	2023-06-24
Publishing country	Switzerland
Document type	Journal Article ; Review
ZDB-ID	2817963-8
ISSN	2296-9357 ; 2296-9381
ISSN (online)	2296-9357
ISSN	2296-9381
DOI	10.1159/000531642
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Article ; Online: Promoting Effects of the Exercise Behavioral Ecological Model on Physical Activity Behaviors of Students.

Wang, Junmin / Li, Qin

American journal of health behavior

2023 Volume 47, Issue 1, Page(s) 109–115

Abstract: Objectives: ...

Abstract	Objectives:
MeSH term(s)	Adolescent ; Humans ; Exercise ; Sedentary Behavior ; Adolescent Behavior ; Risk Factors ; Students/psychology
Language	English
Publishing date	2023-03-21
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	1312417-1
ISSN	1945-7359 ; 1087-3244 ; 0147-0353
ISSN (online)	1945-7359
ISSN	1087-3244 ; 0147-0353
DOI	10.5993/AJHB.47.1.12
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Article ; Online: ESRRB Inhibits the TGFβ Signaling Pathway to Drive Cell Proliferation in Cervical Cancer.

Li, Qin-Shu / Zheng, Peng-Sheng

Cancer research

2023 Volume 83, Issue 18, Page(s) 3095–3114

Abstract: Estrogen-related receptor β (ESRRB) is a member of the orphan nuclear receptor family and mediates stem cell self-renewal and early embryonic development. Previous studies have also reported that ESRRB plays a role in the development and progression of ... ...

Abstract	Estrogen-related receptor β (ESRRB) is a member of the orphan nuclear receptor family and mediates stem cell self-renewal and early embryonic development. Previous studies have also reported that ESRRB plays a role in the development and progression of breast cancer and prostate cancer. In this study, we observed that ESRRB was highly expressed in cervical cancer and was associated with disease progression. Knocking out ESRRB using CRISPR/Cas9 gene editing in cervical cancer cells induced cell-cycle arrest at the transition from the G0-G1 phase to the S phase, resulting in inhibition of cell proliferation in vitro and reduced tumor growth in vivo. Conversely, ectopic expression of ESRRB significantly promoted the proliferation of cervical cancer cells. ESRRB activated transcription of SMAD7, a TGFβ pathway inhibitor, which blocked phosphorylation and nuclear translocation of SMAD2/3 to the nucleus, thereby downregulating CDKN1A and upregulating CCNA2 and MYC. In turn, MYC transactivated ESRRB and upregulated SMAD7, thus forming a positive feedback loop with ESRRB. Together, these findings identify the tumor-promoting function of ESRRB in cervical cancer and reveal a mechanism by which ESRRB stimulates cell proliferation to promote cancer progression. Significance: The ESRRB/SMAD7/MYC-positive feedback loop inhibits TGFβ signaling to activate cell-cycle progression and promote proliferation in cervical cancer, thereby driving tumor growth.
MeSH term(s)	Female ; Humans ; Cell Proliferation ; Receptors, Estrogen ; Signal Transduction ; Transforming Growth Factor beta ; Uterine Cervical Neoplasms/genetics
Chemical Substances	ESRRB protein, human ; Receptors, Estrogen ; Transforming Growth Factor beta
Language	English
Publishing date	2023-06-22
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	1432-1
ISSN	1538-7445 ; 0008-5472
ISSN (online)	1538-7445
ISSN	0008-5472
DOI	10.1158/0008-5472.CAN-23-0067
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Article: Research on eight machine learning algorithms applicability on different characteristics data sets in medical classification tasks.

Zhang, Yiyan / Li, Qin / Xin, Yi

Frontiers in computational neuroscience

2024 Volume 18, Page(s) 1345575

Abstract: With the vigorous development of data mining field, more and more algorithms have been proposed or improved. How to quickly select a data mining algorithm that is suitable for data sets in medical field is a challenge for some medical workers. The ... ...

Abstract	With the vigorous development of data mining field, more and more algorithms have been proposed or improved. How to quickly select a data mining algorithm that is suitable for data sets in medical field is a challenge for some medical workers. The purpose of this paper is to study the comparative characteristics of the general medical data set and the general data sets in other fields, and find the applicability rules of the data mining algorithm suitable for the characteristics of the current research data set. The study quantified characteristics of the research data set with 26 indicators, including simple indicators, statistical indicators and information theory indicators. Eight machine learning algorithms with high maturity, low user involvement and strong family representation were selected as the base algorithms. The algorithm performances were evaluated by three aspects: prediction accuracy, running speed and memory consumption. By constructing decision tree and stepwise regression model to learn the above metadata, the algorithm applicability knowledge of medical data set is obtained. Through cross-verification, the accuracy of all the algorithm applicability prediction models is above 75%, which proves the validity and feasibility of the applicability knowledge.
Language	English
Publishing date	2024-01-31
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2452964-3
ISSN	1662-5188
ISSN	1662-5188
DOI	10.3389/fncom.2024.1345575
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Article ; Online: Amplified P2X

Qin, Lu / Li, Qin / Li, Jianhua

Experimental physiology

2024 Volume 109, Issue 4, Page(s) 524–534

Abstract: Hindlimb ischaemia-reperfusion (IR) is among the most prominent pathophysiological conditions observed in peripheral artery disease (PAD). An exaggerated arterial blood pressure (BP) response during exercise is associated with an elevated risk of ... ...

Abstract	Hindlimb ischaemia-reperfusion (IR) is among the most prominent pathophysiological conditions observed in peripheral artery disease (PAD). An exaggerated arterial blood pressure (BP) response during exercise is associated with an elevated risk of cardiovascular events in individuals with PAD. However, the precise mechanisms leading to this exaggerated BP response are poorly elucidated. The P2X
MeSH term(s)	Rats ; Animals ; Ganglia, Spinal/metabolism ; Rats, Sprague-Dawley ; Neurons, Afferent/physiology ; Reflex ; Neurons/metabolism ; Muscle, Skeletal/metabolism ; Ischemia/metabolism ; Hindlimb/metabolism ; Receptors, Purinergic P2X3/metabolism ; Phenols ; Polycyclic Compounds
Chemical Substances	A-317491 ; Receptors, Purinergic P2X3 ; Phenols ; Polycyclic Compounds
Language	English
Publishing date	2024-01-11
Publishing country	England
Document type	Journal Article
ZDB-ID	1016295-1
ISSN	1469-445X ; 0958-0670
ISSN (online)	1469-445X
ISSN	0958-0670
DOI	10.1113/EP091616
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